LOCUS       NM_024806               7057 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens junctional cadherin complex regulator (JHY),
            transcript variant 1, mRNA.
ACCESSION   NM_024806
VERSION     NM_024806.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7057)
  AUTHORS   Appelbe,O.K., Bollman,B., Attarwala,A., Triebes,L.A.,
            Muniz-Talavera,H., Curry,D.J. and Schmidt,J.V.
  TITLE     Disruption of the mouse Jhy gene causes abnormal ciliary
            microtubule patterning and juvenile hydrocephalus
  JOURNAL   Dev Biol 382 (1), 172-185 (2013)
   PUBMED   23906841
REFERENCE   2  (bases 1 to 7057)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP004318.2, BC068507.1 and AP003040.2.
            
            On Jul 2, 2019 this sequence version replaced NM_024806.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068507.1, AK291625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227349.7/ ENSP00000227349.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AP004318.2         47011-47016
            7-2914              BC068507.1         1-2908
            2915-7057           AP003040.2         14934-19076
FEATURES             Location/Qualifiers
     source          1..7057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..7057
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /note="junctional cadherin complex regulator"
                     /db_xref="GeneID:79864"
                     /db_xref="HGNC:HGNC:26288"
                     /db_xref="MIM:617594"
     exon            1..214
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            215..647
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2640
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C11orf63; juvenile hydrocephalus;
                     jhy protein homolog"
                     /codon_start=1
                     /product="jhy protein homolog isoform 1"
                     /protein_id="NP_079082.2"
                     /db_xref="CCDS:CCDS8438.1"
                     /db_xref="GeneID:79864"
                     /db_xref="HGNC:HGNC:26288"
                     /db_xref="MIM:617594"
                     /translation="MSKRKLIPKLSIQSPVLHTNLNVQSTHPPLKKEDLHRISKDSLE
                     SDSESLTQEIMCHSEFDDRIRGNGMEPDSLDEEESPRWGSLHEMEEEASGKAAQMARE
                     QNHHTWDQGANNRQQPIEDKYSDLRYDPNWKSKKEEGQLLSVEALPESTDSSLENLPL
                     APLYPSQETSMELSGGKGEQKESPQSAASLLGSEFLSPNYEHGARRSKPFSELSDSDL
                     EEKSSSLSPYVKSSSSHNEVFLPGSRGPRRRKSKQHFVEKNKLTLGLPTPKTDSYLQL
                     HNKKRGESHPEQISYPVRVTDKTSIQNAKEMENAAIDPEDKWHQRAQQLKNYQEHWSQ
                     YESTKSSNVPRGQPSDMVNDHQPSRRPAKLKIRKQCKHQNGLKSSTTEEVTASQGNQN
                     NPPRQQQNQNKPLDTSTKPESIVIMHASNNDVQASRALRSHNLKETSNTFAPPKQAFD
                     KVLSKNSTGCDSGLNVNKERGHKDQEEKRFSYQQLHTLSDMDLNNLNELSKRHVLLSQ
                     KGSQFVYHINTHGSTKNKKQLKQPYTETKYRNLEMLWKFHSSSDSQTVRASPDSWLTQ
                     IMEQHQQALVQLTDVQPSEGALSSVTLPPILSRVESESQLSSERSQRNQVKISRSNSE
                     GYLFQLEKGKKHKKRSSSKNTKLKGYQKRDVKLGGLGPDFESIRDKTQKLIQQKEYAK
                     QVKEYNMKTLSILSKPQTEKTQKKSAIPRQKALEYAKTIPKPKPSNLTHQASKEQKNP
                     TYAGKEESLPEISLLEILQNRHEREKQAVAAFKVLHIV"
     exon            648..1167
