LOCUS       NM_003724               9097 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Jrk helix-turn-helix protein (JRK), transcript variant
            1, mRNA.
ACCESSION   NM_003724
VERSION     NM_003724.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9097)
  AUTHORS   Waldron,R., Rodriguez,M.L.A.B., Williams,J.M., Ning,Z., Ahmed,A.,
            Lindsay,A. and Moore,T.
  TITLE     JRK binds satellite III DNA and is necessary for the heat shock
            response
  JOURNAL   Cell Biol Int 48 (8), 1212-1222 (2024)
   PUBMED   38946594
  REMARK    GeneRIF: JRK binds satellite III DNA and is necessary for the heat
            shock response.
REFERENCE   2  (bases 1 to 9097)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 9097)
  AUTHORS   Tian,A., Benchabane,H., Wang,Z., Zimmerman,C., Xin,N., Perochon,J.,
            Kalna,G., Sansom,O.J., Cheng,C., Cordero,J.B. and Ahmed,Y.
  TITLE     Intestinal stem cell overproliferation resulting from inactivation
            of the APC tumor suppressor requires the transcription cofactors
            Earthbound and Erect wing
  JOURNAL   PLoS Genet 13 (7), e1006870 (2017)
   PUBMED   28708826
  REMARK    GeneRIF: in the adult intestine, Ebd acts independently of Ewg in
            physiological Wnt signaling, but cooperates with Ewg to induce the
            hyperactivation of Wnt target gene expression following Apc1 loss.
            These findings have relevance for human tumorigenesis, as Jerky
            (JRK/JH8), the human Ebd homolog, promotes Wnt pathway
            hyperactivation and is overexpressed in colorectal, breast, and
            ovarian cancers
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9097)
  AUTHORS   Pangon,L., Ng,I., Giry-Laterriere,M., Currey,N., Morgan,A.,
            Benthani,F., Tran,P.N., Al-Sohaily,S., Segelov,E., Parker,B.L.,
            Cowley,M.J., Wright,D.C., St Heaps,L., Carey,L., Rooman,I. and
            Kohonen-Corish,M.R.
  TITLE     JRK is a positive regulator of beta-catenin transcriptional
            activity commonly overexpressed in colon, breast and ovarian cancer
  JOURNAL   Oncogene 35 (22), 2834-2841 (2016)
   PUBMED   26455321
  REMARK    GeneRIF: JRK expression was aberrantly elevated in 21% of
            colorectal cancers, 15% of breast and ovarian cancers and was
            associated with increased expression of beta-catenin target genes
            and increased cell proliferation
REFERENCE   5  (bases 1 to 9097)
  AUTHORS   Benchabane,H., Xin,N., Tian,A., Hafler,B.P., Nguyen,K., Ahmed,A.
            and Ahmed,Y.
  TITLE     Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling
            by modulating beta-catenin-TCF activity
  JOURNAL   EMBO J 30 (8), 1444-1458 (2011)
   PUBMED   21399610
REFERENCE   6  (bases 1 to 9097)
  AUTHORS   Moore,T., Hecquet,S., McLellann,A., Ville,D., Grid,D., Picard,F.,
            Moulard,B., Asherson,P., Makoff,A.J., McCormick,D., Nashef,L.,
            Froguel,P., Arzimanoglou,A., LeGuern,E. and Bailleul,B.
  TITLE     Polymorphism analysis of JRK/JH8, the human homologue of mouse
            jerky, and description of a rare mutation in a case of CAE evolving
            to JME
  JOURNAL   Epilepsy Res 46 (2), 157-167 (2001)
   PUBMED   11463517
REFERENCE   7  (bases 1 to 9097)
  AUTHORS   Morita,R., Miyazaki,E., Shah,P.U., Castroviejo,I.P.,
            Delgado-Escueta,A.V. and Yamakawa,K.
  TITLE     Exclusion of the JRK/JH8 gene as a candidate for human childhood
            absence epilepsy mapped on 8q24
  JOURNAL   Epilepsy Res 37 (2), 151-158 (1999)
   PUBMED   10510981
REFERENCE   8  (bases 1 to 9097)
  AUTHORS   Morita,R., Miyazaki,E., Fong,C.Y., Chen,X.N., Korenberg,J.R.,
            Delgado-Escueta,A.V. and Yamakawa,K.
