LOCUS       NM_002226               5773 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript
            variant 1, mRNA.
ACCESSION   NM_002226
VERSION     NM_002226.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5773)
  AUTHORS   Dofash,L., Lyengar,K., Pereira,N., Parmar,J., Folland,C., Laing,N.,
            Kang,P.B., Cairns,A., Lynch,M., Davis,M. and Ravenscroft,G.
  TITLE     Three novel missense variants in two families with JAG2-associated
            limb-girdle muscular dystrophy
  JOURNAL   Neuromuscul Disord 42, 36-42 (2024)
   PUBMED   39121631
  REMARK    GeneRIF: Three novel missense variants in two families with
            JAG2-associated limb-girdle muscular dystrophy.
REFERENCE   2  (bases 1 to 5773)
  AUTHORS   Huang,H., Jiang,Y., Liu,J., Luo,D., Yuan,J., Mu,R., Yu,X., Sun,D.,
            Lin,J., Chen,Q., Li,X., Jiang,M., Xu,J., Chu,B., Yin,C., Zhang,L.,
            Ye,Y., Cao,B., Wang,Q. and Zhang,Y.
  TITLE     Jag1/2 maintain esophageal homeostasis and suppress foregut
            tumorigenesis by restricting the basal progenitor cell pool
  JOURNAL   Nat Commun 15 (1), 4124 (2024)
   PUBMED   38750026
  REMARK    GeneRIF: Jag1/2 maintain esophageal homeostasis and suppress
            foregut tumorigenesis by restricting the basal progenitor cell
            pool.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5773)
  AUTHORS   Mandula,J.K., Sierra-Mondragon,R.A., Jimenez,R.V., Chang,D.,
            Mohamed,E., Chang,S., Vazquez-Martinez,J.A., Cao,Y., Anadon,C.M.,
            Lee,S.B., Das,S., Rocha-Munguba,L., Pham,V.M., Li,R., Tarhini,A.A.,
            Furqan,M., Dalton,W., Churchman,M., Moran-Segura,C.M., Nguyen,J.,
            Perez,B., Kojetin,D.J., Obermayer,A., Yu,X., Chen,A., Shaw,T.I.,
            Conejo-Garcia,J.R. and Rodriguez,P.C.
  TITLE     Jagged2 targeting in lung cancer activates anti-tumor immunity via
            Notch-induced functional reprogramming of tumor-associated
            macrophages
  JOURNAL   Immunity 57 (5), 1124-1140 (2024)
   PUBMED   38636522
  REMARK    GeneRIF: Jagged2 targeting in lung cancer activates anti-tumor
            immunity via Notch-induced functional reprogramming of
            tumor-associated macrophages.
REFERENCE   4  (bases 1 to 5773)
  AUTHORS   Islam,S.S., Al-Mohanna,F.H., Yousef,I.M., Al-Badawi,I.A. and
            Aboussekhra,A.
  TITLE     Ovarian tumor cell-derived JAGGED2 promotes omental metastasis
            through stimulating the Notch signaling pathway in the mesothelial
            cells
  JOURNAL   Cell Death Dis 15 (4), 247 (2024)
   PUBMED   38575576
  REMARK    GeneRIF: Ovarian tumor cell-derived JAGGED2 promotes omental
            metastasis through stimulating the Notch signaling pathway in the
            mesothelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5773)
  AUTHORS   Deng,Y., Madan,A., Banta,A.B., Friedman,C., Trask,B.J., Hood,L. and
            Li,L.
  TITLE     Characterization, chromosomal localization, and the complete 30-kb
            DNA sequence of the human Jagged2 (JAG2) gene
  JOURNAL   Genomics 63 (1), 133-138 (2000)
   PUBMED   10662552
REFERENCE   6  (bases 1 to 5773)
  AUTHORS   Felli,M.P., Maroder,M., Mitsiadis,T.A., Campese,A.F., Bellavia,D.,
            Vacca,A., Mann,R.S., Frati,L., Lendahl,U., Gulino,A. and
            Screpanti,I.
