LOCUS       NM_001261833            3140 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens JRK like (JRKL), transcript variant 2, mRNA.
ACCESSION   NM_001261833
VERSION     NM_001261833.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Wang,K.S., Zhang,Q., Liu,X., Wu,L. and Zeng,M.
  TITLE     PKNOX2 is associated with formal thought disorder in schizophrenia:
            a meta-analysis of two genome-wide association studies
  JOURNAL   J Mol Neurosci 48 (1), 265-272 (2012)
   PUBMED   22648509
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Zeng,Z., Kyaw,H., Gakenheimer,K.R., Augustus,M., Fan,P., Zhang,X.,
            Su,K., Carter,K.C. and Li,Y.
  TITLE     Cloning, mapping, and tissue distribution of a human homologue of
            the mouse jerky gene product
  JOURNAL   Biochem Biophys Res Commun 236 (2), 389-395 (1997)
   PUBMED   9240447
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290579.1, BC109202.2,
            AF004715.1 and CA503357.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001261833.1.
            
            Summary: The function of this gene has not yet been defined,
            however, the encoded protein shares similarity with the human (41%
            identical) and mouse (34% identical) jerky gene products. This
            protein may act as a nuclear regulatory protein. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC341352.1, SRR1163655.111843.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332349.5/ ENSP00000333350.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AK290579.1         20-422
            404-1853            BC109202.2         176-1625
            1854-2222           AF004715.1         1586-1954
            2223-2836           CA503357.1         13-626              c
            2837-3140           AF004715.1         2567-2870
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3140
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /note="JRK like"
                     /db_xref="GeneID:8690"
                     /db_xref="HGNC:HGNC:6200"
                     /db_xref="MIM:603211"
     exon            1..61
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /inference="alignment:Splign:2.1.0"
     exon            62..3140
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1803
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /note="human homolog of mouse jerky gene protein"
                     /codon_start=1
                     /product="jerky protein homolog-like"
                     /protein_id="NP_001248762.1"
                     /db_xref="CCDS:CCDS8308.1"
                     /db_xref="GeneID:8690"
                     /db_xref="HGNC:HGNC:6200"
                     /db_xref="MIM:603211"
                     /translation="MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRD
                     IRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEELDRAMLEWFNQQRAKGNPISGPIC
                     AKRAEFFFYALGMDGDFNPSAGWLTRFKQRHSIREINIRNERLNGDETAVEDFCNNFR
                     DFIERENLQPEQIYNADETGLFWKCLPSRISVIKGKCTVPGHKSIEERVTIMCCANAT
                     GLHKLKLCVVGKAKKPRSFKSTDTLNLPVSYFSQKGAWMDLSIFRQWFDKIFVPQVRE
                     YLRSKGLQEKAVLLLDNSPTHPNENVLRSDDGQIFAKYLPPNVASLIQPSDQGVIATM
                     KRNYRAGLLQNNLEEGNDLKSFWKKLTLLDALYEIAMAWNLVKPVTISRAWKKILPMV
                     EEKESLDFDVEDISVATVAAILQHTKGLENVTTENLEKWLEVDSTEPGYEVLTDSEII
                     RRAQGQADESSENEEEEIELIPEKHINHAAALQWTENLLDYLEQQGDMILPDRLVIRK
                     LRATIRNKQKMTKSSQ"
     regulatory      2812..2817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /note="hexamer: AATAAA"
     polyA_site      2836
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /note="major polyA site"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /note="hexamer: AATAAA"
     polyA_site      3140
                     /gene="JRKL"
                     /gene_synonym="HHMJG"
                     /note="major polyA site"
ORIGIN      
