LOCUS       NM_001098526            1876 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens junction adhesion molecule like (JAML), transcript
            variant 1, mRNA.
ACCESSION   NM_001098526
VERSION     NM_001098526.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Hao,Z., Xin,Z., Chen,Y., Shao,Z., Lin,W., Wu,W., Lin,M., Liu,Q.,
            Chen,D., Wu,D. and Wu,P.
  TITLE     JAML promotes the antitumor role of tumor-resident CD8+ T cells by
            facilitating their innate-like function in human lung cancer
  JOURNAL   Cancer Lett 590, 216839 (2024)
   PUBMED   38570084
  REMARK    GeneRIF: JAML promotes the antitumor role of tumor-resident CD8[+]
            T cells by facilitating their innate-like function in human lung
            cancer.
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Cheng,S., Li,M., Li,C., Dai,Y., Zhuo,J., Wang,J., Qian,J. and
            Hao,Z.
  TITLE     JAML inhibits colorectal carcinogenesis by modulating the tumor
            immune microenvironment
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 382-396 (2024)
   PUBMED   38625487
  REMARK    GeneRIF: JAML inhibits colorectal carcinogenesis by modulating the
            tumor immune microenvironment.
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Wu,Q., Wang,Y.B., Che,X.W., Wang,H. and Wang,W.
  TITLE     Junctional adhesion molecule-like protein as a novel target for
            kaempferol to ameliorate lung adenocarcinoma
  JOURNAL   J Integr Med 21 (3), 268-276 (2023)
   PUBMED   37069006
  REMARK    GeneRIF: Junctional adhesion molecule-like protein as a novel
            target for kaempferol to ameliorate lung adenocarcinoma.
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Wu,Q., Li,R., Wang,Q.X., Zhang,M.Y., Liu,T.T. and Qu,Y.Q.
  TITLE     Junctional adhesion molecule-like protein promotes tumor
            progression via the Wnt/beta-catenin signaling pathway in lung
            adenocarcinoma
  JOURNAL   J Transl Med 20 (1), 260 (2022)
   PUBMED   35672776
  REMARK    GeneRIF: Junctional adhesion molecule-like protein promotes tumor
            progression via the Wnt/beta-catenin signaling pathway in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Fang,L., Yu,W., Yu,G., Zhong,F. and Ye,B.
  TITLE     Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with
            Prognosis and Immune Infiltrates in Lung Adenocarcinoma
  JOURNAL   Med Sci Monit 28, e933503 (2022)
   PUBMED   35034089
  REMARK    GeneRIF: Junctional Adhesion Molecule-Like Protein (JAML) Is
            Correlated with Prognosis and Immune Infiltrates in Lung
            Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Roh,S.E., Jeong,Y., Kang,M.H. and Bae,Y.S.
  TITLE     Junctional adhesion molecules mediate transendothelial migration of
            dendritic cell vaccine in cancer immunotherapy
  JOURNAL   Cancer Lett 434, 196-205 (2018)
   PUBMED   30055289
  REMARK    GeneRIF: Findings suggest that specific JAM family members play an
            important role in the transendothelial migration (TEM) of in
            vitro-generated mouse and human dendritic cells (DCs) from the
            inoculation site to regional lymph nodes (LNs) in DC-based cancer
            immunotherapy.
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Guo,Y.L., Bai,R., Chen,C.X., Liu,D.Q., Liu,Y., Zhang,C.Y. and
            Zen,K.
  TITLE     Role of junctional adhesion molecule-like protein in mediating
            monocyte transendothelial migration
  JOURNAL   Arterioscler Thromb Vasc Biol 29 (1), 75-83 (2009)
   PUBMED   18948633
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Luissint,A.C., Lutz,P.G., Calderwood,D.A., Couraud,P.O. and
            Bourdoulous,S.
  TITLE     JAM-L-mediated leukocyte adhesion to endothelial cells is regulated
            in cis by alpha4beta1 integrin activation
  JOURNAL   J Cell Biol 183 (6), 1159-1173 (2008)
   PUBMED   19064666
  REMARK    GeneRIF: Integrin activation is required for the dissociation of
            JAM-L-VLA-4 complexes and the accumulation of functional JAM-L
            dimers, which indicates that the leukocyte integrin VLA-4 controls
            JAM-L function in cis by controlling its dimerization state.
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Zen,K., Liu,Y., McCall,I.C., Wu,T., Lee,W., Babbin,B.A., Nusrat,A.
            and Parkos,C.A.
  TITLE     Neutrophil migration across tight junctions is mediated by adhesive
            interactions between epithelial coxsackie and adenovirus receptor
            and a junctional adhesion molecule-like protein on neutrophils
  JOURNAL   Mol Biol Cell 16 (6), 2694-2703 (2005)
   PUBMED   15800062
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Moog-Lutz,C., Cave-Riant,F., Guibal,F.C., Breau,M.A., Di Gioia,Y.,
            Couraud,P.O., Cayre,Y.E., Bourdoulous,S. and Lutz,P.G.
  TITLE     JAML, a novel protein with characteristics of a junctional adhesion
            molecule, is induced during differentiation of myeloid leukemia
            cells
  JOURNAL   Blood 102 (9), 3371-3378 (2003)
   PUBMED   12869515
  REMARK    GeneRIF: expressed on leukocytes with a possible role in leukocyte
            transmigration
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC296115.1, AY138965.1, AK097285.1 and AP002800.4.
