LOCUS       NM_014735               4947 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens jade family PHD finger 3 (JADE3), transcript variant
            1, mRNA.
ACCESSION   NM_014735
VERSION     NM_014735.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4947)
  AUTHORS   Munir,M., Embry,A., Doench,J.G., Heaton,N.S., Wilen,C.B. and
            Orchard,R.C.
  TITLE     Genome-wide CRISPR activation screen identifies JADE3 as an
            antiviral activator of NF-kB-dependent IFITM3 expression
  JOURNAL   J Biol Chem 300 (4), 107153 (2024)
   PUBMED   38462163
  REMARK    GeneRIF: Genome-wide CRISPR activation screen identifies JADE3 as
            an antiviral activator of NF-kB-dependent IFITM3 expression.
REFERENCE   2  (bases 1 to 4947)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4947)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4947)
  AUTHORS   Jian,Y., Wang,M., Zhang,Y., Ou,R., Zhu,Z., Ou,Y., Chen,X.,
            Liang,X., Ding,Y., Song,L., Xu,X. and Liao,W.
  TITLE     Jade family PHD finger 3 (JADE3) increases cancer stem cell-like
            properties and tumorigenicity in colon cancer
  JOURNAL   Cancer Lett 428, 1-11 (2018)
   PUBMED   29660380
  REMARK    GeneRIF: JADE3 was markedly upregulated in colon cancer tissues and
            correlated with cancer progression and predicted shorter patient
            survival. JADE3 interacted with the promoters of LGR5 and activated
            its transcription, by increasing the occupancy of p300
            acetyltransferase and histone acetylation on the promoters. These
            findings suggest an oncogenic role of JADE3 by regulating cancer
            stem cell-like traits in the colon cancer.
REFERENCE   5  (bases 1 to 4947)
  AUTHORS   Liu,Y.X., Zhang,S.F., Ji,Y.H., Guo,S.J., Wang,G.F. and Zhang,G.W.
  TITLE     Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated
            with carcinoma cell proliferation in a hepatocellular carcinoma
            patient
  JOURNAL   Oncol Lett 4 (4), 847-851 (2012)
   PUBMED   23205112
REFERENCE   6  (bases 1 to 4947)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   7  (bases 1 to 4947)
  AUTHORS   Tzouanacou,E., Tweedie,S. and Wilson,V.
  TITLE     Identification of Jade1, a gene encoding a PHD zinc finger protein,
            in a gene trap mutagenesis screen for genes involved in
            anteroposterior axis development
  JOURNAL   Mol Cell Biol 23 (23), 8553-8552 (2003)
   PUBMED   14612400
REFERENCE   8  (bases 1 to 4947)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   9  (bases 1 to 4947)
  AUTHORS   Szelei,J., Soto,A.M., Geck,P., Desronvil,M., Prechtl,N.V.,
            Weill,B.C. and Sonnenschein,C.
  TITLE     Identification of human estrogen-inducible transcripts that
            potentially mediate the apoptotic response in breast cancer
  JOURNAL   J Steroid Biochem Mol Biol 72 (3-4), 89-102 (2000)
   PUBMED   10775800
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627143.15, BN000289.1,
            AF127774.1 and AW071647.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014735.4.
