LOCUS       NM_001135048            5378 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens Jun dimerization protein 2 (JDP2), transcript variant
            3, mRNA.
ACCESSION   NM_001135048
VERSION     NM_001135048.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5378)
  AUTHORS   Tian,Y., Shao,J., Bai,S., Xu,Z. and Bi,C.
  TITLE     Palmitic acid-induced microRNA-143-5p expression promotes the
            epithelial-mesenchymal transition of retinal pigment epithelium via
            negatively regulating JDP2
  JOURNAL   Aging (Albany NY) 15 (9), 3465-3479 (2023)
   PUBMED   37179125
  REMARK    GeneRIF: Palmitic acid-induced microRNA-143-5p expression promotes
            the epithelial-mesenchymal transition of retinal pigment epithelium
            via negatively regulating JDP2.
REFERENCE   2  (bases 1 to 5378)
  AUTHORS   Engler,M.J., Mimura,J., Yamazaki,S. and Itoh,K.
  TITLE     JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity
            by suppressing the ATF4-DR5 axis
  JOURNAL   FEBS Open Bio 10 (12), 2771-2779 (2020)
   PUBMED   33108704
  REMARK    GeneRIF: JDP2 is directly regulated by ATF4 and modulates TRAIL
            sensitivity by suppressing the ATF4-DR5 axis.
REFERENCE   3  (bases 1 to 5378)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5378)
  AUTHORS   Xu,Y., Xia,X., Jiang,Y., Wu,D., Wang,S., Fu,S., Yang,N., Zhang,Y.
            and Sun,L.
  TITLE     Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a
            competing endogenous RNA for JDP2 by impairing trophoblastic
            phenotype
  JOURNAL   J Cell Mol Med 24 (8), 4557-4568 (2020)
   PUBMED   32150333
  REMARK    GeneRIF: Down-regulated lncRNA AGAP2-AS1 contributes to
            pre-eclampsia as a competing endogenous RNA for JDP2 by impairing
            trophoblastic phenotype.
REFERENCE   5  (bases 1 to 5378)
  AUTHORS   Yu,W., Deng,W., Zhao,Q., Zhuang,H., Zhang,C. and Jian,Z.
  TITLE     miR-501 acts as an independent prognostic factor that promotes the
            epithelial-mesenchymal transition through targeting JDP2 in
            hepatocellular carcinoma
  JOURNAL   Hum Cell 32 (3), 343-351 (2019)
   PUBMED   30877624
  REMARK    GeneRIF: JDP2 is downregulated in HCC tissues and cells, and
            overexpressed JDP2 facilitated HCC cell invasion and EMT.
REFERENCE   6  (bases 1 to 5378)
  AUTHORS   Wardell,S.E., Boonyaratanakornkit,V., Adelman,J.S., Aronheim,A. and
            Edwards,D.P.
  TITLE     Jun dimerization protein 2 functions as a progesterone receptor
            N-terminal domain coactivator
  JOURNAL   Mol Cell Biol 22 (15), 5451-5466 (2002)
   PUBMED   12101239
REFERENCE   7  (bases 1 to 5378)
  AUTHORS   Jin,C., Li,H., Murata,T., Sun,K., Horikoshi,M., Chiu,R. and
            Yokoyama,K.K.
  TITLE     JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex
            to inhibit the retinoic acid-induced differentiation of F9 cells
  JOURNAL   Mol Cell Biol 22 (13), 4815-4826 (2002)
   PUBMED   12052888
REFERENCE   8  (bases 1 to 5378)
  AUTHORS   Katz,S., Heinrich,R. and Aronheim,A.
  TITLE     The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun
            N-terminal kinase
  JOURNAL   FEBS Lett 506 (3), 196-200 (2001)
   PUBMED   11602244
REFERENCE   9  (bases 1 to 5378)
  AUTHORS   Jin,C., Ugai,H., Song,J., Murata,T., Nili,F., Sun,K., Horikoshi,M.
            and Yokoyama,K.K.
