LOCUS       NM_001099433            2969 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens janus kinase and microtubule interacting protein 1
            (JAKMIP1), transcript variant 1, mRNA.
ACCESSION   NM_001099433 XM_001129178
VERSION     NM_001099433.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   Gordon,D.E., Jang,G.M., Bouhaddou,M., Xu,J., Obernier,K.,
            White,K.M., O'Meara,M.J., Rezelj,V.V., Guo,J.Z., Swaney,D.L.,
            Tummino,T.A., Huttenhain,R., Kaake,R.M., Richards,A.L.,
            Tutuncuoglu,B., Foussard,H., Batra,J., Haas,K., Modak,M., Kim,M.,
            Haas,P., Polacco,B.J., Braberg,H., Fabius,J.M., Eckhardt,M.,
            Soucheray,M., Bennett,M.J., Cakir,M., McGregor,M.J., Li,Q.,
            Meyer,B., Roesch,F., Vallet,T., Mac Kain,A., Miorin,L., Moreno,E.,
            Naing,Z.Z.C., Zhou,Y., Peng,S., Shi,Y., Zhang,Z., Shen,W.,
            Kirby,I.T., Melnyk,J.E., Chorba,J.S., Lou,K., Dai,S.A.,
            Barrio-Hernandez,I., Memon,D., Hernandez-Armenta,C., Lyu,J.,
            Mathy,C.J.P., Perica,T., Pilla,K.B., Ganesan,S.J., Saltzberg,D.J.,
            Rakesh,R., Liu,X., Rosenthal,S.B., Calviello,L., Venkataramanan,S.,
            Liboy-Lugo,J., Lin,Y., Huang,X.P., Liu,Y., Wankowicz,S.A., Bohn,M.,
            Safari,M., Ugur,F.S., Koh,C., Savar,N.S., Tran,Q.D., Shengjuler,D.,
            Fletcher,S.J., O'Neal,M.C., Cai,Y., Chang,J.C.J., Broadhurst,D.J.,
            Klippsten,S., Sharp,P.P., Wenzell,N.A., Kuzuoglu-Ozturk,D.,
            Wang,H.Y., Trenker,R., Young,J.M., Cavero,D.A., Hiatt,J.,
            Roth,T.L., Rathore,U., Subramanian,A., Noack,J., Hubert,M.,
            Stroud,R.M., Frankel,A.D., Rosenberg,O.S., Verba,K.A., Agard,D.A.,
            Ott,M., Emerman,M., Jura,N., von Zastrow,M., Verdin,E.,
            Ashworth,A., Schwartz,O., d'Enfert,C., Mukherjee,S., Jacobson,M.,
            Malik,H.S., Fujimori,D.G., Ideker,T., Craik,C.S., Floor,S.N.,
            Fraser,J.S., Gross,J.D., Sali,A., Roth,B.L., Ruggero,D.,
            Taunton,J., Kortemme,T., Beltrao,P., Vignuzzi,M., Garcia-Sastre,A.,
            Shokat,K.M., Shoichet,B.K. and Krogan,N.J.
  TITLE     A SARS-CoV-2 protein interaction map reveals targets for drug
            repurposing
  JOURNAL   Nature 583 (7816), 459-468 (2020)
   PUBMED   32353859
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Nishimura,Y., Martin,C.L., Vazquez-Lopez,A., Spence,S.J.,
            Alvarez-Retuerto,A.I., Sigman,M., Steindler,C., Pellegrini,S.,
            Schanen,N.C., Warren,S.T. and Geschwind,D.H.
  TITLE     Genome-wide expression profiling of lymphoblastoid cell lines
            distinguishes different forms of autism and reveals shared pathways
  JOURNAL   Hum Mol Genet 16 (14), 1682-1698 (2007)
   PUBMED   17519220
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Steindler,C., Li,Z., Algarte,M., Alcover,A., Libri,V., Ragimbeau,J.
            and Pellegrini,S.
