LOCUS       NM_144570               3695 bp    mRNA    linear   PRI 22-NOV-2024
DEFINITION  Homo sapiens Jupiter microtubule associated homolog 2 (JPT2),
            transcript variant 4, mRNA.
ACCESSION   NM_144570
VERSION     NM_144570.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Chen,X., Song,Q.L., Ji,R., Wang,J.Y., Cao,M.L., Guo,D.Y., Zhang,Y.
            and Yang,J.
  TITLE     JPT2 Affects Trophoblast Functions and Macrophage Polarization and
            Metabolism, and Acts as a Potential Therapeutic Target for
            Recurrent Spontaneous Abortion
  JOURNAL   Adv Sci (Weinh) 11 (16), e2306359 (2024)
   PUBMED   38417123
  REMARK    GeneRIF: JPT2 Affects Trophoblast Functions and Macrophage
            Polarization and Metabolism, and Acts as a Potential Therapeutic
            Target for Recurrent Spontaneous Abortion.
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Gunaratne,G.S., Brailoiu,E., Kumar,S., Yuan,Y., Slama,J.T.,
            Walseth,T.F., Patel,S. and Marchant,J.S.
  TITLE     Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12
  JOURNAL   Sci Signal 16 (799), eadg0485 (2023)
   PUBMED   37607218
  REMARK    GeneRIF: Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12.
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Zeng,T.T., Deng,T.H., Liu,Z., Zhan,J.R., Ma,Y.Z., Yan,Y.Y., Sun,X.,
            Zhu,Y.H., Li,Y., Guan,X.Y. and Li,L.
  TITLE     HN1L/AP-2gamma/PLK1 signaling drives tumor progression and
            chemotherapy resistance in esophageal squamous cell carcinoma
  JOURNAL   Cell Death Dis 13 (12), 1026 (2022)
   PUBMED   36476988
  REMARK    GeneRIF: HN1L/AP-2gamma/PLK1 signaling drives tumor progression and
            chemotherapy resistance in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Nong,S., Wang,Z., Wei,Z., Ma,L., Guan,Y. and Ni,J.
  TITLE     HN1L promotes stem cell-like properties by regulating TGF-beta
            signaling pathway through targeting FOXP2 in prostate cancer
  JOURNAL   Cell Biol Int 46 (1), 83-95 (2022)
   PUBMED   34519127
  REMARK    GeneRIF: HN1L promotes stem cell-like properties by regulating
            TGF-beta signaling pathway through targeting FOXP2 in prostate
            cancer.
REFERENCE   5  (bases 1 to 3695)
  AUTHORS   Roggenkamp,H.G., Khansahib,I., Hernandez,C. LC, Zhang,Y.,
            Lodygin,D., Kruger,A., Gu,F., Mockl,F., Lohndorf,A., Wolters,V.,
            Woike,D., Rosche,A., Bauche,A., Schetelig,D., Werner,R.,
            Schluter,H., Failla,A.V., Meier,C., Fliegert,R., Walseth,T.F.,
            Flugel,A., Diercks,B.P. and Guse,A.H.
  TITLE     HN1L/JPT2: A signaling protein that connects NAADP generation to
            Ca2+ microdomain formation
  JOURNAL   Sci Signal 14 (675) (2021)
   PUBMED   33758062
  REMARK    GeneRIF: HN1L/JPT2: A signaling protein that connects NAADP
            generation to Ca(2+) microdomain formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3695)
  AUTHORS   Karpova,N., Bobinnec,Y., Fouix,S., Huitorel,P. and Debec,A.
  TITLE     Jupiter, a new Drosophila protein associated with microtubules
  JOURNAL   Cell Motil Cytoskeleton 63 (5), 301-312 (2006)
   PUBMED   16518797
REFERENCE   7  (bases 1 to 3695)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 3695)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   9  (bases 1 to 3695)
  AUTHORS   Zhou,G., Wang,J., Zhang,Y., Zhong,C., Ni,J., Wang,L., Guo,J.,
            Zhang,K., Yu,L. and Zhao,S.
  TITLE     Cloning, expression and subcellular localization of HN1 and HN1L
            genes, as well as characterization of their orthologs, defining an
            evolutionarily conserved gene family
  JOURNAL   Gene 331, 115-123 (2004)
   PUBMED   15094197
REFERENCE   10 (bases 1 to 3695)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM837125.1, AK023154.1, BC060853.1, BM474060.1 and AL031710.11.
