LOCUS       NM_002227               5092 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Janus kinase 1 (JAK1), transcript variant 1, mRNA.
ACCESSION   NM_002227
VERSION     NM_002227.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Horesh,M.E., Martin-Fernandez,M., Gruber,C., Buta,S., Le Voyer,T.,
            Puzenat,E., Lesmana,H., Wu,Y., Richardson,A., Stein,D., Hodeib,S.,
            Youssef,M., Kurowski,J.A., Feuille,E., Pedroza,L.A., Fuleihan,R.L.,
            Haseley,A., Hovnanian,A., Quartier,P., Rosain,J., Davis,G.,
            Mullan,D., Stewart,O., Patel,R., Lee,A.E., Rubinstein,R., Ewald,L.,
            Maheshwari,N., Rahming,V., Chinn,I.K., Lupski,J.R., Orange,J.S.,
            Sancho-Shimizu,V., Casanova,J.L., Abul-Husn,N.S., Itan,Y.,
            Milner,J.D., Bustamante,J. and Bogunovic,D.
  TITLE     Individuals with JAK1 variants are affected by syndromic features
            encompassing autoimmunity, atopy, colitis, and dermatitis
  JOURNAL   J Exp Med 221 (6) (2024)
   PUBMED   38563820
  REMARK    GeneRIF: Individuals with JAK1 variants are affected by syndromic
            features encompassing autoimmunity, atopy, colitis, and dermatitis.
            Erratum:[J Exp Med. 2024 Jun 3;221(6):e2023238704302024c. doi:
            10.1084/jem.2023238704302024c.. PMID: 38709237]
REFERENCE   2  (bases 1 to 5092)
  AUTHORS   Shrestha,H., Radler,P.D., Dennaoui,R., Wicker,M.N., Rajbhandari,N.,
            Sun,Y., Peck,A.R., Vistisen,K., Triplett,A.A., Beydoun,R.,
            Sterneck,E., Saur,D., Rui,H. and Wagner,K.U.
  TITLE     The Janus kinase 1 is critical for pancreatic cancer initiation and
            progression
  JOURNAL   Cell Rep 43 (5), 114202 (2024)
   PUBMED   38733583
  REMARK    GeneRIF: The Janus kinase 1 is critical for pancreatic cancer
            initiation and progression.
REFERENCE   3  (bases 1 to 5092)
  AUTHORS   Yu,Z., Zhang,Q., Wei,S., Zhang,Y., Zhou,T., Zhang,Q., Shi,R.,
            Zinovkin,D., Pranjol,Z.I., Zhang,J. and Wang,H.
  TITLE     CD146+CAFs promote progression of endometrial cancer by inducing
            angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway
  JOURNAL   Cell Commun Signal 22 (1), 170 (2024)
   PUBMED   38459564
  REMARK    GeneRIF: CD146[+]CAFs promote progression of endometrial cancer by
            inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5092)
  AUTHORS   Cheng,B., Li,L., Luo,T., Wang,Q., Luo,Y., Bai,S., Li,K., Lai,Y. and
            Huang,H.
  TITLE     Single-cell deconvolution algorithms analysis unveils autocrine
            IL11-mediated resistance to docetaxel in prostate cancer via
            activation of the JAK1/STAT4 pathway
  JOURNAL   J Exp Clin Cancer Res 43 (1), 67 (2024)
   PUBMED   38429845
  REMARK    GeneRIF: Single-cell deconvolution algorithms analysis unveils
            autocrine IL11-mediated resistance to docetaxel in prostate cancer
            via activation of the JAK1/STAT4 pathway.
            Erratum:[J Exp Clin Cancer Res. 2024 Dec 28;43(1):333. doi:
            10.1186/s13046-024-03257-8.. PMID: 39731134]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5092)
  AUTHORS   Huang,Q., Xiao,Y., Lan,T., Lu,Y., Huang,L. and Zheng,D.
  TITLE     WNT7A promotes tumorigenesis of head and neck squamous cell
            carcinoma via activating FZD7/JAK1/STAT3 signaling
  JOURNAL   Int J Oral Sci 16 (1), 7 (2024)
   PUBMED   38246919
  REMARK    GeneRIF: WNT7A promotes tumorigenesis of head and neck squamous
            cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5092)
  AUTHORS   Johnston,J.A., Wang,L.M., Hanson,E.P., Sun,X.J., White,M.F.,
            Oakes,S.A., Pierce,J.H. and O'Shea,J.J.
