LOCUS       NM_002229               1830 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens JunB proto-oncogene, AP-1 transcription factor subunit
            (JUNB), mRNA.
ACCESSION   NM_002229
VERSION     NM_002229.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Lind,J., Aksoy,O., Prchal-Murphy,M., Fan,F., Fulciniti,M.,
            Stoiber,D., Bakiri,L., Wagner,E.F., Zwickl-Traxler,E., Sattler,M.,
            Kollmann,K., Vallet,S. and Podar,K.
  TITLE     Dual therapeutic targeting of MYC and JUNB transcriptional programs
            for enhanced anti-myeloma activity
  JOURNAL   Blood Cancer J 14 (1), 138 (2024)
   PUBMED   39160158
  REMARK    GeneRIF: Dual therapeutic targeting of MYC and JUNB transcriptional
            programs for enhanced anti-myeloma activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Roumeliotou,A., Strati,A., Chamchougia,F., Xagara,A., Tserpeli,V.,
            Smilkou,S., Lagopodi,E., Christopoulou,A., Kontopodis,E.,
            Drositis,I., Androulakis,N., Georgoulias,V., Koinis,F.,
            Kotsakis,A., Lianidou,E. and Kallergi,G.
  TITLE     Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in
            Circulating Tumor Cells (CTCs) from Prostate Cancer Patients
  JOURNAL   Cells 13 (9), 782 (2024)
   PUBMED   38727318
  REMARK    GeneRIF: Comprehensive Analysis of CXCR4, JUNB, and PD-L1
            Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer
            Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Ren,X., Cui,Z., Zhang,Q., Su,Z., Xu,W., Wu,J. and Jiang,H.
  TITLE     JunB condensation attenuates vascular endothelial damage under
            hyperglycemic condition
  JOURNAL   J Mol Cell Biol 15 (12) (2024)
   PUBMED   38140943
  REMARK    GeneRIF: JunB condensation attenuates vascular endothelial damage
            under hyperglycemic condition.
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Luo,Y., Luo,J., An,P., Zhao,Y., Zhao,W., Fang,Z., Xia,Y., Zhu,L.,
            Xu,T., Zhang,X., Zhou,S., Yang,M., Li,J., Zhu,J., Liu,Y., Li,H.,
            Gong,M., Liu,Y., Han,J., Guo,H., Zhang,H., Jiang,W. and Ren,F.
  TITLE     The activator protein-1 complex governs a vascular degenerative
            transcriptional programme in smooth muscle cells to trigger aortic
            dissection and rupture
  JOURNAL   Eur Heart J 45 (4), 287-305 (2024)
   PUBMED   37992083
  REMARK    GeneRIF: The activator protein-1 complex governs a vascular
            degenerative transcriptional programme in smooth muscle cells to
            trigger aortic dissection and rupture.
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Whitehead,A.J., Atcha,H., Hocker,J.D., Ren,B. and Engler,A.J.
  TITLE     AP-1 signaling modulates cardiac fibroblast stress responses
  JOURNAL   J Cell Sci 136 (23) (2023)
   PUBMED   37994565
  REMARK    GeneRIF: AP-1 signaling modulates cardiac fibroblast stress
            responses.
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Hsu,J.C., Bravo,R. and Taub,R.
  TITLE     Interactions among LRF-1, JunB, c-Jun, and c-Fos define a
            regulatory program in the G1 phase of liver regeneration
  JOURNAL   Mol Cell Biol 12 (10), 4654-4665 (1992)
   PUBMED   1406655
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Zafarullah,M., Martel-Pelletier,J., Cloutier,J.M., Gedamu,L. and
            Pelletier,J.P.
  TITLE     Expression of c-fos, c-jun, jun-B, metallothionein and
            metalloproteinase genes in human chondrocyte
  JOURNAL   FEBS Lett 306 (2-3), 169-172 (1992)
   PUBMED   1633872
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Mollinedo,F., Vaquerizo,M.J. and Naranjo,J.R.
  TITLE     Expression of c-jun, jun B and jun D proto-oncogenes in human
            peripheral-blood granulocytes
  JOURNAL   Biochem J 273(Pt 2) (Pt 2), 477-479 (1991)
   PUBMED   1899335
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Nomura,N., Ide,M., Sasamoto,S., Matsui,M., Date,T. and Ishizaki,R.
  TITLE     Isolation of human cDNA clones of jun-related genes, jun-B and
            jun-D
  JOURNAL   Nucleic Acids Res 18 (10), 3047-3048 (1990)
   PUBMED   2112242
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Schutte,J., Viallet,J., Nau,M., Segal,S., Fedorko,J. and Minna,J.
