LOCUS       NM_000215               5386 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens Janus kinase 3 (JAK3), mRNA.
ACCESSION   NM_000215
VERSION     NM_000215.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5386)
  AUTHORS   Tsilifis,C., Spegarova,J.S., Good,R., Griffin,H., Engelhardt,K.R.,
            Graham,S., Hughes,S., Arkwright,P.D., Hambleton,S. and Gennery,A.R.
  TITLE     Omenn Syndrome in Two Infants with Different Hypomorphic Variants
            in Janus Kinase 3
  JOURNAL   J Clin Immunol 44 (4), 98 (2024)
   PUBMED   38598033
  REMARK    GeneRIF: Omenn Syndrome in Two Infants with Different Hypomorphic
            Variants in Janus Kinase 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5386)
  AUTHORS   Liongue,C., Ratnayake,T., Basheer,F. and Ward,A.C.
  TITLE     Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity
            Disrupted in Immune Cell Cancer and Immunodeficiency
  JOURNAL   Int J Mol Sci 25 (5), 2977 (2024)
   PUBMED   38474223
  REMARK    GeneRIF: Janus Kinase 3 (JAK3): A Critical Conserved Node in
            Immunity Disrupted in Immune Cell Cancer and Immunodeficiency.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5386)
  AUTHORS   Le,K., Vollenweider,J., Han,J., Staudinger,N., Stenson,M.,
            Bayraktar,L., Wellik,L.E., Maurer,M.J., McPhail,E.D., Witzig,T.E.
            and Gupta,M.
  TITLE     Dependence of peripheral T-cell lymphoma on constitutively
            activated JAK3: Implication for JAK3 inhibition as a therapeutic
            approach
  JOURNAL   Hematol Oncol 42 (1), e3233 (2024)
   PUBMED   37876297
  REMARK    GeneRIF: Dependence of peripheral T-cell lymphoma on constitutively
            activated JAK3: Implication for JAK3 inhibition as a therapeutic
            approach.
REFERENCE   4  (bases 1 to 5386)
  AUTHORS   Zhao,Y., Mu,Y., Zou,Y., He,Z., Lu,T., Wang,X., Li,W. and Gao,B.
  TITLE     Conjoint research of WGCNA, single-cell transcriptome and
            structural biology reveals the potential targets of IDD development
            and treatment and JAK3 involvement
  JOURNAL   Aging (Albany NY) 15 (24), 14764-14790 (2023)
   PUBMED   38095643
  REMARK    GeneRIF: Conjoint research of WGCNA, single-cell transcriptome and
            structural biology reveals the potential targets of IDD development
            and treatment and JAK3 involvement.
REFERENCE   5  (bases 1 to 5386)
  AUTHORS   Velatooru,L.R., Hu,C.H., Bijani,P., Wang,X., Bojaxhi,P., Chen,H.,
            Duvic,M. and Ni,X.
  TITLE     New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous
            T-Cell Lymphoma
  JOURNAL   Cells 12 (19), 2381 (2023)
   PUBMED   37830594
  REMARK    GeneRIF: New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in
            Cutaneous T-Cell Lymphoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5386)
  AUTHORS   Johnston,J.A., Wang,L.M., Hanson,E.P., Sun,X.J., White,M.F.,
            Oakes,S.A., Pierce,J.H. and O'Shea,J.J.
  TITLE     Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of
            insulin receptor substrates 1 and 2 in T cells. Potential role of
            JAK kinases
  JOURNAL   J Biol Chem 270 (48), 28527-28530 (1995)
   PUBMED   7499365
REFERENCE   7  (bases 1 to 5386)
  AUTHORS   Russell,S.M., Tayebi,N., Nakajima,H., Riedy,M.C., Roberts,J.L.,
            Aman,M.J., Migone,T.S., Noguchi,M., Markert,M.L., Buckley,R.H.,
            O'Shea,J.J. and Leonard,W.J.
  TITLE     Mutation of Jak3 in a patient with SCID: essential role of Jak3 in
            lymphoid development
  JOURNAL   Science 270 (5237), 797-800 (1995)
   PUBMED   7481768
REFERENCE   8  (bases 1 to 5386)
  AUTHORS   Lai,K.S., Jin,Y., Graham,D.K., Witthuhn,B.A., Ihle,J.N. and
            Liu,E.T.
