LOCUS       NM_005090               3355 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens JMJD7-PLA2G4B readthrough (JMJD7-PLA2G4B), transcript
            variant 1, mRNA.
ACCESSION   NM_005090
VERSION     NM_005090.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Ghosh M, Loper R, Gelb MH and Leslie CC.
  TITLE     Identification of the expressed form of human cytosolic
            phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant
            localized to mitochondria and early endosomes
  JOURNAL   J Biol Chem 281 (24), 16615-16624 (2006)
   PUBMED   16617059
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Tao R, Yu Y, Zhang X, Guo Y, Shi J, Zhang X, Xie L, Liu S, Ju G, Xu
            Q, Shen Y and Wei J.
  TITLE     Cytosolic PLA2 genes possibly contribute to the etiology of
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 137B (1), 56-58 (2005)
   PUBMED   15999343
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Morris DW, Ivanov D, Robinson L, Williams N, Stevenson J, Owen MJ,
            Williams J and O'Donovan MC.
  TITLE     Association analysis of two candidate phospholipase genes that map
            to the chromosome 15q15.1-15.3 region associated with reading
            disability
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 129B (1), 97-103 (2004)
   PUBMED   15274049
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Degousee N, Ghomashchi F, Stefanski E, Singer A, Smart BP,
            Borregaard N, Reithmeier R, Lindsay TF, Lichtenberger C, Reinisch
            W, Lambeau G, Arm J, Tischfield J, Gelb MH and Rubin BB.
  TITLE     Groups IV, V, and X phospholipases A2s in human neutrophils: role
            in eicosanoid production and gram-negative bacterial phospholipid
            hydrolysis
  JOURNAL   J Biol Chem 277 (7), 5061-5073 (2002)
   PUBMED   11741884
  REMARK    GeneRIF: circulating human neutrophils express groups V and X
            sPLA(2) (GV and GX sPLA(2)) mRNA and contain GV and GX sPLA(2)
            proteins, whereas GIB, GIIA, GIID, GIIE, GIIF, GIII, and GXII
            sPLA(2)s are undetectable
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Song C, Chang XJ, Bean KM, Proia MS, Knopf JL and Kriz RW.
  TITLE     Molecular characterization of cytosolic phospholipase A2-beta
  JOURNAL   J Biol Chem 274 (24), 17063-17067 (1999)
   PUBMED   10358058
REFERENCE   7  (bases 1 to 3355)
  AUTHORS   Pickard RT, Strifler BA, Kramer RM and Sharp JD.
  TITLE     Molecular cloning of two new human paralogs of 85-kDa cytosolic
            phospholipase A2
  JOURNAL   J Biol Chem 274 (13), 8823-8831 (1999)
   PUBMED   10085124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA096882.1, AF065215.1,
            DA080158.1, BI768993.1 and BU688449.1.
            
            On Aug 13, 2020 this sequence version replaced NM_005090.3.
            
            Summary: This locus represents naturally-occurring readthrough
            transcription between the neighboring jumonji domain containing 7
            (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B)
            genes. Readthrough transcripts encode fusion proteins that share
            amino acid sequence with each individual gene product, including a
            partial JmjC domain and downstream C2 and phospholipase A2 domains.
            Alternatively spliced transcript variants have been observed.
            [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1, also known as cPLA2 beta)
            represents the longer transcript and encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF065215.1, AF121908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 100137047,
                                      100137049
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA096882.1         8-32
            26-1582             AF065215.1         8-1564
            1583-1586           DA080158.1         207-210
            1587-2379           AF065215.1         1569-2361
            2380-2384           BI768993.1         230-234
            2385-3177           AF065215.1         2367-3159
            3178-3355           BU688449.1         14-191              c
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3355
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /note="JMJD7-PLA2G4B readthrough"
                     /db_xref="GeneID:8681"
                     /db_xref="HGNC:HGNC:34449"
     exon            1..97
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3072
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /note="isoform a is encoded by transcript variant 1;
                     jumonji domain containing 7-phospholipase A2, group IVB
                     (cytosolic) read-through"
                     /codon_start=1
                     /product="JMJD7-PLA2G4B protein isoform a"
                     /protein_id="NP_005081.1"
                     /db_xref="GeneID:8681"
                     /db_xref="HGNC:HGNC:34449"
                     /translation="MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRD
                     WVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMP
                     AERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKM
                     PDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQL
                     TEEGTFKVVDEEAMEKAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSH
                     RLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLR
                     AGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGD
                     QKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLS
                     ALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAA
                     ALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGAS
                     GSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLG
                     YPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEF
                     GEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANL
                     QDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLA
                     QATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCL
                     PLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHT
                     FSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTY
                     SQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH"
     exon            98..251
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            252..505
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            506..562
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            563..658
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            659..735
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            736..808
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            809..945
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1077
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1118
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1161
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1216
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1347
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1431
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1469
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1605
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1742
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1965
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2083
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2221
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2326
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2506
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2673
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2860
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3355
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3355
                     /gene="JMJD7-PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /note="major polyA site"
ORIGIN      
        1 aaaggcgggg tctcggccgg cgctgacgca gccatggcgg aggcggcttt ggaagccgtg
       61 cggagcgagt tacgagaatt cccggccgct gcaagggagc tctgcgtgcc tcttgctgtg
      121 ccctacctgg acaaaccccc aactccgctc cacttctacc gggactgggt ctgccccaac
      181 aggccgtgca ttatccgcaa cgctctgcag cactggccgg ccctccagaa gtggtccctc
      241 ccctatttca gagccacagt gggctccaca gaggtgagtg tggccgtgac cccagatggt
      301 tacgcggatg ccgtgagagg ggatcgcttc atgatgccag ctgagcgccg cctgcccctg
      361 agcttcgtgc tggatgtgct ggagggccgg gcccagcacc ctggagtcct ctatgtgcag
      421 aagcagtgct ccaacctgcc cagcgagctg ccccagctgc tgcctgatct ggaatcccat
      481 gtgccctggg cctccgaagc cctgggaaag atgcccgatg ctgtgaactt ctggctgggg
      541 gaggcggctg cagtgacttc tttgcacaag gaccactatg agaacctcta ctgcgtggtc
      601 tcaggagaga agcatttcct gttccatccg cccagcgacc ggcccttcat cccctatgag
      661 ctgtacacgc cggcaaccta ccagctaact gaagagggca cctttaaggt ggtggatgaa
      721 gaggccatgg agaaggcaga ggtgtccagg acctgcctgc tcacggttcg tgtcctgcag
      781 gcccatcgcc taccctctaa ggacctagtg accccctctg actgctacgt gactctctgg
      841 ctgcccacgg cctgcagcca caggctccag acacgcacgg tcaagaacag cagtagccct
      901 gtctggaacc agagctttca cttcaggatc cacaggcagc tcaagaatgt catggaactg
      961 aaagtctttg accaggacct ggtgaccgga gatgaccctg tgttgtcagt actgtttgat
     1021 gcggggactc tgcgggctgg ggagttccgg cgcgagagct tctcactgag ccctcagggt
     1081 gaggggcgcc tggaagttga atttcgcctg cagagtctgg ctgaccgtgg cgagtggctc
     1141 gtcagcaatg gcgttctggt ggcccgggag ctctcctgct tgcacgttca actggaggag
     1201 acaggagacc agaagtcctc agagcacaga gttcagcttg tggttcctgg gtcctgtgag
     1261 ggtccgcagg aggcctctgt gggcactggc accttccgct tccactgccc agcctgctgg
     1321 gagcaggagc tgagtattcg cctgcaggat gcccccgagg agcaactaaa ggcgccactg
     1381 agtgccctgc cctctggtca agtggtgagg cttgtcttcc ccacgtccca ggagcccctg
     1441 atgagagtgg agctgaaaaa agaagcagga ctgagggagc tggccgtgcg actgggcttc
     1501 gggccctgtg cagaggagca ggccttcctg agcaggagga agcaggtggt ggccgcggcc
     1561 ttgaggcagg ccctgcagct ggacggagac ctgcaggagg atgagatccc agtggtagct
     1621 attatggcca ctggtggtgg gatccgggca atgacttccc tgtatgggca gctggctggc
     1681 ctgaaggagc tgggcctctt ggattgcgtc tcctacatca ccggggcctc gggctccacc
     1741 tgggccttgg ccaaccttta tgaggaccca gagtggtctc agaaggacct ggcagggccc
     1801 actgagttgc tgaagaccca ggtgaccaag aacaagctgg gtgtgctggc ccccagccag
     1861 ctgcagcggt accggcagga gctggccgag cgtgcccgct tgggctaccc aagctgcttc
     1921 accaacctgt gggccctcat caacgaggcg ctgctgcatg atgagcccca tgatcacaag
     1981 ctctcagatc aacgggaggc cctgagtcat ggccagaacc ctctgcccat ctactgtgcc
     2041 ctcaacacca aagggcagag cctgaccact tttgaatttg gggagtggtg cgagttctct
     2101 ccctacgagg tcggcttccc caagtacggg gccttcatcc cctctgagct ctttggctcc
     2161 gagttcttta tggggcagct gatgaagagg cttcctgagt cccgcatctg cttcttagaa
     2221 ggtatctgga gcaacctgta tgcagccaac ctccaggaca gcttatactg ggcctcagag
     2281 cccagccagt tctgggaccg ctgggtcagg aaccaggcca acctggacaa ggagcaggtc
     2341 ccccttctga agatagaaga accaccctca acagccggca ggatagctga gtttttcacc
     2401 gatcttctga cgtggcgtcc actggcccag gccacacata atttcctgcg tggcctccat
     2461 ttccacaaag actactttca gcatcctcac ttctccacat ggaaagctac cactctggat
     2521 gggctcccca accagctgac accctcggag ccccacctgt gcctgctgga tgttggctac
     2581 ctcatcaata ccagctgcct gcccctcctg cagcccactc gggacgtgga cctcatcctg
     2641 tcattggact acaacctcca cggagccttc cagcagttgc agctcctggg ccggttctgc
     2701 caggagcagg ggatcccgtt cccacccatc tcgcccagcc ccgaagagca gctccagcct
     2761 cgggagtgcc acaccttctc cgaccccacc tgccccggag cccctgcggt gctgcacttt
     2821 cctctggtca gcgactcctt ccgggagtac tcggcccctg gggtccggcg gacacccgag
     2881 gaggcggcag ctggggaggt gaacctgtct tcatcggact ctccctacca ctacacgaag
     2941 gtgacctaca gccaggagga cgtggacaag ctgctgcacc tgacacatta caatgtctgc
     3001 aacaaccagg agcagctgct ggaggctctg cgccaggcag tgcagcggag gcggcagcgc
     3061 aggccccact gatggccggg gcccctgcca cccctaactc tcattcattc cctggctgct
     3121 gagttgcagg tgggaactgt catcacgcag tgcttcagag cctcgggctc aggtggcacg
     3181 gtcccagggt ccaggctgag ggctgggagc tcccttgcgc ctcagcagtt tgcagtgggg
     3241 taaggaggcc aagcccattt gtgtaatcac ccaaaacccc ccggcctgtg cctgttttcc
     3301 cttctgcgct accttgagta gttggagcac ttgatacatc acagactcat acaaa
//
