LOCUS       NM_004973               6003 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens jumonji and AT-rich interaction domain containing 2
            (JARID2), transcript variant 1, mRNA.
ACCESSION   NM_004973
VERSION     NM_004973.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6003)
  AUTHORS   van der Laan,L., Rooney,K., Haghshenas,S., Silva,A., McConkey,H.,
            Relator,R., Levy,M.A., Valenzuela,I., Trujillano,L.,
            Lasa-Aranzasti,A., Campos,B., Castells,N., Verberne,E.A., Maas,S.,
            Alders,M., Mannens,M.M.A.M., van Haelst,M.M., Sadikovic,B. and
            Henneman,P.
  TITLE     Functional Insight into and Refinement of the Genomic Boundaries of
            the JARID2-Neurodevelopmental Disorder Episignature
  JOURNAL   Int J Mol Sci 24 (18), 14240 (2023)
   PUBMED   37762546
  REMARK    GeneRIF: Functional Insight into and Refinement of the Genomic
            Boundaries of the JARID2-Neurodevelopmental Disorder Episignature.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6003)
  AUTHORS   Sreeshma,B. and Devi,A.
  TITLE     JARID2 and EZH2, the eminent epigenetic drivers in human cancer
  JOURNAL   Gene 879, 147584 (2023)
   PUBMED   37353042
  REMARK    GeneRIF: JARID2 and EZH2, the eminent epigenetic drivers in human
            cancer.
            Review article
REFERENCE   3  (bases 1 to 6003)
  AUTHORS   Huang,D., Wang,R., Tian,L. and Wang,H.
  TITLE     Integrated bioinformatics and experimental validation reveal the
            role of JARID2 in ovarian cancer
  JOURNAL   Epigenomics 15 (8), 487-505 (2023)
   PUBMED   37309591
  REMARK    GeneRIF: Integrated bioinformatics and experimental validation
            reveal the role of JARID2 in ovarian cancer.
REFERENCE   4  (bases 1 to 6003)
  AUTHORS   Gu,Y., Ding,Z., Zhou,Q., Li,J. and Qian,W.
  TITLE     JARID2 regulates epithelial mesenchymal transition through the
            PTEN/AKT signalling pathways in ovarian endometriosis
  JOURNAL   Reprod Biol 23 (1), 100729 (2023)
   PUBMED   36640627
  REMARK    GeneRIF: JARID2 regulates epithelial mesenchymal transition through
            the PTEN/AKT signalling pathways in ovarian endometriosis.
REFERENCE   5  (bases 1 to 6003)
  AUTHORS   Zhang,H., Du,Y., Xin,P. and Man,X.
  TITLE     The LINC00852/miR-29a-3p/JARID2 axis regulates the proliferation
            and invasion of prostate cancer cell
  JOURNAL   BMC Cancer 22 (1), 1269 (2022)
   PUBMED   36471281
  REMARK    GeneRIF: The LINC00852/miR-29a-3p/JARID2 axis regulates the
            proliferation and invasion of prostate cancer cell.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6003)
  AUTHORS   Pasini,D., Cloos,P.A., Walfridsson,J., Olsson,L., Bukowski,J.P.,
            Johansen,J.V., Bak,M., Tommerup,N., Rappsilber,J. and Helin,K.
  TITLE     JARID2 regulates binding of the Polycomb repressive complex 2 to
            target genes in ES cells
  JOURNAL   Nature 464 (7286), 306-310 (2010)
   PUBMED   20075857
  REMARK    GeneRIF: JARID2 is essential for the binding of PcG proteins to
            target genes and, consistent with this, for the proper
            differentiation of embryonic stem cells and normal development
REFERENCE   7  (bases 1 to 6003)
  AUTHORS   Kim,T.G., Kraus,J.C., Chen,J. and Lee,Y.
  TITLE     JUMONJI, a critical factor for cardiac development, functions as a
            transcriptional repressor
  JOURNAL   J Biol Chem 278 (43), 42247-42255 (2003)
   PUBMED   12890668
REFERENCE   8  (bases 1 to 6003)
  AUTHORS   Toyoda,M., Kojima,M. and Takeuchi,T.
