LOCUS       NM_016475               2347 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens JNK1/MAPK8 associated membrane protein (JKAMP),
            transcript variant 1, mRNA.
ACCESSION   NM_016475
VERSION     NM_016475.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Cubero,F.J., Zhao,G., Nevzorova,Y.A., Hatting,M., Al Masaoudi,M.,
            Verdier,J., Peng,J., Schaefer,F.M., Hermanns,N., Boekschoten,M.V.,
            Grouls,C., Gassler,N., Kiessling,F., Muller,M., Davis,R.J.,
            Liedtke,C. and Trautwein,C.
  TITLE     Haematopoietic cell-derived Jnk1 is crucial for chronic
            inflammation and carcinogenesis in an experimental model of liver
            injury
  JOURNAL   J Hepatol 62 (1), 140-149 (2015)
   PUBMED   25173965
  REMARK    GeneRIF: synergistic function of Jnk1 in haematopoietic cells and
            hepatocytes might be relevant for the development of chronic liver
            injury
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   Roy,S.J., Glazkova,I., Frechette,L., Iorio-Morin,C., Binda,C.,
            Petrin,D., Trieu,P., Robitaille,M., Angers,S., Hebert,T.E. and
            Parent,J.L.
  TITLE     Novel, gel-free proteomics approach identifies RNF5 and JAMP as
            modulators of GPCR stability
  JOURNAL   Mol Endocrinol 27 (8), 1245-1266 (2013)
   PUBMED   23798571
  REMARK    GeneRIF: Expression of DP, a receptor largely retained in the ER,
            promoted proteasome recruitment by JAMP.
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Tcherpakov,M., Delaunay,A., Toth,J., Kadoya,T., Petroski,M.D. and
            Ronai,Z.A.
  TITLE     Regulation of endoplasmic reticulum-associated degradation by
            RNF5-dependent ubiquitination of JNK-associated membrane protein
            (JAMP)
  JOURNAL   J Biol Chem 284 (18), 12099-12109 (2009)
   PUBMED   19269966
  REMARK    GeneRIF: RNF5 associates with JAMP in the ER membrane. This
            association results in Ubc13-dependent RNF5-mediated noncanonical
            ubiquitination of JAMP.
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Tcherpakov,M., Broday,L., Delaunay,A., Kadoya,T., Khurana,A.,
            Erdjument-Bromage,H., Tempst,P., Qiu,X.B., DeMartino,G.N. and
            Ronai,Z.
  TITLE     JAMP optimizes ERAD to protect cells from unfolded proteins
  JOURNAL   Mol Biol Cell 19 (11), 5019-5028 (2008)
   PUBMED   18784250
  REMARK    GeneRIF: JAMP is an important component for coordinated clearance
            of misfolded proteins from the endoplasmic reticulum.
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Kadoya,T., Khurana,A., Tcherpakov,M., Bromberg,K.D., Didier,C.,
            Broday,L., Asahara,T., Bhoumik,A. and Ronai,Z.
  TITLE     JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein,
            regulates duration of JNK activity
  JOURNAL   Mol Cell Biol 25 (19), 8619-8630 (2005)
   PUBMED   16166642
  REMARK    GeneRIF: Identification and functional characterization of the
            mouse Jamp ortholog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC381037.1, AL136696.1, BX161501.1, AL121694.4 and HY340214.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016475.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.125270.1,
                                           SRR1803616.15433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616435.5/ ENSP00000479775.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DC381037.1         75-108
            35-1386             AL136696.1         1-1352
            1387-1653           BX161501.1         1453-1719
            1654-1899           AL121694.4         170887-171132       c
            1900-2344           HY340214.1         30-474              c
            2345-2347           AL121694.4         170439-170441       c
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..2347
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="JNK1/MAPK8 associated membrane protein"
                     /db_xref="GeneID:51528"
                     /db_xref="HGNC:HGNC:20184"
                     /db_xref="MIM:611176"
     exon            1..77
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1009
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     JNK-associated membrane protein; Jun N-terminal kinase
                     1-associated membrane protein; medulloblastoma antigen
                     MU-MB-50.4"
                     /codon_start=1
                     /product="JNK1/MAPK8-associated membrane protein isoform
                     1"
                     /protein_id="NP_057559.2"
