LOCUS       NM_016185               1434 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens Jupiter microtubule associated homolog 1 (JPT1),
            transcript variant 1, mRNA.
ACCESSION   NM_016185
VERSION     NM_016185.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Li,H., Fan,S., Gong,Z., Chan,J.Y.K., Tong,M.C.F. and Chen,G.G.
  TITLE     Role of hematological and neurological expressed 1 (HN1) in human
            cancers
  JOURNAL   Crit Rev Oncol Hematol 201, 104446 (2024)
   PUBMED   38992849
  REMARK    GeneRIF: Role of hematological and neurological expressed 1 (HN1)
            in human cancers.
            Review article
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Feng,J., Liu,Y., Fang,T., Zhu,J., Wang,G. and Li,J.
  TITLE     Hematological and neurological expressed 1 (HN1) activates c-Myc
            signaling by inhibiting ubiquitin-mediated proteasomal degradation
            of c-Myc in hepatocellular carcinoma
  JOURNAL   Cell Biol Int 47 (3), 560-572 (2023)
   PUBMED   36403281
  REMARK    GeneRIF: Hematological and neurological expressed 1 (HN1) activates
            c-Myc signaling by inhibiting ubiquitin-mediated proteasomal
            degradation of c-Myc in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Peng,J., Shuopeng,J., Wang,H., Wang,X. and Wang,L.
  TITLE     Thirdhand Smoke May Promote Lung Adenocarcinoma Development through
            HN1
  JOURNAL   Comput Math Methods Med 2023, 3407313 (2023)
   PUBMED   36756386
  REMARK    GeneRIF: Thirdhand Smoke May Promote Lung Adenocarcinoma
            Development through HN1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Cheng,Y., Xiong,H.Y., Li,Y.M., Zuo,H.R., Liu,Y. and Liao,G.L.
  TITLE     LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to
            regulate JPT1 in prostate cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (14), 4668-4677 (2021)
   PUBMED   34337714
  REMARK    GeneRIF: LncRNA HOXA11-AS promotes cell growth by sponging
            miR-24-3p to regulate JPT1 in prostate cancer.
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Chen,J., Qiu,J., Li,F., Jiang,X., Sun,X., Zheng,L., Zhang,W.,
            Li,H., Wu,H., Ouyang,Y., Chen,X., Lin,C., Song,L. and Zhang,Y.
  TITLE     HN1 promotes tumor associated lymphangiogenesis and lymph node
            metastasis via NF-kappaB signaling activation in cervical carcinoma
  JOURNAL   Biochem Biophys Res Commun 530 (1), 87-94 (2020)
   PUBMED   32828320
  REMARK    GeneRIF: HN1 promotes tumor associated lymphangiogenesis and lymph
            node metastasis via NF-kappaB signaling activation in cervical
            carcinoma.
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Laughlin,K.M., Luo,D., Liu,C., Shaw,G., Warrington,K.H. Jr.,
            Qiu,J., Yachnis,A.T. and Harrison,J.K.
  TITLE     Hematopoietic- and neurologic-expressed sequence 1 expression in
            the murine GL261 and high-grade human gliomas
  JOURNAL   Pathol Oncol Res 15 (3), 437-444 (2009)
   PUBMED   19145478
  REMARK    GeneRIF: These data suggest a role for Hn1 in the biology of
            malignant brain tumors.
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Karpova,N., Bobinnec,Y., Fouix,S., Huitorel,P. and Debec,A.
  TITLE     Jupiter, a new Drosophila protein associated with microtubules
  JOURNAL   Cell Motil Cytoskeleton 63 (5), 301-312 (2006)
   PUBMED   16518797
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Zougman,A. and Wisniewski,J.R.
  TITLE     Beyond linker histones and high mobility group proteins: global
            profiling of perchloric acid soluble proteins
  JOURNAL   J Proteome Res 5 (4), 925-934 (2006)
   PUBMED   16602700
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Zhou,G., Wang,J., Zhang,Y., Zhong,C., Ni,J., Wang,L., Guo,J.,
            Zhang,K., Yu,L. and Zhao,S.
  TITLE     Cloning, expression and subcellular localization of HN1 and HN1L
            genes, as well as characterization of their orthologs, defining an
            evolutionarily conserved gene family
  JOURNAL   Gene 331, 115-123 (2004)
   PUBMED   15094197
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Li,D., Gonzalez,O., Bachinski,L.L. and Roberts,R.
