LOCUS       NM_001114632            1409 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens jumonji domain containing 7 (JMJD7), mRNA.
ACCESSION   NM_001114632 XM_001720570 XM_001723659 XM_001725545
VERSION     NM_001114632.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1409)
  AUTHORS   Bilgin,N., Tumber,A., Dhingra,S., Salah,E., Al-Salmy,A.,
            Martin,S.P., Wang,Y., Schofield,C.J. and Mecinovic,J.
  TITLE     Substrate selectivity and inhibition of the human lysyl hydroxylase
            JMJD7
  JOURNAL   Protein Sci 33 (10), e5162 (2024)
   PUBMED   39276004
  REMARK    GeneRIF: Substrate selectivity and inhibition of the human lysyl
            hydroxylase JMJD7.
REFERENCE   2  (bases 1 to 1409)
  AUTHORS   Chowdhury,R., Abboud,M.I., Wiley,J., Tumber,A., Markolovic,S. and
            Schofield,C.J.
  TITLE     Conservation of the unusual dimeric JmjC fold of JMJD7 from
            Drosophila melanogaster to humans
  JOURNAL   Sci Rep 12 (1), 6065 (2022)
   PUBMED   35410347
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1409)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1409)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1409)
  AUTHORS   Markolovic,S., Zhuang,Q., Wilkins,S.E., Eaton,C.D., Abboud,M.I.,
            Katz,M.J., McNeil,H.E., Lesniak,R.K., Hall,C., Struwe,W.B.,
            Konietzny,R., Davis,S., Yang,M., Ge,W., Benesch,J.L.P.,
            Kessler,B.M., Ratcliffe,P.J., Cockman,M.E., Fischer,R., Wappner,P.,
            Chowdhury,R., Coleman,M.L. and Schofield,C.J.
  TITLE     The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of
            TRAFAC GTPases
  JOURNAL   Nat Chem Biol 14 (7), 688-695 (2018)
   PUBMED   29915238
  REMARK    Erratum:[Nat Chem Biol. 2018 Oct;14(10):988. doi:
            10.1038/s41589-018-0104-6.. PMID: 29950663]
REFERENCE   6  (bases 1 to 1409)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1409)
  AUTHORS   Ghosh,M., Loper,R., Gelb,M.H. and Leslie,C.C.
  TITLE     Identification of the expressed form of human cytosolic
            phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant
            localized to mitochondria and early endosomes
  JOURNAL   J Biol Chem 281 (24), 16615-16624 (2006)
   PUBMED   16617059
REFERENCE   8  (bases 1 to 1409)
  AUTHORS   Trewick,S.C., McLaughlin,P.J. and Allshire,R.C.
  TITLE     Methylation: lost in hydroxylation?
  JOURNAL   EMBO Rep 6 (4), 315-320 (2005)
   PUBMED   15809658
REFERENCE   9  (bases 1 to 1409)
  AUTHORS   Song,C., Chang,X.J., Bean,K.M., Proia,M.S., Knopf,J.L. and
            Kriz,R.W.
  TITLE     Molecular characterization of cytosolic phospholipase A2-beta
  JOURNAL   J Biol Chem 274 (24), 17063-17067 (1999)
   PUBMED   10358058
REFERENCE   10 (bases 1 to 1409)
  AUTHORS   Pickard,R.T., Strifler,B.A., Kramer,R.M. and Sharp,J.D.
  TITLE     Molecular cloning of two new human paralogs of 85-kDa cytosolic
            phospholipase A2
  JOURNAL   J Biol Chem 274 (13), 8823-8831 (1999)
   PUBMED   10085124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK289833.1, DA100207.1 and BC139899.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001114632.1.
