LOCUS       NM_002228               3257 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens Jun proto-oncogene, AP-1 transcription factor subunit
            (JUN), mRNA.
ACCESSION   NM_002228 XM_002342087 XM_002345343 XM_002346389
VERSION     NM_002228.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Kurlishchuk,Y., Cindric Vranesic,A., Jessen,M., Kipping,A.,
            Ritter,C., Kim,K., Cramer,P. and von Eyss,B.
  TITLE     A non-canonical repressor function of JUN restrains YAP activity
            and liver cancer growth
  JOURNAL   EMBO J 43 (20), 4578-4603 (2024)
   PUBMED   39210147
  REMARK    GeneRIF: A non-canonical repressor function of JUN restrains YAP
            activity and liver cancer growth.
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Khan,A.W., Aziz,M., Sourris,K.C., Lee,M.K.S., Dai,A.,
            Watson,A.M.D., Maxwell,S., Sharma,A., Zhou,Y., Cooper,M.E.,
            Calkin,A.C., Murphy,A.J., Baratchi,S. and Jandeleit-Dahm,K.A.M.
  TITLE     The Role of Activator Protein-1 Complex in Diabetes-Associated
            Atherosclerosis: Insights From Single-Cell RNA Sequencing
  JOURNAL   Diabetes 73 (9), 1495-1512 (2024)
   PUBMED   38905153
  REMARK    GeneRIF: The Role of Activator Protein-1 Complex in
            Diabetes-Associated Atherosclerosis: Insights From Single-Cell RNA
            Sequencing.
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Law,C., Wacleche,V.S., Cao,Y., Pillai,A., Sowerby,J., Hancock,B.,
            Horisberger,A., Bracero,S., Skidanova,V., Li,Z., Adejoorin,I.,
            Dillon,E., Benque,I.J., Nunez,D.P., Simmons,D.P., Keegan,J.,
            Chen,L., Baker,T., Brohawn,P.Z., Al-Mossawi,H., Hao,L.Y., Jones,B.,
            Rao,N., Qu,Y., Alves,S.E., Jonsson,A.H., Shaw,K.S., Vleugels,R.A.,
            Massarotti,E., Costenbader,K.H., Brenner,M.B., Lederer,J.A.,
            Hultquist,J.F., Choi,J. and Rao,D.A.
  CONSRTM   Accelerating Medicines Partnership: RA/SLE Network
  TITLE     Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in
            lupus
  JOURNAL   Nature 631 (8022), 857-866 (2024)
   PUBMED   38987586
  REMARK    GeneRIF: Interferon subverts an AHR-JUN axis to promote CXCL13[+] T
            cells in lupus.
            Erratum:[Nature. 2024 Aug;632(8025):E6. doi:
            10.1038/s41586-024-07845-8.. PMID: 39060417]
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Wang,Z., Townley,S.L., Zhang,S., Liu,M., Li,M., Labaf,M.,
            Patalano,S., Venkataramani,K., Siegfried,K.R., Macoska,J.A.,
            Han,D., Gao,S., Risbridger,G.P., Taylor,R.A., Lawrence,M.G.,
            He,H.H., Selth,L.A. and Cai,C.
  TITLE     FOXA2 rewires AP-1 for transcriptional reprogramming and lineage
            plasticity in prostate cancer
  JOURNAL   Nat Commun 15 (1), 4914 (2024)
   PUBMED   38851846
  REMARK    GeneRIF: FOXA2 rewires AP-1 for transcriptional reprogramming and
            lineage plasticity in prostate cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Hu,Q., Liu,Z., Liu,Y., Qiu,J., Zhang,X., Sun,J., Zhang,B. and
            Shi,H.
  TITLE     SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination
            and degradation of HBx in hepatocellular carcinoma
  JOURNAL   J Cell Mol Med 28 (11), e18484 (2024)
   PUBMED   38842124
  REMARK    GeneRIF: SIAH2 suppresses c-JUN pathway by promoting the
            polyubiquitination and degradation of HBx in hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Oehler,T. and Angel,P.
  TITLE     A common intermediary factor (p52/54) recognizing 'acidic
            blob'-type domains is required for transcriptional activation by
            the Jun proteins
  JOURNAL   Mol Cell Biol 12 (12), 5508-5515 (1992)
   PUBMED   1448082
  REMARK    Erratum:[Mol Cell Biol 1993 Mar;13(3):1981]
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Hsu,J.C., Bravo,R. and Taub,R.
