LOCUS       NM_006694               1273 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens jumping translocation breakpoint (JTB), mRNA.
ACCESSION   NM_006694
VERSION     NM_006694.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Yeung,C.C.S., Deeg,H.J., Pritchard,C., Wu,D. and Fang,M.
  TITLE     Jumping translocations in myelodysplastic syndromes
  JOURNAL   Cancer Genet 209 (9), 395-402 (2016)
   PUBMED   27751357
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Xu,X.F., Zhou,X.M., Wei,Z.F., Zhang,Z.Y., Ge,J.P., Wei,W.,
            Zhou,W.Q., Cheng,W., Hou,J.Q. and Gao,J.P.
  TITLE     [Downregulation of PAR expression induces the apoptosis of human
            prostate cancer PC3 cells and increases the Bcl-2/Bax ratio]
  JOURNAL   Zhonghua Nan Ke Xue 18 (10), 896-899 (2012)
   PUBMED   23297497
  REMARK    GeneRIF: Downregulation of the PAR expression increases the
            Bax/Bcl-2 ratio and Bax expression, and thus induces the G2-M phase
            arrest and apoptosis of PC3 cells.
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Rousseau,F., Pan,B., Fairbrother,W.J., Bazan,J.F. and Lingel,A.
  TITLE     The structure of the extracellular domain of the jumping
            translocation breakpoint protein reveals a variation of the midkine
            fold
  JOURNAL   J Mol Biol 415 (1), 22-28 (2012)
   PUBMED   22079049
  REMARK    GeneRIF: The JTB structure has a distant relationship to the
            midkine/pleiotrophin fold, particularly in the conservation of
            distinctive disulfide bridge patterns.
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Platica,M., Ionescu,A., Ivan,E., Holland,J.F., Mandeli,J. and
            Platica,O.
  TITLE     PAR, a protein involved in the cell cycle, is functionally related
            to chromosomal passenger proteins
  JOURNAL   Int J Oncol 38 (3), 777-785 (2011)
   PUBMED   21225229
  REMARK    GeneRIF: Due to its involvement in cell cycle and its
            overexpression in several human cancers PAR could represent an
            attractive target for therapeutic intervention.
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Pan,J.S., Cai,J.Y., Xie,C.X., Zhou,F., Zhang,Z.P., Dong,J.,
            Xu,H.Z., Shi,H.X. and Ren,J.L.
  TITLE     Interacting with HBsAg compromises resistance of jumping
            translocation breakpoint protein to ultraviolet radiation-induced
            apoptosis in 293FT cells
  JOURNAL   Cancer Lett 285 (2), 151-156 (2009)
   PUBMED   19487072
  REMARK    GeneRIF: Overexpression of JTB conferred resistance to apoptosis
            induced by ultraviolet radiation
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   Wong,N., Chan,A., Lee,S.W., Lam,E., To,K.F., Lai,P.B., Li,X.N.,
            Liew,C.T. and Johnson,P.J.
  TITLE     Positional mapping for amplified DNA sequences on 1q21-q22 in
            hepatocellular carcinoma indicates candidate genes over-expression
  JOURNAL   J Hepatol 38 (3), 298-306 (2003)
   PUBMED   12586295
  REMARK    GeneRIF: Among ten hepatocellular carcinoma cases with amplicon
            1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and
            COPA in the tumors than the paired adjacent non-malignant liver
            tissues.
REFERENCE   7  (bases 1 to 1273)
  AUTHORS   Platica,O., Chen,S., Ivan,E., Lopingco,M.C., Holland,J.F. and
            Platica,M.
  TITLE     PAR, a novel androgen regulated gene, ubiquitously expressed in
            normal and malignant cells
  JOURNAL   Int J Oncol 16 (5), 1055-1061 (2000)
   PUBMED   10762645
REFERENCE   8  (bases 1 to 1273)
  AUTHORS   Hatakeyama,S., Osawa,M., Omine,M. and Ishikawa,F.
  TITLE     JTB: a novel membrane protein gene at 1q21 rearranged in a jumping
            translocation
  JOURNAL   Oncogene 18 (12), 2085-2090 (1999)
   PUBMED   10321732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL358472.54.