  TITLE     Jamip1 (marlin-1) defines a family of proteins interacting with
            janus kinases and microtubules
  JOURNAL   J Biol Chem 279 (41), 43168-43177 (2004)
   PUBMED   15277531
  REMARK    GeneRIF: Marlin1 has a role in cell polarization, segregation of
            signaling complexes, and vesicle traffic, some of which may involve
            Jak tyrosine kinases
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Couve,A., Restituito,S., Brandon,J.M., Charles,K.J., Bawagan,H.,
            Freeman,K.B., Pangalos,M.N., Calver,A.R. and Moss,S.J.
  TITLE     Marlin-1, a novel RNA-binding protein associates with GABA
            receptors
  JOURNAL   J Biol Chem 279 (14), 13934-13943 (2004)
   PUBMED   14718537
  REMARK    GeneRIF: Marlin-1 functions to regulate the cellular levels of
            GABA(B) R2 subunits, which may have significant effects on the
            production of functional GABA(B) receptor heterodimers
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AM412307.1.
            
            On May 17, 2019 this sequence version replaced NM_001099433.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM412307.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409021.9/ ENSP00000386711.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2969              AM412307.1         7-2975
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..2969
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /note="janus kinase and microtubule interacting protein 1"
                     /db_xref="GeneID:152789"
                     /db_xref="HGNC:HGNC:26460"
                     /db_xref="MIM:611195"
     exon            1..297
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..573
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..2940
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /note="isoform 1 is encoded by transcript variant 1; Jak
                     and microtubule interacting protein 1; multiple
                     coiled-coil GABABR1-binding protein; marlin-1; GABA-B
                     receptor-binding protein; multiple alpha-helices and
                     RNA-linker protein 1"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     1 isoform 1"
                     /protein_id="NP_001092903.1"
                     /db_xref="CCDS:CCDS47005.1"
                     /db_xref="GeneID:152789"
                     /db_xref="HGNC:HGNC:26460"
                     /db_xref="MIM:611195"
                     /translation="MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKV
                     GKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAART
                     AKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKA
                     ARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRV
                     ILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMG
                     VQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE
                     KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDE
                     QEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVD
                     SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQ
                     VGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDL
                     LEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSS
                     ALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIE
                     GTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ
                     EPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIREL
                     EDKLEFQKRHLKELEEKFLFLFLFFSLAFILWP"
     exon            574..1068
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1278
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1398
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1545
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1686
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1746
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1875
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2004
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2088
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2151
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2250
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2352
