LOCUS       NM_021219               4351 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens junctional adhesion molecule 2 (JAM2), transcript
            variant 1, mRNA.
ACCESSION   NM_021219
VERSION     NM_021219.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4351)
  AUTHORS   Khojasteh,M., Soleimani,P., Ghasemi,A., Taghizadeh,P., Rohani,M.
            and Alavi,A.
  TITLE     JAM2 variants can be more common in primary familial brain
            calcification (PFBC) cases than those appear; may be due to a
            founder mutation
  JOURNAL   Neurol Sci 45 (8), 3829-3844 (2024)
   PUBMED   38441788
  REMARK    GeneRIF: JAM2 variants can be more common in primary familial brain
            calcification (PFBC) cases than those appear; may be due to a
            founder mutation.
REFERENCE   2  (bases 1 to 4351)
  AUTHORS   Dong,Y., Zhang,J., Xie,S., Di,S., Fan,B. and Gong,T.
  TITLE     JAM2 is a prognostic biomarker and inhibits proliferation,
            metastasis and epithelial-mesenchymal transition in lung
            adenocarcinoma
  JOURNAL   J Gene Med 26 (2), e3679 (2024)
   PUBMED   38404047
  REMARK    GeneRIF: JAM2 is a prognostic biomarker and inhibits proliferation,
            metastasis and epithelial-mesenchymal transition in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 4351)
  AUTHORS   Peng,Y., Li,H., Fu,Y., Guo,S., Qu,C., Zhang,Y., Zong,B. and Liu,S.
  TITLE     JAM2 predicts a good prognosis and inhibits invasion and migration
            by suppressing EMT pathway in breast cancer
  JOURNAL   Int Immunopharmacol 103, 108430 (2022)
   PUBMED   34923424
  REMARK    GeneRIF: JAM2 predicts a good prognosis and inhibits invasion and
            migration by suppressing EMT pathway in breast cancer.
REFERENCE   4  (bases 1 to 4351)
  AUTHORS   Schottlaender,L.V., Abeti,R., Jaunmuktane,Z., Macmillan,C.,
            Chelban,V., O'Callaghan,B., McKinley,J., Maroofian,R.,
            Efthymiou,S., Athanasiou-Fragkouli,A., Forbes,R., Soutar,M.P.M.,
            Livingston,J.H., Kalmar,B., Swayne,O., Hotton,G., Pittman,A.,
            Mendes de Oliveira,J.R., de Grandis,M., Richard-Loendt,A.,
            Launchbury,F., Althonayan,J., McDonnell,G., Carr,A., Khan,S.,
            Beetz,C., Bisgin,A., Tug Bozdogan,S., Begtrup,A., Torti,E.,
            Greensmith,L., Giunti,P., Morrison,P.J., Brandner,S.,
            Aurrand-Lions,M. and Houlden,H.
  CONSRTM   SYNAPS Study Group
  TITLE     Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary
            Familial Brain Calcification
  JOURNAL   Am J Hum Genet 106 (3), 412-421 (2020)
   PUBMED   32142645
  REMARK    GeneRIF: Along with JAM3 and OCLN, JAM2 is the third tight-junction
            gene in which bi-allelic variants are associated with brain
            calcification, suggesting that defective cell-to-cell adhesion and
            dysfunction of the movement of solutes through the paracellular
            spaces in the neurovascular unit is a key mechanism in CNS
            calcification
REFERENCE   5  (bases 1 to 4351)
  AUTHORS   Cen,Z., Chen,Y., Chen,S., Wang,H., Yang,D., Zhang,H., Wu,H.,
            Wang,L., Tang,S., Ye,J., Shen,J., Wang,H., Fu,F., Chen,X., Xie,F.,
            Liu,P., Xu,X., Cao,J., Cai,P., Pan,Q., Li,J., Yang,W., Shan,P.F.,
            Li,Y., Liu,J.Y., Zhang,B. and Luo,W.
  TITLE     Biallelic loss-of-function mutations in JAM2 cause primary familial
            brain calcification
  JOURNAL   Brain 143 (2), 491-502 (2020)
   PUBMED   31851307
  REMARK    GeneRIF: mutant JAM2 protein resulted in impaired cell-cell
            adhesion functions and reduced integrity of the neurovascular unit
REFERENCE   6  (bases 1 to 4351)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   7  (bases 1 to 4351)
  AUTHORS   Liang,T.W., Chiu,H.H., Gurney,A., Sidle,A., Tumas,D.B., Schow,P.,
            Foster,J., Klassen,T., Dennis,K., DeMarco,R.A., Pham,T., Frantz,G.
            and Fong,S.
