LOCUS       NM_001270941            9153 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens janus kinase and microtubule interacting protein 2
            (JAKMIP2), transcript variant 1, mRNA.
ACCESSION   NM_001270941
VERSION     NM_001270941.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9153)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 9153)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9153)
  AUTHORS   Li,J., Teng,W., Yu,Y., Hou,X. and Shan,Z.
  TITLE     Linkage Analysis of the Chromosome 5q31-33 Region Identifies
            JAKMIP2 as a Risk Factor for Graves' Disease in the Chinese Han
            Population
  JOURNAL   Med Sci Monit 25, 1439-1451 (2019)
   PUBMED   30796769
  REMARK    GeneRIF: individuals with SNP62 (rs12653715 G/C) who were GG
            homozygous had a significantly increased risk of Graves' disease.
            The transmission disequilibrium test (TDT) indicated that SNP62
            (rs12653715) and SNP63 (rs12653081) loci in the Janus kinase and
            microtubule interacting protein 2 (JAKMIP2) gene showed dominant
            transmission from heterozygous parents to the affected offspring.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9153)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9153)
  AUTHORS   Cruz-Garcia,D., Diaz-Ruiz,A., Rabanal-Ruiz,Y., Peinado,J.R.,
            Gracia-Navarro,F., Castano,J.P., Montero-Hadjadje,M., Tonon,M.C.,
            Vaudry,H., Anouar,Y., Vazquez-Martinez,R. and Malagon,M.M.
  TITLE     The Golgi-associated long coiled-coil protein NECC1 participates in
            the control of the regulated secretory pathway in PC12 cells
  JOURNAL   Biochem J 443 (2), 387-396 (2012)
   PUBMED   22250954
REFERENCE   6  (bases 1 to 9153)
  AUTHORS   Amundsen,S.S., Adamovic,S., Hellqvist,A., Nilsson,S.,
            Gudjonsdottir,A.H., Ascher,H., Ek,J., Larsson,K., Wahlstrom,J.,
            Lie,B.A., Sollid,L.M. and Naluai,A.T.
  TITLE     A comprehensive screen for SNP associations on chromosome region
            5q31-33 in Swedish/Norwegian celiac disease families
  JOURNAL   Eur J Hum Genet 15 (9), 980-987 (2007)
   PUBMED   17551518
REFERENCE   7  (bases 1 to 9153)
  AUTHORS   Cruz-Garcia,D., Vazquez-Martinez,R., Peinado,J.R., Anouar,Y.,
            Tonon,M.C., Vaudry,H., Castano,J.P. and Malagon,M.M.
  TITLE     Identification and characterization of two novel (neuro)endocrine
            long coiled-coil proteins
  JOURNAL   FEBS Lett 581 (17), 3149-3156 (2007)
   PUBMED   17572408
  REMARK    GeneRIF: NECC 1 & 2 proteins primarily expressed in
            (neuro)endocrine tissues in vertebrates thus supporting a role for
            these proteins in the regulated secretory pathway.
REFERENCE   8  (bases 1 to 9153)
  AUTHORS   Lae,M., Ahn,E.H., Mercado,G.E., Chuai,S., Edgar,M., Pawel,B.R.,
            Olshen,A., Barr,F.G. and Ladanyi,M.
  TITLE     Global gene expression profiling of PAX-FKHR fusion-positive
            alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas
  JOURNAL   J Pathol 212 (2), 143-151 (2007)
   PUBMED   17471488
REFERENCE   9  (bases 1 to 9153)
  AUTHORS   Hartmann,T.B., Thiel,D., Dummer,R., Schadendorf,D. and
            Eichmuller,S.
  TITLE     SEREX identification of new tumour-associated antigens in cutaneous
            T-cell lymphoma
  JOURNAL   Br J Dermatol 150 (2), 252-258 (2004)
   PUBMED   14996095
REFERENCE   10 (bases 1 to 9153)
  AUTHORS   Barr,F.A. and Short,B.