  TITLE     Human protein tyrosine phosphatase-like gene: expression profile,
            genomic structure, and mutation analysis in families with ARVD
  JOURNAL   Gene 256 (1-2), 237-243 (2000)
   PUBMED   11054553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF266846.1 and AW675726.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016185.3.
            
            Transcript Variant: This variant (1) contains an alternate exon in
            the 3' coding region, resulting in a frameshift and an early stop
            codon, compared to variant 2. It encodes isoform 1, which is
            shorter and has a distinct C-terminus, compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223321.1, AF086910.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409753.8/ ENSP00000387059.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1428              AF266846.1         1-1428
            1429-1434           AW675726.1         7-12                c
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1434
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /note="Jupiter microtubule associated homolog 1"
                     /db_xref="GeneID:51155"
                     /db_xref="HGNC:HGNC:14569"
                     /db_xref="MIM:619242"
     exon            1..171
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..580
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen-regulated protein 2; hematological and
                     neurological expressed 1 protein"
                     /codon_start=1
                     /product="jupiter microtubule associated homolog 1 isoform
                     1"
                     /protein_id="NP_057269.1"
                     /db_xref="CCDS:CCDS45771.1"
                     /db_xref="GeneID:51155"
                     /db_xref="HGNC:HGNC:14569"
                     /db_xref="MIM:619242"
                     /translation="MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRK
                     NKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKGEG
                     DIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG"
     exon            172..314
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /inference="alignment:Splign:2.1.0"
     exon            315..412
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /inference="alignment:Splign:2.1.0"
     exon            413..431
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /inference="alignment:Splign:2.1.0"
     exon            432..1434
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /note="hexamer: ATTAAA"
     polyA_site      694
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /note="major polyA site"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /note="hexamer: AGTAAA"
     polyA_site      1434
                     /gene="JPT1"
                     /gene_synonym="ARM2; HN1; HN1A"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggct cctgcagcgg tggtcggctg ttgggtgtgg agtttcccag cgcccctcgg
       61 gtccgaccct ttgagcgttc tgctccggcg ccagcctacc tcgctcctcg gcgccatgac
      121 cacaaccacc accttcaagg gagtcgaccc caacagcagg aatagctccc gagttttgcg
      181 gcctccaggt ggtggatcca atttttcatt aggttttgat gaaccaacag aacaacctgt
      241 gaggaagaac aaaatggcct ctaatatctt tgggacacct gaagaaaatc aagcttcttg
      301 ggccaagtca gcaggtgcca agtctagtgg tggcagggaa gacttggagt catctggact
      361 gcagagaagg aactcctctg aagcaagctc cggagacttc ttagatctga agggagaagg
      421 tgatattcat gaaaatgtgg acacagactt gccaggcagc ctggggcaga gtgaagagaa
      481 gcccgtgcct gctgcgcctg tgcccagccc ggtggccccg gccccagtgc catccagaag
      541 aaatccccct ggcggcaagt ccagcctcgt cttgggttag ctctgactgt cctgaacgct
      601 gtcgttctgt ctgtttcctc catgcttgtg aactgcacaa cttgagcctg actgtacatc
      661 tcttggattt gtttcattaa aaagaagcac tttatgtact gctgtctttt ttttttttct
      721 tttgaagaac aggtttctct ctgtccttga ctcttgggtc tgtgggccat ggcatgagtg
      781 ttttctagta gtagattgga gggaaagctt tgtgacactt agtactgtgt ttttaagaag
      841 aaataatttg gttccagatg tgttagagga tcttttgtac tgaggttttt aacactttac
      901 ttgggtttac caagcctcaa ctggacagac cataaacagt ccacaggcac cgttcctgcc
      961 aggccccaac ccacagggag tctctccgca gagccttctt ggtgttgccc taacttgcca
     1021 gtggcctttg ctcagagcct cctcctgtga catgtgaaca atgaagaggc ctgcgcctcc
     1081 tgccttgccg cctgcaaagc aaagaaactg ccttttattt tttaacctta aaaagtagcc
     1141 agatagtaac aagactggct ggctgatgag caaagccttt gctctcacgc agaggaaggc
     1201 ttggatgtac aatgaaactg cctggaacta aaagcagtga agcaagggag gcaatcacac
     1261 tgaagcgggt cttcctccag gaacggggtc ccacaggcgt gttgttttaa ataacctgat
     1321 gctgtgtgca tgatgctggt gcttgaccat gaaaggaaag tctcatcctt aaaatgtgtt
     1381 gtacttcaca atcctggact gttgcttcaa gtaaacaata tccacatttt gaaa
//