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1281
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1937
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2232
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2313
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2442
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..7057
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2894..2899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /note="hexamer: AATAAA"
     polyA_site      2917
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /note="major polyA site"
     regulatory      7038..7043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /note="hexamer: AATAAA"
     polyA_site      7057
                     /gene="JHY"
                     /gene_synonym="C11orf63"
                     /note="major polyA site"
ORIGIN      
        1 acggccgttt gcagcctccg tgccagggcc gggggtgcgg ttcgggacgc gggatcctag
       61 gtcgggtcct gccccgccca tgtggcgccg gcgtctgtgt tgtctgcggt ctccagggca
      121 gcgccggggc gggcgggggc ccgggcggcg gcggcggcgg cgcgggagga tgcggggccc
      181 gtccgggtcg cggccgcgga ggagcgccgg gcaggtaacg cttttgtgaa ccacaacttt
      241 aaatatcagc cagctgctcc tatcaacacg agtatcccct gttaattttt tgcatttttc
      301 aagatgagta aacgtaaact aattcccaag ctctctattc aatctcctgt ccttcatacc
      361 aacttaaatg tccagtccac acacccacct ttgaagaaag aagacttaca tcggatttca
      421 aaagactcct tggaatctga ttcagaaagc ctcacgcaag agattatgtg ccattctgag
      481 tttgatgatc gaatccgggg caacggtatg gagcccgaca gcttagacga ggaggaaagc
      541 cctcgatggg gaagcctgca cgagatggaa gaggaagcaa gtggaaaagc agctcagatg
      601 gctcgcgagc aaaaccacca tacctgggac cagggcgcca ataacaggca acaaccaata
      661 gaagacaaat attcagacct ccgctatgac ccgaactgga agagtaagaa ggaggaaggg
      721 cagctgctgt ctgtggaagc gttgccggag tccacggaca gctctttaga aaatctgcct
      781 ttggctcccc tctacccttc ccaggagacg tcaatggaac tctccggggg aaaaggcgag
      841 cagaaagaga gtccacagag tgcagcttct ttacttggta gtgaattttt aagcccaaac
      901 tatgagcatg gtgcccgtcg cagcaagccg ttttcagagc tgagcgacag tgacctggag
      961 gagaagtcga gcagcctttc tccgtacgtg aagagctcaa gttcacataa cgaggttttc
     1021 ctgccgggat cacgtggccc tcggcgaagg aaatccaaac aacattttgt ggaaaaaaac
     1081 aagctcactt tgggattacc caccccgaaa acggactctt atcttcaact tcacaataaa
     1141 aaaagagggg aatctcatcc agaacagatc tcctaccccg tcagagtaac agacaagacg
     1201 tctattcaga atgccaagga aatggaaaat gctgccatcg atcctgaaga taaatggcat
     1261 caaagagcac aacagctaaa gaattaccag gaacactggt ctcaatatga aagtacaaaa
     1321 tcaagcaatg taccaagagg gcaaccttct gacatggtga atgaccatca accttccaga
     1381 agaccagcca agctcaagat tcgaaagcag tgtaaacacc agaatggcct gaagtcttcc
     1441 acaacggaag aggtgactgc cagtcagggg aaccagaata accctcccag gcagcaacaa
     1501 aaccaaaata agcctcttga tacttcaaca aagcctgaat cgattgtgat tatgcatgcc
     1561 tctaacaatg atgtacaagc ctcaagggca cttagaagcc acaatctcaa agaaacctcc
     1621 aatacatttg ctccaccaaa acaggctttt gacaaggtct tatctaaaaa ctctactgga
     1681 tgtgactctg ggctgaatgt taataaagaa agaggacaca aagaccaaga agagaaaaga
     1741 ttttcatatc agcagctaca caccctttct gacatggatt tgaacaacct taatgaactt
     1801 tctaagagac acgtgctcct gagccagaaa ggctctcagt ttgtttatca cataaatact
     1861 catggatcaa ccaaaaataa gaaacaactc aaacagcctt atacagagac aaaatacagg