  TITLE     Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2
            interacts with T, NK, and dendritic cells through JAM 3
  JOURNAL   J Immunol 168 (4), 1618-1626 (2002)
   PUBMED   11823489
  REMARK    GeneRIF: role as an adhesive ligand for interacting with a variety
            of immune cell types
REFERENCE   8  (bases 1 to 4351)
  AUTHORS   Arrate,M.P., Rodriguez,J.M., Tran,T.M., Brock,T.A. and
            Cunningham,S.A.
  TITLE     Cloning of human junctional adhesion molecule 3 (JAM3) and its
            identification as the JAM2 counter-receptor
  JOURNAL   J Biol Chem 276 (49), 45826-45832 (2001)
   PUBMED   11590146
REFERENCE   9  (bases 1 to 4351)
  AUTHORS   Cunningham,S.A., Arrate,M.P., Rodriguez,J.M., Bjercke,R.J.,
            Vanderslice,P., Morris,A.P. and Brock,T.A.
  TITLE     A novel protein with homology to the junctional adhesion molecule.
            Characterization of leukocyte interactions
  JOURNAL   J Biol Chem 275 (44), 34750-34756 (2000)
   PUBMED   10945976
  REMARK    GeneRIF: Cloning and discovery as adhesion receptor for T cells
REFERENCE   10 (bases 1 to 4351)
  AUTHORS   Palmeri,D., van Zante,A., Huang,C.C., Hemmerich,S. and Rosen,S.D.
  TITLE     Vascular endothelial junction-associated molecule, a novel member
            of the immunoglobulin superfamily, is localized to intercellular
            boundaries of endothelial cells
  JOURNAL   J Biol Chem 275 (25), 19139-19145 (2000)
   PUBMED   10779521
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000223.1, BM921497.1,
            AY077698.1, AK294769.1, CX870550.1, AK056079.1, BG540412.1 and
            AI742752.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021219.3.
            
            Summary: This gene belongs to the immunoglobulin superfamily, and
            the junctional adhesion molecule (JAM) family. The protein encoded
            by this gene is a type I membrane protein that is localized at the
            tight junctions of both epithelial and endothelial cells. It acts
            as an adhesive ligand for interacting with a variety of immune cell
            types, and may play a role in lymphocyte homing to secondary
            lymphoid organs. Alternatively spliced transcript variants have
            been found for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.160828.1,
                                           SRR1803614.52505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000480456.6/ ENSP00000420419.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AP000223.1         75299-75322
            25-282              BM921497.1         1-258
            283-1372            AY077698.1         1-1090
            1373-1854           AK294769.1         925-1406
            1855-1890           CX870550.1         815-850
            1891-2125           AK294769.1         1443-1677
            2126-2793           AK056079.1         184-851
            2794-3323           AK056079.1         853-1382
            3324-3324           BG540412.1         52-52
            3325-4344           AK056079.1         1384-2403
            4345-4351           AI742752.1         31-37               c
FEATURES             Location/Qualifiers
     source          1..4351
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..4351
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="junctional adhesion molecule 2"
                     /db_xref="GeneID:58494"
                     /db_xref="HGNC:HGNC:14686"
                     /db_xref="MIM:606870"
     exon            1..631
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..1461
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vascular endothelial junction-associated
                     molecule; junctional adhesion molecule B; JAM-IT/VE-JAM;
                     JAM-2"
                     /codon_start=1