  TITLE     Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of
            insulin receptor substrates 1 and 2 in T cells. Potential role of
            JAK kinases
  JOURNAL   J Biol Chem 270 (48), 28527-28530 (1995)
   PUBMED   7499365
REFERENCE   7  (bases 1 to 5092)
  AUTHORS   Velazquez,L., Fellous,M., Stark,G.R. and Pellegrini,S.
  TITLE     A protein tyrosine kinase in the interferon alpha/beta signaling
            pathway
  JOURNAL   Cell 70 (2), 313-322 (1992)
   PUBMED   1386289
REFERENCE   8  (bases 1 to 5092)
  AUTHORS   Howard,O.M., Dean,M., Young,H., Ramsburg,M., Turpin,J.A.,
            Michiel,D.F., Kelvin,D.J., Lee,L. and Farrar,W.L.
  TITLE     Characterization of a class 3 tyrosine kinase
  JOURNAL   Oncogene 7 (5), 895-900 (1992)
   PUBMED   1373877
REFERENCE   9  (bases 1 to 5092)
  AUTHORS   Pritchard,M.A., Baker,E., Callen,D.F., Sutherland,G.R. and
            Wilks,A.F.
  TITLE     Two members of the JAK family of protein tyrosine kinases map to
            chromosomes 1p31.3 and 9p24
  JOURNAL   Mamm Genome 3 (1), 36-38 (1992)
   PUBMED   1581631
REFERENCE   10 (bases 1 to 5092)
  AUTHORS   Wilks,A.F., Harpur,A.G., Kurban,R.R., Ralph,S.J., Zurcher,G. and
            Ziemiecki,A.
  TITLE     Two novel protein-tyrosine kinases, each with a second
            phosphotransferase-related catalytic domain, define a new class of
            protein kinase
  JOURNAL   Mol Cell Biol 11 (4), 2057-2065 (1991)
   PUBMED   1848670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606517.14, BC009079.1,
            AB209057.1 and AC093427.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002227.3.
            
            Summary: This gene encodes a membrane protein that is a member of a
            class of protein-tyrosine kinases (PTK) characterized by the
            presence of a second phosphotransferase-related domain immediately
            N-terminal to the PTK domain. The encoded kinase phosphorylates
            STAT proteins (signal transducers and activators of transcription)
            and plays a key role in interferon-alpha/beta, interferon-gamma,
            and cytokine signal transduction. This gene plays a crucial role in
            effecting the expression of genes that mediate inflammation,
            epithelial remodeling, and metastatic cancer progression. This gene
            is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune
            and inflammation response and is a therapeutic target for
            alleviating cytokine storms. The kinase activity of this gene is
            directly inhibited by the suppressor of cytokine signalling 1
            (SOCS1) protein. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2020].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.1147.1,
                                           SRR11853561.958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 treatment
            MANE Ensembl match     :: ENST00000342505.5/ ENSP00000343204.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL606517.14        51553-51597         c
            46-224              BC009079.1         1-179
            225-4246            AB209057.1         1-4022
            4247-5092           AC093427.2         61662-62507
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..5092
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /note="Janus kinase 1"
                     /db_xref="GeneID:3716"
                     /db_xref="HGNC:HGNC:6190"
                     /db_xref="MIM:147795"
     exon            1..217
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            218..300
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..3759
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tyrosine-protein kinase JAK1"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK1 isoform 1"
                     /protein_id="NP_002218.2"
                     /db_xref="CCDS:CCDS41346.1"
                     /db_xref="GeneID:3716"
                     /db_xref="HGNC:HGNC:6190"
                     /db_xref="MIM:147795"
                     /translation="MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSD
                     REPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMS
                     LRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFA
                     QGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYK
                     RYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLET
                     LTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSV
                     EKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKM
                     ELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAI
                     NKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYS
                     LHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQP
                     VYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL
                     DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRK
                     SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDP
                     GIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKT
                     LIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIV
                     SEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES
                     GGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK
                     NKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIET
                     DKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF
                     LKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLI
                     EGFEALLK"
     exon            301..499
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..623
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..777
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..941
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1284
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1470
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1628
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1752
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1942
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2049
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2193
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2281
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2409
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2545
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2697
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2848
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2943
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3136
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3261
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3434
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3552
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3663
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..5092
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5071..5076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /note="hexamer: AATAAA"
     polyA_site      5092
                     /gene="JAK1"
                     /gene_synonym="AIIDE; JAK1A; JAK1B; JTK3"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcgctga gcgcaggccg cggcggccgc ggagtatcct ggagctgcag acagtgcggg
       61 cctgcgccca gtcccggctg tcctcgccgc gacccctcct cagccctggg cgcgcgcacg
      121 ctggggcccc gcggggctgg ccgcctagcg agcctgccgg tcgaccccag ccagcgcagc
      181 gacggggcgc tgcctggccc aggcgcacac ggaagtgcgc ttctctgaag tagctttgga
      241 aagtagagaa gaaaatccag tttgcttctt ggagaacact ggacagctga ataaatgcag
      301 tatctaaata taaaagagga ctgcaatgcc atggctttct gtgctaaaat gaggagctcc
      361 aagaagactg aggtgaacct ggaggcccct gagccagggg tggaagtgat cttctatctg
      421 tcggacaggg agcccctccg gctgggcagt ggagagtaca cagcagagga actgtgcatc
      481 agggctgcac aggcatgccg tatctctcct ctttgtcaca acctctttgc cctgtatgac
      541 gagaacacca agctctggta tgctccaaat cgcaccatca ccgttgatga caagatgtcc
      601 ctccggctcc actaccggat gaggttctat ttcaccaatt ggcatggaac caacgacaat
      661 gagcagtcag tgtggcgtca ttctccaaag aagcagaaaa atggctacga gaaaaaaaag
      721 attccagatg caacccctct ccttgatgcc agctcactgg agtatctgtt tgctcaggga
      781 cagtatgatt tggtgaaatg cctggctcct attcgagacc ccaagaccga gcaggatgga
      841 catgatattg agaacgagtg tctagggatg gctgtcctgg ccatctcaca ctatgccatg
      901 atgaagaaga tgcagttgcc agaactgccc aaggacatca gctacaagcg atatattcca
      961 gaaacattga ataagtccat cagacagagg aaccttctca ccaggatgcg gataaataat
     1021 gttttcaagg atttcctaaa ggaatttaac aacaagacca tttgtgacag cagcgtgtcc
     1081 acgcatgacc tgaaggtgaa atacttggct accttggaaa ctttgacaaa acattacggt
     1141 gctgaaatat ttgagacttc catgttactg atttcatcag aaaatgagat gaattggttt
     1201 cattcgaatg acggtggaaa cgttctctac tacgaagtga tggtgactgg gaatcttgga
     1261 atccagtgga ggcataaacc aaatgttgtt tctgttgaaa aggaaaaaaa taaactgaag
     1321 cggaaaaaac tggaaaataa acacaagaag gatgaggaga aaaacaagat ccgggaagag
     1381 tggaacaatt tttcttactt ccctgaaatc actcacattg taataaagga gtctgtggtc
     1441 agcattaaca agcaggacaa caagaaaatg gaactgaagc tctcttccca cgaggaggcc
