LOCUS       NM_001005920            1934 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens jumonji domain containing 8 (JMJD8), transcript
            variant 1, mRNA.
ACCESSION   NM_001005920 XM_290722
VERSION     NM_001005920.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1934)
  AUTHORS   Guo,J. and Zhao,J.
  TITLE     USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular
            carcinoma
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119617 (2024)
   PUBMED   37898375
  REMARK    GeneRIF: USP22-JMJD8 axis promotes Lenvatinib resistance in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1934)
  AUTHORS   Yi,J., Wang,L., Du,J., Wang,M., Shen,H., Liu,Z., Qin,Y., Liu,J.,
            Hu,G., Xiao,R., Ding,J., Chen,X., Wang,H., Huang,H., Ouyang,G. and
            Liu,W.
  TITLE     ER-localized JmjC domain-containing protein JMJD8 targets STING to
            promote immune evasion and tumor growth in breast cancer
  JOURNAL   Dev Cell 58 (9), 760-778 (2023)
   PUBMED   37054705
  REMARK    GeneRIF: ER-localized JmjC domain-containing protein JMJD8 targets
            STING to promote immune evasion and tumor growth in breast cancer.
REFERENCE   3  (bases 1 to 1934)
  AUTHORS   Liang,X., Zhang,H., Wang,Z., Zhang,X., Dai,Z., Zhang,J., Luo,P.,
            Zhang,L., Hu,J., Liu,Z., Bi,C. and Cheng,Q.
  TITLE     JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA
            Damage Repair to Facilitate Stemness Maintenance, Chemoresistance,
            and Immunosuppression in Pan-Cancer
  JOURNAL   Front Immunol 13, 875786 (2022)
   PUBMED   35898493
  REMARK    GeneRIF: JMJD8 Is an M2 Macrophage Biomarker, and It Associates
            With DNA Damage Repair to Facilitate Stemness Maintenance,
            Chemoresistance, and Immunosuppression in Pan-Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1934)
  AUTHORS   Su,Y., Wang,X., Guo,Z. and Wang,J.
  TITLE     Aberrant JmjC domain-containing protein 8 (JMJD8) expression
            promotes activation of AKT and tumor epithelial-mesenchymal
            transition
  JOURNAL   Oncogene 39 (41), 6451-6467 (2020)
   PUBMED   32879443
  REMARK    GeneRIF: Aberrant JmjC domain-containing protein 8 (JMJD8)
            expression promotes activation of AKT and tumor
            epithelial-mesenchymal transition.
            Erratum:[Oncogene. 2021 Apr;40(17):3180-3186. doi:
            10.1038/s41388-021-01643-6.. PMID: 33772145]
REFERENCE   5  (bases 1 to 1934)
  AUTHORS   Su,Y. and Wang,J.
  TITLE     JmjC domain-containing protein 8 (JMJD8) represses Ku70/Ku80
            expression via attenuating AKT/NF-kappaB/COX-2 signaling
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (12), 118541 (2019)
   PUBMED   31473257
  REMARK    GeneRIF: The research provided data to establish the role of JMJD8
            in regulating tumor cell proliferation and their sensitivity to
            ionizing irradiation or chemo-therapy drug, and the
            AKT/NF-kappaB/COX-2 signaling mediated expression of Ku70/Ku80 was
            involved.
REFERENCE   6  (bases 1 to 1934)
  AUTHORS   Yeo,K.S., Tan,M.C., Wong,W.Y., Loh,S.W., Lam,Y.L., Tan,C.L.,
            Lim,Y.Y. and Ea,C.K.
  TITLE     JMJD8 is a positive regulator of TNF-induced NF-kappaB signaling
  JOURNAL   Sci Rep 6, 34125 (2016)
   PUBMED   27671354
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1934)
  AUTHORS   Boeckel,J.N., Derlet,A., Glaser,S.F., Luczak,A., Lucas,T.,
            Heumuller,A.W., Kruger,M., Zehendner,C.M., Kaluza,D.,
            Doddaballapur,A., Ohtani,K., Treguer,K. and Dimmeler,S.
  TITLE     JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by
            Interacting With Pyruvate Kinase M2 in Endothelial Cells
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (7), 1425-1433 (2016)
   PUBMED   27199445
  REMARK    GeneRIF: Jmjd8 is upregulated during endothelial differentiation
            and regulates endothelial sprouting and metabolism by interacting
            with pyruvate kinase M2.