  TITLE     JH8, a gene highly homologous to the mouse jerky gene, maps to the
            region for childhood absence epilepsy on 8q24
  JOURNAL   Biochem Biophys Res Commun 248 (2), 307-314 (1998)
   PUBMED   9675132
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Sep 18;250(2):536]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AC108002.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 17, 2019 this sequence version replaced NM_003724.3.
            
            Summary: This gene encodes a conserved protein that is similar to
            DNA-binding proteins, such as major centromere autoantigen B
            (CENPB). Inactivation of the related gene in mice resulted in
            epileptic seizures. Childhood Absence Epilepsy (CAE) has been
            mapped to the same chromosomal location (8q24.3) as this gene.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.31307.1,
                                           SRR11853558.23564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMN03267757
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612905.2/ ENSP00000482410.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC108002.3         62152-62187
            37-9097             AC108002.3         65599-74659
FEATURES             Location/Qualifiers
     source          1..9097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..9097
                     /gene="JRK"
                     /gene_synonym="jerky; JH8"
                     /note="Jrk helix-turn-helix protein"
                     /db_xref="GeneID:8629"
                     /db_xref="HGNC:HGNC:6199"
                     /db_xref="MIM:603210"
     exon            1..36
                     /gene="JRK"
                     /gene_synonym="jerky; JH8"
                     /inference="alignment:Splign:2.1.0"
     exon            37..9097
                     /gene="JRK"
                     /gene_synonym="jerky; JH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..2205
                     /gene="JRK"
                     /gene_synonym="jerky; JH8"
                     /note="isoform a is encoded by transcript variant 1; jerky
                     protein homolog; jerky homolog; Jrk homolog"
                     /codon_start=1
                     /product="jerky protein homolog isoform a"
                     /protein_id="NP_003715.3"
                     /db_xref="CCDS:CCDS75796.1"
                     /db_xref="GeneID:8629"
                     /db_xref="HGNC:HGNC:6199"
                     /db_xref="MIM:603210"
                     /translation="MASKPAAGKSRGEKRKRVVLTLKEKIDICTRLEKGESRKALMQE
                     YNVGMSTLYDIRAHKAQLLRFFASSDSNKALEQRRTLHTPKLEHLDRVLYEWFLGKRS
                     EGVPVSGPMLIEKAKDFYEQMQLTEPCVFSGGWLWRFKARHGIKKLDASSEKQSADHQ
                     AAEQFCAFFRSLAAEHGLSAEQVYNADETGLFWRCLPNPTPEGGAVPGPKQGKDRLTV
                     LMCANATGSHRLKPLAIGKCSGPRAFKGIQHLPVAYKAQGNAWVDKEIFSDWFHHIFV
                     PSVREHFRTIGLPEDSKAVLLLDSSRAHPQEAELVSSNVFTIFLPASVASLVQPMEQG