            
            Summary: This gene encodes a member of a family of large proteins
            containing PHD (plant homeo domain)-type zinc fingers. The encoded
            protein may be associated in a nuclear complex that functions in
            histone H4 acetylation. Alternative splicing results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Aug 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000289.1, D86969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614628.5/ ENSP00000481850.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL627143.15        73213-73224
            13-3387             BN000289.1         1-3375
            3388-3953           AF127774.1         3119-3684
            3954-4774           AF127774.1         3686-4506
            4775-4947           AW071647.1         2-174               c
FEATURES             Location/Qualifiers
     source          1..4947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..4947
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /note="jade family PHD finger 3"
                     /db_xref="GeneID:9767"
                     /db_xref="HGNC:HGNC:22982"
                     /db_xref="MIM:300618"
     exon            1..299
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            300..356
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2782
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /note="PHD finger protein 16; jade family PHD finger
                     protein 3"
                     /codon_start=1
                     /product="protein Jade-3"
                     /protein_id="NP_055550.1"
                     /db_xref="CCDS:CCDS14271.1"
                     /db_xref="GeneID:9767"
                     /db_xref="HGNC:HGNC:22982"
                     /db_xref="MIM:300618"
                     /translation="MKRHRPVSSSDSSDESPSTSFTSGSMYRIKSKIPNEHKKPAEVF
                     RKDLISAMKLPDSHHINPDSYYLFADTWKEEWEKGVQVPASPDTVPQPSLRIIAEKVK
                     DVLFIRPRKYIHCSSPDTTEPGYINIMELAASVCRYDLDDMDIFWLQELNEDLAEMGC
                     GPVDENLMEKTVEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGNDMV
                     FCDKCNVCVHQACYGILKVPEGSWLCRSCVLGIYPQCVLCPKKGGALKTTKTGTKWAH
                     VSCALWIPEVSIACPERMEPITKISHIPPSRWALVCNLCKLKTGACIQCSIKSCITAF
                     HVTCAFEHGLEMKTILDEGDEVKFKSYCLKHSQNRQKLGEAEYPHHRAKEQSQAKSEK
                     TSLRAQKLRELEEEFYSLVRVEDVAAELGMPTLAVDFIYNYWKLKRKSNFNKPLFPPK
                     EDEENGLVQPKEESIHTRMRMFMHLRQDLERVRNLCYMISRREKLKLSHNKIQEQIFG
                     LQVQLLNQEIDAGLPLTNALENSLFYPPPRITLKLKMPKSTPEDHRNSSTETDQQPHS
                     PDSSSSVHSIRNMQVPQESLEMRTKSYPRYPLESKNNRLLASLSHSRSEAKESSPAWR
                     TPSSECYHGQSLGKPLVLQAALHGQSSIGNGKSQPNSKFAKSNGLEGSWSGNVTQKDS
                     SSEMFCDQEPVFSPHLVSQGSFRKSTVEHFSRSFKETTNRWVKNTEDLQCYVKPTKNM
                     SPKEQFWGRQVLRRSAGRAPYQENDGYCPDLELSDSEAESDGNKEKVRVRKDSSDREN
                     PPHDSRRDCHGKSKTHPLSHSSMQR"
     exon            357..436
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            437..594
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            595..785
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            786..997
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1165
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1282