  TITLE     jun-B inhibits and c-fos stimulates the transforming and
            trans-activating activities of c-jun
  JOURNAL   Cell 59 (6), 987-997 (1989)
   PUBMED   2513129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018761.6 and BC009466.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002229.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.470646.1, SRR7346977.94962.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302754.6/ ENSP00000303315.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC018761.6         136205-136214
            11-1826             BC009466.1         1-1816
            1827-1830           AC018761.6         138031-138034
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1830
                     /gene="JUNB"
                     /gene_synonym="AP-1"
                     /note="JunB proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:3726"
                     /db_xref="HGNC:HGNC:6205"
                     /db_xref="MIM:165161"
     exon            1..1830
                     /gene="JUNB"
                     /gene_synonym="AP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1330
                     /gene="JUNB"
                     /gene_synonym="AP-1"
                     /note="activator protein 1; transcription factor jun-B;
                     jun B proto-oncogene; transcription factor AP-1 subunit
                     JunB"
                     /codon_start=1
                     /product="transcription factor JunB"
                     /protein_id="NP_002220.1"
                     /db_xref="CCDS:CCDS12280.1"
                     /db_xref="GeneID:3726"
                     /db_xref="HGNC:HGNC:6205"
                     /db_xref="MIM:165161"
                     /translation="MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLA
                     DPYRSLKAPGARGPGPEGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTT
                     PTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLG
                     ATGGPPAGPGGVYAGPEPPPVYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPH
                     APPFAGGHPAQLGLGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRL
                     RNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSN
                     GCQLLLGVKGHAF"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JUNB"
                     /gene_synonym="AP-1"
                     /note="hexamer: AGTAAA"
     polyA_site      1830
                     /gene="JUNB"
                     /gene_synonym="AP-1"
                     /note="major polyA site"
ORIGIN      
        1 gggaccttga gagcggccag gccagcctcg gagccagcag ggagctggga gctgggggaa
       61 acgacgccag gaaagctatc gcgccagaga gggcgacggg ggctcgggaa gcctgacagg
      121 gcttttgcgc acagctgccg gctggctgct acccgcccgc gccagccccc gagaacgcgc
      181 gaccaggcac ccagtccggt caccgcagcg gagagctcgc cgctcgctgc agcgaggccc
      241 ggagcggccc cgcagggacc ctccccagac cgcctgggcc gcccggatgt gcactaaaat
      301 ggaacagccc ttctaccacg acgactcata cacagctacg ggatacggcc gggcccctgg
      361 tggcctctct ctacacgact acaaactcct gaaaccgagc ctggcggtca acctggccga
      421 cccctaccgg agtctcaaag cgcctggggc tcgcggaccc ggcccagagg gcggcggtgg
      481 cggcagctac ttttctggtc agggctcgga caccggcgcg tctctcaagc tcgcctcttc
      541 ggagctggaa cgcctgattg tccccaacag caacggcgtg atcacgacga cgcctacacc
      601 cccgggacag tacttttacc cccgcggggg tggcagcggt ggaggtgcag ggggcgcagg
      661 gggcggcgtc accgaggagc aggagggctt cgccgacggc tttgtcaaag ccctggacga
      721 tctgcacaag atgaaccacg tgacaccccc caacgtgtcc ctgggcgcta ccggggggcc
      781 cccggctggg cccgggggcg tctacgccgg cccggagcca cctcccgttt acaccaacct
      841 cagcagctac tccccagcct ctgcgtcctc gggaggcgcc ggggctgccg tcgggaccgg
      901 gagctcgtac ccgacgacca ccatcagcta cctcccacac gcgccgccct tcgccggtgg
      961 ccacccggcg cagctgggct tgggccgcgg cgcctccacc ttcaaggagg aaccgcagac
     1021 cgtgccggag gcgcgcagcc gggacgccac gccgccggtg tcccccatca acatggaaga
     1081 ccaagagcgc atcaaagtgg agcgcaagcg gctgcggaac cggctggcgg ccaccaagtg
     1141 ccggaagcgg aagctggagc gcatcgcgcg cctggaggac aaggtgaaga cgctcaaggc
     1201 cgagaacgcg gggctgtcga gtaccgccgg cctcctccgg gagcaggtgg cccagctcaa
     1261 acagaaggtc atgacccacg tcagcaacgg ctgtcagctg ctgcttgggg tcaagggaca
     1321 cgccttctga acgtcccctg cccctttacg gacaccccct cgcttggacg gctgggcaca
     1381 cgcctcccac tggggtccag ggagcaggcg gtgggcaccc accctgggac ctaggggcgc
     1441 cgcaaaccac actggactcc ggccctccta ccctgcgccc agtccttcca cctcgacgtt
     1501 tacaagcccc cccttccact tttttttgta tgtttttttt ctgctggaaa cagactcgat
     1561 tcatattgaa tataatatat ttgtgtattt aacagggagg ggaagagggg gcgatcgcgg
     1621 cggagctggc cccgccgcct ggtactcaag cccgcgggga cattgggaag gggacccccg
     1681 ccccctgccc tcccctctct gcaccgtact gtggaaaaga aacacgcact tagtctctaa
     1741 agagtttatt ttaagacgtg tttgtgtttg tgtgtgtttg ttctttttat tgaatctatt
     1801 taagtaaaaa aaaaattggt tctttattaa
//