  TITLE     A kinase-deficient splice variant of the human JAK3 is expressed in
            hematopoietic and epithelial cancer cells
  JOURNAL   J Biol Chem 270 (42), 25028-25036 (1995)
   PUBMED   7559633
REFERENCE   9  (bases 1 to 5386)
  AUTHORS   Rolling,C., Treton,D., Beckmann,P., Galanaud,P. and Richard,Y.
  TITLE     JAK3 associates with the human interleukin 4 receptor and is
            tyrosine phosphorylated following receptor triggering
  JOURNAL   Oncogene 10 (9), 1757-1761 (1995)
   PUBMED   7538655
REFERENCE   10 (bases 1 to 5386)
  AUTHORS   Musso,T., Johnston,J.A., Linnekin,D., Varesio,L., Rowe,T.K.,
            O'Shea,J.J. and McVicar,D.W.
  TITLE     Regulation of JAK3 expression in human monocytes: phosphorylation
            in response to interleukins 2, 4, and 7
  JOURNAL   J Exp Med 181 (4), 1425-1431 (1995)
   PUBMED   7535338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA405504.1, U31601.1, U09607.1,
            AC007201.1 and BF512748.1.
            
            On Dec 27, 2019 this sequence version replaced NM_000215.3.
            
            Summary: The protein encoded by this gene is a member of the Janus
            kinase (JAK) family of tyrosine kinases involved in cytokine
            receptor-mediated intracellular signal transduction. It is
            predominantly expressed in immune cells and transduces a signal in
            response to its activation via tyrosine phosphorylation by
            interleukin receptors. Mutations in this gene are associated with
            autosomal SCID (severe combined immunodeficiency disease).
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3434126.1,
                                           SRR14038194.3063212.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458235.7/ ENSP00000391676.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               DA405504.1         52-243
            193-1879            U31601.1           238-1924
            1880-2583           U09607.1           1925-2628
            2584-3257           U31601.1           2629-3302
            3258-3742           U09607.1           3303-3787
            3743-3841           AC007201.1         6093-6191           c
            3842-4016           U09607.1           3890-4064
            4017-5351           AC007201.1         4583-5917           c
            5352-5386           BF512748.1         14-48               c
FEATURES             Location/Qualifiers
     source          1..5386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..5386
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /note="Janus kinase 3"
                     /db_xref="GeneID:3718"
                     /db_xref="HGNC:HGNC:6193"
                     /db_xref="MIM:600173"
     exon            1..37
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            38..234
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3425
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /EC_number="2.7.10.2"
                     /note="Janus kinase 3 (a protein tyrosine kinase,
                     leukocyte); leukocyte Janus kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK3"
                     /protein_id="NP_000206.2"
                     /db_xref="CCDS:CCDS12366.1"
                     /db_xref="GeneID:3718"
                     /db_xref="HGNC:HGNC:6193"
                     /db_xref="MIM:600173"
                     /translation="MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFS
                     FGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRI
                     RFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQG
                     ECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVR
                     RALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGD
                     GGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPG
                     LPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTG
                     GSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSL
                     RELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQL
                     SQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCM
                     ESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWK
                     LQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLE
                     MLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYED
                     RQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAP