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1753
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1871
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..4947
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4927..4932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /note="hexamer: ATTAAA"
     polyA_site      4947
                     /gene="JADE3"
                     /gene_synonym="JADE-3; PHF16"
                     /note="major polyA site"
ORIGIN      
        1 acagtgtcag gaatacaata gtgctccgcg ccgcctcagc cgccgccgcc gcccaaccgc
       61 ctgcccagcg ctgaggcctg acgggccggg cggacgaggg ccgagggcgg gagctgaggc
      121 gcggggggcg gccccggcgg ggggcggggg cgaggagggg attaaggggc aggtgcgagg
      181 gagggaagag aagaaagcga gcggttaggg gggcggttac cactccgacc ggactcaccc
      241 ggcacattgc cgggccgcgg cgtggagccg ggcaggagcc gcgagccagc tgcgcgaagg
      301 atgctccagg atgaaacgcc ataggcctgt cagcagcagt gacagttcag acgaaagtcc
      361 ttccacttcc tttacttctg gctcaatgta taggatcaag tcaaaaattc caaatgaaca
      421 caagaaacct gctgaggtat tccggaagga cctcatcagt gccatgaaac ttccagattc
      481 tcaccacatt aatcctgata gctattacct ctttgctgat acatggaagg aagaatggga
      541 aaagggagtc caggtaccag ccagtccaga caccgttcca cagccttctc tcaggattat
      601 agctgagaag gtaaaggacg ttctgtttat ccgaccccgg aagtatattc actgctccag
      661 cccagacacc acagagcctg gctacatcaa catcatggag ttggcagcat ctgtttgccg
      721 ctatgaccta gatgacatgg acatcttctg gcttcaggaa ctcaatgaag accttgcaga
      781 aatgggttgt gggccagttg atgagaatct tatggaaaag acagtagaag tcctggaacg
      841 ccattgccat gaaaatatga accatgctat tgagacagag gaagggctag gcatagagta
      901 tgatgaagat gtgatctgtg atgtgtgccg gtctccagac agtgaagaag ggaatgatat
      961 ggtgttctgt gataagtgta acgtctgtgt gcatcaggcc tgctatggca tcctcaaggt
     1021 cccagaaggc agctggctgt gtcgctcctg tgtcctgggc atttatccgc aatgtgtgtt
     1081 atgtccaaag aaaggtggag ccctgaagac caccaagaca gggactaaat gggctcatgt
     1141 cagctgtgcc ctgtggatcc cagaggtcag cattgcttgt cctgagagga tggaaccgat
     1201 cacgaagatc tcccacatcc cacccagtcg gtgggcctta gtctgcaact tgtgcaagtt
     1261 gaagacgggg gcttgtattc agtgctctat aaaaagctgc atcactgcct tccacgtcac
     1321 ctgtgccttt gagcacggcc tagagatgaa gaccatccta gatgagggag acgaagtgaa
     1381 gttcaagtca tattgcctca agcatagcca aaacaggcag aaacttggag aagctgagta
     1441 cccccaccac agggctaaag agcagagcca ggccaaaagt gagaaaacca gcctgcgggc
     1501 acagaagctt cgggagctgg aggaggagtt ctattccttg gtacgagtgg aagatgtggc
     1561 cgcagagctg ggtatgccca cgctagctgt ggactttatc tataactact ggaaactgaa
     1621 gcggaaaagt aacttcaata agccattatt tcctccaaag gaggatgaag aaaatgggct
     1681 ggtgcagcca aaagaggaaa gcattcacac tcgaatgaga atgtttatgc atctacgcca
     1741 ggacctggag agggtccgaa atctgtgcta tatgataagc agacgagaga agctgaagct
     1801 gtcacacaac aaaatacagg aacagatctt cggtttgcaa gtccagcttc ttaaccaaga
     1861 aattgatgca gggcttcctt tgacaaatgc acttgaaaac tcactgtttt acccaccacc
     1921 aagaattacc ttgaagttaa aaatgcccaa atcaacccca gaagaccaca gaaacagctc
     1981 cacagaaacc gatcagcagc cccactctcc tgacagcagc tcatctgttc acagtataag
     2041 gaacatgcag gtgcctcagg agtcactaga aatgagaaca aaatcgtatc cgagataccc
     2101 actagagagc aagaataacc gtttgctggc cagtctcagc cattctagga gtgaagcaaa
     2161 ggagtccagt cctgcttgga gaaccccgtc ctcggagtgc tatcatgggc agtcactggg
     2221 aaagcctctg gtccttcagg ctgccctcca tggacagtct tccattggga atgggaaaag
