LOCUS       NM_032801               3765 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens junctional adhesion molecule 3 (JAM3), transcript
            variant 1, mRNA.
ACCESSION   NM_032801 NM_031470
VERSION     NM_032801.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3765)
  AUTHORS   Peng,J., Chen,Y. and Yin,A.
  TITLE     JAM3 promotes cervical cancer metastasis by activating the
            HIF-1alpha/VEGFA pathway
  JOURNAL   BMC Womens Health 24 (1), 293 (2024)
   PUBMED   38760803
  REMARK    GeneRIF: JAM3 promotes cervical cancer metastasis by activating the
            HIF-1alpha/VEGFA pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3765)
  AUTHORS   Shi,Y., Feng,X., Zhang,Y., Gao,J., Bao,W., Wang,J.D. and Bai,J.F.
  TITLE     Downregulation of JAM3 occurs in cholangiocarcinoma by
            hypermethylation: A potential molecular marker for diagnosis and
            prognosis
  JOURNAL   J Cell Mol Med 28 (2), e18038 (2024)
   PUBMED   38124399
  REMARK    GeneRIF: Downregulation of JAM3 occurs in cholangiocarcinoma by
            hypermethylation: A potential molecular marker for diagnosis and
            prognosis.
REFERENCE   3  (bases 1 to 3765)
  AUTHORS   Li,X., He,S., Zhao,X., Sun,D., Wu,S., Xu,D. and Li,Y.
  TITLE     High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in
            high-risk human papillomavirus-infected patients
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (12), 1820-1829 (2023)
   PUBMED   38448375
  REMARK    GeneRIF: High-grade cervical lesions diagnosed by JAM3/PAX1
            methylation in high-risk human papillomavirus-infected patients.
REFERENCE   4  (bases 1 to 3765)
  AUTHORS   Yang,W., Guo,C., Herman,J.G., Zhu,C., Lv,H., Su,X., Zhang,L.,
            Zhang,M. and Guo,M.
  TITLE     Epigenetic silencing of JAM3 promotes esophageal cancer development
            by activating Wnt signaling
  JOURNAL   Clin Epigenetics 14 (1), 164 (2022)
   PUBMED   36461092
  REMARK    GeneRIF: Epigenetic silencing of JAM3 promotes esophageal cancer
            development by activating Wnt signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3765)
  AUTHORS   Chen,C.P., Wang,L.K., Chen,C.Y., Chen,C.Y., Kuo,Y.H. and Wu,Y.H.
  TITLE     Decreased junctional adhesion molecule 3 expression induces
            reactive oxygen species production and apoptosis in
            trophoblastsdagger
  JOURNAL   Biol Reprod 107 (5), 1264-1278 (2022)
   PUBMED   35871541
  REMARK    GeneRIF: Decreased junctional adhesion molecule 3 expression
            induces reactive oxygen species production and apoptosis in
            trophoblastsdagger.
REFERENCE   6  (bases 1 to 3765)
  AUTHORS   Cunningham,S.A., Rodriguez,J.M., Arrate,M.P., Tran,T.M. and
            Brock,T.A.
  TITLE     JAM2 interacts with alpha4beta1. Facilitation by JAM3
  JOURNAL   J Biol Chem 277 (31), 27589-27592 (2002)
   PUBMED   12070135
  REMARK    GeneRIF: Facilitates JAM2 interaction with alpha4beta1
            GeneRIF: Functions as a facilitator for JAM2/alpha4beta1
            interactions
REFERENCE   7  (bases 1 to 3765)
  AUTHORS   Phillips,H.M., Renforth,G.L., Spalluto,C., Hearn,T., Curtis,A.R.,
            Craven,L., Havarani,B., Clement-Jones,M., English,C., Stumper,O.,
            Salmon,T., Hutchinson,S., Jackson,M.S. and Wilson,D.I.