                     RDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQ
                     LQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL
                     QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAK
                     LLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSP
                     SAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSF
                     SALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS"
     exon            235..358
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            359..470
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            471..616
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            617..911
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1034
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1192
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1304
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1491
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1619
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1751
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1836
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1964
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2097
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2249
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2400
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2540
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2730
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2855
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3028
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3146
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3257
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..5386
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5365..5370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /note="hexamer: AATAAA"
     polyA_site      5386
                     /gene="JAK3"
                     /gene_synonym="JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK"
                     /note="major polyA site"
ORIGIN      
        1 gcccgccctt cgaaagtcca gggtccctgc ccgctaggca agttgcactc atggcacctc
       61 caagtgaaga gacgcccctg atccctcagc gttcatgcag cctcttgtcc acggaggctg
      121 gtgccctgca tgtgctgctg cccgctcggg gccccgggcc cccccagcgc ctatctttct
      181 cctttgggga ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc agcggcatcc
      241 tgcctgtgta ccactccctc tttgctctgg ccacggagga cctgtcctgc tggttccccc
      301 cgagccacat cttctccgtg gaggatgcca gcacccaagt cctgctgtac aggattcgct
      361 tttacttccc caattggttt gggctggaga agtgccaccg cttcgggcta cgcaaggatt
      421 tggccagtgc tatccttgac ctgccagtcc tggagcacct ctttgcccag caccgcagtg
      481 acctggtgag tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt gagtgtctca
      541 gcctggccgt gttggacctg gcccggatgg cgcgagagca ggcccagcgg ccgggagagc
      601 tgctgaagac tgtcagctac aaggcctgcc tacccccaag cctgcgcgac ctgatccagg
      661 gcctgagctt cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc ctgcgccgcg
      721 tggccgcctg ccaggcagac cggcactcgc tcatggccaa gtacatcatg gacctggagc
      781 ggctggatcc agccggggcc gccgagacct tccacgtggg cctccctggg gcccttggtg
      841 gccacgacgg gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc tggacccagg
      901 gagaacagga ggtcctccag cccttctgcg actttccaga aatcgtagac attagcatca
      961 agcaggcccc gcgcgttggc ccggccggag agcaccgcct ggtcactgtt accaggacag
     1021 acaaccagat tttagaggcc gagttcccag ggctgcccga ggctctgtcg ttcgtggcgc
     1081 tcgtggacgg ctacttccgg ctgaccacgg actcccagca cttcttctgc aaggaggtgg
     1141 caccgccgag gctgctggag gaagtggccg agcagtgcca cggccccatc actctggact
     1201 ttgccatcaa caagctcaag actgggggct cacgtcctgg ctcctatgtt ctccgccgca
     1261 gcccccagga ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc cttggtcctg
     1321 attataaggg ctgcctcatc cggcgcagcc ccacaggaac cttccttctg gttggcctca
     1381 gccgacccca cagcagtctt cgagagctcc tggcaacctg ctgggatggg gggctgcacg
     1441 tagatggggt ggcagtgacc ctcacttcct gctgtatccc cagacccaaa gaaaagtcca
     1501 acctgatcgt ggtccagaga ggtcacagcc cacccacatc atccttggtt cagccccaat
     1561 cccaatacca gctgagtcag atgacatttc acaagatccc tgctgacagc ctggagtggc
     1621 atgagaacct gggccatggg tccttcacca agatttaccg gggctgtcgc catgaggtgg
     1681 tggatgggga ggcccgaaag acagaggtgc tgctgaaggt catggatgcc aagcacaaga
     1741 actgcatgga gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg taccggcatc
     1801 tcgtgctgct ccacggcgtg tgcatggctg gagacagcac catggtgcag gaatttgtac