  TITLE     Jumonji is a nuclear protein that participates in the negative
            regulation of cell growth
  JOURNAL   Biochem Biophys Res Commun 274 (2), 332-336 (2000)
   PUBMED   10913339
REFERENCE   9  (bases 1 to 6003)
  AUTHORS   Lee,Y., Song,A.J., Baker,R., Micales,B., Conway,S.J. and Lyons,G.E.
  TITLE     Jumonji, a nuclear protein that is necessary for normal heart
            development
  JOURNAL   Circ Res 86 (9), 932-938 (2000)
   PUBMED   10807864
REFERENCE   10 (bases 1 to 6003)
  AUTHORS   Berge-Lefranc,J.L., Jay,P., Massacrier,A., Cau,P., Mattei,M.G.,
            Bauer,S., Marsollier,C., Berta,P. and Fontes,M.
  TITLE     Characterization of the human jumonji gene
  JOURNAL   Hum Mol Genet 5 (10), 1637-1641 (1996)
   PUBMED   8894700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136162.18, AK292861.1,
            AL021938.1 and CA435807.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004973.3.
            
            Summary: This gene encodes a Jumonji- and AT-rich interaction
            domain (ARID)-domain-containing protein. The encoded protein is a
            DNA-binding protein that functions as a transcriptional repressor.
            This protein interacts with the Polycomb repressive complex 2
            (PRC2) which plays an essential role in regulating gene expression
            during embryonic development. This protein facilitates the
            recruitment of the PRC2 complex to target genes. Alternate splicing
            results in multiple transcript variants. Mutations in this gene are
            associated with chronic myeloid malignancies. [provided by RefSeq,
            May 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.33792.1,
                                           SRR1803613.85949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341776.7/ ENSP00000341280.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL136162.18        48844-48903
            61-1676             AK292861.1         1-1616
            1677-1677           AL021938.1         26091-26091         c
            1678-4395           AK292861.1         1618-4335
            4396-5983           AL021938.1         500-2087            c
            5984-6003           CA435807.1         16-35               c
FEATURES             Location/Qualifiers
     source          1..6003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..6003
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /note="jumonji and AT-rich interaction domain containing
                     2"
                     /db_xref="GeneID:3720"
                     /db_xref="HGNC:HGNC:6196"
                     /db_xref="MIM:601594"
     exon            1..516
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..4212
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Jumonji; jumonji-like protein; jumonji/ARID
                     domain-containing protein 2; jumonji homolog; jumonji, AT
                     rich interactive domain 2"
                     /codon_start=1
                     /product="protein Jumonji isoform 1"
                     /protein_id="NP_004964.2"
                     /db_xref="CCDS:CCDS4533.1"
                     /db_xref="GeneID:3720"
                     /db_xref="HGNC:HGNC:6196"
                     /db_xref="MIM:601594"
                     /translation="MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQ
                     KRQHAEGIAGSLKTVNGLLGNDQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEE
                     GPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTF
                     LCLRGSPALPNSMVYFGSSQDEEEVEEEDDETEDVKTATNNASSSCQSTPRKGKTHKH
                     VHNGHVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPST
                     GSSAKGLAATHHHPPLHRSAQDLRKQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSK
                     TVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLS
                     LGGASKSTGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQA
                     EKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKEVPERSLERNRPKRATAGKST
                     PGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKE
                     FHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPN
                     VQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLAD
                     MLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGH
                     TENDHHKFHPLPRFEPKNGLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVK
                     EEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQEYWRLVEE
                     KDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTI
                     PWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQANG
                     TPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVH
                     FATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDEL
                     RDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQICQHLC
                     YLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKN
                     GSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS"
     exon            517..652
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            653..794
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            795..964
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1141
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1377
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..2416
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2919
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3012
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3131
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3202
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3317
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3423
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3606
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3737
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3921
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4029
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..6003
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5962..5967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /note="hexamer: AATAAA"
     regulatory      5968..5973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /note="hexamer: AACAAA"
     polyA_site      5983
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
                     /note="major polyA site"
     polyA_site      6003
                     /gene="JARID2"
                     /gene_synonym="DIDDF; JMJ"
ORIGIN      
        1 ggagttgact cttctgctcg cactgctgct gcagcacaaa cgtgacttcc aacatttttt
       61 atttatcttt cccttttctt ttccaagatg taactacgga tcagacacta aggaccttca
      121 cgtttcgctg atgtagtttt tggaggaaaa agggggggga gtgaagggcg tcggtttttt
      181 tttgtgtgtg tgtgtatgtg tttcggggga aattttccat tatgagtgtt ttactaaagt
      241 gaattttttt ttgtttgctt cgttcgtctt tggctctttt tttttccttc ccaatttcgg
      301 atttatttca aggcgaatct ggctttgggg gaagaggaag aaaagtcgga ttacaagatc