  TITLE     Golgins in the structure and dynamics of the Golgi apparatus
  JOURNAL   Curr Opin Cell Biol 15 (4), 405-413 (2003)
   PUBMED   12892780
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB072234.1, AB011127.1,
            EF512550.1 and AC126775.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001270941.1.
            
            Summary: The protein encoded by this gene is reported to be a
            component of the Golgi matrix. It may act as a golgin protein by
            negatively regulating transit of secretory cargo and by acting as a
            structural scaffold of the Golgi. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.134871.1,
                                           SRR1803612.274132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616793.5/ ENSP00000479248.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               DB072234.1         122-307
            187-421             AB011127.1         1-235
            422-1161            EF512550.1         1-740
            1162-1219           AB011127.1         976-1033
            1220-2884           EF512550.1         799-2463
            2885-3625           AB011127.1         2636-3376
            3626-9153           AC126775.2         24816-30343
FEATURES             Location/Qualifiers
     source          1..9153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..9153
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /note="janus kinase and microtubule interacting protein 2"
                     /db_xref="GeneID:9832"
                     /db_xref="HGNC:HGNC:29067"
                     /db_xref="MIM:611197"
     exon            1..273
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..550
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2884
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /note="isoform 1 is encoded by transcript variant 1; Jak
                     and microtubule interacting protein 2; neuroendocrine long
                     coiled-coil protein 1; CTCL tumor antigen HD-CL-04"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     2 isoform 1"
                     /protein_id="NP_001257870.1"
                     /db_xref="CCDS:CCDS75352.1"
                     /db_xref="GeneID:9832"
                     /db_xref="HGNC:HGNC:29067"
                     /db_xref="MIM:611197"
                     /translation="MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKV
                     SKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSR
                     TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLK
                     TAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDR
                     IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHC
                     SSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLA
                     KRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL
                     KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMA
                     SFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAERE
                     AKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAE
                     NHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGV
                     KDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMM
                     ELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLS
