LOCUS       NM_001360236            3743 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens Josephin domain containing 1 (JOSD1), transcript
            variant 3, mRNA.
ACCESSION   NM_001360236 XM_005261876
VERSION     NM_001360236.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3743)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3743)
  AUTHORS   Wu,X., Luo,Q., Zhao,P., Chang,W., Wang,Y., Shu,T., Ding,F., Li,B.
            and Liu,Z.
  TITLE     JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired
            chemoresistance in gynaecological cancer by stabilizing MCL1
  JOURNAL   Cell Death Differ 27 (1), 55-70 (2020)
   PUBMED   31043700
  REMARK    GeneRIF: JOSD1 inhibits mitochondrial apoptotic signalling to drive
            acquired chemoresistance in gynaecological cancer by stabilizing
            MCL1.
REFERENCE   3  (bases 1 to 3743)
  AUTHORS   Wang,X., Zhang,L., Zhang,Y., Zhao,P., Qian,L., Yuan,Y., Liu,J.,
            Cheng,Q., Xu,W., Zuo,Y., Guo,T., Yu,Z. and Zheng,H.
  TITLE     JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by
            Deubiquitinating and Stabilizing SOCS1
  JOURNAL   Viral Immunol 30 (5), 342-349 (2017)
   PUBMED   28355105
  REMARK    GeneRIF: In this study, the authors report that JOSD1 plays an
            important role in regulating type-I interferon (IFN-I)-mediated
            antiviral activity. JOSD1 physically interacts with SOCS1, which is
            an essential negative regulator of many cytokines signaling, and
            enhances SOCS1 stability by deubiquitinating K48-linked
            polyubiquitination of SOCS1.
REFERENCE   4  (bases 1 to 3743)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 3743)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3743)
  AUTHORS   Sakai,N., Terami,H., Suzuki,S., Haga,M., Nomoto,K., Tsuchida,N.,
            Morohashi,K., Saito,N., Asada,M., Hashimoto,M., Harada,D.,
            Asahara,H., Ishikawa,T., Shimada,F. and Sakurada,K.
  TITLE     Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by
            large-scale gain and loss of function studies
  JOURNAL   J Endocrinol 198 (3), 489-497 (2008)
   PUBMED   18579725
  REMARK    GeneRIF: The gain of function studies indicated that Josephin
            domain containing 1 activate NR5A1 gene expression.
REFERENCE   7  (bases 1 to 3743)
  AUTHORS   Albrecht,M., Hoffmann,D., Evert,B.O., Schmitt,I., Wullner,U. and
            Lengauer,T.
  TITLE     Structural modeling of ataxin-3 reveals distant homology to
            adaptins
  JOURNAL   Proteins 50 (2), 355-370 (2003)
   PUBMED   12486728
REFERENCE   8  (bases 1 to 3743)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021707.2, DB152274.1, HY026936.1, BC015026.3 and CA449010.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001360236.1.