      361 aaccaccacc aacaacaata aaaaccacca ggatattttt ttgcaaattt ctgacggctt
      421 taaattcatg aagcaattgt ccccttttgc aatcagcatt tggatctcag aatgagcaag
      481 gaaagaccca agaggaatat cattcagaag aaatacgatg acagtgatgg gattccgtgg
      541 tcagaagaac gggtggtacg taaagtcctt tatttgtctc tgaaggagtt caagaattcc
      601 cagaagaggc agcatgcgga aggcattgct gggagcctga aaactgtgaa tgggctcctt
      661 ggtaatgacc agtctaaggg attaggacca gcatcagaac agtcagagaa tgaaaaggac
      721 gatgcatccc aagtgtcctc cactagcaac gatgttagtt cttcagattt tgaagaaggg
      781 ccgtcgagga aaaggcccag gctgcaagca caaaggaagt ttgctcagtc tcagccgaat
      841 agtcccagca caactccagt aaagatagtg gagccattgc taccccctcc agctactcag
      901 atatcagacc tctctaaaag gaagcctaag acagaagatt ttcttacctt tctctgcctt
      961 cgaggttctc ctgcgctgcc caacagcatg gtgtattttg gaagctctca ggatgaggag
     1021 gaagtcgagg aggaagatga tgagacagaa gacgtcaaaa cagccaccaa caatgcttca
     1081 tcttcatgcc agtcgacccc caggaaagga aaaacccaca aacatgttca caacgggcat
     1141 gttttcaatg gttccagcag gtcaacacgg gagaaggaac ctgttcaaaa acacaaaagc
     1201 aaagaggcca ctcccgcaaa ggagaagcac agcgatcacc gggctgacag ccgccgggag
     1261 caggcttcag ctaaccaccc cgcagcggcc ccctccacgg gttcctcggc caaggggctt
     1321 gctgccaccc atcaccaccc ccctctgcat cggtcggctc aggacttacg gaaacaggtt
     1381 tctaaggtaa acggagtcac tcgaatgtca tctctgggtg caggtgtaac cagtgccaaa
     1441 aagatgcgcg aggtcagacc ttcaccatcc aaaactgtga agtacactgc cacggtgacg
     1501 aagggggctg tcacatacac caaagccaag agagaactgg tcaaggacac caaacccaat
     1561 caccacaagc ccagttccgc tgtcaaccac acaatctcag ggaaaactga aagtagcaat
     1621 gcaaaaaccc gcaaacaggt gctatccctc gggggggcgt ccaagtccac tgggcccgcc
     1681 gtcaatggcc tcaaggtcag tggcaggttg aacccaaagt catgcactaa ggaggtgggg
     1741 gggcggcagc tgcgggaggg cctgcagctg cgggaggggc tgcggaactc caagaggaga
     1801 ctggaagagg cacaccaggc ggagaagccg cagtcgcccc ccaagaagat gaaaggggcg
     1861 gctggccccg ccgaaggccc tggcaagaag gccccggccg agagaggtct gctgaacgga
     1921 cacgtgaaga aggaagtgcc ggagcgcagt ctggagagga atcggccgaa gcgggccacg
     1981 gccgggaaga gcacgccagg cagacaagca catggcaagg cggacagcgc ctcctgtgaa
     2041 aatcgttcta cctcgcaacc ggagtccgtg cacaagccgc aggactcggg caaggccgag
     2101 aagggcggcg gcaaggccgg gtgggcggcc atggacgaga tccccgtcct caggccctcc
     2161 gccaaggagt tccacgatcc gctcatctac atcgagtcgg tccgcgctca ggtggagaag
     2221 ttcgggatgt gcagggtgat cccccctccg gactggcggc ccgagtgcaa gctcaacgat
     2281 gagatgcggt ttgtcacgca gattcagcac atccacaagc tgggccggcg ctggggcccc
     2341 aacgtgcagc ggctggcctg catcaagaag cacctcaaat ctcagggcat caccatggac
     2401 gagctcccgc tcataggggg ctgtgagctc gacctggcct gctttttccg gctgattaat
     2461 gagatgggcg gcatgcagca agtgactgac ctcaaaaaat ggaacaaact agcagacatg
     2521 ctgcgcatcc ccagaactgc ccaggaccgg ctggccaagc tgcaggaggc ctactgccag
     2581 tacctactct cctacgactc cctgtcccca gaggagcacc ggcggctgga gaaggaggtg
     2641 ctgatggaga aggagatcct ggagaagcgc aaggggccgc tggaaggcca cacagagaac
     2701 gaccaccaca agttccaccc tctgccccgc ttcgagccca agaatgggct catccacggc
     2761 gtggccccca ggaacggctt ccgcagcaag ctcaaggagg tgggccaggc ccagttgaag
     2821 actggccggc ggcgactctt cgctcaggaa aaagaagtgg tcaaggaaga ggaggaggac
     2881 aaaggcgtcc tcaatgactt ccacaagtgc atctataagg gaaggtctgt ttctctaaca
     2941 actttttatc gaacagcgag gaatatcatg agcatgtgtt tcagcaagga gcctgcccca
     3001 gccgaaatcg agcaagagta ctggaggcta gtggaagaga aggactgcca cgtggcagtg
     3061 cactgcggca aggtggacac caacactcac ggcagtggat tcccagtagg aaaatcagaa
     3121 cccttttcga ggcatggatg gaacctcacc gtcctcccca ataacacagg gtccatcctg
