LOCUS       NM_023007               2484 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens jumonji domain containing 4 (JMJD4), transcript
            variant 1, mRNA.
ACCESSION   NM_023007
VERSION     NM_023007.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Tang,Y., Feng,M., Su,Y., Ma,T., Zhang,H., Wu,H., Wang,X., Shi,S.,
            Zhang,Y., Xu,Y., Hu,S., Wei,K. and Xu,D.
  TITLE     Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is
            Protective Against Dilated Cardiomyopathy
  JOURNAL   Circulation 147 (22), 1684-1704 (2023)
   PUBMED   37066795
  REMARK    GeneRIF: Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and
            Is Protective Against Dilated Cardiomyopathy.
            Erratum:[Circulation. 2024 Jul 9;150(2):e64. doi:
            10.1161/CIR.0000000000001268.. PMID: 38976614]
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Ho,Y.J., Shih,C.P., Yeh,K.T., Shi,B., Gong,Z., Lin,Y.M. and Lu,J.W.
  TITLE     Correlation between high expression levels of jumonji
            domain-containing 4 and short survival in cases of colon
            adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 503 (3), 1442-1449 (2018)
   PUBMED   30029884
  REMARK    GeneRIF: It observed significant positivity of JMJD4 between 59
            paired samples from colon adenocarcinoma (CA) tissue and adjacent
            normal tissue. JMJD4 protein expression in CA differed
            significantly according to the histological grade and M-class
            (distant metastasis).
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Feng,T., Yamamoto,A., Wilkins,S.E., Sokolova,E., Yates,L.A.,
            Munzel,M., Singh,P., Hopkinson,R.J., Fischer,R., Cockman,M.E.,
            Shelley,J., Trudgian,D.C., Schodel,J., McCullagh,J.S., Ge,W.,
            Kessler,B.M., Gilbert,R.J., Frolova,L.Y., Alkalaeva,E.,
            Ratcliffe,P.J., Schofield,C.J. and Coleman,M.L.
  TITLE     Optimal translational termination requires C4 lysyl hydroxylation
            of eRF1
  JOURNAL   Mol Cell 53 (4), 645-654 (2014)
   PUBMED   24486019
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Liu,W., Ma,Q., Wong,K., Li,W., Ohgi,K., Zhang,J., Aggarwal,A. and
            Rosenfeld,M.G.
  TITLE     Brd4 and JMJD6-associated anti-pause enhancers in regulation of
            transcriptional pause release
  JOURNAL   Cell 155 (7), 1581-1595 (2013)
   PUBMED   24360279
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136378.14.
            
            On Aug 3, 2020 this sequence version replaced NM_023007.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011928.2, AK022579.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620518.5/ ENSP00000477669.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AL136378.14        41050-41340         c
            292-457             AL136378.14        40689-40854         c
            458-583             AL136378.14        39945-40070         c
            584-851             AL136378.14        39452-39719         c
            852-998             AL136378.14        38919-39065         c
            999-2484            AL136378.14        37229-38714         c
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..2484
                     /gene="JMJD4"
                     /note="jumonji domain containing 4"
                     /db_xref="GeneID:65094"
                     /db_xref="HGNC:HGNC:25724"
                     /db_xref="MIM:620928"
     exon            1..291
                     /gene="JMJD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1283
                     /gene="JMJD4"
                     /note="isoform 1 is encoded by transcript variant 1; jmjC
                     domain-containing protein 4; jumonji domain-containing
                     protein 4; C4 lysyl hydroxylase; 2-oxoglutarate- and
                     Fe(II)-dependent oxygenase; lysyl-hydroxylase JMJD4;
                     2-oxoglutarate and iron-dependent oxygenase JMJD4"
                     /codon_start=1
                     /product="2-oxoglutarate and iron-dependent oxygenase
                     JMJD4 isoform 1"
                     /protein_id="NP_075383.3"
                     /db_xref="CCDS:CCDS1561.2"
                     /db_xref="GeneID:65094"
                     /db_xref="HGNC:HGNC:25724"
                     /db_xref="MIM:620928"
                     /translation="MDRETRALADSHFRGLGVDVPGVGQAPGRVAFVSEPGAFSYADF
                     VRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEY
                     NSNPKEHMTLRDYITYWKEYIQAGYSSPRGCLYLKDWHLCRDFPVEDVFTLPVYFSSD
                     WLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKKWLLFPPGQEEA
                     LRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVHNLDD
                     TISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINF
                     EEFYHFLKVIAEKRLLVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQRVD
                     TSAFSPQPKELLQQLREAVDAAAAP"
     exon            292..457
                     /gene="JMJD4"
                     /inference="alignment:Splign:2.1.0"
     exon            458..583
                     /gene="JMJD4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..851
                     /gene="JMJD4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..998
                     /gene="JMJD4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..2484
                     /gene="JMJD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JMJD4"
                     /note="hexamer: AATAAA"
     polyA_site      1391
                     /gene="JMJD4"
                     /note="major polyA site"
     polyA_site      2442
                     /gene="JMJD4"
                     /note="major polyA site"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JMJD4"
                     /note="hexamer: AATGAA"
     polyA_site      2484
                     /gene="JMJD4"
ORIGIN      
        1 ggagggtcct tcgacccgtg ctgagctgga tggaccgcga gacgcgcgcc ctcgccgaca
       61 gccacttccg aggcctgggg gtcgatgtcc ccggcgtcgg ccaggctccg ggccgggtag
      121 ccttcgtctc ggagccgggc gccttctcct acgccgactt tgtgcggggc ttcttgctgc
      181 ccaacctgcc ctgcgtgttt tccagcgcct tcacgcaggg ctggggcagc cggcggcgct
      241 gggtgacgcc cgcggggagg cccgacttcg accacctgct acggacctac ggagacgtgg
      301 ttgtaccagt tgcaaactgt ggggtccagg aatacaactc gaaccccaaa gagcacatga
      361 ctctcagaga ctacatcacc tactggaaag agtacataca ggcgggctac tcctctccca
      421 ggggctgtct ctacctcaaa gactggcact tgtgcaggga ctttccggtg gaggacgttt
      481 tcaccctgcc tgtgtacttc tcgtccgact ggctgaatga gttctgggat gcactggatg
      541 tggatgacta ccgctttgtc tacgcggggc ctgcgggcag ctggtccccg ttccatgctg
      601 acatcttccg ctccttcagc tggtctgtca atgtctgtgg gaggaagaag tggctcctct
      661 tccccccagg gcaggaagag gccctgcggg accgccacgg caacctgccc tacgacgtga
      721 cctccccagc actctgcgac acacacctgc acccacggaa ccagcttgct ggcccaccct
      781 tggagatcac gcaggaagcg ggcgagatgg tgtttgtgcc cagtggctgg caccaccagg
      841 tgcacaacct ggatgacacc atctccatca accacaactg ggtcaatggc ttcaacctgg
      901 ccaacatgtg gcgcttcttg cagcaggagc tatgcgccgt gcaggaggag gtcagcgagt
      961 ggagggactc catgcccgac tggcaccacc actgccaggt catcatgagg tcctgctcgg
     1021 gcatcaactt tgaagagttt taccacttcc tcaaggtcat cgctgagaag aggctcctgg
     1081 tcctgaggga ggcagccgct gaggacggtg ctgggttggg tttcgaacag gcagcctttg
     1141 atgttgggcg catcacagag gtgctggcct ccttggttgc gcaccccgac ttccagagag
     1201 tggacaccag cgcgttctca ccacagccca aagagctgct gcagcagctg agagaggctg
     1261 ttgatgctgc tgcggcccca tagcacctgt cgtgaggata gaaggacggg tggaagagag
     1321 gcagcctcct gctccggggc ccttccagaa ataaagaccg ccctccctgt gacctggggc
     1381 ccacccctgt cgaggcttgt ggcctggctg ttcatggcca ctgcctgggt gcctgttttc
     1441 aggtgaggcc caatgaggtc agggacccaa gatgggatgt ggcccttctg acctgcagca
     1501 ggcctgctgg gagctcggag atggtgccag gacctggctc ttttgggggc cctgcctcct
     1561 taggccagga cgcctgagct gacaggagtc tgtgtctggt gtgccttctc tggtggctcc
     1621 tcttaatagg ccagccctgt cccctcgtct caggccattg gaccacccct ggctctgccc
     1681 tgtgggttca gggaggggtt ggagcagtgc tgggcaagct caccagggcc tccaggcagg
     1741 gctggggttg gcctccatca cctccaggtg atgggctgtg gaaccagcgg cctgcgcctt
     1801 cctctgggta cccagagtgg agggctgggt tgggctggcc tttgccacct ccctgccttt
     1861 gcagggcctg tggacagctg gagaggccac agatggggtg gaatcccatc tgctgctgaa
     1921 tcctcacctg ggcctgaggg actgtgcctg ctgtgcactc acagctgggt cttcccaagg
     1981 atgctgttct caggagtggt gggtccccag cccctcttca cactgggtat gatggaggtg
     2041 tgggcgggct cgtccaggcc gatcaaggca cagcagtgag cagcggaggc ctgtggtggg
     2101 gaatggactc tcgtgggatc ctcttgcaga ggatgcccca ggcctgaacc ctctagtgga
     2161 tccacagttt gtggagactg gcactctccc agccctgtcc ttgaccgaga gtccagcatt
     2221 ttttcagttg gcccctggtt ggctgcctca ccccagcagg ggaggaggca tccgaatcca
     2281 cagggacggc acgtgccatg gctatgcaca ttgcctgccc gtggcatcaa ctggggccgc
     2341 tggcacttgt ctaggatgga agcccccaag aagggcaggg gtttctgtct gctctgttca
     2401 gtgaatcatg tgaagtgctt gcaaaggcag ctttacacag taggtgcttc atatgtgtct
     2461 gtcgaatgaa tgcgctccag ccaa
//
