LOCUS       NM_005354               1929 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens JunD proto-oncogene, AP-1 transcription factor subunit
            (JUND), transcript variant 1, mRNA.
ACCESSION   NM_005354
VERSION     NM_005354.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Schnoegl,D., Hiesinger,A., Huntington,N.D. and Gotthardt,D.
  TITLE     AP-1 transcription factors in cytotoxic lymphocyte development and
            antitumor immunity
  JOURNAL   Curr Opin Immunol 85, 102397 (2023)
   PUBMED   37931499
  REMARK    GeneRIF: AP-1 transcription factors in cytotoxic lymphocyte
            development and antitumor immunity.
            Review article
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Chang,Y., Chen,L., Tang,J., Chen,G., Ji,J. and Xu,M.
  TITLE     USP7-mediated JUND suppresses RCAN2 transcription and elevates
            NFATC1 to enhance stem cell property in colorectal cancer
  JOURNAL   Cell Biol Toxicol 39 (6), 3121-3140 (2023)
   PUBMED   37535148
  REMARK    GeneRIF: USP7-mediated JUND suppresses RCAN2 transcription and
            elevates NFATC1 to enhance stem cell property in colorectal cancer.
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Zhang,D., Pan,G., Cheng,N., Sun,L., Zhou,X., Li,C. and Zhao,J.
  TITLE     JUND facilitates proliferation and angiogenesis of esophageal
            squamous cell carcinoma cell via MAPRE2 up-regulation
  JOURNAL   Tissue Cell 81, 102010 (2023)
   PUBMED   36608637
  REMARK    GeneRIF: JUND facilitates proliferation and angiogenesis of
            esophageal squamous cell carcinoma cell via MAPRE2 up-regulation.
REFERENCE   4  (bases 1 to 1929)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1929)
  AUTHORS   Short,J.D. and Pfarr,C.M.
  TITLE     Translational regulation of the JunD messenger RNA
  JOURNAL   J Biol Chem 277 (36), 32697-32705 (2002)
   PUBMED   12105216
  REMARK    GeneRIF: Translation initiation from alternative AUG and non-AUG
            sites in human, mouse and rat.
REFERENCE   7  (bases 1 to 1929)
  AUTHORS   Franklin,C.C., McCulloch,A.V. and Kraft,A.S.
  TITLE     In vitro association between the Jun protein family and the general
            transcription factors, TBP and TFIIB
  JOURNAL   Biochem J 305 (Pt 3) (Pt 3), 967-974 (1995)
   PUBMED   7848298
REFERENCE   8  (bases 1 to 1929)
  AUTHORS   Berger,I. and Shaul,Y.
  TITLE     Structure and function of human jun-D
  JOURNAL   Oncogene 6 (4), 561-566 (1991)
   PUBMED   1903194
REFERENCE   9  (bases 1 to 1929)
  AUTHORS   Mollinedo,F., Vaquerizo,M.J. and Naranjo,J.R.
  TITLE     Expression of c-jun, jun B and jun D proto-oncogenes in human
            peripheral-blood granulocytes
  JOURNAL   Biochem J 273(Pt 2) (Pt 2), 477-479 (1991)
   PUBMED   1899335
REFERENCE   10 (bases 1 to 1929)
  AUTHORS   Nomura,N., Ide,M., Sasamoto,S., Matsui,M., Date,T. and Ishizaki,R.
  TITLE     Isolation of human cDNA clones of jun-related genes, jun-B and
            jun-D
  JOURNAL   Nucleic Acids Res 18 (10), 3047-3048 (1990)
   PUBMED   2112242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK223630.1, CB050506.1,
            BQ130444.1 and AW027337.1.
            
            On May 17, 2019 this sequence version replaced NM_005354.5.
            
            Summary: The protein encoded by this intronless gene is a member of
            the JUN family, and a functional component of the AP1 transcription
            factor complex. This protein has been proposed to protect cells
            from p53-dependent senescence and apoptosis. Alternative
            translation initiation site usage results in the production of
            different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) encodes two isoforms resulting
            from the use of alternative in-frame translation initiation codons.