  TITLE     Interactions among LRF-1, JunB, c-Jun, and c-Fos define a
            regulatory program in the G1 phase of liver regeneration
  JOURNAL   Mol Cell Biol 12 (10), 4654-4665 (1992)
   PUBMED   1406655
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Lin,A., Frost,J., Deng,T., Smeal,T., al-Alawi,N., Kikkawa,U.,
            Hunter,T., Brenner,D. and Karin,M.
  TITLE     Casein kinase II is a negative regulator of c-Jun DNA binding and
            AP-1 activity
  JOURNAL   Cell 70 (5), 777-789 (1992)
   PUBMED   1516134
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1423636]
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Bengal,E., Ransone,L., Scharfmann,R., Dwarki,V.J., Tapscott,S.J.,
            Weintraub,H. and Verma,I.M.
  TITLE     Functional antagonism between c-Jun and MyoD proteins: a direct
            physical association
  JOURNAL   Cell 68 (3), 507-519 (1992)
   PUBMED   1310896
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136985.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002228.3.
            
            Summary: This gene is the putative transforming gene of avian
            sarcoma virus 17. It encodes a protein which is highly similar to
            the viral protein, and which interacts directly with specific
            target DNA sequences to regulate gene expression. This gene is
            intronless and is mapped to 1p32-p31, a chromosomal region involved
            in both translocations and deletions in human malignancies.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC068522.1, CR541724.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371222.4/ ENSP00000360266.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3257              AL136985.11        67374-70630         c
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.1"
     gene            1..3257
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="Jun proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:3725"
                     /db_xref="HGNC:HGNC:6204"
                     /db_xref="MIM:165160"
     exon            1..3257
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /inference="alignment:Splign:2.1.0"
     CDS             978..1973
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="Jun activation domain binding protein; jun
                     oncogene; v-jun avian sarcoma virus 17 oncogene homolog;
                     transcription factor AP-1; activator protein 1;
                     enhancer-binding protein AP1; proto-oncogene c-Jun; v-jun
                     sarcoma virus 17 oncogene homolog; proto-oncogene cJun;
                     transcription factor AP-1 subunit Jun"
                     /codon_start=1
                     /product="transcription factor Jun"
                     /protein_id="NP_002219.1"
                     /db_xref="CCDS:CCDS610.1"
                     /db_xref="GeneID:3725"
                     /db_xref="HGNC:HGNC:6204"
                     /db_xref="MIM:165160"
                     /translation="MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLAD
                     PVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKN
                     VTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFS
                     ASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQ
                     HPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLER
                     IARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="major polyA site"
     regulatory      2710..2715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="hexamer: AATAAA"
     polyA_site      2728
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="major polyA site"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="hexamer: AATAAA"
     polyA_site      3257
                     /gene="JUN"
                     /gene_synonym="AP-1; AP1; c-Jun; cJUN; p39"
                     /note="major polyA site"
ORIGIN      
        1 gctcagagtt gcactgagtg tggctgaagc agcgaggcgg gagtggaggt gcgcggagtc