            
            Transcript Variant: This variant (3) contains a different 5'
            non-coding exon compared to variant 1. Variants 1, 2, and 3 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6380202.49004.9,
                                           SRR6380202.128726.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683374.1/ ENSP00000506752.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL021707.2         73425-73425         c
            2-475               DB152274.1         1-474
            476-499             HY026936.1         422-445
            500-3665            BC015026.3         1-3166
            3666-3743           CA449010.1         18-95               c
FEATURES             Location/Qualifiers
     source          1..3743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..3743
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /note="Josephin domain containing 1"
                     /db_xref="GeneID:9929"
                     /db_xref="HGNC:HGNC:28953"
                     /db_xref="MIM:615323"
     exon            1..144
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /inference="alignment:Splign:2.1.0"
     exon            145..960
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             776..1384
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /EC_number="3.4.19.12"
                     /note="josephin domain-containing 1; josephin
                     domain-containing protein 1"
                     /codon_start=1
                     /product="josephin-1"
                     /protein_id="NP_001347165.1"
                     /db_xref="CCDS:CCDS13976.1"
                     /db_xref="GeneID:9929"
                     /db_xref="HGNC:HGNC:28953"
                     /db_xref="MIM:615323"
                     /translation="MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNV
                     FQDSNAFTRDTLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWD
                     KRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMP
                     EWIGGESELRKFLKHHLRGKNCELLLVVPEEVEAHQSWRTDV"
     exon            961..1089
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1284
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..3743
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /note="hexamer: ATTAAA"
     polyA_site      3665
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /note="major polyA site"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
                     /note="hexamer: AATAAA"
     polyA_site      3743
                     /gene="JOSD1"
                     /gene_synonym="dJ508I15.2"
ORIGIN      
        1 cccagttggc ggcgcgcact ccaggtggcg gccggctgcg gtgaggggac cgccagcggc
       61 gagcagtccc ggcggccctg gggtctgcgg ccgggggcgc ggcgggaggg cgtctgggcc
      121 tgcgctcacg tgacgggcgg ggagggccgc ggccagaggg ctagaatccg cgccttccga
      181 gggagccgcg ccctgcgggc cccaccgtac ccgaggggat ggagggctgc ccccgaggcc
      241 cccgcgcggc tcgcggtccc acgcctgccg gcccgcgcta gctactcgac tcgtgcgcta
      301 aatttatccg tcacccaggc cttgtctccc gagtcattgg cgtcgtggtt caaaagaaat
      361 ggaagaaaag gagcgatgtg accgattgtg ttcggtcctc ctgctttgag gcctggcatt
      421 tgcagaggga aacagcaaga aaatcgtggg gattttggag gggggtggga gggaagggtg
      481 gggaaacgga aacaaggtct tacattttat gtgttttttt aaattctgca ctttgacagt
      541 ggtagcaaaa taaaagtaat ccaaaagtta tttttctatt gagaagagag aagaggtggg
      601 ttttattttt ttccttttga ttccaatctt ttctcccagt gacaaagcat aaatcatgga
      661 caccagagaa taaggtggac ctcaggaatc cggaaaagac tgagaagctt acattcttcc
      721 tctagaggga agagtggggt gtttatagcc atctctggaa cctaaaacaa aaaacatgag
      781 ttgtgtgcca tggaaaggag acaaggccaa atctgaatca ttggagctgc cccaggcagc
