LOCUS       NP_002217               1238 aa            linear   PRI 27-APR-2025
DEFINITION  protein jagged-2 isoform a precursor [Homo sapiens].
ACCESSION   NP_002217
VERSION     NP_002217.3
DBSOURCE    REFSEQ: accession NM_002226.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1238)
  AUTHORS   Dofash,L., Lyengar,K., Pereira,N., Parmar,J., Folland,C., Laing,N.,
            Kang,P.B., Cairns,A., Lynch,M., Davis,M. and Ravenscroft,G.
  TITLE     Three novel missense variants in two families with JAG2-associated
            limb-girdle muscular dystrophy
  JOURNAL   Neuromuscul Disord 42, 36-42 (2024)
   PUBMED   39121631
  REMARK    GeneRIF: Three novel missense variants in two families with
            JAG2-associated limb-girdle muscular dystrophy.
REFERENCE   2  (residues 1 to 1238)
  AUTHORS   Huang,H., Jiang,Y., Liu,J., Luo,D., Yuan,J., Mu,R., Yu,X., Sun,D.,
            Lin,J., Chen,Q., Li,X., Jiang,M., Xu,J., Chu,B., Yin,C., Zhang,L.,
            Ye,Y., Cao,B., Wang,Q. and Zhang,Y.
  TITLE     Jag1/2 maintain esophageal homeostasis and suppress foregut
            tumorigenesis by restricting the basal progenitor cell pool
  JOURNAL   Nat Commun 15 (1), 4124 (2024)
   PUBMED   38750026
  REMARK    GeneRIF: Jag1/2 maintain esophageal homeostasis and suppress
            foregut tumorigenesis by restricting the basal progenitor cell
            pool.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1238)
  AUTHORS   Mandula,J.K., Sierra-Mondragon,R.A., Jimenez,R.V., Chang,D.,
            Mohamed,E., Chang,S., Vazquez-Martinez,J.A., Cao,Y., Anadon,C.M.,
            Lee,S.B., Das,S., Rocha-Munguba,L., Pham,V.M., Li,R., Tarhini,A.A.,
            Furqan,M., Dalton,W., Churchman,M., Moran-Segura,C.M., Nguyen,J.,
            Perez,B., Kojetin,D.J., Obermayer,A., Yu,X., Chen,A., Shaw,T.I.,
            Conejo-Garcia,J.R. and Rodriguez,P.C.
  TITLE     Jagged2 targeting in lung cancer activates anti-tumor immunity via
            Notch-induced functional reprogramming of tumor-associated
            macrophages
  JOURNAL   Immunity 57 (5), 1124-1140 (2024)
   PUBMED   38636522
  REMARK    GeneRIF: Jagged2 targeting in lung cancer activates anti-tumor
            immunity via Notch-induced functional reprogramming of
            tumor-associated macrophages.
REFERENCE   4  (residues 1 to 1238)
  AUTHORS   Islam,S.S., Al-Mohanna,F.H., Yousef,I.M., Al-Badawi,I.A. and
            Aboussekhra,A.
  TITLE     Ovarian tumor cell-derived JAGGED2 promotes omental metastasis
            through stimulating the Notch signaling pathway in the mesothelial
            cells
  JOURNAL   Cell Death Dis 15 (4), 247 (2024)
   PUBMED   38575576
  REMARK    GeneRIF: Ovarian tumor cell-derived JAGGED2 promotes omental
            metastasis through stimulating the Notch signaling pathway in the
            mesothelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1238)
  AUTHORS   Deng,Y., Madan,A., Banta,A.B., Friedman,C., Trask,B.J., Hood,L. and
            Li,L.
  TITLE     Characterization, chromosomal localization, and the complete 30-kb
            DNA sequence of the human Jagged2 (JAG2) gene
  JOURNAL   Genomics 63 (1), 133-138 (2000)
   PUBMED   10662552
REFERENCE   6  (residues 1 to 1238)
  AUTHORS   Felli,M.P., Maroder,M., Mitsiadis,T.A., Campese,A.F., Bellavia,D.,
            Vacca,A., Mann,R.S., Frati,L., Lendahl,U., Gulino,A. and
            Screpanti,I.
  TITLE     Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid
            and stromal thymus components: distinct ligand-receptor
            interactions in intrathymic T cell development
  JOURNAL   Int Immunol 11 (7), 1017-1025 (1999)
   PUBMED   10383933
REFERENCE   7  (residues 1 to 1238)
  AUTHORS   Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
            Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
            Artavanis-Tsakonas,S.
  TITLE     Human ligands of the Notch receptor
  JOURNAL   Am J Pathol 154 (3), 785-794 (1999)
   PUBMED   10079256
REFERENCE   8  (residues 1 to 1238)
  AUTHORS   Valsecchi,C., Ghezzi,C., Ballabio,A. and Rugarli,E.I.
  TITLE     JAGGED2: a putative Notch ligand expressed in the apical ectodermal
            ridge and in sites of epithelial-mesenchymal interactions
  JOURNAL   Mech Dev 69 (1-2), 203-207 (1997)
   PUBMED   9486542
REFERENCE   9  (residues 1 to 1238)
  AUTHORS   Luo,B., Aster,J.C., Hasserjian,R.P., Kuo,F. and Sklar,J.