  TITLE     Identification of mouse Jun dimerization protein 2 as a novel
            repressor of ATF-2
  JOURNAL   FEBS Lett 489 (1), 34-41 (2001)
   PUBMED   11231009
REFERENCE   10 (bases 1 to 5378)
  AUTHORS   Aronheim,A., Zandi,E., Hennemann,H., Elledge,S.J. and Karin,M.
  TITLE     Isolation of an AP-1 repressor by a novel method for detecting
            protein-protein interactions
  JOURNAL   Mol Cell Biol 17 (6), 3094-3102 (1997)
   PUBMED   9154808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF111167.2, BE389064.1, BC051303.1, AC009363.4 and BU740697.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135048.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.112690.1,
                                           ERR279830.10779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651602.1/ ENSP00000498745.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AF111167.2         173008-173202
            196-208             BE389064.1         2-14
            209-221             AF111167.2         173216-173228
            222-699             BE389064.1         28-505
            700-1724            BC051303.1         672-1696
            1725-3341           AC009363.4         27104-28720
            3342-3972           BU740697.1         17-647              c
            3973-5378           AC009363.4         29352-30757
FEATURES             Location/Qualifiers
     source          1..5378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..5378
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /note="Jun dimerization protein 2"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
     exon            1..231
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..455
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..746
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /note="isoform a is encoded by transcript variant 3;
                     progesterone receptor co-activator"
                     /codon_start=1
                     /product="jun dimerization protein 2 isoform a"
                     /protein_id="NP_001128520.1"
                     /db_xref="CCDS:CCDS9842.1"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
                     /translation="MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLG
                     AMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQR
                     ESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQL
                     EKK"
     exon            456..560
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..5378
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1704..1709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /note="hexamer: AGTAAA"
     polyA_site      1726
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /note="major polyA site"
     regulatory      3949..3954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /note="hexamer: AATAAA"
     polyA_site      3972
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
     regulatory      5355..5360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /note="hexamer: AATAAA"
     polyA_site      5378
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
ORIGIN      
        1 gccgcccgcc acagcctgcg ggagggacgc tcggcggccg cgacgggggg cgctggcggc
       61 ggcggacgct gcagcggcgg cggggctggc gccgcggcgg ctcccgggcc gggacaggcc
