LOCUS       NM_144646               1286 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens joining chain of multimeric IgA and IgM (JCHAIN),
            mRNA.
ACCESSION   NM_144646
VERSION     NM_144646.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Wang,M., Wu,Y., Li,X., Dai,M. and Li,S.
  TITLE     IGJ suppresses breast cancer growth and metastasis by inhibiting
            EMT via the NF-kappaB signaling pathway
  JOURNAL   Int J Oncol 63 (3) (2023)
   PUBMED   37539706
  REMARK    GeneRIF: IGJ suppresses breast cancer growth and metastasis by
            inhibiting EMT via the NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Chen,Q., Menon,R.P., Masino,L., Tolar,P. and Rosenthal,P.B.
  TITLE     Structural basis for Fc receptor recognition of immunoglobulin M
  JOURNAL   Nat Struct Mol Biol 30 (7), 1033-1039 (2023)
   PUBMED   37095205
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Li,Y., Wang,G., Li,N., Wang,Y., Zhu,Q., Chu,H., Wu,W., Tan,Y.,
            Yu,F., Su,X.D., Gao,N. and Xiao,J.
  TITLE     Structural insights into immunoglobulin M
  JOURNAL   Science 367 (6481), 1014-1017 (2020)
   PUBMED   32029689
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Frutiger,S., Hughes,G.J., Paquet,N., Luthy,R. and Jaton,J.C.
  TITLE     Disulfide bond assignment in human J chain and its covalent pairing
            with immunoglobulin M
  JOURNAL   Biochemistry 31 (50), 12643-12647 (1992)
   PUBMED   1472500
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Bastian,A., Kratzin,H., Eckart,K. and Hilschmann,N.
  TITLE     Intra- and interchain disulfide bridges of the human J chain in
            secretory immunoglobulin A
  JOURNAL   Biol Chem Hoppe Seyler 373 (12), 1255-1263 (1992)
   PUBMED   1292512
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Max,E.E., McBride,O.W., Morton,C.C. and Robinson,M.A.
  TITLE     Human J chain gene: chromosomal localization and associated
            restriction fragment length polymorphisms
  JOURNAL   Proc Natl Acad Sci U S A 83 (15), 5592-5596 (1986)
   PUBMED   3016707
REFERENCE   8  (bases 1 to 1286)
  AUTHORS   Max,E.E. and Korsmeyer,S.J.
  TITLE     Human J chain gene. Structure and expression in B lymphoid cells
  JOURNAL   J Exp Med 161 (4), 832-849 (1985)
   PUBMED   2984306
REFERENCE   9  (bases 1 to 1286)
  AUTHORS   Tartakoff,A. and Vassalli,P.
  TITLE     Plasma cell immunoglobulin M molecules. Their biosynthesis,
            assembly, and intracellular transport
  JOURNAL   J Cell Biol 83 (2 Pt 1), 284-299 (1979)
   PUBMED   115892
REFERENCE   10 (bases 1 to 1286)
  AUTHORS   Mole,J.E., Bhown,A.S. and Bennett,J.C.
  TITLE     Primary structure of human J chain: alignment of peptides from
            chemical and enzymatic hydrolyses
  JOURNAL   Biochemistry 16 (16), 3507-3513 (1977)
   PUBMED   407930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038982.1, BP221304.1 and BP418109.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144646.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.34465.1,
                                           SRR1163655.579552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254801.9/ ENSP00000254801.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               BC038982.1         40-651
            613-821             BC038982.1         653-861
            822-975             BP221304.1         94-247
            976-1286            BP418109.1         124-434
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1286
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /note="joining chain of multimeric IgA and IgM"
                     /db_xref="GeneID:3512"
                     /db_xref="HGNC:HGNC:5713"
                     /db_xref="MIM:147790"
     exon            1..82
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..498
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /note="immunoglobulin J chain; IgJ chain; immunoglobulin J
                     polypeptide, linker protein for immunoglobulin alpha and
                     mu polypeptides"
                     /codon_start=1
                     /product="immunoglobulin J chain precursor"
                     /protein_id="NP_653247.1"
                     /db_xref="CCDS:CCDS3545.1"
                     /db_xref="GeneID:3512"
                     /db_xref="HGNC:HGNC:5713"
                     /db_xref="MIM:147790"
                     /translation="MKNHLLFWGVLAVFIKAVHVKAQEDERIVLVDNKCKCARITSRI
                     IRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELD
                     NQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD"
     exon            83..206
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /inference="alignment:Splign:2.1.0"
     exon            207..287
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /inference="alignment:Splign:2.1.0"
     exon            288..1286
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1265..1270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /note="hexamer: ATTAAA"
     polyA_site      1286
                     /gene="JCHAIN"
                     /gene_synonym="IGCJ; IGJ; JCH"
                     /note="major polyA site"
ORIGIN      
        1 agaagaagtg aagtcaagat gaagaaccat ttgcttttct ggggagtcct ggcggttttt
       61 attaaggctg ttcatgtgaa agcccaagaa gatgaaagga ttgttcttgt tgacaacaaa
      121 tgtaagtgtg cccggattac ttccaggatc atccgttctt ccgaagatcc taatgaggac
      181 attgtggaga gaaacatccg aattattgtt cctctgaaca acagggagaa tatctctgat
      241 cccacctcac cattgagaac cagatttgtg taccatttgt ctgacctctg taaaaaatgt
      301 gatcctacag aagtggagct ggataatcag atagttactg ctacccagag caatatctgt
      361 gatgaagaca gtgctacaga gacctgctac acttatgaca gaaacaagtg ctacacagct
      421 gtggtcccac tcgtatatgg tggtgagacc aaaatggtgg aaacagcctt aaccccagat
      481 gcctgctatc ctgactaatt taagtcattg ctgactgcat agctcttttt cttgagaggc
      541 tctccatttt gattcagaaa gttagcatat ttattaccaa tgaatttgaa accagggctt
      601 tttttttttt ttgggtgatg taaaaccaac tccctgccac caaaataatt aaaatagtca
      661 cattgttatc tttattaggt aatcacttct taattatatg ttcatactct aagtatcaaa
      721 atcttccaat tatcatgctc acctgaaaga ggtatgctct cttaggaata cagtttctag
      781 cattaaacaa ataaacaagg ggagaaaata aaactcaagg actgaaaatc aggaggtgta
      841 ataaaatgtt cctcgcattc ccccccgctt tttttttttt ttttgacttt gccttggaga
      901 gccagagctt ccgcattttc tttactattc tttttaaaaa aagtttcact gtgtagagaa
      961 catatatgca taaacatagg tcaattatat gtctccatta gaaaaataat aattggaaaa
     1021 catgttctag aactagttac aaaaataatt taaggtgaaa tctctaatat ttataaaagt
     1081 agcaaaataa atgcataatt aaaatatatt tggacataac agacttggaa gcagatgata
     1141 cagacttctt tttttcataa tcaggttagt gtaagaaatt gccatttgaa acaatccatt
     1201 ttgtaactga accttatgaa atatatgtat ttcatggtac gtattctcta gcacagtctg
     1261 agcaattaaa tagattcata agcata
//