                     IRRDFMRNFINPPVPLQGPHARYNMNDAIFSVACAWNAVPSHVFRRAWRKLWPSVAFA
                     EGSSSEEELEAECFPVKPHNKSFAHILELVKEGSSCPGQLRQRQAASWGVAGREAEGG
                     RPPAATSPAEVVWSSEKTPKADQDGRGDPGEGEEVAWEQAAVAFDAVLRFAERQPCFS
                     AQEVGQLRALRAVFRSQQQVRRRRGALGAVVKVEALQEGPGGCGATAQSPLPCSSTAG
                     DN"
     regulatory      9072..9077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JRK"
                     /gene_synonym="jerky; JH8"
                     /note="hexamer: AATAAA"
     polyA_site      9097
                     /gene="JRK"
                     /gene_synonym="jerky; JH8"
                     /note="major polyA site"
ORIGIN      
        1 acttccggcc ggcggcggct gctccgggtg agcaggcccc tgaagtgctg tgcctggaga
       61 taccattgtg gaccctggag aggcacctgc tgcttatgcg gtaaaacctc taccacccca
      121 aacctggtca gtttgagggg agccgctgcc atagtatcca cagagaaggc cggagttcca
      181 gccgtgtgga gcagcagagg ggagtctgac agggtcacct cctccacaga gagaattggc
      241 agctgactgc actgccagga gccaaggcct aggtgtgtgg agcctggaag accagggata
      301 cctgaggcag gaggtgcagc gtgtggagtg agaaacccga gagggactgg ggcctgtgct
      361 caggatcagc agagcaggca ggcagagtgg agagggagag acggagcccc agaaggggag
      421 caggaggaga gggaagtagt ggcagcagcc caggccaggc gtgtgtcctg caagtgctag
      481 gaccagccac ccctccccat ggcctccaag ccggctgccg ggaagagcag aggggagaag
      541 cggaagaggg tggtgctgac actgaaggag aagattgaca tctgcacgcg cctggagaag
      601 ggcgagagcc ggaaggcact gatgcaggag tacaatgtgg gcatgtccac cctctacgac
      661 atcagggccc acaaggcgca gctgctccgg ttcttcgcca gctccgactc caacaaggcg
      721 ctggagcagc ggcgcacgct gcacacgccc aagctggagc acctggaccg cgtcctgtac
      781 gagtggttcc tggggaagcg ctccgagggc gtccccgtgt caggccccat gctcatcgag
      841 aaggccaagg acttctacga gcagatgcag ctcactgagc cctgcgtgtt ctccggaggg
      901 tggctttggc gctttaaggc cagacacggc attaaaaagc tagatgcatc cagtgaaaag
      961 cagtcagccg accaccaggc cgcggagcag ttctgtgcgt ttttcaggag cttggctgct
     1021 gagcacgggc tgtccgccga gcaggtttac aacgctgatg agaccggcct tttctggcgg
     1081 tgcctgccaa atcccactcc ggaaggcggg gctgtgcctg gccccaagca gggcaaggac
     1141 cggctgaccg tgctgatgtg tgccaacgcc acgggctccc acaggctcaa gcccttggcc
     1201 atcgggaagt gcagcggtcc cagggctttc aaaggcatcc agcacctgcc cgtcgcctat
     1261 aaggcccagg ggaacgcctg ggtggacaag gagatttttt ccgattggtt ccatcatatc
     1321 tttgtgccct cggtgagaga gcacttcaga accataggtt tgccggaaga cagcaaagcc
     1381 gttctcttgc tggacagctc ccgggctcac ccgcaggagg ccgagctggt gtccagtaac
     1441 gttttcacca tcttcctgcc tgccagcgtg gcctcattgg tgcagcccat ggagcagggc
     1501 attcggagag atttcatgag gaacttcatt aaccctccgg tccccctgca gggcccccac
     1561 gcccgctaca acatgaacga tgccatattc agcgtggcct gtgcctggaa cgcagtccct
     1621 agccacgtct tcaggcgggc ctggaggaag ctgtggccgt cggttgcgtt tgccgaaggc
     1681 tcctcctctg aggaggagtt ggaggcagag tgcttcccag tgaagcccca caacaagtcc
     1741 tttgcacaca tcctggagct tgtgaaggaa ggctcctcct gcccgggcca gcttcgccag
     1801 cgccaggccg ccagctgggg ggtagcggga agggaggcag aagggggacg gccccctgct