            
            On Nov 23, 2018 this sequence version replaced NM_006694.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.928683.1,
                                           SRR3476690.1070256.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271843.9/ ENSP00000271843.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AL358472.54        57796-58300         c
            506-543             AL358472.54        57602-57639         c
            544-626             AL358472.54        57319-57401         c
            627-706             AL358472.54        56452-56531         c
            707-1273            AL358472.54        54895-55461         c
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1273
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /note="jumping translocation breakpoint"
                     /db_xref="GeneID:10899"
                     /db_xref="HGNC:HGNC:6201"
                     /db_xref="MIM:604671"
     exon            1..505
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..863
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /note="protein JTB; prostate androgen-regulated protein;
                     jumping translocation breakpoint protein"
                     /codon_start=1
                     /product="protein JTB precursor"
                     /protein_id="NP_006685.1"
                     /db_xref="CCDS:CCDS1057.1"
                     /db_xref="GeneID:10899"
                     /db_xref="HGNC:HGNC:6201"
                     /db_xref="MIM:604671"
                     /translation="MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTS
                     NLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALME
                     QRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI"
     exon            506..543
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /inference="alignment:Splign:2.1.0"
     exon            544..626
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /inference="alignment:Splign:2.1.0"
     exon            627..706
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1273
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /note="hexamer: AATAAA"
     polyA_site      1030
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /note="major polyA site"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
                     /note="hexamer: AATAAA"
     polyA_site      1273
                     /gene="JTB"
                     /gene_synonym="hJT; HJTB; HSPC222; PAR"
ORIGIN      
        1 accgacgcgg aagactataa gccccagcgg gcgacgaccg aacgcccccg ggaacaccgg
       61 gccccgagct cggtcccgcg cccgaggatc ctccacgggg ctagatggct gcgtcggggg
      121 cgggagcgga ggtgagcggg cgctagggcc gcgagccccc gccggccctt cctccagcgc
      181 cctgcggacc ccgcagaagg cgctcgcctc cctagcccgc aaaaacatat cgatttttct
      241 cgctgtggca acggggacgt cctgatagat cctctgctcc aataggcaac tccggccttc
      301 cctgccctga cctggaacct ctgggagggc tgcagagtaa gtgccgcctc tgcgctccga
      361 cggaggcacg aggcctgtgg agtaggtccc tctgttccga caggtgcgac acttggcgct
      421 ccatgcttgc gggtgccggg aggcctggcc tcccccaggg ccgccacctc tgctggttgc
      481 tctgtgcttt caccttaaag ctctgccaag cagaggctcc cgtgcaggaa gagaagctgt
      541 cagcaagcac ctcaaatttg ccatgctggc tggtggaaga gtttgtggta gcagaagagt
      601 gctctccatg ctctaatttc cgggctaaaa ctacccctga gtgtggtccc acaggatatg
      661 tagagaaaat cacatgcagc tcatctaaga gaaatgagtt caaaagctgc cgctcagctt
      721 tgatggaaca acgcttattt tggaagttcg aaggggctgt cgtgtgtgtg gccctgatct
      781 tcgcttgtct tgtcatcatt cgtcagcgac aattggacag aaaggctctg gaaaaggtcc
      841 ggaagcaaat cgagtccata tagctacatt ccacccttgt atcctgggtc ttagagaccc
      901 tatctcagac agtgaaagtg aaatggactg atttgcactc ttggttcttt ggagccttgt
      961 ggtggaatcc ccttttcccc atcttcttct ttcagatcat taatgagcag aataaaaaga
     1021 gtaaaatggt ttccttccct tctgtaactt ggagcaggaa gtcatggggg cagagaggga
     1081 aaggaggtgg ttacttaagg ccccaatcta ccaagtcttc cccaccactt ctcccttgtt
     1141 ttccccctct tctactactt atttcaaact tctgggatac aatttcagct aaaacgttta
     1201 tttctcactc aaaacttatt tcccctcaac cctataccca aagaagaaat aaaatcacag
     1261 atacataaca gaa
//