                     EKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQI
                     KDLEEKFLFLFLFFSLAFILWP"
     exon            551..1048
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1258
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1357
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1504
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1645
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1702
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1822
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1951
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2035
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2098
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2197
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2296
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2350
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2416
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2485
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2563
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2767
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2833
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2904
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..9153
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /note="hexamer: AATAAA"
     polyA_site      3445
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /note="major polyA site"
     regulatory      4824..4829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /note="hexamer: AATAAA"
     polyA_site      4846
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
     regulatory      9132..9137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
                     /note="hexamer: AACAAG"
     polyA_site      9153
                     /gene="JAKMIP2"
                     /gene_synonym="JAMIP2; NECC1"
ORIGIN      
        1 gagctcaccc catcctccga gagggaggag gcccaactgg tgatgctgct gctgctgctg
       61 ctgccgccgc cgccgcctct attgctgata ctctagtggg gctggaaggg tggttcctat
      121 tcgcaccatc gccaaccaga gacagaggga aaaaaaaaac cggcagccac tgctgatgtt
      181 gggttcggag gctgcatccg actcggtcac aaggaaaatg gattcagttt gcatctctcc
      241 ctcctttaaa cagcttctcc gggtctcagc atgggcttcc agggcagcga ttgaggagac
      301 cttaccaagg agcaccacac agtagatgct gagacatcgt actccaggat aagaaacagt
      361 aacatggcag cacctgcttg aaagaaatta aaaaccaaca gactccattt agaaaggaac
      421 aatgtccaag aaagggcgaa ataagggcga gaagcccgag gcactcattg ttgcccttca
      481 agctgccaat gaagacctca ggaccaagct cacagacatt cagatagagc tgcatcaaga
      541 gaagtccaag gtatcaaagc ttgaaagaga gaagactcaa gaagcgaaga ggattcgtga
      601 gctggagcag cgcaagcaca cggtgctggt gacagaactc aaagccaagc tccatgagga
      661 gaagatgaag gagctgcagg ctgtgaggga gaaccttatc aagcagcacg agcaggaaat
      721 gtcaaggacg gtgaaggtac gtgatggaga gatccagagg ctcaagtctg ctctctgtgc
      781 tctccgcgac ggcagcagtg acaaagtaag gacagcgctc accattgagg cccgggagga
      841 ggcccggaaa ctgtttgaca cagagcgcct taagctctta caggaaattg cggacctgaa
      901 aacggccaag aagcaggtgg acgaggctct gagcaatatg atccaagcag ataaaatcaa
      961 ggctggggac cttcggagtg agcatcagtc ccaccaagaa gccatctcga agatcaagtg
     1021 ggagtcggag cgggatattc ggaggctgat ggatgaaatc aaagccaagg acaggatcat
     1081 cttttccctg gaaaaggaac tggagaccca gacaggctat gtacagaaac tccaacttca