     1861 gccacgtcgc cagcagaggt tgtgtggagt tcagaaaaga ctccgaaagc tgaccaggac
     1921 ggcagaggag atcctggtga gggcgaggag gtggcctggg agcaggcggc cgtggccttt
     1981 gacgcagtcc tgcgctttgc ggagcggcag ccatgcttca gtgcgcagga agtggggcag
     2041 ctgcgggcgc tgcgtgccgt gttccggagc cagcagcagg tgaggaggcg gcgtggtgcc
     2101 ctcggggctg tggtcaaggt tgaagccctc caggagggcc ctggtggctg tggggccaca
     2161 gctcagtctc ccttgccctg ctcatccaca gcaggtgaca actgatggct tctctgccct
     2221 gccctggcca ctggccctgt ttctccccac accctggagt ggcatggtcc tgtgccccga
     2281 ccccacctga ggcaggaggg catgtgcaga cactcaagag cccttccagg agtgggtcgc
     2341 ccacgggtgt ggctcgggtg cccaggacgg tctgtgcccg aggttcctgt caatacaggt
     2401 tttattttat cacttgccgt gtcatccgaa agtgaggaaa tgttttggaa gggtccaccc
     2461 tagcctagaa caagccagag ccgcaccctg gctggaatgg gggccaggct gagccgatct
     2521 ggtctcgtgt tcgctggctg atcattgcag tatcagaggg tggagatgtc agtctgtcca
     2581 cgtggagaga agttgccctc caggccgaca ggaggccatg cccaccgccc ctggacaggc
     2641 ttcgtctcag aaggctctat ctgctgggct ggcggccatc cccgtgttgg gtggaccccg
     2701 agcacggttg cctgaggtcc gatggcccga gagctgggac tcagttcttg gcctgctagc
     2761 ggctgaacag gccgcacatc tcacttcagt tgtggcctca ttcagcagaa tgactctgga
     2821 accatcctct gttacccgca gatcctgtcc catgggctct ggccccaaga tgttgggggg
     2881 ccccacggag agttgacttg gtagagttcc tttctgggaa gaaagtagga gtggctgacc
     2941 aggccctgct catcacccgg atagaggaca cggaccctgt gtggtatttt ggcattttgg
     3001 ctcagagtcc aatgtaccat gttgcccaga atttcatact tatggccttt acatgaatac
     3061 gtcttgatca gacattcaga gattagtctt aggtttgcac gtaagtcact gaaaacagta
     3121 aaacaggctg cttagatttc tagcagtatg tgtgctctta tccccagctg ttagcacgtt
     3181 agtaatactt ttggggagga gttgtctgtc ctggtcagtt ttcacagagg cggttgtaag
     3241 aggatgtggt tattttctcc atgtctgtag ttgctttgcg gcatctccat ttcacgggca
     3301 acactcactg cctgcagctg agattccaga acgccctgtg tccacagtga ttagcctcgt
     3361 ctttcagcga gcataaaata ggtgcattgt ccttttcttt tcttgaggca gggtctcact
     3421 ctgttgacca ggctggagtg aagtggtgtg atcccagctc actgcagcct cgacctccct
     3481 ggcttgagtg atcctcccgc cccagcctcc tgagtagctg ggactagagg cacgcaccac
     3541 cgcgcctttt tatttttttt gtagagacag ggtctcactg tgttgcccag gctggtcttg
     3601 aactcttggc ctcaagcgat cctccttcct catccttcta aagtgctggg attacaggtg
     3661 tgagccacag cactcggcct aaataggttt ttcttgctat gttattttca gtgctttgcc
     3721 cttgaattct tttcctctct taaattcata tcatttggcc gagtcagcac gtagtttgca
     3781 ttccagcgtc tgctgttgat tccactgaaa cctctgttct catgaaggag aggatttggc
     3841 tcgctgtggt ttctcgtact ttcacatctc tgtagataca ggggcaaaag tcattgctga
     3901 cagagcccta tctatgtcct ggaagtgtgt gtttcttgct ttgaatgcat gtgtgaagat
     3961 tataaaagcc aaatagtttt taaagatctc ggtgctgaac gacagtccca gttcccattt
     4021 gtgtcccatt gtctttgtgg tgtcacccgc actgtttgct tcattgtctg gggaacttct
     4081 gcacatcatg tactttgtgc catttctggg ctcacgtgtc actcctaata gagcctctta
     4141 accaagactg ctggattgca gctgcttgag gcaacacagg aggttagaac atgtcccgag
     4201 ggctctgaaa cagtaggaca tcctgggtgg gtggagctgg ggagggcatg ggcaggccag