       61 aggcagacag acagacacag ccagccagcc aggtcggcag tatagtccga actgcaaatc
      121 ttattttctt ttcaccttct ctctaactgc ccagagctag cgcctgtggc tcccgggctg
      181 gtgtttcggg agtgtccaga gagcctggtc tccagccgcc cccgggagga gagccctgct
      241 gcccaggcgc tgttgacagc ggcggaaagc agcggtaccc acgcgcccgc cgggggaagt
      301 cggcgagcgg ctgcagcagc aaagaacttt cccggctggg aggaccggag acaagtggca
      361 gagtcccgga gccaactttt gcaagccttt cctgcgtctt aggcttctcc acggcggtaa
      421 agaccagaag gcggcggaga gccacgcaag agaagaagga cgtgcgctca gcttcgctcg
      481 caccggttgt tgaacttggg cgagcgcgag ccgcggctgc cgggcgcccc ctccccctag
      541 cagcggagga ggggacaagt cgtcggagtc cgggcggcca agacccgccg ccggccggcc
      601 actgcagggt ccgcactgat ccgctccgcg gggagagccg ctgctctggg aagtgagttc
      661 gcctgcggac tccgaggaac cgctgcgcac gaagagcgct cagtgagtga ccgcgacttt
      721 tcaaagccgg gtagcgcgcg cgagtcgaca agtaagagtg cgggaggcat cttaattaac
      781 cctgcgctcc ctggagcgag ctggtgagga gggcgcagcg gggacgacag ccagcgggtg
      841 cgtgcgctct tagagaaact ttccctgtca aaggctccgg ggggcgcggg tgtcccccgc
      901 ttgccacagc cctgttgcgg ccccgaaact tgtgcgcgca gcccaaacta acctcacgtg
      961 aagtgacgga ctgttctatg actgcaaaga tggaaacgac cttctatgac gatgccctca
     1021 acgcctcgtt cctcccgtcc gagagcggac cttatggcta cagtaacccc aagatcctga
     1081 aacagagcat gaccctgaac ctggccgacc cagtggggag cctgaagccg cacctccgcg
     1141 ccaagaactc ggacctcctc acctcgcccg acgtggggct gctcaagctg gcgtcgcccg
     1201 agctggagcg cctgataatc cagtccagca acgggcacat caccaccacg ccgaccccca
     1261 cccagttcct gtgccccaag aacgtgacag atgagcagga gggcttcgcc gagggcttcg
     1321 tgcgcgccct ggccgaactg cacagccaga acacgctgcc cagcgtcacg tcggcggcgc
     1381 agccggtcaa cggggcaggc atggtggctc ccgcggtagc ctcggtggca gggggcagcg
     1441 gcagcggcgg cttcagcgcc agcctgcaca gcgagccgcc ggtctacgca aacctcagca
     1501 acttcaaccc aggcgcgctg agcagcggcg gcggggcgcc ctcctacggc gcggccggcc
     1561 tggcctttcc cgcgcaaccc cagcagcagc agcagccgcc gcaccacctg ccccagcaga
     1621 tgcccgtgca gcacccgcgg ctgcaggccc tgaaggagga gcctcagaca gtgcccgaga
     1681 tgcccggcga gacaccgccc ctgtccccca tcgacatgga gtcccaggag cggatcaagg
     1741 cggagaggaa gcgcatgagg aaccgcatcg ctgcctccaa gtgccgaaaa aggaagctgg
     1801 agagaatcgc ccggctggag gaaaaagtga aaaccttgaa agctcagaac tcggagctgg
     1861 cgtccacggc caacatgctc agggaacagg tggcacagct taaacagaaa gtcatgaacc
     1921 acgttaacag tgggtgccaa ctcatgctaa cgcagcagtt gcaaacattt tgaagagaga
     1981 ccgtcggggg ctgaggggca acgaagaaaa aaaataacac agagagacag acttgagaac
     2041 ttgacaagtt gcgacggaga gaaaaaagaa gtgtccgaga actaaagcca agggtatcca
     2101 agttggactg ggttgcgtcc tgacggcgcc cccagtgtgc acgagtggga aggacttggc
     2161 gcgccctccc ttggcgtgga gccagggagc ggccgcctgc gggctgcccc gctttgcgga
     2221 cgggctgtcc ccgcgcgaac ggaacgttgg acttttcgtt aacattgacc aagaactgca
     2281 tggacctaac attcgatctc attcagtatt aaagggggga gggggagggg gttacaaact
     2341 gcaatagaga ctgtagattg cttctgtagt actccttaag aacacaaagc ggggggaggg
     2401 ttggggaggg gcggcaggag ggaggtttgt gagagcgagg ctgagcctac agatgaactc
     2461 tttctggcct gccttcgtta actgtgtatg tacatatata tattttttaa tttgatgaaa
     2521 gctgattact gtcaataaac agcttcatgc ctttgtaagt tatttcttgt ttgtttgttt
     2581 gggtatcctg cccagtgttg tttgtaaata agagatttgg agcactctga gtttaccatt
     2641 tgtaataaag tatataattt ttttatgttt tgtttctgaa aattccagaa aggatattta
     2701 agaaaataca ataaactatt ggaaagtact cccctaacct cttttctgca tcatctgtag
     2761 atactagcta tctaggtgga gttgaaagag ttaagaatgt cgattaaaat cactctcagt
     2821 gcttcttact attaagcagt aaaaactgtt ctctattaga ctttagaaat aaatgtacct
     2881 gatgtacctg atgctatggt caggttatac tcctcctccc ccagctatct atatggaatt
     2941 gcttaccaaa ggatagtgcg atgtttcagg aggctggagg aaggggggtt gcagtggaga
     3001 gggacagccc actgagaagt caaacatttc aaagtttgga ttgtatcaag tggcatgtgc
     3061 tgtgaccatt tataatgtta gtagaaattt tacaataggt gcttattctc aaagcaggaa
     3121 ttggtggcag attttacaaa agatgtatcc ttccaatttg gaatcttctc tttgacaatt
     3181 cctagataaa aagatggcct ttgcttatga atatttataa cagcattctt gtcacaataa
     3241 atgtattcaa ataccaa
//