     1141 gaaggaggct ttggacgaac aactctttct ggtcaaggag gctgagtgca acatgagcag
     1201 cccaaaacga gaaattccag gaagggcagg tgatggttcc gaacactgca gcagtcctga
     1261 tttgcgaaga aatcaaaaga gaatagctga attgaatgcc actataagaa aattagaaga
     1321 caggaatacc ttgcttggag atgaacgaaa tgaactgtta aaacgtgtgc gggaaaccga
     1381 aaagcaatgt aaacctctcc tggaaaggaa caagtgcctc gccaagagaa acgatgaact
     1441 gatggtgtcc ttgcagcgca tggaagaaaa actaaaagcc gttaccaagg aaaattcaga
     1501 aatgagagaa aaaataacat cccatccacc cctgaagaaa ttaaaatctc tgaatgacct
     1561 cgaccaagct aatgaagaac aagaaacaga gtttctaaaa cttcaggtca ttgagcaaca
     1621 gaacattatt gatgagctca caagggaccg agaaaagctc atccgtagaa gaaagcatag
     1681 aagaagttcc aagccaatta agaggcctgt tttggacccg tttattggct atgatgagga
     1741 ctctatggat tcagagacat catccatggc ctcatttaga acagacagaa caccagctac
     1801 tcctgatgat gacttggatg aaagtttagc agctgaagaa tctgaactaa gatttcgaca
     1861 attaacaaaa gaatatcagg ccctccaaag agcatatgcc ctcctacagg agcagacggg
     1921 aggcatcatc gacgctgaac gagaagccaa ggctcaagaa cagctccaag cagaggtgct
     1981 aaggtataaa gccaaaattg aagacctgga agcgactctg gctcagaaag ggcaggattc
     2041 acactgggta gaagataaac aacttttcat taagagaaac caggagcttt tagaaaagat
     2101 agaaaaacag gaggcagaaa atcaccggtt acaacaagaa ctacaggacg ccagagacca
     2161 gaatgagctg ctggagtttc gaaacctaga gctagaagag agagagagac gatcccctcc
     2221 atttaatctc caaattcacc cattctcaga tggtgtgagt gctctacaga tctactgtat
     2281 gaaagaaggt gttaaggatg tgaacatccc tgatctcata aagcagcttg atatcttggg
     2341 tgataatggg aatttaagaa atgaagaaca agtggccata attcaggcca gcactgtgct
     2401 gtccctggca gagaagtgga tccagcagat tgaaggagct gaggctgccc tacaccagaa
     2461 aatgatggaa ttggaaagtg acatggaaca gttctgcaaa ataaaaggct atctggagga
     2521 agaactagac tacagaaaac aagctcttga ccaagcatat atgagaatcc aggaactaga
     2581 agctactttg tacaatgctc tacagcaaga aactgttatc aagtttggtg aattattaag
     2641 tgaaaaacag caagaggagc tgaggacggc agtagaaaag ttacggcggc aaatgctgag
     2701 gaagagcaga gagtatgact gtcagattct tcaggagaga atggagctct tacagcaagc
     2761 ccatcagaga attcgtgact tagaagataa aacagacatc cagaaaagac aaataaaaga
     2821 cttagaagaa aagtttctgt ttctattctt gttcttctct cttgccttta ttctatggcc
     2881 ttgatgtcaa ggtgcctctt aaagagtaac cgaaaacatg gataagatcc caggaagaca
     2941 agtgcttcta aaccttcaaa gatggcaaaa ttgtttacac cagtgagagg gagatcaaaa
     3001 gctaagaact accctgtagc caggactaca actgtgtatt ttaaagccat tattcaaggt
     3061 ttcttacttg acagttccta cacaaccctg ttgaaaatct acaatatatg ctgcatttaa
     3121 tgaaacatgt atatgtcaaa tcagaagaga agaactataa acatatattg tgtaaagaaa
     3181 aagttcagca atggaactag tttctgcaga tcaagcaaag atgtgtcttg ggcatggaac
     3241 caaagttaca atgaaatatt caacccctgc tgtgcagggg ggtcatttta atgtaacacc
     3301 acaccccatg gaaacactag tcctgataat aaacatcatt ttaaaagatc aaaacaaaca
     3361 aacaaaaaaa acaagggtgg gtggggagtg aagcacgagg aatacctatg aagagctatt
     3421 tacaataaaa tgtttcattt gaaaagtctg gtttcttact acagggattt gcttttctgt
     3481 ctttatgatt gttttaaact caggaacaga gacatccgca tcgtaaatgg gaagaaaaac
     3541 actctctgtt ttgtttttct gcaaaaggtg gagcttgtgg aattcattcc acagacgaca
     3601 gatgagaagt ggatcacagt gaccacaaca aaactggtaa cgaagtcaaa ggacccgagc
     3661 gaatgtgaca tgtgaaataa aagcagattc gatgcttcct tgtcctactc tcacatctgc
     3721 attcctctat caacaatgga ctgatctcat tcatattgaa aactaagaag atgatactgt
     3781 aaatcacatg ctccctgact tagttctgtt tagaacgcca acatctatag ggaacatggg