            
            On May 17, 2019 this sequence version replaced NM_001098526.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY138965.1, AJ515553.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356289.10/ ENSP00000348635.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC296115.1         84-99
            17-1636             AY138965.1         1-1620
            1637-1874           AK097285.1         1583-1820
            1875-1876           AP002800.4         116325-116326       c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..1876
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /note="junction adhesion molecule like"
                     /db_xref="GeneID:120425"
                     /db_xref="HGNC:HGNC:19084"
                     /db_xref="MIM:609770"
     exon            1..71
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            72..134
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1276
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; adhesion molecule AMICA; dendritic-cell
                     specific protein CREA7-1; adhesion molecule, interacts
                     with CXADR antigen 1; dendritic-cell specific protein
                     CREA7-4; adhesion molecule interacting with CXADR antigen
                     1"
                     /codon_start=1
                     /product="junctional adhesion molecule-like isoform 1
                     precursor"
                     /protein_id="NP_001091996.1"
                     /db_xref="CCDS:CCDS41723.1"
                     /db_xref="GeneID:120425"
                     /db_xref="HGNC:HGNC:19084"
                     /db_xref="MIM:609770"
                     /translation="MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVF
                     QSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLL
                     LQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQST
                     EVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGS
                     IMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLV
                     IIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEG
                     EKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQ
                     AF"
     exon            135..289
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            290..515
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            516..625
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            626..863
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1002
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1096
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1183
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1876
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /note="hexamer: GATAAA"
     polyA_site      1636
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /note="major polyA site"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
                     /note="hexamer: AATACA"
     polyA_site      1876
                     /gene="JAML"
                     /gene_synonym="AMICA; AMICA1; CREA7-1; CREA7-4; Gm638"
ORIGIN      
        1 agttgagctt ggggactgca gctgtgggga gatttcagtg cattgcctcc cctgggtgct
       61 cttcatcttg gatttgaaag ttgagagcag catgttttgc ccactgaaac tcatcctgct
      121 gccagtgtta ctggattatt ccttgggcct gaatgacttg aatgtttccc cgcctgagct
      181 aacagtccat gtgggtgatt cagctctgat gggatgtgtt ttccagagca cagaagacaa
      241 atgtatattc aagatagact ggactctgtc accaggagag cacgccaagg acgaatatgt
      301 gctatactat tactccaatc tcagtgtgcc tattgggcgc ttccagaacc gcgtacactt
      361 gatgggggac atcttatgca atgatggctc tctcctgctc caagatgtgc aagaggctga
      421 ccagggaacc tatatctgtg aaatccgcct caaaggggag agccaggtgt tcaagaaggc
      481 ggtggtactg catgtgcttc cagaggagcc caaagagctc atggtccatg tgggtggatt
      541 gattcagatg ggatgtgttt tccagagcac agaagtgaaa cacgtgacca aggtagaatg
      601 gatattttca ggacggcgcg caaaggagga gattgtattt cgttactacc acaaactcag
      661 gatgtctgtg gagtactccc agagctgggg ccacttccag aatcgtgtga acctggtggg
      721 ggacattttc cgcaatgacg gttccatcat gcttcaagga gtgagggagt cagatggagg
      781 aaactacacc tgcagtatcc acctagggaa cctggtgttc aagaaaacca ttgtgctgca
      841 tgtcagcccg gaagagcctc gaacactggt gaccccggca gccctgaggc ctctggtctt
      901 gggtggtaat cagttggtga tcattgtggg aattgtctgt gccacaatcc tgctgctccc
      961 tgttctgata ttgatcgtga agaagacctg tggaaataag agttcagtga attctacagt
     1021 cttggtgaag aacacgaaga agactaatcc agagataaaa gaaaaaccct gccattttga
     1081 aagatgtgaa ggggagaaac acatttactc cccaataatt gtacgggagg tgatcgagga
     1141 agaagaacca agtgaaaaat cagaggccac ctacatgacc atgcacccag tttggccttc
     1201 tctgaggtca gatcggaaca actcacttga aaaaaagtca ggtgggggaa tgccaaaaac
     1261 acagcaagcc ttttgagaag aatggagagt cccttcatct cagcagcggt ggagactctc
     1321 tcctgtgtgt gtcctgggcc actctaccag tgatttcaga ctcccgctct cccagctgtc
     1381 ctcctgtctc attgtttggt caatacactg aagatggaga atttggagcc tggcagagag
     1441 actggacagc tctggaggaa caggcctgct gaggggaggg gagcatggac ttggcctctg
     1501 gagtgggaca ctggccctgg gaaccaggct gagctgagtg gcctcaaacc ccccgttgga
     1561 tcagaccctc ctgtgggcag ggttcttagt ggatgagtta ctgggaagaa tcagagataa
     1621 aaaccaaccc aaatcattcc tctggcacat tatttctaaa taagtgttgt ttgtggaaat
     1681 cgtcctattt ttatgcctcg gttgaggggg caagtaaagt cctggtgagg aatttacagt
     1741 tagaaacttt tggaaaaact gaagttcctg gaggaaagcc aaaccgtgct aacacactag
     1801 aggctggttt tggtcctggg aaaggtttgg ggtgaatggg ttggaagtag ggtatgaata
     1861 cagttttggg atttaa
//