     1921 aacttagaaa tgttatggaa attccattct tcttctgaca gccagacggt tagagcttct
     1981 ccagattcat ggctcaccca gataatggag cagcatcagc aagccttggt gcagctgacc
     2041 gacgtgcagc ccagtgaagg ggccttatcc agcgtcacgc ttccacctat actgtcaagg
     2101 gtagaaagtg aatcccaact cagttcagag agaagccaaa gaaaccaagt gaaaattagc
     2161 cgtagcaatt ctgaaggcta tctgtttcaa ctggaaaagg gaaaaaagca taagaaaaga
     2221 agcagcagta agaacaccaa gctgaaaggt tatcagaaaa gagacgtgaa gcttggaggc
     2281 ctcggacctg actttgagtc catcagagac aaaacgcaaa aattaataca gcaaaaggaa
     2341 tatgcaaaac aagtcaagga gtacaacatg aagacactat ccattctatc aaaaccacaa
     2401 acagaaaaaa ctcaaaagaa atctgctatc cctcggcaga aggctttgga atacgctaag
     2461 accatcccca aacccaaacc atcaaatctg actcatcaag catcaaagga acaaaaaaat
     2521 ccaacctatg ctgggaaaga agaaagttta cctgaaatct cactgctgga aatactgcag
     2581 aacagacacg aaagggaaaa acaggctgtg gctgctttca aagtccttca catcgtatag
     2641 acaacatttg ataggaagga gaccaaaaat ggtccaggaa tgaacgtgga gaaaagaaac
     2701 gccaaccacc ttctctgcgt tgagagtaat ggcctattat tatcatctat ctgccgtcca
     2761 tgtttgcttt ctgcaggatt taaaatatga ggcccaattg gattatggtg ccatatttta
     2821 ctttctagga agaaaatttt ttaaattatt tattttcaaa tcagttagaa ttggagctga
     2881 ataataacta gagaataaag cttttgtttt atattgatct tttgatttct tcatctctac
     2941 cccattcctt agcataatgg aaaccttaaa gttacccaga aataaatgta gctgtgtttc
     3001 tctcttacct tcctagtaag aaaaacaagt ataaacattt cagtttctcc taaaatgaac
     3061 tcagtcatcc ataaattttg tgataacatt tcaaaatatt actaaaatct ccaagtttgg
     3121 caaagggctt atatatatta agttgaggcc gggcacagtg gctcacgcct gtaatcccag
     3181 cactttggga agctgaggca gttgaatagc ttgaggccag gagtttgaga ccagcctggg
     3241 caacatggtg aaaccccatc tctactaaaa atacaaaaat tagctaggcg tggtggcgca
     3301 tgtctatagt tccaggtact caggaggctg aggcacaaga attgcttgaa cccgggaggc
     3361 agaggttaca gtgagccgag attgtaccat tgcactccag cctgggcaac aaagcaagac
     3421 tctgtctgaa caacaacaac aaaaggttcc tgccctgaca gattctctgg tcggggtcac
     3481 agggatgtta agacagctgg ctgcctgggt cttcgctgac catgctgtcc tgggtggcac
     3541 tttctgccac tgccacagtg gccccctctc tgtagaatgc agttttctta ggtccagggg
     3601 tattgcaggc aacaaggacc tttcacacag ggaagccact ccttgcccct ctaccacctc
     3661 ttccttcctt ttcctataga ggaaaagttc gttttgggct gatccctgag gaattcttcc
     3721 aatttcttta tcctgaaacc agtgtaacag gaccctatgt gctccaaact gggcttatct
     3781 tgtatgcttt atccaaagaa atatacatga ttaccccaga gaccttttct actatatcaa
     3841 tagtagggtt acttgtctat gtaatttaaa aatatggtgc ctctattgga gaatctgctt
     3901 atcaactcaa tgagcaaaac attgcccaac tagaagaggt gaagcaggct tccatcaaac
     3961 aaatccagga tgcaattgat ttggagaagt cgcagcgctc actggttcag aagcgccatt
     4021 acctttttga tgtgcagagg aataacattg ctatggctgt ggaggttact tactgggaat
     4081 gactgcatag agtgtataag gaagtaaaga atcgcctgga ctatcatata tctgtgcaga
     4141 acatgatgcg ttgaaaggaa caagagcaca tgataaattg ggtgcagagc atctctgcac
     4201 aacaggaaaa ggagacaatt gccaagtgca tttgggacct aaagctgttg gcaaagaaga
     4261 ctcatgcaca gccagttatg taaatgtatc tatcccaatt gagagagcca gaaacagttg
     4321 actgactaaa tggaaactag gctatgtggc aaaatctttc tgtattgccc tctactgaag
     4381 tagatagttt atatctccta aaaatgaaac atttgttccc tatactgaga gaactcaatc
     4441 tattggccaa tcagatgttt cccatccttc ttactcagca tttgagttgt tccatgatca