        1 aggggcggag cgactgccgc gcgatagtca gggagctgtg cgggtcctgg ttgcaagaga
       61 gtctatttgc cagccaaccc cagcccggga ggggatcagg gccaccaggt tgctggtaag
      121 gatgaaagac tgagtgtgtt aagactgttg aagtgagcct gtgtaagaga aggaaggatt
      181 ttgtggattg ctacattgtg agtgtggggt gagtcccaga acctcgctat gtcagggaaa
      241 cggaagcgtg tggtgttgac tattaaagat aagcttgata taataaagaa acttgaagac
      301 ggaggttctt ccaaacaact ggcagtgatt tatggaattg gtgaaacaac agttcgggat
      361 ataagaaaaa ataaggaaaa gattataact tatgcaagca gttctgattc cacaagtctt
      421 ttggccaaga ggaaatctat gaagccatcc atgtatgagg aattggacag ggcaatgctg
      481 gaatggttca accagcaaag agcaaaaggg aatcccatat ctggaccaat ttgtgcaaaa
      541 agggcagagt tcttctttta tgctttggga atggatggtg attttaaccc ctctgccggt
      601 tggctaactc gttttaagca gcggcacagc attagagaga ttaacattag aaatgaaaga
      661 ttaaatggag atgagactgc ggtggaagat ttttgtaata actttcgaga ttttattgaa
      721 cgagagaatt tacagcctga acaaatctac aatgcagatg aaactggact cttttggaag
      781 tgcttgcctt ctaggatttc agtaatcaaa ggtaaatgca ctgtccctgg gcacaaatca
      841 attgaagaaa gagtcacaat catgtgttgt gccaatgcaa caggtttaca caaacttaaa
      901 ctttgtgttg tggggaaagc aaagaaacct cgctccttta aatcaactga caccttaaac
      961 ctgccagtct cttatttcag ccaaaaaggt gcatggatgg atctttccat tttccgacaa
     1021 tggtttgata aaatttttgt gccgcaagtt cgagagtatt taagatctaa aggcttgcag
     1081 gaaaaggctg tgctcttgtt ggataattca ccaacacatc caaatgaaaa tgtcctaagg
     1141 tcagatgatg gccaaatatt tgctaaatat ttaccaccta atgtggcctc attgattcag
     1201 ccttcagatc agggagtcat agcaacgatg aagagaaatt atcgtgcagg tcttctccag
     1261 aacaacttgg aagaaggtaa tgacctgaaa tcattctgga agaagctaac tctgttggat
     1321 gcactttatg aaatagcaat ggcatggaac ttagtaaaac cagttaccat tagcagagca
     1381 tggaagaaga ttctccctat ggtagaggag aaagagagcc tggactttga tgttgaagat
     1441 atttctgtgg ctactgtggc tgccatttta caacacacca aaggattgga aaatgtgact
     1501 actgagaacc ttgaaaaatg gcttgaagta gacagtactg aaccaggcta tgaagtgtta
     1561 actgatagcg aaatcatcag aagagcacaa ggccaggcag atgaatccag tgaaaatgag
     1621 gaggaggaaa tagaactaat tccagagaaa catattaatc atgcagctgc cctccagtgg
     1681 actgaaaatt tattggatta tctagaacaa caaggtgata tgattctacc tgatagactg
     1741 gtaatacgta aacttcgagc caccatcaga aataaacaga agatgacaaa gtcaagtcaa
     1801 taatgtcatt tcaattttat tgttctgctc attgtgtttg tgacaaactc tttgcaatat
     1861 ggcttaattt tctttgtgtt ctgaattctc agacttggtc ctgtgaaata caggcacaaa
     1921 atgtatctga agtggtttga ggattatgtg ttttcatcat ctgtgtcttt tgtcctttta
     1981 tttgtacaga taatcagaag atgatactga atagatataa attacatgta cacatgtatt
     2041 cactttttag aatctgcaat tataccttct gtaacagtgg cattccctta attttctagt
     2101 gaaagttaga gataactgaa cagactgaag cacttttctg aaatcttttg cttgatttat
     2161 gaaggctgcc atagttatct tttcttgtgt taaccatctt aaatgatgtt ttgtatattt
     2221 taatagactg ataggatgag aaagatttat attattagat ttcaggatga tttataataa
     2281 ttcaaaaatg aaattcaata atggggaaat aattatgaat tatagaaatt atgccttcat
     2341 tctcttacat ttgtgtgggt tgcaagaggg ggagattatt ctggaaatga agtaaatatg
     2401 ggaagttatt gccaaatgag agagaaacta tgggaaagct gatctataaa gaggcattct
     2461 gatcaattca tttgtaggaa actgggaaat aaaaacctgg ggaactttag gttatttata
     2521 caaagggaat aaataggctg attttaattt ggtaagttga tctttttatt atgaatttgg
     2581 taatagtata ggtttattat ttattcatct aattttatag tacaggtttt gtaatgttac
     2641 atgtgatgat atgagctccc accttatatg ggggaacatc ttgggaattt gagatttaat
     2701 aagttttttt tttttttttt ttagtgtttt tactgcatac tcacaaatgt tgtctataat
     2761 ttgaaaaata ttgtcatatc tggccctttg atgagaaaag gaaattacaa taataaagtt
     2821 ttatgatttt aaataagtca tatgtttgta tcctgtttta tgaagaaagc agaaataatt
     2881 actgaaagtg ccagacacta aggaatatta ttgtttatta ttttaataca tataaaaagg
     2941 gattaatctg ctaaaatgta atctaaatca gaattttgat aaattttttt tgtaaactaa
     3001 gtatgtttat tcaagacatt gaaactactt tgcacatatg aatattaatg taacttgtaa
     3061 tttaaaagta aagtgtttcc atgctatttc atgttttggc caaaaatttt taaaaaataa
     3121 attacaattg ttctctatta
//
