LOCUS       NP_653171                190 aa            linear   PRI 27-APR-2025
DEFINITION  jupiter microtubule associated homolog 2 isoform 4 [Homo sapiens].
ACCESSION   NP_653171
VERSION     NP_653171.1
DBSOURCE    REFSEQ: accession NM_144570.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 190)
  AUTHORS   Chen,X., Song,Q.L., Ji,R., Wang,J.Y., Cao,M.L., Guo,D.Y., Zhang,Y.
            and Yang,J.
  TITLE     JPT2 Affects Trophoblast Functions and Macrophage Polarization and
            Metabolism, and Acts as a Potential Therapeutic Target for
            Recurrent Spontaneous Abortion
  JOURNAL   Adv Sci (Weinh) 11 (16), e2306359 (2024)
   PUBMED   38417123
  REMARK    GeneRIF: JPT2 Affects Trophoblast Functions and Macrophage
            Polarization and Metabolism, and Acts as a Potential Therapeutic
            Target for Recurrent Spontaneous Abortion.
REFERENCE   2  (residues 1 to 190)
  AUTHORS   Gunaratne,G.S., Brailoiu,E., Kumar,S., Yuan,Y., Slama,J.T.,
            Walseth,T.F., Patel,S. and Marchant,J.S.
  TITLE     Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12
  JOURNAL   Sci Signal 16 (799), eadg0485 (2023)
   PUBMED   37607218
  REMARK    GeneRIF: Convergent activation of two-pore channels mediated by the
            NAADP-binding proteins JPT2 and LSM12.
REFERENCE   3  (residues 1 to 190)
  AUTHORS   Zeng,T.T., Deng,T.H., Liu,Z., Zhan,J.R., Ma,Y.Z., Yan,Y.Y., Sun,X.,
            Zhu,Y.H., Li,Y., Guan,X.Y. and Li,L.
  TITLE     HN1L/AP-2gamma/PLK1 signaling drives tumor progression and
            chemotherapy resistance in esophageal squamous cell carcinoma
  JOURNAL   Cell Death Dis 13 (12), 1026 (2022)
   PUBMED   36476988
  REMARK    GeneRIF: HN1L/AP-2gamma/PLK1 signaling drives tumor progression and
            chemotherapy resistance in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 190)
  AUTHORS   Nong,S., Wang,Z., Wei,Z., Ma,L., Guan,Y. and Ni,J.
  TITLE     HN1L promotes stem cell-like properties by regulating TGF-beta
            signaling pathway through targeting FOXP2 in prostate cancer
  JOURNAL   Cell Biol Int 46 (1), 83-95 (2022)
   PUBMED   34519127
  REMARK    GeneRIF: HN1L promotes stem cell-like properties by regulating
            TGF-beta signaling pathway through targeting FOXP2 in prostate
            cancer.
REFERENCE   5  (residues 1 to 190)
  AUTHORS   Roggenkamp,H.G., Khansahib,I., Hernandez,C. LC, Zhang,Y.,
            Lodygin,D., Kruger,A., Gu,F., Mockl,F., Lohndorf,A., Wolters,V.,
            Woike,D., Rosche,A., Bauche,A., Schetelig,D., Werner,R.,
            Schluter,H., Failla,A.V., Meier,C., Fliegert,R., Walseth,T.F.,
            Flugel,A., Diercks,B.P. and Guse,A.H.
  TITLE     HN1L/JPT2: A signaling protein that connects NAADP generation to
            Ca2+ microdomain formation
  JOURNAL   Sci Signal 14 (675) (2021)
   PUBMED   33758062
  REMARK    GeneRIF: HN1L/JPT2: A signaling protein that connects NAADP
            generation to Ca(2+) microdomain formation.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 190)
  AUTHORS   Karpova,N., Bobinnec,Y., Fouix,S., Huitorel,P. and Debec,A.
  TITLE     Jupiter, a new Drosophila protein associated with microtubules
  JOURNAL   Cell Motil Cytoskeleton 63 (5), 301-312 (2006)
   PUBMED   16518797
REFERENCE   7  (residues 1 to 190)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (residues 1 to 190)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   9  (residues 1 to 190)
  AUTHORS   Zhou,G., Wang,J., Zhang,Y., Zhong,C., Ni,J., Wang,L., Guo,J.,
            Zhang,K., Yu,L. and Zhao,S.
  TITLE     Cloning, expression and subcellular localization of HN1 and HN1L
            genes, as well as characterization of their orthologs, defining an
            evolutionarily conserved gene family
  JOURNAL   Gene 331, 115-123 (2004)
   PUBMED   15094197
REFERENCE   10 (residues 1 to 190)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM837125.1, AK023154.1, BC060853.1, BM474060.1 and AL031710.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023154.1, BC060853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248098.8/ ENSP00000248098.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..190
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     Protein         1..190
                     /product="jupiter microtubule associated homolog 2 isoform
                     4"
                     /note="hematological and neurological expressed 1-like
                     protein; HN1 like; CRAMP_1 like; HN1-like protein;
                     hematological and neurological expressed 1 like"
                     /calculated_mol_wt=19932
     Region          1..190
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Region          10..>48
                     /region_name="JUPITER"
                     /note="Microtubule-Associated protein Jupiter; pfam17054"
                     /db_xref="CDD:293659"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            45
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            69
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            97
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17924679,
                     ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            132
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     Site            144
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H910.1)"
     CDS             1..190
                     /gene="JPT2"
                     /gene_synonym="C16orf34; HN1L; L11"
                     /coded_by="NM_144570.3:35..607"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS10441.1"
                     /db_xref="GeneID:90861"
                     /db_xref="HGNC:HGNC:14137"
                     /db_xref="MIM:619241"
ORIGIN      
        1 mfqvpdsegg ragsramkpp ggessnlfgs peeatpssrp nrmasnifgp teepqnipkr
       61 tnppggkgsg ifdestpvqt rqhlnppggk tsdifgspvt atsrlahpnk pkdhvflceg
      121 eepksdlkaa rsipagaepg ekgsarkagp akeqepmptv dsheprlgpr prshnkvlnp
      181 pggkssisfy
//