      841 acccccacaa atctaccatg agaaacagcg cagggagctt tgtgccctcc acgccctcaa
      901 taacgtcttc caggacagca atgccttcac ccgggatacg ctgcaagaga ttttccagag
      961 gttgtctcca aacaccatgg tgacacctca caagaagagc atgctgggaa atggcaacta
     1021 cgatgtgaat gtcattatgg cagcacttca gaccaaaggc tatgaagctg tttggtggga
     1081 caagcgcagg gatgtcggtg tcattgccct cactaacgtc atgggcttca tcatgaatct
     1141 gccctccagc ctatgctggg gtccactgaa actgcccctc aaaaggcagc actggatctg
     1201 tgttcgagag gtgggagggg cctactacaa cctcgactcc aaactcaaga tgcccgagtg
     1261 gattggaggc gagagcgagc tcaggaagtt tctaaaacat catttgcgag gaaagaactg
     1321 tgaactcctg ctggtggtac cagaagaggt agaggctcat cagagttgga ggaccgatgt
     1381 gtaacagttc tgcccaacct ccctctcgcc tcagcccctt cagtcctctg tgacgtgctg
     1441 tggcctctac agtgggtctg cccttgccac ttccccaaac atctcatcaa gtttttcccc
     1501 ttcagatctg acagtgcaat aggacagacg tgtggactgt tataagaact actcagtgtt
     1561 ttgttcctgg gcaaggaagg taggagttct gtgcacttaa ggccagtggt cacaaaccct
     1621 tgttttattt aagagacaga ggagaaagtg gagcggggag ggaatcctag cttattttcc
     1681 cttttctatg aggacttgac acaggttctg ctgagttgtc actgctgctc cagactcacc
     1741 tagagatgct gcctccactt tccatcctgt ctgggtctga aaacagtggg tctgcagata
     1801 gtgcccacaa accccatgtg actggtttga aggacccaga gcataaaggt ctctcaggaa
     1861 accatgtcca aaaccctagc agcggtacag catgctgtct ccaaccctta tccccaggtt
     1921 taagggtggt ttatggccat acgtggaggt tttttgttgt tgtttttgag actgagtttc
     1981 actcttgttg cccaggctgg agtgcaatgg caccatctcg gctcactgca acctccacct
     2041 cctggttcaa gcgattctca ggcctcagct tcccaagtag ttgggattac aggcgcctgc
     2101 caccacacct ggctaatttt gtatttttag tagagatggg gtttctccat gttggtcagg
     2161 ctggtctcaa actcccgacc tcaagtgatc tgcccgcctt ggcctcccaa agtgctggga
     2221 ttacaggcgt gagccaccgc acccggcaga gttttataat gaaaaattaa ctaatattct
     2281 agtatgaagt gaggaggata ctgaacagga tgtggctaaa gccaacctgg gacagccatg
     2341 gggtggcttg gtttcttcac tccagtgttg tccctaccat ttcgcagcat tgatttagga
     2401 ggctctggga caaaagagaa gccaaagagc agttttccca gttcactcac tctggcaaaa
     2461 tcaggaaaaa aaagtctgct tttgacatca aattccacta atttggggca gcgttgggtg
     2521 aggaaagtat tgtgaagaca ggcttcttgg agtaggggca gccacaattc agtagacact
     2581 ctaggctcgg aggctgccac tgtagttgcc aagctcaggt tgggtggttc tgtgctgtat
     2641 ggatggaata ggacctgggc tggtcatctt catgtcgttt cctctctgta tcaatggaag
     2701 ttcaacccgc ccctacctct tcagatagtt gtaggccact tttctcttgt aactttggaa
     2761 aacaaaagag gagaaataag tatcatacca tatgcgtgtc tccaaagtgg atgtggttgc
     2821 ctcaaggcag gtggcaggca ggggtgacct gctggccctc agatcaatgg tcgtggcagg
     2881 tctgagagct gtcccactgg ccagacttct ctccagcagc aaagccagcc tggggcttgc
     2941 atgttgatcc tgagcaagct taacggggtg aagctgggct ttctcccccc tgtgactgga
     3001 gtgcatgttg acaccagcac tttttctgca catgtatctt caatccaaca aggccgtttt
     3061 tttaatgctg agtaacaggc caccaagcgg ctactgcgtt atatcttctc agcaactggc
     3121 cgcagtctct tctgcaccat tttctacacc agacctgctt ggcaccacag ggagctcttt
     3181 tcctgccctg cacaatgaca ttccaaccac caccagccag acattacagc caaccttgct
     3241 gattgtcaca agcaggacct tggggccact ggcactgtca gatagtaagc catttcttgg
     3301 gtagaggagg aaactcctct ccacaaatcc acttgggcct gtgcaaatgg cacttgaaag
     3361 agtccccatg cacttggagt ccatgagcca atgggatatg caaagacgct taaacatttc
     3421 agggctggtt tctctgttca tatccaattc tggtgcttag gaacagggac ccatgctgat
     3481 gcccaagggc aaaaagcccc acttccttta aggaagtgaa caggcctgac cctgatgccc
     3541 aataacgggc aaccctaggc tttttgtttt tcttgctttt attccttttt gttgttggcc
     3601 ttgtgctgcg tttgtttaca aaagatgtat tttgtttaac caaatattaa aaatggaaaa
     3661 ctccatatat gtctccttgt ctgcctgaat tctataattg tgtaaagaaa aataaacttt
     3721 agtatgacgc tgttttaaaa gga
//