     4261 ctggccgagc tcctggctgg ctctcctgag tcctctggac atggcttgtc cctgtcagac
     4321 tgtagctctt caggacctga gctcttcccg ttcttgatct gctcttgtgc tgactgtgct
     4381 gggctgatgg gtaggcgctt gtccccagtg agtggctgtg tcctcagggt gcccctcttc
     4441 cagaccaact gcagcaaggc ctggagcctg actctaggtg cagcccttgt ggctggaatc
     4501 ccttgtgcca cccaggggac tcgggccctg ctcctcctgc agcccctcct cacctgggct
     4561 cgctgctgga gtgaggtttt tagggagccc agagcgtact catctctgag ctgctgggcc
     4621 cagctgcctg gtgcatacct cttgcctcgg tcctgtcccc cagaacgctt tatggagact
     4681 gccgtgtcct ccgagcactt tgttttcact tcctgacccg tctcagaagc tcaagtggtt
     4741 gaatgtttta gcctcagaat ctttttcccc aagccctctc aggtggagcc ccgctgtacc
     4801 agacaccaca gcacagctct gtgaggctgt gtctcttcac tctgtttctg gggctgctga
     4861 ggcccctggg aagccctgga gcttgccaga gcagagcgag aaagtctctg gtcctgttta
     4921 aatgcctccg cgttttatct gtgagcacca ggctggagcc actccctgtc ttctcacagt
     4981 gcccctgcaa gttgcagcct cagttttcca gtggctcgtg gggtagcagg tgctgcgtca
     5041 tatggtttgg gacctctgtg gctgcttcca gcctgctaat agaacctctt tccaccactg
     5101 ccttcatctt tggggtggca cccctgagtg ctcaggcctg agggcgctcc tgtgtcctca
     5161 ctcgggacag gcagcctcca ctctgggagc tcccatccct cgggatgccc aggagaggcc
     5221 atactttcag ggtggcatgg tgaattcagg ggttaggatg ggtaggtggt ctttcagccc
     5281 cttctacgtt ggggttggtt tacagaacac ctgtcctgcc tgtgccagcc tggccttctg
     5341 cgagcacccc aggcacgctg tcctggaagt tgtctgtctc ctgcatagga gggtctagag
     5401 cagaccttgc cctgggcctg tctgtgcgtg acttccatat gcttcattcg tgctcagcca
     5461 tggctgagca tgcgatggag agcacctgga ctgcccctga cgtcgcaggc cactgttctt
     5521 atccagtggg ccaagtgatt gattgctagt ggtggagttg attggaagaa aggaagtcgc
     5581 agcccctgcc cacggcttcc ccagctcgct ggggttggag gactgtcatc agttgtcccc
     5641 agttaaagtc catttggagg aggttcaggg tcccagtggc tggatgtgct tgtggaggga
     5701 cacggtttga ggcaggggtt tgcagaaggt gtagactgca tccattcttg ggaggctgtg
     5761 gcacagggca gcgacaactt gggacaaatc aagacccgtc cacactgcac ctcagggacc
     5821 tcacctcacg ccccacataa atgtgcttat tggggatccg ggtgtggtgg cttctgcctg
     5881 aaatcccagt actctggaag gccacggcag gaggatcact ttagttcagg agtttgaaac
     5941 cagcctgggc aacataggga gaccccatct ctacagaaag taaaagaaaa tgagccaggt
     6001 gtggtggcat gtgcctgtaa ccccagctac tcaggaggcc gaggcgggag gatccccaag
     6061 cccaggagtt tgaggctgca gtgagttatg gcctctgcac tccagcctgg gtgacagagt
     6121 gagagaccta atctctaaaa acaaaaaata acaaaatgtg ctttggggtc aggtgtggag
     6181 atcagggtcg gggaggtcat gaggtaggta ggggtcagga tgtggacagt catgggctgg
     6241 tgggtgtggc agccgtgagg ggtgggtggt ggcctgggag gcagggcctg ggcagggctt
     6301 ctgcacttct gctgcttacc cagccccctc tgggttcgag gactctcctt gacaagggct
     6361 gagctctcgg gcactgcgtt ggactcagct gcctactggg aggctgggga gaatggacct
     6421 gtgagacctt gtttgtcctc ttccctgccc agctcttgta gaccccaggc ctggctgtcc
     6481 gcagggccag gagctgcagc catggcagcc accagcctcc cacatgagcc ccagctccca
     6541 gccccacacg cccactcctt tgcccatgtg gtgtcagctc tggcctctgc ttctacacat
     6601 ggaccctcag accttgcaca tctgttgttt cccttgcagg gcagtgatga tgacatgaaa
     6661 tgaggtgggg tcactcctgt ttagggatga gactggggcc cagggagggg caggtgtgaa