  TITLE     Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid
            and stromal thymus components: distinct ligand-receptor
            interactions in intrathymic T cell development
  JOURNAL   Int Immunol 11 (7), 1017-1025 (1999)
   PUBMED   10383933
REFERENCE   7  (bases 1 to 5773)
  AUTHORS   Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
            Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
            Artavanis-Tsakonas,S.
  TITLE     Human ligands of the Notch receptor
  JOURNAL   Am J Pathol 154 (3), 785-794 (1999)
   PUBMED   10079256
REFERENCE   8  (bases 1 to 5773)
  AUTHORS   Valsecchi,C., Ghezzi,C., Ballabio,A. and Rugarli,E.I.
  TITLE     JAGGED2: a putative Notch ligand expressed in the apical ectodermal
            ridge and in sites of epithelial-mesenchymal interactions
  JOURNAL   Mech Dev 69 (1-2), 203-207 (1997)
   PUBMED   9486542
REFERENCE   9  (bases 1 to 5773)
  AUTHORS   Luo,B., Aster,J.C., Hasserjian,R.P., Kuo,F. and Sklar,J.
  TITLE     Isolation and functional analysis of a cDNA for human Jagged2, a
            gene encoding a ligand for the Notch1 receptor
  JOURNAL   Mol Cell Biol 17 (10), 6057-6067 (1997)
   PUBMED   9315665
REFERENCE   10 (bases 1 to 5773)
  AUTHORS   Shawber,C., Boulter,J., Lindsell,C.E. and Weinmaster,G.
  TITLE     Jagged2: a serrate-like gene expressed during rat embryogenesis
  JOURNAL   Dev Biol 180 (1), 370-376 (1996)
   PUBMED   8948600
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF029778.1, AL512356.6,
            U69180.1, AF003521.1, AJ712299.1, BX105691.1, AA775404.1 and
            AI276672.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002226.4.
            
            Summary: The Notch signaling pathway is an intercellular signaling
            mechanism that is essential for proper embryonic development.
            Members of the Notch gene family encode transmembrane receptors
            that are critical for various cell fate decisions. The protein
            encoded by this gene is one of several ligands that activate Notch
            and related receptors. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029778.1, AF020201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331782.8/ ENSP00000328169.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AF029778.1         49-102
            55-190              AF029778.1         104-239
            191-193             AL512356.6         153325-153327       c
            194-1856            AF029778.1         242-1904
            1857-2420           U69180.1           163-726
            2421-3424           AF029778.1         2469-3472
            3425-3784           AF003521.1         3101-3460
            3785-4701           AF029778.1         3833-4749
            4702-4804           AJ712299.1         428-530
            4805-4864           AF003521.1         4478-4537
            4865-5125           BX105691.1         1-261
            5126-5126           AL512356.6         126383-126383       c
            5127-5194           BX105691.1         263-330
            5195-5396           AA775404.1         286-487             c
            5397-5773           AI276672.1         25-401              c
FEATURES             Location/Qualifiers
     source          1..5773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..5773
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /note="jagged canonical Notch ligand 2"
                     /db_xref="GeneID:3714"
                     /db_xref="HGNC:HGNC:6189"
                     /db_xref="MIM:602570"
     exon            1..422
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..4073
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein jagged-2; jagged 2"
                     /codon_start=1