     4501 tttttttatt gttgtttttt ttgctgttgt tgttgttttt agacagactc tcgctctgtc
     4561 acccaggctg gagtgcagtg gcacaatctc ggttcactgc aactccgcct cctggattca
     4621 agcgattctc ctgtctcagc ctcccttcaa gcaattctcc tgtctcagcc tcccgagtag
     4681 ccgagattgc aagcgtgcac taccacgccc ggctaatttt tatactttta gtagaggcag
     4741 ggtttcgcca tgttgaccag gctggtcttg aactcctgat ctcaggtgat ccgcccacct
     4801 tggccttcca aagtgctggg attacaggcg ttagctacta cacctggccc tatgatcact
     4861 tttgaataag cagtttgcct ttgttaaatc ttggtgcctg actaaagatt accaggttat
     4921 agtttaaatt tgtaattaat tctaccatct tgcaataaag tgacaattga atgaaacaca
     4981 aataaataaa gaataaagtt gaaaaaaaat gaaggtacat ctggctgtgc ctgctcagat
     5041 agaacaaatc ctaatgttgt tctaacagag catcaagaca ttagttagaa accctccaac
     5101 aagtccagaa acacctaatg caggcaactc tgagagacac actttatcaa agctccttac
     5161 tccaagtaca taaatttgct ggccattttg ccatcacaaa tatcttaaaa tattgtcaaa
     5221 tgtgtgtttt cacacacaca aaaatagata agacaaaagc attccatagt ttactactga
     5281 atacaaatgt taataaatat tttttagttt ttaaatcttt tttaatattg caagaattcc
     5341 cagtcttaaa atcattactg gagagtttaa ttttctactt ccttccttat attagatgga
     5401 cattacattt ttagataggc atatccagaa gtggataatt tgaacatcaa tttggggaaa
     5461 atctgtttat ctatacgtgt ggtgtaagga ctagctttgg aaatgtactc ctatgttgta
     5521 tacattttac atataccaaa atgtagcata aaagatgcct gtatgaaacc ttctcttaaa
     5581 actgaaagca gttagaattg agagtctgca aagataacaa gtatctgaag ataaacagaa
     5641 aactggtgaa tcatgtttca gtgggatttg gaaaatgtaa tatatgaggc attagacagg
     5701 aaaatcacag gccaaaacta ctcctaaaat gtatttataa gagaagaggc ccttctaggt
     5761 gcatgaagac atttctagaa atatgaggta gaatgaataa ccttcattaa ttgtttccga
     5821 aatggcctta aattcgaact taatttggaa gagaaaaaga atgcatatag agacattcat
     5881 atttaaaggg atagggtaaa atttttaaat attccatttg tattatctta aaatagttta
     5941 gagcttggaa agtttgtcac attcaactgc cagtttttca gaagatgaaa tggaggtgaa
     6001 gagaaaggtt acatgactcg gaagtccatc agtcctactg agagtaatgg gaggggagcc
     6061 aggtctgaat ctcccatctt tgaacaccag gaatagtact ttttatttgt ctatggaaag
     6121 aggttgtcct tgtttctctg tgtggatgag caacatatag ttgctatgaa tttctatttt
     6181 ggacctgaat ttccaccaag ttcaattttt agaaatatgc attactatgt acctaatagt
     6241 tttttagcat gtacaatctg ccaacttcct tacaacattg ataaaagtag aatacacata
     6301 taaagcaact caaacttaga aactgaccaa taaaagagac actatttatt ttcttttttt
     6361 tttccagaac atttcaaaaa cttcccatac tgtttttctg ttagcttaag cgttgttaaa
     6421 tccttcactt tcacacctac tgtcaagaac ccaaatttgg ctgaagcagc ttaagtgatt
     6481 cagttcatgt caaacaacat ttcacaggat tcttaccccc aaggcaactc tttactatcc
     6541 agtacataag actctagaac attaaaattc tttatatagt gccatgtggc atctaaaata
     6601 actttggcta ggaaataaaa catatttgca gaaagtttgg ggttgaaatc aaagaatgga
     6661 tcaaagtggc ccttcatttg gctccacgtc atctcacaat agtgaaatac agcagaatgt
     6721 cactaaacta ccataaaact aaggggagag attttgcaaa aacagggagt gacagacacg
     6781 ttttttgctc ctgttttaaa gtaaattgta ctaatgacaa caatagtgat cttttatagg
     6841 cccaagttgg atcagtgatc aattcatagc atttctgttt caaatattca aaagcaaaaa
     6901 ataatctgcc aattagaaaa caaaaaactt caaacttaag tgatgtaatg atggagcacc
     6961 tgtatttgac tagatgttat atacatgcca ttgaaagaca tagtacctaa tctgcctaat
     7021 gtctataaac tggtgcaaat aaaagacatt taaacca
//