      121 tgggcaccgg gcggagctcc gcggccgggc ggcagcggcg cggagcgggc acggcgcctg
      181 cagccgggcc ccggccccgg gggcgccgcc tccccccgca ccttctgcac ggctggcctg
      241 ccactcctcc tgctatgatg cctgggcaga tcccggaccc ttcggtgacc acaggctccc
      301 tgccagggct tggccccctg accgggctcc ccagctcggc cctgactgtg gaggagctga
      361 aatacgctga catccgcaac ctcggggcca tgattgcacc cttgcacttc ctggaggtga
      421 aactgggcaa gaggccccag cccgtgaaaa gtgagctaga tgaggaagag gagcgaagga
      481 aaaggcgccg ggagaagaac aaagtcgcag cagcccgatg ccggaacaag aagaaggagc
      541 gcacggagtt tctgcagcgg gaatccgagc ggctggaact catgaacgca gagctgaaga
      601 cccagattga ggagctgaag caggagcggc agcagctcat cctgatgctg aaccgacacc
      661 gccccacctg catcgtccgg accgacagtg tcaagacccc cgagtcagaa ggcaacccac
      721 tgctcgagca gctcgagaag aagtgaccat gggctgggag gaggtggagg aggaggaaga
      781 ggagaaggaa aagtgacgaa gagagaggag gaggggggcc ccagatggcc cttcctttgg
      841 tgcatgaaaa actgtacaat gaggttcagc acagccagca tcagccgagc ttttttgtga
      901 aactcagatc agccacccag gaggaagagc gggctgagga aacccagagg gaccaagcgc
      961 tgagaccaaa gttgaccctc gggtagggtt gtcctgcctg gggccccact tgaaggaggc
     1021 aggacagagg caccgaggcc agggagacgc ccaacgaggc agccctgggc tcttctctgg
     1081 cctcttcacc agggcaccca tccaaggaac ctccgaacag ccaggaaaag ccatgagttg
     1141 caaccaaaac gcggctgagg atggaactca gaatgaaact gcaacccacc tgcccccagc
     1201 cctgcccctc gccctgatgc gaagctggag aggggcgtgc tgcggggccc tgatgccccc
     1261 acccacctcg gtccagcgcg gccctgccca ggaggcggca gccgggcgca ccctcgccag
     1321 ccctgctgga gtttgctgtg ggcactgagg cgcgggcgcc cttccaaagc acatactcac
     1381 cgaatgttta cagactggct gtcctggcag ggctttcaac tgcacatgtt ttttatactt
     1441 tccttttttt tttttttttt aatatttttt acaaaaaaaa agattttata caagcaatat
     1501 atatatggat ttctataatc actcgatgtg atacagtata aatatgctat ggtttgtttg
     1561 ttatgaacag atagccacca gttacggccg ttgtgtgtaa ctcctaagta ctgtagtctc
     1621 tgggtgtcgg gggtggccag ggcgggggcg gggtgcattt ccatccttgt aaacccttca
     1681 tagtactcag tcctgtatcg ctcagtaaac attgctctta cttacatagc cgccttgcgt
     1741 ggtgtctgcc tggggaatgg gtgcaaggcc ctctcagggt cggagactgt ttggagcctc
     1801 tgctataggc ctgttcattt tcacaacagc tctcctattt cacagatgag gaagctaagg
     1861 ctcagagaca ttaagccacc tgcagttact attttgagag cagtcagagt gttcgctcac
     1921 tctgcagatg ttttctgagg gcctgttgtg tgtgccaggc cctgagaatt cactggagga
     1981 tgaaacagac ctaagtcttg cccttgtggg gcctccagta aggagtgaat cctgtgcttg
     2041 ctccataagt tgtctcattt cgtcttcatg gcagccttgc cagggaacag cacttgtccc
     2101 caattcacag atggcgaatt agaggtccag ggaattaaac tcgcagacac catttgttga
     2161 agacttattt tgtgacaagc agacatagtc tcttcccttc tcacaagagc acaaactagg
     2221 cacgattctt ctcattttac agatggttta actgaggctc agagaaggta agcgacttat
     2281 ccaaggtaac ccagctagca agggatagag ctggtgtttg aactctccct ccagaggcct
     2341 gtgactctcc tcctgtcacc aacccactat gattgtcctc atggttgaat aggaagctta
     2401 tgaggccaca gttatagatt tagtttctgg gaaggctgga tagagttcca ggttgtccca
     2461 tgatcacaga gtgaaccaac taccctggtc aatgtgtgtc tgacccaggg aagggtgtgg
     2521 atggcttctc tgccccctca cctcgacagc tgaatccctg ccacccaggg ccggagcagc
     2581 tcagtggcat tcactcagtg cctgctgtgt acctggcact cggcagttct caaggcatgt
     2641 cacgcatgag gaaggcggga gaggtgtttt tagcttcctt gtatactgaa gcttgcaaag
     2701 gctacagttt acccaactaa acttgactcc tgcattctaa tcatgtgttc tttctcctcc