REFERENCE   8  (bases 1 to 1934)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 1934)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1934)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z92544.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001005920.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1033979.1, AF370420.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609261.6/ ENSP00000477481.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               Z92544.1           9159-9259
            102-191             Z92544.1           9338-9427
            192-240             Z92544.1           9584-9632
            241-337             Z92544.1           9712-9808
            338-406             Z92544.1           9895-9963
            407-526             Z92544.1           10052-10171
            527-594             Z92544.1           10259-10326
            595-729             Z92544.1           10406-10540
            730-1934            Z92544.1           10619-11823
FEATURES             Location/Qualifiers
     source          1..1934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1934
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /note="jumonji domain containing 8"
                     /db_xref="GeneID:339123"
                     /db_xref="HGNC:HGNC:14148"
     exon            1..101
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..810
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; jmjC domain-containing protein 8; jumonji
                     domain-containing protein 8"
                     /codon_start=1
                     /product="jmjC domain-containing protein 8 isoform 1
                     precursor"
                     /protein_id="NP_001005920.3"
                     /db_xref="CCDS:CCDS45369.2"
                     /db_xref="GeneID:339123"
                     /db_xref="HGNC:HGNC:14148"
                     /translation="MAPASRLLALWALAAVALPGSGAEGDGGWRPGGPGAVAEEERCT
                     VERRADLTYAEFVQQYAFVRPVILQGLTDNSRFRALCSRDRLLASFGDRVVRLSTANT
                     YSYHKVDLPFQEYVEQLLHPQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPFGLLG
                     TAPAYSFGIAGAGSGVPFHWHGPGYSEVIYGRKRWFLYPPEKTPEFHPNKTTLAWLRD
                     TYPALPPSARPLECTIRAGEVLYFPDRWWHATLNLDTSVFISTFLG"
     exon            102..191
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            192..240
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            241..337
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            338..406
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            407..526
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            527..594
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            595..729
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1934
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /note="hexamer: AGTAAA"
     polyA_site      1934
                     /gene="JMJD8"
                     /gene_synonym="C16orf20; PP14397"
                     /note="major polyA site"
ORIGIN      
        1 gagggcggca ggctcatggc gccggcgtcg cggttgctcg cgctctgggc gctggcggct
       61 gtggctctac ccggctccgg ggcggagggc gacggcgggt ggcgcccggg cgggccgggg
      121 gccgtggcgg aggaggagcg ctgcacggtg gagcgtcggg ccgacctcac ctacgcggag
      181 ttcgtgcagc agtacgcctt cgtcaggccc gtcatcctgc agggactcac ggacaactcg
      241 aggttccggg ccctgtgctc ccgcgacagg ttgctggctt cgtttgggga cagagtggtc
      301 cggctgagca ccgccaacac ctactcctac cacaaagtgg acttgccctt ccaggagtat
      361 gtggagcagc tgctgcaccc ccaggacccc acctccctgg gcaatgacac cctgtacttc
      421 ttcggggaca acaacttcac cgagtgggcc tctctctttc ggcactactc cccaccccca
      481 tttggcctgc tgggaaccgc tccagcttac agctttggaa tcgcaggagc tggctcgggg
      541 gtgcccttcc actggcatgg acccgggtac tcagaagtga tctacggtcg taagcgctgg
      601 ttcctttacc cacctgagaa gacgccagag ttccacccca acaagaccac gctggcctgg
      661 ctccgggaca catacccagc cctgccaccg tctgcacggc ccctggagtg taccatccgg
      721 gctggtgagg tgctgtactt ccccgaccgc tggtggcatg ctacgctcaa ccttgacacc
      781 agcgtcttca tctccacctt cctcggctag ccaaaacagc tggcaggact gccggtcaca
      841 caccagcacg tcccacctcg tgctcacgga ttttattaca cagatagtgg cggcaatggc
      901 ctcagcccag cccaccctca cctgcttttc cagcccacaa agggggacga tcacggccca
      961 gcaaaagcga tgctgagagg ggaaacagtc cagagtccaa cagcagaact tgggggaagc
     1021 ggtcggggtg gccaggaaca taaactatgt ataggggccg ggggcttctg cccagggctc
     1081 ccctggacca ggacgccagg tagggcaggg aacctcagta gtcctccacc cagccattct
     1141 cagagatgaa tgcgtcaata acctccttca tagccaagtt ggggatgagc tgttcctggg
     1201 tcagggggct ccgggtcacg gggtcaaaat gacccacacg ctgcagtgac aagaagggca
     1261 gagggcagtc atggggccca ggaccatgcc actggccctg ctcccccagc cgcaggcctc
     1321 acctgcaggt gctcctcgat gtccttgcgg tcgtaggtga tgccactggg cgtgatgcac
     1381 ggctcccgca tcagctcaaa gctgatcttg ccacacaggt agtcggggat gtctcgcttc
     1441 tgtggcacag gggcacacgg tcagaggctg aaaaggggca ctgcacgagc acctgccagc
     1501 catcggcagc aagcgacaca cactcacctt cctcttctca tccacctgag aaaaaagctc
     1561 gtccatgtcc gccatgtact tgtcctgtga agagttgagt gctgtgcttg ggggagacac
     1621 cccacctccc tcctccatgg ggcacagacc caacacaagg cggggatgct cccacgccac
     1681 gtgcacacac acagacccac atgtgggtgg ggggcaccct cacgtgcttg gcctcaatgc
     1741 aggcctgctg ggcccggacg tggctgtcgt cctcatcacc ctcgtggttt cgctggcact
     1801 cttccagctc cctgggggtt gaccaggagc cggtcagaga tggacctggc cagatgtctg
     1861 accacacccc aatctcagag ctaacatcca cacttcccca catttcctgc ttgccagtaa
     1921 agccttcgat aaac
//