            The longer isoform (JunD-FL) is derived from an upstream AUG (S1
            ORF, PMID:12105216), while the shorter isoform (deltaJunD) is
            derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq
            represents the longer isoform (JunD-FL).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK223630.1, SRR1163657.559005.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252818.5/ ENSP00000252818.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1345              AK223630.1         1-1345
            1346-1439           CB050506.1         360-453
            1440-1863           BQ130444.1         15-438              c
            1864-1929           AW027337.1         408-473
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1929
                     /gene="JUND"
                     /gene_synonym="AP-1"
                     /note="JunD proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:3727"
                     /db_xref="HGNC:HGNC:6206"
                     /db_xref="MIM:165162"
     exon            1..1929
                     /gene="JUND"
                     /gene_synonym="AP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1182
                     /gene="JUND"
                     /gene_synonym="AP-1"
                     /note="isoform JunD-FL is encoded by transcript variant 1;
                     transcription factor jun-D; activator protein 1; jun D
                     proto-oncogene; transcription factor AP-1 subunit JunD;
                     transcription factor JunD"
                     /codon_start=1
                     /product="transcription factor JunD isoform JunD-FL"
                     /protein_id="NP_005345.3"
                     /db_xref="CCDS:CCDS32959.1"
                     /db_xref="GeneID:3727"
                     /db_xref="HGNC:HGNC:6206"
                     /db_xref="MIM:165162"
                     /translation="METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSM
                     MKKDALTLSLSEQVAAALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGLLKLASPE
                     LERLIIQSNGLVTTTPTSSQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGAAAA
                     AAAAAAGGPSGTATGSAPPGELAPAAAAPEAPVYANLSSYAGGAGGAGGAATVAFAAE
                     PVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRL
                     RNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNS
                     GCQLLPQHQVPAY"
     regulatory      1844..1849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JUND"
                     /gene_synonym="AP-1"
                     /note="hexamer: AGTAAA"
     polyA_site      1863
                     /gene="JUND"
                     /gene_synonym="AP-1"
                     /note="major polyA site"
ORIGIN      
        1 aggagccgcc gccagtggag ggccgggcgc tgcggccgcg gccggggcgg gcgcagggcc
       61 gagcggacgg gggggcgcgg gccccccggg aggccgcggc cactcccccc cgggccggcg
      121 cggcggggga ggcggaggat ggaaacaccc ttctacggcg atgaggcgct gagcggcctg
      181 ggcggcggcg ccagtggcag cggcggcagc ttcgcgtccc cgggccgctt gttccccggg
      241 gcgcccccga cggccgcggc cggcagcatg atgaagaagg acgcgctgac gctgagcctg
      301 agtgagcagg tggcggcagc gctcaagcct gcggccgcgc cgcctcctac ccccctgcgc
      361 gccgacggcg cccccagcgc ggcacccccc gacggcctgc tcgcctctcc cgacctgggg
      421 ctgctgaagc tggcctcccc cgagctcgag cgcctcatca tccagtccaa cgggctggtc
      481 accaccacgc cgacgagctc acagttcctc taccccaagg tggcggccag cgaggagcag
      541 gagttcgccg agggcttcgt caaggccctg gaggatttac acaagcagaa ccagctcggc
      601 gcgggcgcgg ccgctgccgc cgccgccgcc gccgccgggg ggccctcggg cacggccacg
      661 ggctccgcgc cccccggcga gctggccccg gcggcggccg cgcccgaagc gcctgtctac
      721 gcgaacctga gcagctacgc gggcggcgcc gggggcgcgg ggggcgccgc gacggtcgcc
      781 ttcgctgccg aacctgtgcc cttcccgccg ccgccacccc caggcgcgtt ggggccgccg
      841 cgcctggctg cgctcaagga cgagccacag acggtgcccg acgtgccgag cttcggcgag
      901 agcccgccgt tgtcgcccat cgacatggac acgcaggagc gcatcaaggc ggagcgcaag
      961 cggctgcgca accgcatcgc cgcctccaag tgccgcaagc gcaagctgga gcgcatctcg
     1021 cgcctggaag agaaagtgaa gaccctcaag agtcagaaca cggagctggc gtccacggcg
     1081 agcctgctgc gcgagcaggt ggcgcagctc aagcagaaag tcctcagcca cgtcaacagc
     1141 ggctgccagc tgctgcccca gcaccaggtg cccgcgtact gagtccgcgc gcggggcgca
     1201 tgcgcggcca ccctccccaa ggggcgggct cgcggggggg tgtcgtgggc gccccggact
     1261 tggagagggt gcggccctgg ggaccccccc tccccgagtg tgcccaggaa ctcagagagg
     1321 gcgcggcccc cggggattcc ccccccccga gggtgcccag gactcgacaa gctggacccc
     1381 ctgctcccgg gggggcgagc gcatgacccc cccgccctcg cgctgcctct ttcccccgcg
     1441 cggccgcccc gtgttgcaca aacccgcgcg tctcggctgc ccctttgtac accgcgccgc
     1501 ggaagggggc tccgaggggg cgcagcctca aaccctgcct ttcctttact tttacttttt
     1561 tttttttttc tttggaagag agaagaacag agtgttcgat tctgccctat ttatgtttct
     1621 actcgggaac aaacgttggt tgtgtgtgtg tgtgttttct tgtgttggtt ttttaaagaa
     1681 atgggaagaa gaaaaaaaaa ttctccgccc ctttcctcga tctcgctccc cccttcggtt
     1741 ctttcgaccg gtcccccctc ccttttttgt tctgttttgt tttgttttgc tacgagtcca
     1801 cattcctgtt tgtaatcctt ggttcgcccg gttttctgtt ttcagtaaag tctcgttacg
     1861 ccagctcggc tctccgcctc cttcttcccc cgccggggcc tggcgggctg ggcggggcct
     1921 ggttcgctt
//