     3181 cgtcacctcg gtgctgtgcc tggagtgact attccctggc taaatattgg catggtcttt
     3241 tctacctcat gctggtctcg agaccaaaat caccttccat acattgacta cttacacact
     3301 ggtgctgact gcatttggta ttgcattcct gctgaggagg agaacaagct ggaagatgtg
     3361 gtccacaccc tgctgcaagc caatggcacc ccagggctgc agatgctgga aagcaacgtc
     3421 atgatctccc cggaggtgct gtgcaaagag gggatcaagg tgcacaggac cgtgcagcag
     3481 agtggccagt ttgtcgtctg cttcccggga tcctttgtgt ccaaagtgtg ctgtgggtac
     3541 agcgtgtctg aaaccgtgca ctttgctacc acccagtgga caagtatggg ctttgagacc
     3601 gccaaggaaa tgaagcgtcg ccatatagct aagccattct ccatggagaa gttactctac
     3661 cagattgcac aagcagaagc aaaaaaagaa aacggtccca ctctcagtac catctcagcc
     3721 ctcctggatg agctcaggga tacagagctg cggcagcgca ggcagctgtt cgaggctggc
     3781 ctccactcct ccgcacgcta tggcagccac gatggcagca gcacggtggc ggacgggaag
     3841 aaaaagcctc gaaagtggct gcagttggag acgtcagaga ggaggtgtca gatctgccag
     3901 cacctgtgct acctgtccat ggtggtacaa gagaacgaaa acgtcgtgtt ctgtctggag
     3961 tgtgctctgc gccacgtgga gaaacagaag tcctgccgag ggctgaagtt gatgtaccgc
     4021 tacgatgagg aacagattat cagtctggtc aatcagatct gcggcaaagt gtctggtaaa
     4081 aacggcagca ttgagaactg tctcagtaaa cccacaccaa aaagaggtcc ccgcaagaga
     4141 gcgacagtgg acgtgccccc ctcccgtctg tcagcctcca gttcatccaa aagtgcttcg
     4201 agctcatcat gaagatgcca acgcccgtgg tcgatttata tatatttttt tgtaattatt
     4261 atattctagt ttggagtact tgctgtagga ttcaagctgt ctttgcacta gctctaaaga
     4321 agattttctt ctggttttag agaactaatt ttgttttagc attaaactgt tgaacttttt
     4381 tttgtactta gaaaacctag atactgcagt cagattttgg aaactgccgt atagtcactg
     4441 ttttaaaaac cccggagggg ctgtattaat ttgtattgcc ccatggctga caaaagcctt
     4501 tttttttggt tttgattttt ttttttttgt aactgttggg gggaaaaagg ctttttaacc
     4561 catttttgaa gagggtgaag tttggagaac aaatttaaaa accatcagtc atgtgagcag
     4621 attttttaga agggatagga gacacacgcg cacacacaca cacacacgaa acttgaaatg
     4681 gctttgcttt ggctgtcgtc ttctgccgtg tgccagatga gcttgtgatc tgggaagccg
     4741 gggcaccccc gttttgtttc tctgggcggt tgtggcagct gaaggcggac gttgtttcct
     4801 aaccataggt ggaacgagga gacgggagcg agtgggctct ccaccagcac atcactatgc
     4861 atctgttcca ggaaagaaga aaagcgagcg aggaagacgg aaaagactgc ctgccttgga
     4921 ggggtcacat gagggagacc tgtgcctgat ttcattagga aatccattct gttatttttt
     4981 ggtgctgttg gctactttat caaaaaaccc ttcaatagca tccttaagat ttaaaaaaaa
     5041 aaaaaaaaaa aaggaaaaaa aagtgatgga agccgtaagt gcttctttgt catcgacgtg
     5101 caatctttct aacattccat ctccatctca ccgcttcttg tttgacacct tcacaagtca
     5161 gcattaatct ttcttttaaa acttgtttca tttatgatca tgtagagagc cactaggagg
     5221 cctgcagtta tttttgaatg tgaaaatgca tttgcgttca tcttgtctat tttttctctt
     5281 catgttgtaa caaaaaggaa aaaagaaaaa aaaatcccat cccttttgta catatgcctg
     5341 taaattgttt taaatacttg agcctttttc tcggtggggg gtggggaggg gggtgagaag
     5401 acaagatgaa gaaaagcctt acatttcagt ttcttcatcg gttggattgg atgcttacag
     5461 ggtttttctt gtaacattta taagtgctgc ttacatcact gaacaacaac aaaaaaataa
     5521 taatggagta gctgttgccc ttctccggtt gtgtgtacag tatgtgtgga ataaaaaagg
     5581 gaaactgttt tcacaagctg ttctttgttt cataattgga ttcatcaatc ccgtagctac
     5641 ccatattgca ctgagcttgc cagtggtgac tgccaggaac gtcctatgat ccactttgtt
     5701 ggttgttgtt gcagaagact gaactgtttt ggaatattta acaattacag aaacagtcaa
     5761 gtgttttcca atgtggttgt ccggtttcta tggccttgct gtgtactttc cctctttttg
     5821 acagtaaact tctgcctatg gcttacagtt tgacatttaa tttattagcg ctgctctgca
     5881 cccctccctt gggagggaga cttcatgtgg tttattgcga gttttttgtt tacttttcag
     5941 gtttgtacta caaggtttaa taataaaaac aaagtttttt ggacatttgt ctgtcttgtg
     6001 gaa
//