                     /product="protein jagged-2 isoform a precursor"
                     /protein_id="NP_002217.3"
                     /db_xref="CCDS:CCDS9998.1"
                     /db_xref="GeneID:3714"
                     /db_xref="HGNC:HGNC:6189"
                     /db_xref="MIM:602570"
                     /translation="MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGEL
                     LSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNS
                     FYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEE
                     LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFF
                     GHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDEC
                     VPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCT
                     CPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN
                     PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCI
                     PGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCH
                     SGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF
                     GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC
                     DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDP
                     CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP
                     GWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC
                     YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG
                     RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLA
                     GQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCAR
                     LTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSF
                     SPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLC
                     GAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKD
                     VLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKD
                     PGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE"
     exon            423..773
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..831
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1083
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1144
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1275
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1395
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1509
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1623
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1737
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1784
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1958
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2109
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2262
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2376
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2490
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2604
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2721
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2749
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2835
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2949
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3065
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3308
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3440
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3597
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..5773
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4987..4992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /note="hexamer: ATTAAA"
     polyA_site      5029
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /note="major polyA site"
     regulatory      5746..5751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /note="hexamer: AATGAA"
     regulatory      5754..5759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /note="hexamer: AATGAA"
     polyA_site      5764
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
     polyA_site      5773
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
ORIGIN      
        1 agtctcgttc cgaacttgtt ggctgcggtg ccgggagcgc gggcgcgcag agccgaggcc
       61 gggacccgct gccttcaccg ccgccgccgt cgccgccggg tgggagccgg gccgggcagc
      121 cggagcgcgg ccgccagcga gccggagctg ccgccgcccc tgcacgcccg ccgcccaggc
      181 ccgcgcgccg cggcgctgcg ctcgaccccg cccgcgccgc cgccgccgcc gcctctgccg
      241 ctgccgctgc ctctgcgggc gctcggaggg cgggcgggcg ctgggaggcc ggcgcggcgg
      301 ctgggagccg ggcgcgggcg gcggcggcgg ggccgggcgg gcgggtcgcg ggggcaatgc
      361 gggcgcaggg ccgggggcgc cttccccggc ggctgctgct gctgctggcg ctctgggtgc
      421 aggcggcgcg gcccatgggc tatttcgagc tgcagctgag cgcgctgcgg aacgtgaacg
      481 gggagctgct gagcggcgcc tgctgtgacg gcgacggccg gacaacgcgc gcggggggct
      541 gcggccacga cgagtgcgac acgtacgtgc gcgtgtgcct taaggagtac caggccaagg
      601 tgacgcccac ggggccctgc agctacggcc acggcgccac gcccgtgctg ggcggcaact
      661 ccttctacct gccgccggcg ggcgctgcgg gggaccgagc gcgggcgcgg gcccgggccg
      721 gcggcgacca ggacccgggc ctcgtcgtca tccccttcca gttcgcctgg ccgcgctcct
      781 ttaccctcat cgtggaggcc tgggactggg acaacgatac caccccgaat gaggagctgc
      841 tgatcgagcg agtgtcgcat gccggcatga tcaacccgga ggaccgctgg aagagcctgc
      901 acttcagcgg ccacgtggcg cacctggagc tgcagatccg cgtgcgctgc gacgagaact
      961 actacagcgc cacttgcaac aagttctgcc ggccccgcaa cgactttttc ggccactaca
     1021 cctgcgacca gtacggcaac aaggcctgca tggacggctg gatgggcaag gagtgcaagg
     1081 aagctgtgtg taaacaaggg tgtaatttgc tccacggggg atgcaccgtg cctggggagt
     1141 gcaggtgcag ctacggctgg caagggaggt tctgcgatga gtgtgtcccc taccccggct
     1201 gcgtgcatgg cagttgtgtg gagccctggc agtgcaactg tgagaccaac tggggcggcc
     1261 tgctctgtga caaagacctg aactactgtg gcagccacca cccctgcacc aacggaggca
     1321 cgtgcatcaa cgccgagcct gaccagtacc gctgcacctg ccctgacggc tactcgggca
     1381 ggaactgtga gaaggctgag cacgcctgca cctccaaccc gtgtgccaac gggggctctt
     1441 gccatgaggt gccgtccggc ttcgaatgcc actgcccatc gggctggagc gggcccacct
     1501 gtgcccttga catcgatgag tgtgcttcga acccgtgtgc ggccggtggc acctgtgtgg
     1561 accaggtgga cggctttgag tgcatctgcc ccgagcagtg ggtgggggcc acctgccagc
     1621 tggacgccaa tgagtgtgaa gggaagccat gccttaacgc tttttcttgc aaaaacctga
     1681 ttggcggcta ttactgtgat tgcatcccgg gctggaaggg catcaactgc catatcaacg
     1741 tcaacgactg tcgcgggcag tgtcagcatg ggggcacctg caaggacctg gtgaacgggt
     1801 accagtgtgt gtgcccacgg ggcttcggag gccggcattg cgagctggaa cgagacgagt
     1861 gtgccagcag cccctgccac agcggcggcc tctgcgagga cctggccgac ggcttccact
     1921 gccactgccc ccagggcttc tccgggcctc tctgtgaggt ggatgtcgac ctttgtgagc
     1981 caagcccctg ccggaacggc gctcgctgct ataacctgga gggtgactat tactgcgcct
     2041 gccctgatga ctttggtggc aagaactgct ccgtgccccg cgagccgtgc cctggcgggg
     2101 cctgcagagt gatcgatggc tgcgggtcag acgcggggcc tgggatgcct ggcacagcag
     2161 cctccggcgt gtgtggcccc catggacgct gcgtcagcca gccagggggc aacttttcct
     2221 gcatctgtga cagtggcttt actggcacct actgccatga gaacattgac gactgcctgg
     2281 gccagccctg ccgcaatggg ggcacatgca tcgatgaggt ggacgccttc cgctgcttct
     2341 gccccagcgg ctgggagggc gagctctgcg acaccaatcc caacgactgc cttcccgatc
     2401 cctgccacag ccgcggccgc tgctacgacc tggtcaatga cttctactgt gcgtgcgacg
     2461 acggctggaa gggcaagacc tgccactcac gcgagttcca gtgcgatgcc tacacctgca
     2521 gcaacggtgg cacctgctac gacagcggcg acaccttccg ctgcgcctgc ccccccggct
     2581 ggaagggcag cacctgcgcc gtcgccaaga acagcagctg cctgcccaac ccctgtgtga
     2641 atggtggcac ctgcgtgggc agcggggcct ccttctcctg catctgccgg gacggctggg
     2701 agggtcgtac ttgcactcac aataccaacg actgcaaccc tctgccttgc tacaatggtg