     3841 ccagagagca tctctgaatc tttcatttcc aaaatactgt ttttcaaatg gctgcttaaa
     3901 attgcctgca aatgaatatg ctatatgatt tgggcaaaaa cacagcagaa tcaatgagta
     3961 aatttctacc aagagtcggg tttgccacag agatgtgaat attaaactaa actattattt
     4021 tttaaagaat cctcacatgc ctagagcatt ctgacctctt cttgtttaga gtgataacat
     4081 tttttcccag acagatgaca gcaacaagat agctctactt ttttatatgg aaataacatt
     4141 atgttactga caaggtcatt ttctaccaga gacaattaga ggactggtac ttttcctaag
     4201 ttgtgtatta ctgagtcttg gagtcatctc tgagagcaaa tgtatgttcc tgaaaagcta
     4261 attttacacc tcatttactg tagataacag aacaacctca atttttcaaa tttttgaagt
     4321 tttatttatg gggctagaat tcccatgcat agagaatatg tgtagggagc cagaaactct
     4381 ttctatgaaa tgctatacaa atctttccat atgtgggttc actatcatcc ttcagtttta
     4441 gcactggcat ttgcaaagcc agaacaataa ctgaagaatg tacaataaaa actagaatgc
     4501 tggggtccca ctttttgttc ttacatttac tgctgaccca ggtatctttg gcccagtcac
     4561 ttaacctctc tgtgcctcag tttcctcatc tgcaaaatgg ggttaaaatg ctttttcata
     4621 aagttttatt tgcaatttta gaacaagagg tgcttaaagt agcacaatgt gctttgtaat
     4681 tattacaagt gctgtattat ttgactttct tgtgttgttg acaaaaagat tccctcatgt
     4741 aataaaatag tgcttcagtt tggttaaatt taagcactat agcactgaag cttgcttatc
     4801 aagctacttg ggacattatt agcaataaaa attgagagat tcaaaaccag gatctttaat
     4861 aatctatagg aaatagatca tctcatgcta ttgaacaaga tagaagagtg tgtcatttct
     4921 atgataagca tctcccagct ctcttgattg catatgcatg ccatcataca gaaccccact
     4981 tttaccacag gagagccagt cattaaacaa aggcttggag caaactgaca gtatcacata
     5041 attagcttga ttatctttta ttctggagga aagccaggtg gtatgcccta ctgggaagat
     5101 acaaaacaga ctatcctgct gtattctttt tttttttttt ttttgagatg gagtcttgct
     5161 ctgttgccca tgctggagtg cattggcaca atctcggctc atggcaagct ccacctcctg
     5221 gattcaagtg attctcctgc ctcaacctcc ctagtagctg ggattacagg tgcacaccac
     5281 cacacctggc taatttttgt atttttagta gagacagggt ttcactatgc tggtcaggct
     5341 ggtctcgaac tcctgacctc aagtgatctg cctgcctcag cctcccaaag tgctaggatt
     5401 acaggtgtaa gccactgtgc ccggcctcct gctggattct ttattcaact aggtaggttc
     5461 cagattaaat atgagccata tgctcattag gcaagaaatg tgaaagaggg tgcctctaca
     5521 gtgttggtga cccaacacta gccaacttga gtcagaaaat atggaagagg ataaattact
     5581 ctcacatatc taagactttt ccatttttct tcactttctg ttgcagggcc catatgagta
     5641 aatctatatt ccgtctgctc caacacacac cttccttctc ttaattttgc tttcccaccc
     5701 accaagaaat ttgtaagtca aaatttattt ccatgagtaa ctatttctaa atgattgaaa
     5761 atttttgaaa aagtggtatg gtttatatac ctaatctgct tatctgctat aagtcatatg
     5821 agaacaacag ctaggatgat tgtccaagca gctttagatg tgtttagggc caggcaaaag
     5881 gtttgcttgt tttttctttt tgcttaagat ctgggagatt agcaaatttc tcaagactat
     5941 agactgaact gtaattttta ccaactcttg ctcatgagcc tcaaaatgaa tatatccttg
     6001 aataaagtat aaatatttca atagatacat ctctctatta tccattttca caattataaa
     6061 agcatcagca aaattgtgga tatgtgttcc agtcactcat ggatccatgg aaatggaccg
     6121 tgtttaaatg aatgcttccc ttggatggga tgttcagcaa tagcaaaaaa aaaaaaaaaa
     6181 aagttatcaa taactgagat ttcctgtggc cccacttctg catctgtact accgagatgc
     6241 atttggctac tgagtttgta gcagtcagaa cagcattctt ccgggttcat taacttaatt
     6301 tttctcaata aaatattcat accctggaaa ataaacataa ctgactacta aagataattt
     6361 gagataaata aaagacccaa tttaaatagt tattcaggat agaaaaattt catgaaagag
     6421 gggaaaaaca tagagagact atctttgact atcatactta aaaagcatct attactaaat