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2406
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2472
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2541
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2619
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2823
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2889
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2969
                     /gene="JAKMIP1"
                     /gene_synonym="Gababrbp; JAMIP1; MARLIN1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccacccgc gtgcggcacg cgccggccgc ctgcccggat cgcggccacc agtgccgcgg
       61 cctctcgact cccgccccgc cgagccgcgc gcgcgactgc catcctcctc aattgctttt
      121 tacgattttt tttgtgcatg cattcatttt ctgttccgtt ttgtcctttt taaggcggtg
      181 gcggcggcga cagcggcgta agctcgcagc ggggaggggg cggccggagg atgcggcgcg
      241 gggctgcgct cgctacgtcc gctgctgctg cccggctcgg gcctgagcgc cgagcaggat
      301 cccaagtgat ggtggtttcc tcggagggcg agctgagtcc tgcgcgactg gttagcacgg
      361 tggagctggt agccacgcct gctggctggc gtgcgtgaac aggtgtggac cgcaggatct
      421 cagcactctg acccaagggg aagcatgtcg aagaaaggcc ggagcaaggg cgagaagccc
      481 gagatggaga cggacgcggt gcagatggcc aacgaggagc tgcgggccaa gctgaccagc
      541 attcagatcg agttccagca ggaaaaaagc aaggtgggca aactgcgcga gcggctgcag
      601 gaggcgaagc tggagcgcga gcaggagcag cgacggcaca cggcctacat ttcggagctc
      661 aaggccaagc tgcatgagga gaagaccaag gagctgcagg cgctgcgcga ggggctcatc
      721 cggcagcacg agcaggaggc ggcgcgcacc gccaagatca aggagggcga gctgcagcgg
      781 ctgcaggcca cgctgaacgt gctgcgcgac ggcgcggccg acaaggtcaa gacggcgctg
      841 ctgaccgagg cgcgcgagga ggcgcgcagg gccttcgatg gagagcgcct gcggctgcag
      901 caggagatcc tggagctcaa ggcagcgcgc aagcaggcag aggaggcgct cagtaactgc
      961 atgcaggctg acaagaccaa ggcagccgac ctgcgtgccg cctaccaggc gcaccaagac
     1021 gaggtgcacc gcatcaagcg cgagtgcgag cgcgacatcc gcaggctgat ggatgagatc
     1081 aaagggaaag accgtgtgat tctggccttg gagaaggaac ttggcgtgca ggctgggcag
     1141 acccagaagc tgcttctgca gaaagaggct ttggatgagc agctggttca ggtcaaggag
     1201 gccgagcggc accacagtag tccaaagaga gagctcccgc ccgggatcgg ggacatggtg
     1261 gagctcatgg gcgtccagga tcaacatatg gacgagcgag atgtgaggcg atttcaacta
     1321 aaaattgctg aactgaattc agtgatacgg aagctggaag acagaaatac gctgttggca
     1381 gatgagagga atgaactgct gaaacgctca cgagagaccg aggttcagct gaagcccctg
     1441 gtggagaaga acaagcggat gaacaagaag aatgaggatc tgttgcagag tatccagagg
     1501 atggaggaga aaatcaagaa cctcacgcgg gaaaacgtgg aaatgaaaga aaagctgtca
     1561 gcgcaggcgt ctctgaagcg gcatacctcc ttgaatgacc tcagcctgac gagggatgag
     1621 caggagatcg agttcctgag gctgcaggtg ctggagcagc agcacgtcat tgacgacctc
     1681 tcactggaga gagaacggct gttgcgctcc aaaaggcatc gagggaaaag tctgaaaccg
     1741 cccaagaagc atgttgtgga gacatttttt ggatttgatg aggagtctgt ggactcagaa
     1801 acgttgtccg aaacatccta caacacagac aggacagaca ggaccccagc cacgcccgaa
     1861 gaagacttgg acgatgccac agcccgagag gaggctgacc tgcgcttctg ccagctgacc
     1921 cgggagtacc aggccctgca acgcgcctac gccctgctcc aggagcaggt gggaggcacg
     1981 ctggacgctg agagggaggc ccggactcgg gagcagctac aagctgatct gctgaggtgt
     2041 caggccaaaa tcgaagattt ggagaagtta ctggttgaga agggacagga ttccaagtgg
     2101 gttgaagaga agcagctgct catcagaaca aaccaagact tgctggaaaa gatttacaga
     2161 ctggaaatgg aagagaacca gctgaagaat gaaatgcaag acgccaagga tcagaacgag
     2221 ctgttagaat tcagagtgct agaactcgaa gagagagaga ggaggtcgcc agcatttaac
     2281 ctccaaatca ccaccttccc cgagaaccac agcagcgctc tccagctgtt ctgtcaccag
     2341 gaaggagtta aggatgtgaa tgtttctgaa cttatgaaga aattagatat ccttggcgat
     2401 aacgggaatt tgagaaatga agaacaggtt gcaataatcc aagctggaac tgtgcttgcc
     2461 ctgtgtgaaa agtggctgaa gcaaatagag gggaccgagg ccgccctgac ccagaagatg
     2521 ctggacctgg agaaggagaa ggacctgttc agcaggcaga agggctacct ggaagaggag
     2581 ctcgactacc ggaagcaagc ccttgaccag gcttacctga aaatccaaga cctggaggcc
     2641 acactgtaca cagcgctgca gcaggagccg gggcggaggg ccggtgaggc gctgagcgag
     2701 ggccagcggg aggacctgca ggctgctgtg gaaaaggtgc gcaggcagat cctcaggcag
     2761 agccgcgagt tcgacagcca gatcctgcgg gagcgcatgg agctgctgca gcaggcccag
     2821 cagagaatcc gagaactgga ggacaaactg gagtttcaga agcggcacct gaaagaactg
     2881 gaggaaaagt ttttgttcct ttttttgttt ttctcactag cattcattct gtggccttga
     2941 tgacttcagt gagccaagaa ctcgggttg
//