     2761 gcatctgtgt tgacggcgtc aactggttcc gctgcgagtg tgcacctggc ttcgcggggc
     2821 ctgactgccg catcaacatc gacgagtgcc agtcctcgcc ctgtgcctac ggggccacgt
     2881 gtgtggatga gatcaacggg tatcgctgta gctgcccacc cggccgagcc ggcccccggt
     2941 gccaggaagt gatcgggttc gggagatcct gctggtcccg gggcactccg ttcccacacg
     3001 gaagctcctg ggtggaagac tgcaacagct gccgctgcct ggatggccgc cgtgactgca
     3061 gcaaggtgtg gtgcggatgg aagccttgtc tgctggccgg ccagcccgag gccctgagcg
     3121 cccagtgccc actggggcaa aggtgcctgg agaaggcccc aggccagtgt ctgcgaccac
     3181 cctgtgaggc ctggggggag tgcggcgcag aagagccacc gagcaccccc tgcctgccac
     3241 gctccggcca cctggacaat aactgtgccc gcctcacctt gcatttcaac cgtgaccacg
     3301 tgccccaggg caccacggtg ggcgccattt gctccgggat ccgctccctg ccagccacaa
     3361 gggctgtggc acgggaccgc ctgctggtgt tgctttgcga ccgggcgtcc tcgggggcca
     3421 gtgctgtgga ggtggccgtg tccttcagcc ctgccaggga cctgcctgac agcagcctga
     3481 tccagggcgc ggcccacgcc atcgtggccg ccatcaccca gcgggggaac agctcactgc
     3541 tcctggctgt caccgaggtc aaggtggaga cggttgttac gggcggctct tccacaggtc
     3601 tgctggtgcc tgtgctgtgt ggtgccttca gcgtgctgtg gctggcgtgc gtggtcctgt
     3661 gcgtgtggtg gacacgcaag cgcaggaaag agcgggagag gagccggctg ccgcgggagg
     3721 agagcgccaa caaccagtgg gccccgctca accccatccg caaccccatt gagcggccgg
     3781 ggggccacaa ggacgtgctc taccagtgca agaacttcac gccgccgccg cgcagggcgg
     3841 acgaggcgct gcccgggccg gccggccacg cggccgtcag ggaggatgag gaggacgagg
     3901 atctgggccg cggtgaggag gactccctgg aggcggagaa gttcctctca cacaaattca
     3961 ccaaagatcc tggccgctcg ccggggaggc cggcccactg ggcctcaggc cccaaagtgg
     4021 acaaccgcgc ggtcaggagc atcaatgagg cccgctacgc cggcaaggag taggggcggc
     4081 tgccagctgg gccgggaccc agggccctcg gtgggagcca tgccgtctgc cggacccgga
     4141 ggccgaggcc atgtgcatag tttctttatt ttgtgtaaaa aaaccaccaa aaacaaaaac
     4201 caaatgttta ttttctacgt ttctttaacc ttgtataaat tattcagtaa ctgtcaggct
     4261 gaaaacaatg gagtattctc ggatagttgc tatttttgta aagtttccgt gcgtggcact
     4321 cgctgtatga aaggagagag caaagggtgt ctgcgtcgtc accaaatcgt agcgtttgtt
     4381 accagaggtt gtgcactgtt tacagaatct tccttttatt cctcactcgg gtttctctgt
     4441 ggctccaggc caaagtgccg gtgagaccca tggctgtgtt ggtgtggccc atggctgttg
     4501 gtgggacccg tggctgatgg tgtggcctgt ggctgtcggt gggactcgtg gctgtcaatg
     4561 ggacctgtgg ctgtcggtgg gacctacggt ggtcggtggg accctggtta ttgatgtggc
     4621 cctggctgcc ggcacggccc gtggctgttg acgcacctgt ggttgttagt ggggcctgag
     4681 gtcatcggcg tggcccaagg ctggcaggtc aacctcgcgc ttgctggcca gtccaccctg
     4741 cctgccgtct gtgcttcctc ctgcccagaa cgcccgctcc agcgatctct ccactgtgct
     4801 ttcagaagtg cccttcctgc tgcgcagttc tcccatcctg ggacggcggc agtattgaag
     4861 ctcgtgacaa gtgccttcac acagacccct cgcaactgtc cacgcgtgcc gtggcaccag
     4921 gcgctgccca cctgccggcc ccggccgccc ctcctcgtga aagtgcattt ttgtaaatgt
     4981 gtacatatta aaggaagcac tctgtatatt tgattgaata atgccaccat tccggcctcc
     5041 cttgttcttt cggtgctgtc ccttttgtat tgagagtgag gttgggggag agccacgccg
     5101 gcagagaggc ttggggcagt ggggcgcgtg ctgggtattg gcccacgtgg ctgtggtggc
     5161 tgtagagggc gagacggttc tgttgagtcg gggcctgcca gggcctcgaa tgcgttggca
     5221 tgccaaggtg gtggatgcag gtttggccaa aaccttcctg ggaatgggga ggggggtgtc
     5281 taggtgcctg gcacccgacc ctgactaaaa cagctgaaaa cagttttata aaatagtata
     5341 aaattgctta cccacgaata cgtatcaagg tcttaaggaa ttaacaggtc aaaattttta
     5401 ttcattcatt tattcctttg ttttgcttgg tcattcagag gcaaggtcag catttgatgg
     5461 aggcaggaga gaagcagccc ttccacctgg ccctggagct ggttttgccc ctcactgctt
     5521 gagccaactg gaacgtggca tggtggcctc agggctgggc atggaaggcc gactccaagg
     5581 ctgactccga gccgcctgtc agtgatgtgc aagtctttac cctgctgtga ggggtaggag
     5641 gtcaactgag tcaaggagca aagccaagaa ccagatctgt acaaaagaga aaaaaaaagt
     5701 cctgctgaca gcctgggagt gaggctgcct tgcacaggca gaacaaatga ataaatgaat
     5761 gaacgaataa aaa
//