            
            Summary: This gene encodes a highly conserved protein with a JmjC
            domain, which are part of the cupin metalloenzyme superfamily. JmjC
            proteins may function as 2-oxoglutarate-Fe(II)-dependent
            dioxygenases. Most tissues also express read-through transcripts
            from this gene into the downstream phospholipase A2, group IVB
            (cytosolic) gene, some of which may encode fusion proteins
            combining the N-terminus of this protein with the phospholipase A2,
            group IVB protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.114844.1,
                                           SRR1163658.317015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397299.9/ ENSP00000380467.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK289833.1         8-13
            7-14                DA100207.1         7-14
            15-1409             BC139899.1         1-1395
FEATURES             Location/Qualifiers
     source          1..1409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1409
                     /gene="JMJD7"
                     /note="jumonji domain containing 7"
                     /db_xref="GeneID:100137047"
                     /db_xref="HGNC:HGNC:34397"
     exon            1..97
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..984
                     /gene="JMJD7"
                     /EC_number="1.14.11.63"
                     /note="jmjC domain-containing protein 7; jumonji
                     domain-containing protein 7; L-lysine (3S)-hydroxylase
                     JMJD7"
                     /codon_start=1
                     /product="bifunctional peptidase and (3S)-lysyl
                     hydroxylase JMJD7"
                     /protein_id="NP_001108104.1"
                     /db_xref="CCDS:CCDS45240.1"
                     /db_xref="GeneID:100137047"
                     /db_xref="HGNC:HGNC:34397"
                     /translation="MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRD
                     WVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMP
                     AERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKM
                     PDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQL
                     TEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWF
                     HHVQQSQGCIAVNFWYDMEYDLKYSYFQLLDSLTKASGLD"
     exon            98..251
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     exon            252..505
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     exon            506..562
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     exon            563..658
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     exon            659..735
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     exon            736..895
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1409
                     /gene="JMJD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1392..1397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JMJD7"
                     /note="hexamer: AATAAA"
     polyA_site      1409
                     /gene="JMJD7"
                     /note="major polyA site"
ORIGIN      
        1 aaaggcgggg tctcggccgg cgctgacgca gccatggcgg aggcggcttt ggaagccgtg
       61 cggagcgagt tacgagaatt cccggccgct gcaagggagc tctgcgtgcc tcttgctgtg
      121 ccctacctgg acaaaccccc aactccgctc cacttctacc gggactgggt ctgccccaac
      181 aggccgtgca ttatccgcaa cgctctgcag cactggccgg ccctccagaa gtggtccctc
      241 ccctatttca gagccacagt gggctccaca gaggtgagtg tggccgtgac cccagatggt
      301 tacgcggatg ccgtgagagg ggatcgcttc atgatgccag ctgagcgccg cctgcccctg
      361 agcttcgtgc tggatgtgct ggagggccgg gcccagcacc ctggagtcct ctatgtgcag
      421 aagcagtgct ccaacctgcc cagcgagctg ccccagctgc tgcctgatct ggaatcccat
      481 gtgccctggg cctccgaagc cctgggaaag atgcccgatg ctgtgaactt ctggctgggg
      541 gaggcggctg cagtgacttc tttgcacaag gaccactatg agaacctcta ctgcgtggtc
      601 tcaggagaga agcatttcct gttccatccg cccagcgacc ggcccttcat cccctatgag
      661 ctgtacacgc cggcaaccta ccagctaact gaagagggca cctttaaggt ggtggatgaa
      721 gaggccatgg agaaggtgcc ctggatccca ctggacccct tggcgccaga cctagcacgg
      781 taccctagtt acagtcaggc ccaggccctt cgctgcacgg tgcgggccgg tgagatgctc
      841 tatctgccgg ctctgtggtt ccaccacgtc cagcagtccc agggctgcat cgcagtgaat
      901 ttctggtatg acatggaata cgacctcaag tatagttact tccagctgct cgactccctc
      961 accaaggctt caggccttga ctgatggagc actggtgaac accaccaagc acgcctcggg
     1021 ggacggagcc agcccctccc tggccaggtc aattctcgag agagcctgga gtgtgcatgc
     1081 tggctgctgg ccccgggtcc agcatggctt gagatcagct ttggaggatc ttggaatgtg
     1141 gtcataagga ctcaaggtgc caggcaggtc tgggtgaggg ttctcaggaa gttgccacac
     1201 aggtgagcag agtggggatc aggtgcagcg gcacctctcc ccagcgctgt gatgttgggc
     1261 gagtcactgc gtctcgggca ttggtgtcct gtcagtaaag agataataat ggctgtacct
     1321 cgcggggctg ttgtgggctt ggagatgatg tctatgagga ccagcatgga gctggcacac
     1381 aggacatgtt gaataaaagg tagctgtga
//