     1861 acctgggggc catagacatg tatctgcgaa aacgtggcca cctggtgcca gccagctgga
     1921 agctgcaggt ggtcaaacag ctggcctacg ccctcaacta tctggaggac aaaggcctgc
     1981 cccatggcaa tgtctctgcc cggaaggtgc tcctggctcg ggagggggct gatgggagcc
     2041 cgcccttcat caagctgagt gaccctgggg tcagccccgc tgtgttaagc ctggagatgc
     2101 tcaccgacag gatcccctgg gtggcccccg agtgtctccg ggaggcgcag acacttagct
     2161 tggaagctga caagtggggc ttcggcgcca cggtctggga agtgtttagt ggcgtcacca
     2221 tgcccatcag tgccctggat cctgctaaga aactccaatt ttatgaggac cggcagcagc
     2281 tgccggcccc caagtggaca gagctggccc tgctgattca acagtgcatg gcctatgagc
     2341 cggtccagag gccctccttc cgagccgtca ttcgtgacct caatagcctc atctcttcag
     2401 actatgagct cctctcagac cccacacctg gtgccctggc acctcgtgat gggctgtgga
     2461 atggtgccca gctctatgcc tgccaagacc ccacgatctt cgaggagaga cacctcaagt
     2521 acatctcaca gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc tatgacccgc
     2581 taggcgacaa tacaggtgcc ctggtggccg tgaaacagct gcagcacagc gggccagacc
     2641 agcagaggga ctttcagcgg gagattcaga tcctcaaagc actgcacagt gatttcattg
     2701 tcaagtatcg tggtgtcagc tatggcccgg gccgccagag cctgcggctg gtcatggagt
     2761 acctgcccag cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc ctcgatgcca
     2821 gccgcctcct tctctattcc tcgcagatct gcaagggcat ggagtacctg ggctcccgcc
     2881 gctgcgtgca ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag gcacacgtca
     2941 agatcgctga cttcggccta gctaagctgc tgccgcttga caaagactac tacgtggtcc
     3001 gcgagccagg ccagagcccc attttctggt atgcccccga atccctctcg gacaacatct
     3061 tctctcgcca gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc ttcacctact
     3121 gcgacaaaag ctgcagcccc tcggccgagt tcctgcggat gatgggatgt gagcgggatg
     3181 tccccgccct ctgccgcctc ttggaactgc tggaggaggg ccagaggctg ccggcgcctc
     3241 ctgcctgccc tgctgaggtt cacgagctca tgaagctgtg ctgggcccct agcccacagg
     3301 accggccatc attcagcgcc ctgggccccc agctggacat gctgtggagc ggaagccggg
     3361 ggtgtgagac tcatgccttc actgctcacc cagagggcaa acaccactcc ctgtcctttt
     3421 catagctcct gcccgcagac ctctggatta ggtctctgtt gactggctgt gtgaccttag
     3481 gcccggagct gcccctctct gggcctcaga ggccttatga gggtcctcta cttcaggaac
     3541 acccccatga cattgcattt gggggggctc ccgtggcctg tagaatagcc tgtggccttt
     3601 gcaatttgtt aaggttcaag acagatgggc atatgtgtca gtggggctct ctgagtcctg
     3661 gcccaaagaa gcaaggaacc aaatttaaga ctctcgcatc ttcccaaccc cttaagccct
     3721 ggccccctga gtttcctttt ctgtctctct ctttttattt tttttatttt tatttttatt
     3781 tttgagacag agcctcgctc tgttacccag ggtggagtgc agtggtgcga tctcggctca
     3841 gtgcaacctc tgcttcccag gttcaagcga ttctcctgcc tcagcctccc gagtagctgg
     3901 gattacaggt gtgcaccacc acacccggct aatttttttt atttttaata gagatgaggt
     3961 ttcaccatga tggccaggct gatctcgaac tcctaacctc aagtgatcct cccacctcag
     4021 cctcccaaag tgttggaata ataggcatga gccactgcac ccaggctttt ttttttttaa
     4081 atttattatt attattttta agagacagga tcttgctacg ttgcccaggc tggtcttgaa
     4141 ctcctgggct acagtgatcc tcctgcctta tcctcctaaa tagctgggac tacagcacct
     4201 agttttgagt ttcctgtctt atttccaatg gggacattca tgtagctttt tttttttttt
     4261 tttttttgag acggagtctc gctctgtcgc ccaggctgga gtacagtggc gcaatctagg
     4321 ctcactgcaa gctccgcctc ctgggttcac accattctct cgcctcagcc tcccaagtag
     4381 ctgggactac aggcgcccgc caccacaccc ggctaatttt ttgtattttt agtagagacg
     4441 gggtttcacc ttgttagcca ggatggtttc catctcctga cctcgtgatc tgcccgtctc
     4501 ggcctcccaa agtgctggga ttacaggcat gagccactgc gcccggccct catgtagctt
     4561 taaatgtatg atctgacttc tgctccccga tctctgtttc tctggaggaa gccaaggaca
     4621 agagcagttg ctgtggctgg gactctgcct tttaggggag cccgtgtatc tctttgggat
     4681 cctgaaaggg ggcaggaaag gctggggtcc cagtccaccc taatggtatc tgagtgtcct
     4741 agggcttcag ttttcccacc tgtccaatgg gaccctttct gtcctcaccc tacaaggggc
     4801 acaaagggat gacaccaaac ctggcaggaa cttttcacgc aatcaaggga aggaaaggca
     4861 ttcctggcag agggaacagc atgccaagcg tgagaaggct cagagtaagg aggttaagag
     4921 cccaagtatt ggagcctaca gttttgcccc ttccatgcag tgtgacagtg ggcaagttcc
     4981 tttccctctc tgggtctcag ttctgtcccc tgcaaaatgg tcagagctta ccccttggct
     5041 gtgcagggtc aactttctga ctggtgagag ggattctcat gcaggttaag cttctgctgc
     5101 tcctcctcac ctgcaaagct tttctgccac ttttgcctcc ttggaaaact cttatccatc
     5161 tctcaaaact ccagctacca catccttgca gccttccctc atataccccc actactactg
     5221 tagccctgtc cttccctcca gccccactct ggccctgggg ctggggaagt gtctgtgtcc
     5281 agctgtctcc cctgacctca gggttccttg ggggctgggc tgaggcctca gtacagaggg
     5341 ggctctggaa atgtttgttg actgaataaa ggaattcagt ggaaaa
//