  TITLE     Narrowing the critical region within 11q24-qter for hypoplastic
            left heart and identification of a candidate gene, JAM3, expressed
            during cardiogenesis
  JOURNAL   Genomics 79 (4), 475-478 (2002)
   PUBMED   11944976
  REMARK    GeneRIF: JAM3 is a strong candidate gene for hypoplastic left heart
            syndrome
REFERENCE   8  (bases 1 to 3765)
  AUTHORS   Liang,T.W., Chiu,H.H., Gurney,A., Sidle,A., Tumas,D.B., Schow,P.,
            Foster,J., Klassen,T., Dennis,K., DeMarco,R.A., Pham,T., Frantz,G.
            and Fong,S.
  TITLE     Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2
            interacts with T, NK, and dendritic cells through JAM 3
  JOURNAL   J Immunol 168 (4), 1618-1626 (2002)
   PUBMED   11823489
  REMARK    GeneRIF: molecular cloning & role as VE-JAM/JAM 2 receptor
REFERENCE   9  (bases 1 to 3765)
  AUTHORS   Aurrand-Lions,M., Johnson-Leger,C., Wong,C., Du Pasquier,L. and
            Imhof,B.A.
  TITLE     Heterogeneity of endothelial junctions is reflected by differential
            expression and specific subcellular localization of the three JAM
            family members
  JOURNAL   Blood 98 (13), 3699-3707 (2001)
   PUBMED   11739175
REFERENCE   10 (bases 1 to 3765)
  AUTHORS   Arrate,M.P., Rodriguez,J.M., Tran,T.M., Brock,T.A. and
            Cunningham,S.A.
  TITLE     Cloning of human junctional adhesion molecule 3 (JAM3) and its
            identification as the JAM2 counter-receptor
  JOURNAL   J Biol Chem 276 (49), 45826-45832 (2001)
   PUBMED   11590146
  REMARK    GeneRIF: Cloning of human junctional adhesion molecule 3 (JAM3) and
            its identification as the JAM2 counter-receptor.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ416101.1 and AP001775.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_032801.4.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. The protein encoded by this immunoglobulin
            superfamily gene member is localized in the tight junctions between
            high endothelial cells. Unlike other proteins in this family, the
            this protein is unable to adhere to leukocyte cell lines and only
            forms weak homotypic interactions. The encoded protein is a member
            of the junctional adhesion molecule protein family and acts as a
            receptor for another member of this family. A mutation in an intron
            of this gene is associated with hemorrhagic destruction of the
            brain, subependymal calcification, and congenital cataracts.
            Alternative splicing results in multiple transcript
            variants.[provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057284.1, AJ416101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299106.9/ ENSP00000299106.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3515              AJ416101.1         148-3662
            3516-3765           AP001775.4         25377-25626
FEATURES             Location/Qualifiers
     source          1..3765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..3765
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /note="junctional adhesion molecule 3"
                     /db_xref="GeneID:83700"
                     /db_xref="HGNC:HGNC:15532"
                     /db_xref="MIM:606871"