            
            On Nov 23, 2018 this sequence version replaced NM_144570.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023154.1, BC060853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248098.8/ ENSP00000248098.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               BM837125.1         24-494
            472-3016            AK023154.1         472-3016
            3017-3654           BC060853.1         3013-3650
            3655-3681           BM474060.1         570-596
            3682-3695           AL031710.11        4223-4236
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3695
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /note="Jupiter microtubule associated homolog 2"
                     /db_xref="GeneID:90861"
                     /db_xref="HGNC:HGNC:14137"
                     /db_xref="MIM:619241"
     exon            1..78
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..607
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /note="isoform 4 is encoded by transcript variant 4;
                     hematological and neurological expressed 1-like protein;
                     HN1 like; CRAMP_1 like; HN1-like protein; hematological
                     and neurological expressed 1 like"
                     /codon_start=1
                     /product="jupiter microtubule associated homolog 2 isoform
                     4"
                     /protein_id="NP_653171.1"
                     /db_xref="CCDS:CCDS10441.1"
                     /db_xref="GeneID:90861"
                     /db_xref="HGNC:HGNC:14137"
                     /db_xref="MIM:619241"
                     /translation="MFQVPDSEGGRAGSRAMKPPGGESSNLFGSPEEATPSSRPNRMA
                     SNIFGPTEEPQNIPKRTNPPGGKGSGIFDESTPVQTRQHLNPPGGKTSDIFGSPVTAT
                     SRLAHPNKPKDHVFLCEGEEPKSDLKAARSIPAGAEPGEKGSARKAGPAKEQEPMPTV
                     DSHEPRLGPRPRSHNKVLNPPGGKSSISFY"
     exon            79..227
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /inference="alignment:Splign:2.1.0"
     exon            228..370
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /inference="alignment:Splign:2.1.0"
     exon            371..419
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /inference="alignment:Splign:2.1.0"
     exon            420..3695
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /note="hexamer: ATTAAA"
     polyA_site      3036
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /note="major polyA site"
     regulatory      3664..3669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /note="hexamer: AATAAA"
     polyA_site      3695
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
ORIGIN      
        1 ggcgcgcggc gagctgaggg tggcggcggt cgacatgttc caggtcccgg atagcgaggg
       61 cggccgcgcc ggctccaggg ccatgaagcc cccaggagga gaatcgagca atctttttgg
      121 aagtccagaa gaagctactc cttccagcag gcctaatagg atggcatcta atatttttgg
      181 accaacagaa gaacctcaga acatacccaa gaggacaaat cccccagggg gtaaaggaag
      241 tggtatcttt gacgaatcaa cccccgtgca gactcgacag cacctgaacc cacctggagg
      301 gaagaccagc gacatttttg ggtctccggt cactgccact tcacgcttgg cacacccaaa
      361 caaacccaag gatcatgttt tcttatgtga aggagaagaa ccaaaatcgg atcttaaagc
      421 tgcaaggagc atcccggctg gagcagagcc aggtgagaaa ggcagcgcca gaaaagcagg
      481 ccccgccaag gagcaggagc ccatgcccac agtcgacagc catgagcccc ggctggggcc
      541 gcggcctcgc tctcacaaca aggtcctgaa cccaccggga ggcaaatcca gcatctcctt
      601 ctactaagag aagccactgc tccacccgga gccagaccag aaactcaaga gatagggtag
      661 ccatgttttc atttcctttt gcccaaatga gcggggtggg aagagggtta gtcttatgtg
      721 agcctggctg ctcagcgtct cctggccgtc atgacagctg cttggagacc cgtgccttcc