                     /product="junctional adhesion molecule B isoform 1
                     precursor"
                     /protein_id="NP_067042.1"
                     /db_xref="CCDS:CCDS42911.1"
                     /db_xref="GeneID:58494"
                     /db_xref="HGNC:HGNC:14686"
                     /db_xref="MIM:606870"
                     /translation="MARRSRHRLLLLLLRYLVVALGYHKAYGFSAPKDQQVVTAVEYQ
                     EAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRS
                     DAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEG
                     NPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARN
                     SVGYRRCPGKRMQVDDLNISGIIAAVVVVALVISVCGLGVCYAQRKGYFSKETSFQKS
                     NSSSKATTMSENDFKHTKSFII"
     exon            632..697
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            698..805
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            806..958
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1161
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1261
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1369
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1385
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1428
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..4351
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="hexamer: ATTAAA"
     polyA_site      1528
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="major polyA site"
     regulatory      1692..1697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="hexamer: ATTAAA"
     polyA_site      1712
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
     regulatory      3994..3999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="hexamer: ATTAAA"
     polyA_site      4013
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="hexamer: AATACA"
     polyA_site      4297
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
     regulatory      4327..4332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
                     /note="hexamer: ATTAAA"
     polyA_site      4351
                     /gene="JAM2"
                     /gene_synonym="C21orf43; CD322; IBGC8; JAM-B; JAMB;
                     PRO245; VE-JAM; VEJAM"
ORIGIN      
        1 agaaagaagt tttgagccaa cgaggggaag aaaggagttg gggcaaaaca ggaggcgttt
       61 ccctacccgc atacatcccc gtccccgaga cacccaatcc ccccaccccc agcctgcccg
      121 cgcctcccgc ccccagctcc tcgccctggg gacagctggc agccccgcgc ggaccagaca
      181 caaagccgat caatcccgga ggcgtggggg cggagggacg acccgccggg gctttcccgg
      241 gcgctgctct cctcctgctg ccccctcgct aggacccggc ggacgcctcg tctggttttc
      301 acgccctcta gcccctaccc ccacaccccc aaaacagaac agacccccat ccctgggctg
      361 gaggacccgc ctcttggcag ccagctgaga aggcgccccg gggaggggga aactgacatc
      421 ccatctagag ccgtccctcc tcttcctccc ctcccgactc tctgctcctt tcccgcccca
      481 gaagttcaag ggcccccggc ctcctgcgct cctgccgccg ggaccctcga cctcctcaga
      541 gcagccggct gccgccccgg gaagatggcg aggaggagcc gccaccgcct cctcctgctg
      601 ctgctgcgct acctggtggt cgccctgggc tatcataagg cctatgggtt ttctgcccca
      661 aaagaccaac aagtagtcac agcagtagag taccaagagg ctattttagc ctgcaaaacc
      721 ccaaagaaga ctgtttcctc cagattagag tggaagaaac tgggtcggag tgtctccttt
      781 gtctactatc aacagactct tcaaggtgat tttaaaaatc gagctgagat gatagatttc
      841 aatatccgga tcaaaaatgt gacaagaagt gatgcgggga aatatcgttg tgaagttagt
      901 gccccatctg agcaaggcca aaacctggaa gaggatacag tcactctgga agtattagtg
      961 gctccagcag ttccatcatg tgaagtaccc tcttctgctc tgagtggaac tgtggtagag
     1021 ctacgatgtc aagacaaaga agggaatcca gctcctgaat acacatggtt taaggatggc
     1081 atccgtttgc tagaaaatcc cagacttggc tcccaaagca ccaacagctc atacacaatg
     1141 aatacaaaaa ctggaactct gcaatttaat actgtttcca aactggacac tggagaatat
     1201 tcctgtgaag cccgcaattc tgttggatat cgcaggtgtc ctgggaaacg aatgcaagta
     1261 gatgatctca acataagtgg catcatagca gccgtagtag ttgtggcctt agtgatttcc