     2761 atccctggac ttaggataac tagttgctgg tgatgacttc gtgtcaagaa cagcagtgaa
     2821 cctgggttgc ttcccaaatt gtggacgagg ccttctggga tgggcagaag tggagaatgg
     2881 tgattaacac acctgtgatc cctccctcgc tcactcctct cagtttccct ccacccaaca
     2941 cacttggtgt ggactcccct gcaccccgcc ctagaaacag gacctggtcc tctcactgtc
     3001 agctgtggca gaaggttgtg gcagcgggtt gccttctgtc tcgggggtct tgaggctgtc
     3061 ggtccggacg atgcaggtga ggcagtgtca gttctgcatc aggaacccct cgcgctgtaa
     3121 tcctttgata tttttcaagc catgagaaaa atgaagtgga cttaccaggg tccctccagt
     3181 gacctagtgg atgttcttac aggactgccg tgtgccactg gctgtggctt ccctggtcct
     3241 gtgcttggcc accgggagct ggcatctcca aaatagagcc tccttagcct gtgcaggtgg
     3301 gctgtcttcc aaagtcacca caccagtgac ttgtgctgtg cggagccttc ctcaccagga
     3361 ccactggctg ctcctgtggc tagaagtcac aattataggc ttcattgcaa gagccagcat
     3421 ttgagtttct tctgggcacc tgccactgtg catgtgtgac ctcaactgct ttgtgcaccc
     3481 tgactggggg gtaggtgcta gcgttccaac attacagatg agaaaaccga ggcacacaga
     3541 agaggtaacc tgcccaaggt cacaggtgtt aggtggcaga gccaagatgt tattgtcagt
     3601 ctgacttcag gtgcataaaa cctgaggctg agcctcccca tgagaggaaa aatgtgtttg
     3661 tggtgtgacc tcagttgcca gggaacttgt gcaggaagcc gggagagatg gcacagaccc
     3721 acctgtgctc acagtacatg ttaagaattc ccaagtctca ggcaaaccat ctccaagggt
     3781 gttcacagaa gacacacctt aaaggcaaac gggttcatga tgtaatcttc tattgactag
     3841 ctgtgaacct catttttctt atctgtgaag tgggaacagt aataatccaa gtctttttat
     3901 ggagttatca agatcaaaaa aggaatggat atacaaagtg ttttgtgaaa taaaagctcc
     3961 ctaaaatggt aattattttg tcctctgtta gtgtcggtag ttattgatat ctacatagta
     4021 caggttattt aaatatgttt tattctgtaa agatgggctg ccaagtttgt gttctgaccc
     4081 tgtacgtggt ccctatggtg tgatgaatgc ctgggatcgc agactcctgg atctgttcag
     4141 ctcctgactg gtcacaacca gccatgctgg atgcatcatt ccctccctgg gcctcagtgt
     4201 gccctcctgc caggtggtca cacataagac ctgtgccacc tctgcccagg gttcctatga
     4261 gaatcaatcg agttgatgaa tgcaaccatg gcctgagaaa gacaagacgc tttagctatc
     4321 agatgggcag aaacaagtat gtgttggtaa gaatatggat taaaggttgg gaggccaaga
     4381 tgggtggatc atgaggtcag aagattgaga ccaccctgga taacacggtg aaaccctgtc
     4441 tctactaata atacaaaaaa ttagccgggc atggtggcac gtgcctgtag tcccagctac
     4501 tcgggaggct gaggcaggag aatcacttgg acctgggagg tggaggttgc agtgagccaa
     4561 gattgcgcca ctgcactcca gcctgggtga cagagcgaga ctccatctca aaaaaaacaa
     4621 aacaaaaaaa atgtggatta aaggaaactt agatatgctg ccagtgagaa actgtgcaaa
     4681 gcaatttgga aataaccagt aaaactaaag ctaaacgcat cctttgacct agcagttttc
     4741 ctcctagtct tgggaggaac tctagcacag gggcaaaagg aaatgtacaa gaatgttcac
     4801 tgatggcttt gtttgtattt ttaaaaagtt gaaaacaacc taaatgatga tcagcataag
     4861 aacaaataaa ttgtggtatt ttcctaaaat tgaatattac tcaacaggta aaaaagaatg
     4921 aaccagagct atatgtatca atatggataa atctcagaaa cctactgttg agatggaggg
     4981 taggggagtg aactgcggaa ggataccact tatgtcatat ttctaactaa atgtatacgt
     5041 tgatacttta ttgtttatgg ctacacacac atctgggtaa tagaggtata aaagcctgca
     5101 caagaatgct gtcaatatca caatcagtca tagggagtgc tcctgggagg gccgcggaga
     5161 ggagggaact agggatgcca ctgcaagggt aagtaggacg ctggacttca acttcaacta
     5221 tacacataac atttcattta tttttttaaa atccccatca aatgtagaat gacaggattt
     5281 ttcagaggtg ggtgatgtgt gcacagatgt gggctatctt ctccacactc ctctgtatat
     5341 ttgatattct ttgcaataaa agagaacaag ccacaata
//