      781 agatggctgg gagatgcctc tgtggggatg aaatggggca cccctggcca tcactcatgt
      841 gtagtccagg tttgagagga actggaaggg gggtgagggt ggggaggtgg ggcagggcat
      901 ggtccttgga tcaacagccc gccagctgat tggatgtcta ggaatgactg aaagaaacca
      961 aaacagcctg tccactgctg ctgtgggatg gaggaggcgt aagcagaaac actaacagta
     1021 tattgacctc ttagcagaac cgcttccatt ctggagatca cggctgctaa atccagcatc
     1081 cccacttcat tttaccccca gcatattgtt ctgtagtctt ttcttgaaac atcttgattg
     1141 cttttcctcg gcagctttca aaaaaccaaa taataatagt tatccgtctt ctacttcatg
     1201 gaagattgtt ttggtgccct gaccctctga agtgcccagt tcctgccatc tgaaacctcg
     1261 gcctgatctg atctcatgtt ggaatctgcc tgtctttcac acagggctgg tcttggtcct
     1321 ttacatgcca gttttgcttg tgaattcttg cttttttcct ctcatcagcc ttaagtttag
     1381 gcgtttgttg ttctccagtg atgtagacag ttcccttcac aagtcacagt tcttcccata
     1441 aatgaggccc gctgacctct gcgggacttt aaaaatctat tcagatattt ccgagtaagt
     1501 ggcttgttta aattcttcct gtgtctttct ttattcctta attggttggt ggaaagaaga
     1561 gatgcttggg aaccttgggt tcttaggttt ggattcttta ataatatcta aaaagctaaa
     1621 ttttaaatac cagctttaca taaatgattg ttgactctgg tctgtttctg acacctttcc
     1681 agaaaaaagt caattgttca ggtacaccaa agaggaagaa gagctgtgga ggccaccctc
     1741 tacaaagctt tatagaactt ctggatctaa ctcacaaaca agcttccaga agagactaga
     1801 gaccttaggc caggagatga aggagttcag tagcaaagtc acacctgtcc aattccctga
     1861 gctttgctca ctcagctaat gggatggcaa aggtggtggt gctttcatct tcaggcagaa
     1921 gcctctgccc atccccctca agggctgcag gcccagttct catgctgccc ttgggtgggc
     1981 atctgttaac agaggagaac gtctgggtgg cggcagcagc tttgctctga gtgcctacaa
     2041 agctaatgct tggtgctaga aacatcatca ttattaaact tcagaaaagc agcagccatg
     2101 ttcagtcagg ctcatgctgc ctcactgctt aagtgcctgc aggagccgcc tgccaagctc
     2161 cccttcctac acctggcaca ctggggtctg cacaaggctt tgtcaaccaa agacagcttc
     2221 ccccttttga ttgcctgtag actttggagc caagaaacac tctgtgtgac tctacacaca
     2281 cttcaggtgg tttgtgcttc aaagtcattg atgcaacttg aaaggaaaca gtttaatggt
     2341 ggaaatgaac taccatttat aacttctgtt tttttattga gaaaatgatt cacgaattcc
     2401 aaatcagatt gccaggaaga aataggacgt gacggtactg ggccctgtga ttctcccagc
     2461 ccttgcagtc cgctaggtga gaggaaaagc tctttacttc cgcccctggc agggacttct
     2521 gggttatggg agaaaccaga gatgggaatg aggaaaatat gaactacagc agaagcccct
     2581 gggcagctgt gatggagccc ctgacattac tcttcttgca tctgtcctgc cttctttccc
     2641 tctgcgaggc agtggggtgg gattcagagt gcttagtctg ctcactggga gaagaagagt
     2701 tcctgcgcat gcaagccctg ctgtgtggct gtcgtttaca tttgggaggt gtcctgtatg
     2761 tctgtacgtt ggggactgcc tgtatttgga agatttaaaa acctagcatc ctgttctcac
     2821 cctctaagct gcattgagaa atgactcgtc tctgtatttg tattaagcct taacactttt
     2881 cttaagtgca ttcggtgcca acatttttta gagctgtacc aaaacaaaaa gcctgtactc
     2941 acatcacaat gtcattttga taggagcgtt ttgttatttt tacaaggcag aatggggtgt
     3001 aacagttgaa ttaaacttag caatcacgtg ctcagagctt ttgcctgtca gttgtgtgtg
     3061 tcccttatag tcccttcccc cacagctctt gctgaaagag tttgccttgt tttgttttgt
     3121 tgttttgtat ttagccagag gatgccaaaa ttagtcttct caaagctttg agtagagtaa
     3181 gtgtgggaat aagccagttt ttttttttct gtttctgtaa cttaaatgaa cgggtttttt
     3241 tcccttgtat gccacttgtc ctaacatgtc cttaaggtgt ttaacctgcc tctgacctgg
     3301 cttgcaatgc ataggtgagg agaagcagag agcttgtcat atgcaagtcc tgtcaagaaa
     3361 acaggtgggc atggtggctc aggtctgtag tctttgggtc tttgggaggc cagggtggga
     3421 ggatcacttg agctcaggag tttgagacca gcctagacaa catactacga ccctgtctat
     3481 acaaaaaaaa acttctctaa attagccgga tgtggtggtg catgcctgta gtcccagcta
     3541 ctcgggaggc tgagtgaggc aggaggatca cttgagacca ggaggttgtg gctgtagtga
     3601 gtgatgatca tgccactgca cttcagcctg gaccacagag caagaccctg tgtaaaaaaa
     3661 taaaataaaa aacagattgg atgtctttct tctga
//