     1321 gtttgtggcc ttggtgtatg ctatgctcag aggaaaggct acttttcaaa agaaacctcc
     1381 ttccagaaga gtaattcttc atctaaagcc acgacaatga gtgaaaatga tttcaagcac
     1441 acaaaatcct ttataattta aagactccac tttagagata caccaaagcc accgttgtta
     1501 cacaagttat taaactatta taaaactctg ctttgtccga catttgcaaa gaggtacacg
     1561 aggaaatgga attggtattt cattttaatt ttcatgacta ctaactcacc tgaacttgct
     1621 attttaaaca aatagttctg tcgacaccta aaatataatc tggcttcttg tgtctggact
     1681 aagttaaaag aattaaaata ctttgtaatg tcctgggctt tgggaaatgt taaccacgtc
     1741 ctaacttcta gagaacgtta ctaaaatata acatactgat tgtgaagtca atccacaggt
     1801 catgaaaata taaatcagac tctgcacgag agtctgattt agggggtcca acaaatactc
     1861 tgacagatgc aaaaggaacc tctggtctca tttctgccag aatcctcttt tctcccctaa
     1921 tatcatcctt attctgatgc tcgttcatca ctaacacacc cacagaaagg aggaagcggg
     1981 atgggtctta tgcccaagga tttgcacttt gtgtttactt ccattcctgg gaactaaaag
     2041 caacatcaaa agaaatgcct aatggctgga gcccacaggt gtgcaccaca ggatttgcct
     2101 ggtgtgtgtc actgatttct tcattaaacg taatttagat ggtcaaacac aaacccaagt
     2161 ggcttatttc acccctactg ctgcttgcca ctgcttcctt cttgtaagat ttctttgaag
     2221 aggatcagtg actttgacat cagaactcac cactggagcc tacacaagtt tgcagatacc
     2281 tttccctgca ggagtggtga cttcacatct ttctgtctct aaaaattgtg cagtgacatt
     2341 ccgggccaag tcccttagtc aggggttgac aattctgctt ttggacaagg agggatgtgg
     2401 agggaagaag taatagtcta ccaggaaaat gagacgaaaa agctcagtat gactccctgc
     2461 atctggtacc cctcttgaaa cacagtgggc acatgagcaa tggctcaaac gaaaagtgga
     2521 tctaatgtgg gtttctcaac cgatgaacca caaaagcttc cagctactat tacaatgtga
     2581 aaattccaat gatccgttta ccagagcaat tagactatgt taaaaattca tatcatttgt
     2641 aacttctttt aattactgaa ttgatattaa aaacaaaata tggctagggc atgtcctatt
     2701 cttctgggca aatgtggatg aaaaggtcac ttgctacctt tgacaactat gaacatgatg
     2761 gttaatcttc tttctttttt tttttttttt tttgagacgg agtctcactc tgtcgcccag
     2821 gctggagtac agtggcacaa tcttggctca ctgcaacctc cgcctcccct ccgcctccca
     2881 gattcaagca cttctcctgc ctcagcctcc caagtagctg agattatagg cgtgtaccac
     2941 cacacctggc taatttttgt attttagtag agaagggttt caccatgttg gccaggctgg
     3001 tctcaaacct ctgacctcaa atgatccacc cccatcagcc tcccaaagtg ctgggattat
     3061 aggcatgagc cactgcactg ggcaggttaa tcttctttca aaagagtctg ctctttctac
     3121 ccaattggcg aagcaaatcc ccaggattca ccgaacaaat ggattaagca cccactgagt
     3181 gcctagcatg tgcctggaca ccaggccacc gggaagatgc tccccctttg acttgtctat
     3241 gacatgctat gtctctcacc agatcccttc ctggaggtcg ggcttctgta acatggctct
     3301 gcccccaaaa taaaattttc accacgagtc agggatcggc aaacattttc tgtaaagagc
     3361 cagaaagtag atattttaag tcataaggtc cctgttaaca actacttgac tctgccattg
     3421 tagcacaaag gcagccacag acaaaacaag caagtagtca tgtctgtgtt ccaataagac
     3481 tttatttaca aaaacagcag gcacagacaa gatttggccc acaggcatag attcccaact
     3541 catggtggtg aagtacagaa aaaaacacct gtctacaagc ttttgtaaga aatcaggcta
     3601 aatgttacct atgttttggt tggaagattt ctttggtttg aggaatgctt tcctcttgca
     3661 ttggcatgcc aagaggatag atgactctga aagacgcctc ttcagacata cctgtcatca
     3721 cacaagatca acttcttcag tttaaatgac acaaatccat attgtggaag gaaaatatgt
     3781 agtgccttag cttcactaat agttgtaaaa cttcttttta agacatcaaa ggctagagga
     3841 ttcattttat gcagtgcgaa catctaataa cactctctgt gtcaaatata tattgtacat
     3901 taccttaaac tattgtaata gctaggtaaa aatccttgta taaaagaatg ttttccccca
     3961 cacaaagggc agagtattga gcactaattt cctattaaaa gtatatatat gtatctgtgg
     4021 gtcactggtg tccagacttg tatttgcatt tgtgtttact tgaggaactt gaacactaac
     4081 aactggtaaa atcccattgt aattcttaca gcattttgac tttattttcc tgcagtgaat
     4141 tgtgttgtgt aaagattagg gctttaaaat cttattagca agctttgttt tgttttaatt
     4201 attgttgctg ttgtaactag atttaattta tttttagttg gaggtttgac ctaagtctgg
     4261 accaattgat tgcttttcaa tacaactttg caaagaactt cctttttcca caggtggctt
     4321 tgttcgatta aagtctacac taataaaaat a
//
