LOCUS       NM_001270639             834 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Josephin domain containing 2 (JOSD2), transcript
            variant 1, mRNA.
ACCESSION   NM_001270639
VERSION     NM_001270639.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Yuan,T., Zeng,C., Liu,J., Zhao,C., Ge,F., Li,Y., Qian,M., Du,J.,
            Wang,W., Li,Y., Liu,Y., Dai,X., Zhou,J., Chen,X., Ma,S., Zhu,H.,
            He,Q. and Yang,B.
  TITLE     Josephin domain containing 2 (JOSD2) promotes lung cancer by
            inhibiting LKB1 (Liver kinase B1) activity
  JOURNAL   Signal Transduct Target Ther 9 (1), 11 (2024)
   PUBMED   38177135
  REMARK    GeneRIF: Josephin domain containing 2 (JOSD2) promotes lung cancer
            by inhibiting LKB1 (Liver kinase B1) activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 834)
  AUTHORS   Ge,F., Liu,X., Zhang,H., Yuan,T., Zhu,H., Yang,B. and He,Q.
  TITLE     Deubiquitinating enzyme JOSD2 affects susceptibility of non-small
            cell lung carcinoma cells to anti-cancer drugs through DNA damage
            repair
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 52 (5), 533-543 (2023)
   PUBMED   37899394
  REMARK    GeneRIF: Deubiquitinating enzyme JOSD2 affects susceptibility of
            non-small cell lung carcinoma cells to anti-cancer drugs through
            DNA damage repair.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 834)
  AUTHORS   Wang,Y., Li,Z.X., Wang,J.G., Li,L.H., Shen,W.L. and Dang,X.W.
  TITLE     Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a
            cancer stem cell phenotype in hepatocellular carcinoma
  JOURNAL   Genes Genomics 45 (2), 215-224 (2023)
   PUBMED   36583817
  REMARK    GeneRIF: Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to
            promote a cancer stem cell phenotype in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 834)
  AUTHORS   Huang,Y., Zeng,J., Liu,T., Xu,Q., Song,X. and Zeng,J.
  TITLE     Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma
            progression through interacting with and inhibiting CTNNB1
            degradation
  JOURNAL   Cell Biol Int 46 (7), 1089-1097 (2022)
   PUBMED   35568970
  REMARK    GeneRIF: Deubiquitinating enzyme JOSD2 promotes hepatocellular
            carcinoma progression through interacting with and inhibiting
            CTNNB1 degradation.
REFERENCE   5  (bases 1 to 834)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 834)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 834)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 834)
  AUTHORS   Weeks,S.D., Grasty,K.C., Hernandez-Cuebas,L. and Loll,P.J.
  TITLE     Crystal structure of a Josephin-ubiquitin complex: evolutionary
            restraints on ataxin-3 deubiquitinating activity
  JOURNAL   J Biol Chem 286 (6), 4555-4565 (2011)
   PUBMED   21118805
REFERENCE   9  (bases 1 to 834)
  AUTHORS   Tzvetkov,N. and Breuer,P.
  TITLE     Josephin domain-containing proteins from a variety of species are
            active de-ubiquitination enzymes
  JOURNAL   Biol Chem 388 (9), 973-978 (2007)
   PUBMED   17696782
REFERENCE   10 (bases 1 to 834)
  AUTHORS   Baek,K.H.
  TITLE     Cytokine-regulated protein degradation by the ubiquitination system
  JOURNAL   Curr Protein Pept Sci 7 (2), 171-177 (2006)
   PUBMED   16611142
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY056543.1 and BC062416.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001270639.1.
            
            Summary: This gene encodes a protein containing a Josephin domain.
            Josephin domain-containing proteins are deubiquitinating enzymes
            which catalyze the hydrolysis of the bond between the C-terminal
            glycine of the ubiquitin peptide and protein substrates.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2, 4 and
            5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062416.1, BG774911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267761, SAMN03267763
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598418.6/ ENSP00000468956.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY056543.1         166-178
            14-834              BC062416.1         1-821
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..834
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /note="Josephin domain containing 2"
                     /db_xref="GeneID:126119"
                     /db_xref="HGNC:HGNC:28853"
                     /db_xref="MIM:615324"
     exon            1..75
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /inference="alignment:Splign:2.1.0"
     exon            76..238
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..659
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     josephin-2; josephin domain-containing protein 2"
                     /codon_start=1
                     /product="josephin-2 isoform 1"
                     /protein_id="NP_001257568.1"
                     /db_xref="CCDS:CCDS12797.1"
                     /db_xref="GeneID:126119"
                     /db_xref="HGNC:HGNC:28853"
                     /db_xref="MIM:615324"
                     /translation="MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQLFSQEAAD
                     EICKRLAPDSRLNPHRSLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVL
                     GLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLA
                     AALAQGLCEVLLVVTKEVEEKGSWLRTD"
     exon            239..364
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /inference="alignment:Splign:2.1.0"
     exon            365..559
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /inference="alignment:Splign:2.1.0"
     exon            560..834
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      812..817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /note="hexamer: AATAAA"
     polyA_site      834
                     /gene="JOSD2"
                     /gene_synonym="SBBI54"
                     /note="major polyA site"
ORIGIN      
        1 actcggagcc cagagccgcc gcccaggaag gggatgcgga aacccctggc tcggtggagc
       61 ggagaggcag gcgggcagga gccgaggacg gcatgtccca ggccccggga gcacagccga
      121 gcccacccac cgtgtaccac gaacggcagc gcctggagct gtgtgctgtc cacgccctca
      181 acaacgttct gcagcagcag ctctttagcc aggaggctgc cgatgagatc tgcaagaggt
      241 tggccccaga ctcccggctg aaccctcatc gcagcctcct gggcaccggc aactatgatg
      301 tcaatgtgat catggccgct ctgcaggggc tgggcctggc cgccgtgtgg tgggacagga
      361 ggaggcccct gtcccagctg gccctgcccc aggtactggg gctgatcctg aacctgccct
      421 cgcccgtgtc gctggggctg ctgtcactgc cgctgcgccg gcggcactgg gtggccctgc
      481 gccaggtgga cggtgtctac tacaacctgg actccaagct gcgggcgccc gaggccctgg
      541 gggatgagga cggagtcagg gccttcctgg cggctgcgct ggcccagggc ctgtgcgagg
      601 tgctgctggt agtgaccaag gaggtggagg agaagggcag ctggctgcgg acagactgac
      661 catggctgac catcggcgcc cacagcgcag tccctgcgca tccccctccg gctgcgcaca
      721 ctgcatgcct gggaaaggcc agcacttcat ggaccctggg gaggccccgc cccctcccca
      781 cacccctgct ccccactgcc gctgctgcct caataaatct gctgatttgc tgcc
//