     exon            1..88
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..945
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; junctional adhesion molecule C"
                     /codon_start=1
                     /product="junctional adhesion molecule C isoform 1
                     precursor"
                     /protein_id="NP_116190.3"
                     /db_xref="CCDS:CCDS8494.2"
                     /db_xref="GeneID:83700"
                     /db_xref="HGNC:HGNC:15532"
                     /db_xref="MIM:606871"
                     /translation="MALRRPPRLRLCARLPDFFLLLLFRGCLIGAVNLKSSNRTPVVQ
                     EFESVELSCIITDSQTSDPRIEWKKIQDEQTTYVFFDNKIQGDLAGRAEILGKTSLKI
                     WNVTRRDSALYRCEVVARNDRKEIDEIVIELTVQVKPVTPVCRVPKAVPVGKMATLHC
                     QESEGHPRPHYSWYRNDVPLPTDSRANPRFRNSSFHLNSETGTLVFTAVHKDDSGQYY
                     CIASNDAGSARCEEQEMEVYDLNIGGIIGGVLVVLAVLALITLGICCAYRRGYFINNK
                     QDGESYKNPGKPDGVNYIRTDEEGDFRHKSSFVI"
     exon            89..154
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            155..268
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            269..421
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            422..624
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            625..724
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            725..854
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            855..909
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            910..3765
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3494..3499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /note="hexamer: TATAAA"
     polyA_site      3518
                     /gene="JAM3"
                     /gene_synonym="JAM-2; JAM-3; JAM-C; JAMC"
                     /note="major polyA site"
ORIGIN      
        1 gcaaccctcg acatggcgct gaggcggcca ccgcgactcc ggctctgcgc tcggctgcct
       61 gacttcttcc tgctgctgct tttcaggggc tgcctgatag gggctgtaaa tctcaaatcc
      121 agcaatcgaa ccccagtggt acaggaattt gaaagtgtgg aactgtcttg catcattacg
      181 gattcgcaga caagtgaccc caggatcgag tggaagaaaa ttcaagatga acaaaccaca
      241 tatgtgtttt ttgacaacaa aattcaggga gacttggcgg gtcgtgcaga aatactgggg
      301 aagacatccc tgaagatctg gaatgtgaca cggagagact cagcccttta tcgctgtgag
      361 gtcgttgctc gaaatgaccg caaggaaatt gatgagattg tgatcgagtt aactgtgcaa
      421 gtgaagccag tgacccctgt ctgtagagtg ccgaaggctg taccagtagg caagatggca
      481 acactgcact gccaggagag tgagggccac ccccggcctc actacagctg gtatcgcaat
      541 gatgtaccac tgcccacgga ttccagagcc aatcccagat ttcgcaattc ttctttccac
      601 ttaaactctg aaacaggcac tttggtgttc actgctgttc acaaggacga ctctgggcag
      661 tactactgca ttgcttccaa tgacgcaggc tcagccaggt gtgaggagca ggagatggaa
      721 gtctatgacc tgaacattgg cggaattatt gggggggttc tggttgtcct tgctgtactg
      781 gccctgatca cgttgggcat ctgctgtgca tacagacgtg gctacttcat caacaataaa
      841 caggatggag aaagttacaa gaacccaggg aaaccagatg gagttaacta catccgcact
      901 gacgaggagg gcgacttcag acacaagtca tcgtttgtga tctgagaccc gcggtgtggc
      961 tgagagcgca cagagcgcac gtgcacatac ctctgctaga aactcctgtc aaggcagcga
     1021 gagctgatgc actcggacag agctagacac tcattcagaa gcttttcgtt ttggccaaag
     1081 ttgaccacta ctcttcttac tctaacaagc cacatgaata gaagaatttt cctcaagatg