  TITLE     Isolation and functional analysis of a cDNA for human Jagged2, a
            gene encoding a ligand for the Notch1 receptor
  JOURNAL   Mol Cell Biol 17 (10), 6057-6067 (1997)
   PUBMED   9315665
REFERENCE   10 (residues 1 to 1238)
  AUTHORS   Shawber,C., Boulter,J., Lindsell,C.E. and Weinmaster,G.
  TITLE     Jagged2: a serrate-like gene expressed during rat embryogenesis
  JOURNAL   Dev Biol 180 (1), 370-376 (1996)
   PUBMED   8948600
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF029778.1, AL512356.6,
            U69180.1, AF003521.1, AJ712299.1, BX105691.1, AA775404.1 and
            AI276672.1.
            
            On Jul 8, 2002 this sequence version replaced NP_002217.2.
            
            Summary: The Notch signaling pathway is an intercellular signaling
            mechanism that is essential for proper embryonic development.
            Members of the Notch gene family encode transmembrane receptors
            that are critical for various cell fate decisions. The protein
            encoded by this gene is one of several ligands that activate Notch
            and related receptors. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029778.1, AF020201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331782.8/ ENSP00000328169.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1238
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     Protein         1..1238
                     /product="protein jagged-2 isoform a precursor"
                     /note="protein jagged-2; jagged 2"
                     /calculated_mol_wt=130697
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2688
     mat_peptide     24..1238
                     /product="Protein jagged-2. /id=PRO_0000007629"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y219.3)"
                     /calculated_mol_wt=130697
     Region          28..196
                     /region_name="MNNL"
                     /note="N terminus of Notch ligand C2-like domain;
                     pfam07657"
                     /db_xref="CDD:462222"
     Site            153
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y219.3)"
     Region          178..240
                     /region_name="DSL"
                     /note="delta serrate ligand; smart00051"
                     /db_xref="CDD:128366"
     Region          307..345
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(307,310,325)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          351..381
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          385..421
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(385,388,402)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          423..458
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(423,426,440)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          461..496
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(461,464,477)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          500..534
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          536..571
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(536,539,553)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            570
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y219.3)"
     Site            619
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y219.3)"
     Region          636..671
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(636,639,653)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          676..709
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..746
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Site            752
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y219.3)"
     Region          757..787
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          789..824
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(789,792,806)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          827..863
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(827,830,844)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          872..943
                     /region_name="VWC_out"
                     /note="von Willebrand factor (vWF) type C domain;
                     smart00215"
                     /db_xref="CDD:214565"
     Site            1058
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y219.3)"
     Site            1081..1101
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y219.3)"
     Region          1114..1139
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y219.3)"
     Site            1123
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y219.3)"
     Region          1156..1238
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y219.3)"
     CDS             1..1238
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /coded_by="NM_002226.5:357..4073"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS9998.1"
                     /db_xref="GeneID:3714"
                     /db_xref="HGNC:HGNC:6189"
                     /db_xref="MIM:602570"
ORIGIN      
        1 mraqgrgrlp rrlllllalw vqaarpmgyf elqlsalrnv ngellsgacc dgdgrttrag
       61 gcghdecdty vrvclkeyqa kvtptgpcsy ghgatpvlgg nsfylppaga agdrararar
      121 aggdqdpglv vipfqfawpr sftliveawd wdndttpnee lliervshag minpedrwks
      181 lhfsghvahl elqirvrcde nyysatcnkf crprndffgh ytcdqygnka cmdgwmgkec
      241 keavckqgcn llhggctvpg ecrcsygwqg rfcdecvpyp gcvhgscvep wqcncetnwg
      301 gllcdkdlny cgshhpctng gtcinaepdq yrctcpdgys grncekaeha ctsnpcangg
      361 schevpsgfe chcpsgwsgp tcaldideca snpcaaggtc vdqvdgfeci cpeqwvgatc
      421 qldanecegk pclnafsckn liggyycdci pgwkginchi nvndcrgqcq hggtckdlvn
      481 gyqcvcprgf ggrhcelerd ecasspchsg glcedladgf hchcpqgfsg plcevdvdlc
      541 epspcrngar cynlegdyyc acpddfggkn csvprepcpg gacrvidgcg sdagpgmpgt
      601 aasgvcgphg rcvsqpggnf scicdsgftg tycheniddc lgqpcrnggt cidevdafrc
      661 fcpsgwegel cdtnpndclp dpchsrgrcy dlvndfycac ddgwkgktch srefqcdayt
      721 csnggtcyds gdtfrcacpp gwkgstcava knssclpnpc vnggtcvgsg asfscicrdg
      781 wegrtcthnt ndcnplpcyn ggicvdgvnw frcecapgfa gpdcrinide cqsspcayga
      841 tcvdeingyr cscppgragp rcqevigfgr scwsrgtpfp hgsswvedcn scrcldgrrd
      901 cskvwcgwkp cllagqpeal saqcplgqrc lekapgqclr ppceawgecg aeeppstpcl
      961 prsghldnnc arltlhfnrd hvpqgttvga icsgirslpa travardrll vllcdrassg
     1021 asavevavsf spardlpdss liqgaahaiv aaitqrgnss lllavtevkv etvvtggsst
     1081 gllvpvlcga fsvlwlacvv lcvwwtrkrr kerersrlpr eesannqwap lnpirnpier
     1141 pgghkdvlyq cknftppprr adealpgpag haavredeed edlgrgeeds leaekflshk
     1201 ftkdpgrspg rpahwasgpk vdnravrsin earyagke
//