     1501 ttgtcctttg tgtccctggt agatggctac ttccggctca cagcagatgc ccatcattac
     1561 ctctgcaccg acgtggcccc cccgttgatc gtccacaaca tacagaatgg ctgtcatggt
     1621 ccaatctgta cagaatacgc catcaataaa ttgcggcaag aaggaagcga ggaggggatg
     1681 tacgtgctga ggtggagctg caccgacttt gacaacatcc tcatgaccgt cacctgcttt
     1741 gagaagtctg agcaggtgca gggtgcccag aagcagttca agaactttca gatcgaggtg
     1801 cagaagggcc gctacagtct gcacggttcg gaccgcagct tccccagctt gggagacctc
     1861 atgagccacc tcaagaagca gatcctgcgc acggataaca tcagcttcat gctaaaacgc
     1921 tgctgccagc ccaagccccg agaaatctcc aacctgctgg tggctactaa gaaagcccag
     1981 gagtggcagc ccgtctaccc catgagccag ctgagtttcg atcggatcct caagaaggat
     2041 ctggtgcagg gcgagcacct tgggagaggc acgagaacac acatctattc tgggaccctg
     2101 atggattaca aggatgacga aggaacttct gaagagaaga agataaaagt gatcctcaaa
     2161 gtcttagacc ccagccacag ggatatttcc ctggccttct tcgaggcagc cagcatgatg
     2221 agacaggtct cccacaaaca catcgtgtac ctctatggcg tctgtgtccg cgacgtggag
     2281 aatatcatgg tggaagagtt tgtggaaggg ggtcctctgg atctcttcat gcaccggaaa
     2341 agcgatgtcc ttaccacacc atggaaattc aaagttgcca aacagctggc cagtgccctg
     2401 agctacttgg aggataaaga cctggtccat ggaaatgtgt gtactaaaaa cctcctcctg
     2461 gcccgtgagg gcatcgacag tgagtgtggc ccattcatca agctcagtga ccccggcatc
     2521 cccattacgg tgctgtctag gcaagaatgc attgaacgaa tcccatggat tgctcctgag
     2581 tgtgttgagg actccaagaa cctgagtgtg gctgctgaca agtggagctt tggaaccacg
     2641 ctctgggaaa tctgctacaa tggcgagatc cccttgaaag acaagacgct gattgagaaa
     2701 gagagattct atgaaagccg gtgcaggcca gtgacaccat catgtaagga gctggctgac
     2761 ctcatgaccc gctgcatgaa ctatgacccc aatcagaggc ctttcttccg agccatcatg
     2821 agagacatta ataagcttga agagcagaat ccagatattg tttcagaaaa aaaaccagca
     2881 actgaagtgg accccacaca ttttgaaaag cgcttcctaa agaggatccg tgacttggga
     2941 gagggccact ttgggaaggt tgagctctgc aggtatgacc ccgaagggga caatacaggg
     3001 gagcaggtgg ctgttaaatc tctgaagcct gagagtggag gtaaccacat agctgatctg
     3061 aaaaaggaaa tcgagatctt aaggaacctc tatcatgaga acattgtgaa gtacaaagga
     3121 atctgcacag aagacggagg aaatggtatt aagctcatca tggaatttct gccttcggga
     3181 agccttaagg aatatcttcc aaagaataag aacaaaataa acctcaaaca gcagctaaaa
     3241 tatgccgttc agatttgtaa ggggatggac tatttgggtt ctcggcaata cgttcaccgg
     3301 gacttggcag caagaaatgt ccttgttgag agtgaacacc aagtgaaaat tggagacttc
     3361 ggtttaacca aagcaattga aaccgataag gagtattaca ccgtcaagga tgaccgggac
     3421 agccctgtgt tttggtatgc tccagaatgt ttaatgcaat ctaaatttta tattgcctct
     3481 gacgtctggt cttttggagt cactctgcat gagctgctga cttactgtga ttcagattct
     3541 agtcccatgg ctttgttcct gaaaatgata ggcccaaccc atggccagat gacagtcaca
     3601 agacttgtga atacgttaaa agaaggaaaa cgcctgccgt gcccacctaa ctgtccagat
     3661 gaggtttatc aacttatgag gaaatgctgg gaattccaac catccaatcg gacaagcttt
     3721 cagaacctta ttgaaggatt tgaagcactt ttaaaataag aagcatgaat aacatttaaa
     3781 ttccacagat tatcaagtcc ttctcctgca acaaatgccc aagtcatttt ttaaaaattt
     3841 ctaatgaaag aagtttgtgt tctgtccaaa aagtcactga actcatactt cagtacatat
     3901 acatgtataa ggcacactgt agtgcttaat atgtgtaagg acttcctctt taaatttggt
     3961 accagtaact tagtgacaca taatgacaac caaaatattt gaaagcactt aagcactcct
     4021 ccttgtggaa agaatatacc accatttcat ctggctagtt caccatcaca actgcattac
     4081 caaaagggga tttttgaaaa cgaggagttg accaaaataa tatctgaaga tgattgcttt
     4141 tccctgctgc cagctgatct gaaatgtttt gctggcacat taatcataga taaagaaaga
     4201 ttgatggact tagccctcaa atttcagtat ctatacagta ctagaccatg cattcttaaa
     4261 atattagata ccaggtagta tatattgttt ctgtacaaaa atgactgtat tctctcacca
     4321 gtaggactta aactttgttt ctccagtggc ttagctcctg ttcctttggg tgatcactag
     4381 cacccatttt tgagaaagct ggttctacat ggggggatag ctgtggaata gataatttgc
     4441 tgcatgttaa ttctcaagaa ctaagcctgt gccagtgctt tcctaagcag tataccttta
     4501 atcagaactc attcccagaa cctggatgct attacacatg cttttaagaa acgtcaatgt
     4561 atatcctttt ataactctac cactttgggg caagctattc cagcactggt tttgaatgct
     4621 gtatgcaacc agtctgaata ccacatacgc tgcactgttc ttagagggtt tccatactta
     4681 ccaccgatct acaagggttg atccctgttt ttaccatcaa tcatcaccct gtggtgcaac
     4741 acttgaaaga cccggctaga ggcactatgg acttcaggat ccactagaca gttttcagtt
     4801 tgcttggagg tagctgggta atcaaaaatg tttagtcatt gattcaatgt gaacgattac
     4861 ggtctttatg accaagagtc tgaaaatctt tttgttatgc tgtttagtat tcgtttgata
     4921 ttgttacttt tcacctgttg agcccaaatt caggattggt tcagtggcag caatgaagtt
     4981 gccatttaaa tttgttcata gcctacatca ccaaggtctc tgtgtcaaac ctgtggccac
     5041 tctatatgca ctttgtttac tctttataca aataaatata ctaaagactt ta
//