     6481 tgaatgtcaa acttttcttt aatgccaccc tacttttagg aaatagaatt tgctgaaaaa
     6541 aattacaacc cttctgactt atgctatata aattaaatta ttaccaacag ttaggtttta
     6601 ggggtggaag aatagatctt gatttaattt tttttttttt ttttggccca caaataactg
     6661 ctcatacagg ttgtatgtgt cttcccaagt ccataaggta gagctgatat agaaggcctg
     6721 ggttatcact taggtagaga gcaaatgtgt tctccactag taataggaga aataaagttt
     6781 gccaaataaa ttttgctgca gtattttgtt tcaactttgc tttcaatttt aaataaatct
     6841 ctggcaaact tgttcctttt tgcccattga ctgtcaaatt ttcctgtaaa cccattgtgt
     6901 aattcttatg tttgctttaa cataattcac aagttcattg tttcaaaatg aagcacgtct
     6961 ttttaacctg cctaggtttt tgtagaaact gtaaaaagaa tattcattgg ttttgtgttg
     7021 atgtttaaat aattggatca tctgtgttat attacatcaa gatagatgga cagcatagaa
     7081 attttatttt taaaatattt aattgcatta tttcaatctg tcaaagagtg gcacagaata
     7141 cacacacaaa cacacacaca cacacacaca cacacagagc aatagaaatt tgctctgtaa
     7201 tttgggagtt gcattgcttg ttgccttttg tgaaattttc ataacagtgt tttggtaatt
     7261 aatgacagct tttggcagtt taattctatc attttactaa tttagattta tctattacat
     7321 tgaaaaaatt caatataact tttgaatgat aaacattcaa agcaaatctt agatgactgt
     7381 ttatgtcatg agtttatgct tccaatatgg acccaagccc ctctttaagc agacttctag
     7441 gtcttaagtg aggaaagatg tcattgtgtt ctactgcctt gtcatttcta tataatgtag
     7501 tatcttgaga tctaatttca ggcatattgg caagaagata cagacataat ggaaagttgg
     7561 agctaatccc tgtaaggcct cttcaagtgc caaattctat tattccattt cagaatgggg
     7621 cagggcagat tcacaatcct ttgctgtcat tagtttggcg gtttagttct tcctaaataa
     7681 atctcttgct gggagtccaa gtccaatgct taatcaaaat tcctaaagat agctactcag
     7741 aaggctaagg tggcaggata gcttgggccc aggagtttca taacggcctg ggcaacatgg
     7801 tgagacctca tctcaaaaaa aaaaaaaaaa aagaaagaaa gaaaagaggg agagaggaaa
     7861 aaaactacta aagatatact tataggggca atgtagcaaa aataggatta taatttccta
     7921 tattcaaatt aatgtggcag agatacacgt ggttgatttg gtgagggttc ctgtttttgt
     7981 ttttttctgc attacggtct ttgtacccat gcttatattt tcatccttgt tatatgcaaa
     8041 gttctgtagg gtgagaatgg taaagttaaa caactttgag cccaattttg cccacaatca
     8101 agatcccacg aacttactaa agagtggatg atgcaatttt ccaactaaaa cagatcccca
     8161 gcatctgtta gtaacaacac ttctatttga ctgacatctc acagactgtg cctataccag
     8221 ccattaacca tagcaacttc ccacaatgag gcagatcaaa atccaaacat ttttataaat
     8281 atgtgatgta aatatatgca cagatatatt ctgtacatag tatgatggtg tgagcgctta
     8341 ctaaacgtgt acttctgttc taggatgcag gacttcaaga aaggtttttt ctgcgctgct
     8401 gctgcttctg ctgggaactc atgtttttgt cgagcattta gtgtttgaac tcttcccatc
     8461 cttgactacc tcttctctcc cttaccccac cttctgttca ctactattat ttccaattgt
     8521 tgactgaggc agagaccact cggtttttca attatccagg cccataaacc agcaaatagg
     8581 ttttttttat ttgtttggtt ggttggttga tgtttctttt ttttgaaaga gcaacagaaa
     8641 gttcagcaca atctacagta ttaaaattag ccaaaagtcc catatcttta ttagctaaaa
     8701 attccatctc aacagggttc atgcatgttt tagccttcaa gatccaatac tttggggact
     8761 caagtataga gctaatgtgt ttgaatacat aattccccag gtgtttactg tgttaatgta
     8821 gccaagggtc caatttcaca gagctttcat tcaatcaact gcctcaattg gggttctttc
     8881 tttccatctc attagcatga ctccatatat cacttcagtg cttgtttatt aatgaaagaa
     8941 aaataaaaat tgactgagtt tcaccagaat gatcctctga agtacaccga atatgtacat
     9001 gtactgtatg tattaccgta gagattggaa tcaacttact gtatgtaaag ttttatgaat
     9061 ggttatttta taatttatgt atttaatata ggaatcgatg aactctggtg ttttagttta
     9121 tataaaaata aaacaagctg cattttttaa aaa
//