     2281 tcagcctaac tccaagtttg ccaaatccaa tggcctggag ggcagctggt ctgggaatgt
     2341 cacccaaaaa gacagctcga gtgagatgtt ctgtgaccag gagcctgtgt tcagccccca
     2401 cttggtcagt cagggcagct ttagaaaatc cactgtagaa cactttagta ggtcctttaa
     2461 agagaccacc aataggtggg tgaagaacac agaggacctc cagtgctatg tgaagccaac
     2521 caagaatatg agccccaagg agcagttctg gggtagacag gttctcaggc ggtctgcagg
     2581 gagagctcca tatcaggaaa atgatggcta ttgcccagat ttggagctga gtgattcaga
     2641 ggcagaaagt gatgggaata aagaaaaagt cagggtaagg aaagatagct cagacaggga
     2701 aaatcctccc catgactcta gacgggattg ccatggtaaa agcaagacac atcccctttc
     2761 ccacagttca atgcaaaggt gattagaaac ttccaaggat gacccaacct ttgcctttgc
     2821 cccatatatt ggggaaaacc catacaccaa aaggatttta gcatatgtta agaggaattg
     2881 cagtgaaaag gataacattt ttccatagta aattgtcttg cagtttttga aaatgtttca
     2941 agtctagttt ttacaagcac attacagtaa ttgcaggttg tccagaggtt ggtttgtcag
     3001 aggctattgg gaacagctgg gcccagggta tttgctcagt aaatattttg gggcagcttt
     3061 ccggttatat aacacattga caagtatatg tattaagagt ccttgcattg ttaactgatt
     3121 tgcaagagac catgattatc agacactaaa actacttatc ttttgaagct acagcatgtg
     3181 actccccaga gctcctgtct gtaggaagtt tctaattcca ctggtatcta taaacccttt
     3241 tcaggggaga gaccaggaga ccaccatctt agatactgtc aaactcacta ctgtcttcct
     3301 ttgttctgca caaggttgag tttctttcac agtatcttaa cttactgagt caatactcct
     3361 catgcttatc agtgtccagt gcctgttcct aaacttgctt gttggggaca cactcataac
     3421 tatttcacct gactgacaag cataaaaggc taacttgtgg atagtgttta caaaagtaca
     3481 aaagtactac ttccaaggaa aatgctctga ttctctgttt aggcatttgt gaaggattcc
     3541 agagcctttc ccaaagtgag accatttctg gggtatttgt accaggtcag ggtttttgtg
     3601 ttgttttcaa ataagtttga ctaaaataag tttggctgac agtttttgta tacctgcttt
     3661 aatgtttata aaatttttat tgaggtataa ttaaaatata gtaaaatgca cagaggttaa
     3721 gtattcttac ctgctttaat tttgaaacag atttttattg tcaaacagaa tttgaaagca
     3781 tgtgtttaac acatggatat aatttagctt tgtgtcacct ttgaatctga ggcagtttcc
     3841 caaacaaaaa ggctggagcc atttttcaga agttgcttat accctgttcc caaactatca
     3901 gccttgatta atttctagta ggaagagaat aattacattt gcgggggggg gggtggataa
     3961 aaacatgtct gcttctcatt taaataagag agaaatgatg ccgtttttta aatgtgaagc
     4021 agactataat tctcagctct cttttcttct tagccttaaa ttaatattct ctttcttcta
     4081 gttttggaaa gtgtagtggg aatattcaga caaaagaggc cattttccat ttttaaagct
     4141 tcttactggt gaaacagccc agttgtagta ggtgccagtc agtcaaggca ggggccctct
     4201 ctccgtcaat atggaaaact cagcagtttt cctctccccc agttgtgttc ttgtaacgtt
     4261 gttaatgggt tcctttgctt tttgctttct ccttttctga aaatgtatgt gttttgcctc
     4321 tcttttggct acatcttcaa aatatttctt ttgtgcctat gtacatgtgt aaacatgcca
     4381 tagcatgtgt ggtaggtgtc ctgtattttg tttgggaaaa aaactatcaa aatgaggaag
     4441 agaatttccc ctatttatgc actaggtttc tgtgcttttt ctttgagttc tctggagtag
     4501 atattaattt gataccttca tggtaatgaa attatgatgg agctgtgtta taaattcctt
     4561 atgtcagagg ccagtgcggt agcctttgtc ccttcatgcc tttcaattct gagtgggagg
     4621 aaaagcaaac atcaaaacag tgcttcagcc aaattccata tgtaatgcca ttgggagagt
     4681 attgactaaa atatcattcg tcagggaaat atagttgtaa tatttttaca ggatattcct
     4741 aggtaaatga aggagccttc agttgtaaat ttcaattacc ccaaaatgta tttgctacat
     4801 tttgttgttt gaagtattac ctcttaacct tctttgttaa tttttttcat tttgtcttat
     4861 atagtccagt tttccaagat aagctcagtc ctttttcaaa tgtccccttt ttaccaatac
     4921 tttttcatta aattatgaaa actgcta
//