     1141 gacccggtaa atataaccac aaggaagcga aactgggtgc gttcactgag ttgggttcct
     1201 aatctgtttc tggcctgatt cccgcatgag tattagggtg atcttaaaga gtttgctcac
     1261 gtaaacgccc gtgctgggcc ctgtgaagcc agcatgttca ccactggtcg ttcagcagcc
     1321 acgacagcac catgtgagat ggcgaggtgg ctggacagca ccagcagcgc atcccggcgg
     1381 gaacccagaa aaggcttctt acacagcagc cttacttcat cggcccacag acaccaccgc
     1441 agtttcttct taaaggctct gctgatcggt gttgcagtgt ccattgtgga gaagcttttt
     1501 ggatcagcat tttgtaaaaa caaccaaaat caggaaggta aattggttgc tggaagaggg
     1561 atcttgcctg aggaaccctg cttgtccaac agggtgtcag gatttaagga aaaccttcgt
     1621 cttaggctaa gtctgaaatg gtactgaaat atgcttttct atgggtcttg tttattttat
     1681 aaaattttac atctaaattt ttgctaagga tgtattttga ttattgaaaa gaaaatttct
     1741 atttaaactg taaatatatt gtcatacaat gttaaataac ctattttttt aaaaaagttc
     1801 aacttaaggt agaagttcca agctactagt gttaaattgg aaaatatcaa taattaagag
     1861 tattttaccc aaggaatcct ctcatggaag tttactgtga tgttcctttt ctcacacaag
     1921 ttttagcctt tttcacaagg gaactcatac tgtctacaca tcagaccata gttgcttagg
     1981 aaacctttaa aaattccagt taagcaatgt tgaaatcagt ttgcatctct tcaaaagaaa
     2041 cctctcaggt tagctttgaa ctgcctcttc ctgagatgac taggacagtc tgtacccaga
     2101 ggccacccag aagccctcag atgtacatac acagatgcca gtcagctcct ggggttgcgc
     2161 caggcgcccc cgctctagct cactgttgcc tcgctgtctg ccaggaggcc ctgccatcct
     2221 tgggccctgg cagtggctgt gtcccagtga gctttactca cgtggccctt gcttcatcca
     2281 gcacagctct caggtgggca ctgcagggac actggtgtct tccatgtagc gtcccagctt
     2341 tgggctcctg taacagacct ctttttggtt atggatggct cacaaaatag ggcccccaat
     2401 gctatttttt ttttttaagt ttgtttaatt atttgttaag attgtctaag gccaaaggca
     2461 attgcgaaat caagtctgtc aagtacaata acatttttaa aagaaaatgg atcccactgt
     2521 tcctctttgc cacagagaaa gcacccagac gccacaggct ctgtcgcatt tcaaaacaaa
     2581 ccatgatgga gtggcggcca gtccagcctt ttaaagaacg tcaggtggag cagccaggtg
     2641 aaaggcctgg cggggaggaa agtgaaacgc ctgaatcaaa agcagttttc taattttgac
     2701 tttaaatttt tcatccgccg gagacactgc tcccatttgt ggggggacat tagcaacatc
     2761 actcagaagc ctgtgttctt caagagcagg tgttctcagc ctcacatgcc ctgccgtgct
     2821 ggactcagga ctgaagtgct gtaaagcaag gagctgctga gaaggagcac tccactgtgt
     2881 gcctggagaa tggctctcac tactcacctt gtctttcagc ttccagtgtc ttgggttttt
     2941 tatactttga cagctttttt ttaattgcat acatgagact gtgttgactt tttttagtta
     3001 tgtgaaacac tttgccgcag gccgcctggc agaggcagga aatgctccag cagtggctca
     3061 gtgctccctg gtgtctgctg catggcatcc tggatgctta gcatgcaagt tccctccatc
     3121 attgccacct tggtagagag ggatggctcc ccaccctcag cgttggggat tcacgctcca
     3181 gcctccttct tggttgtcat agtgataggg tagccttatt gccccctctt cttataccct
     3241 aaaaccttct acactagtgc catgggaacc aggtctgaaa aagtagagag aagtgaaagt
     3301 agagtctggg aagtagctgc ctataactga gactagacgg aaaaggaata ctcgtgtatt
     3361 ttaagatatg aatgtgactc aagactcgag gccgatacga ggctgtgatt ctgcctttgg
     3421 atggatgttg ctgtacacag atgctacaga cttgtactaa cacaccgtaa tttggcattt
     3481 gtttaacctc atttataaaa gcttcaaaaa aacccaaaca ttgcttcatt ctttgttatt
     3541 tgctcttacg ttgggtttgt ctcttcttcc tagcatttca gtggttaggc atgcacacta
     3601 aaaatgctat caatcaccca tccaccaggg aagtcagtgc tgggcaggag gtcagcctgt
     3661 gtgctcaaga gcagtgctgc gcctctccgc caccgagccc acctgtgttg cggttcccac
     3721 ttgggatggc agtgggcaga tctcagtggc atcccatccc ccaaa
//