     6721 gttgctgagg gcagagggag acccagggct acctgctcct aatgaccagc ctcacgttct
     6781 ccactgctca ctccctgctg ttcaccagct gcatgacctt gagcagtgca ctcaactgta
     6841 aacagaggtg aaaacactcc tttaccaact gttttagggg ccactcttgt ttgaggcctt
     6901 gaacctcctt tcagttccgt ggtggtcctg agcctctgaa tctgggtatg gcccctgctg
     6961 ggtcctggtc tcttaggcag cacgatggcc tccctgctca aggccctgca cccaggggca
     7021 gattgtggga ggcccactgg ccatggctgg gccctatcgc agagagcctg tcagcacggc
     7081 catttccaca cccaggctgg ctgggaagca agctacgagg tgctcaaagg ccctctatgt
     7141 ctgcaggtag ccccgtccca cacaggcgag gatcgttggg cctccttagt agccaaagga
     7201 actgaggtcc agagcaggga atgtgttgcc cagtgtcagc atggtctgct ctggggtcag
     7261 gcgtcttgcc ctggtcctaa gccaccccaa gccaaggcat gtccctgggc ccatttcctc
     7321 tctcgaggtc ttgggttccc tatttctgat gtgtgtgaaa ggaaggcctg tcctctgggg
     7381 tgaccatgag gctcagtggg aggagctgcc aggcttgagc tgggacttgg cacctggcca
     7441 gccttttttc tatttcattg taccttgatg ggctgtcagt tctgaagaga aaaaatacac
     7501 taggaatcca ttcttcctcc accattctcc ctggcagagg gaagtgacta cacccctatg
     7561 gtgtggacat actgacgctc ctccatgaag cagcaaagtt ctgttgtttc aggagactgt
     7621 gggccttgag gatgtggtag tgacctcacc agaggagttg gcaattccta agtgctgcct
     7681 ggaggcctct acagagacat aatgttggag aacttctgcc acatggcagt gctgggtaag
     7741 acccctctgt ccccaccagt gcccttgagg ttatgggtgt tggtaggtct gtggcctcca
     7801 tctccatgac gatggtgtta aggactgcat gtttgtgtcc ccccccaaag tttatatgtt
     7861 gaaaccctga cccccaggag ggtggtatta ggaggtgggg cctttgggag gtgactaggc
     7921 ttaggtgaga tcgtgagggt ggggctcgcc gatgagatcg agtccttata agaaaaggaa
     7981 ggaactagag cgaggtcact ttgtgctgtg tgagcataca agaaaactgc catcttcaag
     8041 ctgggtgcag tggctcacgc ctgtaatccc agcactggaa ggccaaggca ttaggattgc
     8101 atgagtccag gagttcgaga ccagcctagg catgataaga ccttattgct aaaaaaaaaa
     8161 aaaaaggaaa taaaatagaa aattgccatc tgcaaatgag aaagccttca gccgacacca
     8221 gactgccagt gcctttgata ttggactttc agtccccaga tctgtgaaaa attaatttat
     8281 gttgtttaag acacctagcc tgtggtattt tgttatcgca atcaaaactg actgagacag
     8341 gcagtaagga gagaacagag gttccagcct gcttcaggtc caggcagttc tgccattgcc
     8401 cctaactcct cagtgccagt catgggccag gcccctgggg gacttggaat gagtaaaaca
     8461 tgcacctatt gttaaggttc acctggtcca gaaggggagg cagacccacc tgcccaccat
     8521 gacccggaca gaggcaataa atacggagca cctcatggcc agggcctgga ggattcccac
     8581 cataccctac ccagcgccaa taacagaggg accctggagt tgtgtacgca agatagcagt
     8641 tcagtgcttg cacacatact agttgagaag ggaaatcagg gctaatgaaa cagctcaact
     8701 gtctggcaga gccaggctcc ttctgccatg atacagtttg gatgtttgtc cctttctaat
     8761 cttatatgga aatttgatcc ccagtgttga aggtggggcc tggtgggaaa tgttcctgtt
     8821 atcgggatgg atccttcatg aatagcctgg tgccatcttt gtggtaacaa gtgagttctc
     8881 acttgattag tttctgtgag aactgtttgt taaaaagagc ctggtggcac ctccctccct
     8941 tcttcctcct gctcttgcta tgtgatgctg ctgccctttg ccttccgtca tgagtggaag
     9001 ctccctgaag cccccaccag aagcaaatgc tggcaccatg ctgcttgtac agcctgcaga
     9061 actgtgagcc aaataaacct cttttcttta taaatta
//