                     /db_xref="CCDS:CCDS45116.1"
                     /db_xref="GeneID:51528"
                     /db_xref="HGNC:HGNC:20184"
                     /db_xref="MIM:611176"
                     /translation="MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQK
                     YCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAA
                     IITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIY
                     YAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFP
                     YIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQ
                     DLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH"
     exon            78..169
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            170..324
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            325..531
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            532..713
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            714..790
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            791..2347
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="hexamer: AATAAA"
     polyA_site      1646
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="major polyA site"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="hexamer: AATAAA"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="hexamer: TATAAA"
     polyA_site      2280
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
     polyA_site      2296
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /note="hexamer: ATTAAA"
     polyA_site      2347
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
ORIGIN      
        1 gtggcccgga tgttcggtgc agctgccaga tccgctgatc tagtgcttct cgaaaaaaac
       61 cttcaggcgg cccatggctg tcgatattca accagcatgc cttggacttt attgtgggaa
      121 gaccctatta tttaaaaatg gctcaactga aatatatgga gaatgtgggg tatgcccaag
      181 aggacagaga acgaatgcac agaaatattg tcagccttgc acagaatctc ctgaacttta
      241 tgattggctc tatcttggat ttatggcaat gcttcctctg gttttacatt ggttcttcat
      301 tgaatggtac tcggggaaaa agagttccag cgcacttttc caacacatca ctgcattatt
      361 tgaatgcagc atggcagcta ttatcacctt acttgtgagt gatccagttg gtgttcttta
      421 tattcgttca tgtcgagtat tgatgctttc tgactggtac acgatgcttt acaacccaag
      481 tccagattac gttaccacag tacactgtac tcatgaagcc gtctacccac tatataccat
      541 tgtatttatc tattacgcat tctgcttggt attaatgatg ctgctccgac ctcttctggt
      601 gaagaagatt gcatgtgggt tagggaaatc tgatcgattt aaaagtattt atgctgcact
      661 ttacttcttc ccaattttaa ccgtgcttca ggcagttggt ggaggccttt tatattacgc
      721 cttcccatac attatattag tgttatcttt ggttactctg gctgtgtaca tgtctgcttc
      781 tgaaatagag aactgctatg atcttctggt cagaaagaaa agacttattg ttctcttcag
      841 ccactggtta cttcatgcct atggaataat ctccatttcc agagtggata aacttgagca
      901 agatttgccc cttttggctt tggtacctac accagccctt ttttacttgt tcactgcaaa
      961 atttaccgaa ccttcaagga tactctcaga aggagccaat ggacactgag tgtagacatg
     1021 tgaaatgcca aaaacctgag aagtgctcct aataaaaaag taaatcaatc ttaacagtgt
     1081 atgagaacta ttctatcata tatgggaaca agattgtcag tatatcttaa tgtttgggtt
     1141 tgtctttgtt ttgtttatgg ttagacttac agacttggaa aatgcaaaac tctgtaatac
     1201 tctgttacac agggtaatat tatctgctac actggaaggc cgctaggaag cccttgcttc
     1261 tctcaacagt tcagctgttc tttagggcaa aatcatgttt ctgtgtacct agcaatgtgt
     1321 tcccatttta ttaagaaaag ctttaacacg tgtaatctgc agtccttaac agtggcgtaa
     1381 ttgtacttac ctgttgtgtt tcagtttgtt tttcacctat aatgaattgt aaaaacaaac
     1441 atacttgtgg ggtctgatag caaacataga aatgatgtat attgtttttt gttatctatt
     1501 tattttcatc aatacagtat tttgatgtat tgcaaaaata gataataatt tatataacag
     1561 gttttctgtt tatagattgg ttcaagattt gtttggatta ttgttcctgt aaagaaaaca
     1621 ataataaaaa gcttacctac ataaaatttc aatgttttga cacttaattg ttgtttggca
     1681 caatagtatg gaagtaattc aaactggtaa atagtttcct ctcatatctc gggtatatat
     1741 acataccata ttttattgat ccagagatac ttatttcact ttgtgacatc tctgaattag
     1801 gatgcatctt acaactgatg gcttattaga tttaatgaaa tacagaagat acacagaata
     1861 aaaagggttt tcctgtggtt ggtttgtggt ttgtgatagg tgttctgtga tgtttatgct
     1921 ttgaaggcct taagactcat ggttgcaacc atggaagcaa aatgaaattt ttagctctta
     1981 acctaacaac ctgaccatgt ttatccattt ttattgttta gaagtttatt tactgatact
     2041 tggtggaggt tgtgtgaatt agttaaattt taaatgttta agacttctat taacagctgc
     2101 aaaatatgaa agtaagtgca ctcacttttc ctgtagtagt ctgtcttttg aattcacagc
     2161 agttgtatcc ttgagttact ttgttaatgt atttttctca gtacatttaa ccactgggaa
     2221 atgaaccctt gtacgaatgt gtttcttctt ctctgtagga ataaaaaata aatataaaaa
     2281 ttttatttgt attgcacaca tttggggggt tattagtgtt cattaaaatt ctgagttgcc
     2341 caaagaa
//
