LOCUS       NM_001388185            6757 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens jade family PHD finger 2 (JADE2), transcript variant
            5, mRNA.
ACCESSION   NM_001388185 XM_005271945
VERSION     NM_001388185.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6757)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6757)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6757)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   4  (bases 1 to 6757)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 6757)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   6  (bases 1 to 6757)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 6757)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 6757)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   9  (bases 1 to 6757)
  AUTHORS   Tzouanacou,E., Tweedie,S. and Wilson,V.
  TITLE     Identification of Jade1, a gene encoding a PHD zinc finger protein,
            in a gene trap mutagenesis screen for genes involved in
            anteroposterior axis development
  JOURNAL   Mol Cell Biol 23 (23), 8553-8552 (2003)
   PUBMED   14612400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005355.1 and AC106763.2.
            
            On Oct 19, 2020 this sequence version replaced XM_005271945.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.23645.1,
                                           SRR11853563.26986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681547.2/ ENSP00000505514.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC005355.1         65434-65775
            343-400             AC005355.1         75622-75679
            401-495             AC005355.1         77753-77847
            496-653             AC106763.2         130178-130335       c
            654-814             AC106763.2         122397-122557       c
            815-1026            AC106763.2         121430-121641       c
            1027-1194           AC106763.2         120020-120187       c
            1195-1311           AC106763.2         117777-117893       c
            1312-1776           AC106763.2         115807-116271       c
            1777-1894           AC106763.2         108625-108742       c
            1895-2023           AC106763.2         105491-105619       c
            2024-6757           AC106763.2         99160-103893        c
FEATURES             Location/Qualifiers
     source          1..6757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..6757
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /note="jade family PHD finger 2"
                     /db_xref="GeneID:23338"
                     /db_xref="HGNC:HGNC:22984"
                     /db_xref="MIM:610515"
     exon            1..342
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..2847
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /EC_number="2.3.2.27"
                     /note="isoform 4 is encoded by transcript variant 5; PHD
                     finger protein 15; jade family PHD finger protein 2; E3
                     ubiquitin-protein ligase Jade-2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Jade-2 isoform 4"
                     /protein_id="NP_001375114.1"
                     /db_xref="CCDS:CCDS78061.1"
                     /db_xref="GeneID:23338"
                     /db_xref="HGNC:HGNC:22984"
                     /db_xref="MIM:610515"
                     /translation="MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQ
                     NEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPV
                     VRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERP
                     ELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVF
                     CDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHV
                     SCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFH
                     VTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTL
                     RKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDE
                     VDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQM
                     KLIEQDLCRERSGRRAKGKKSDSKRKGCEGSKGSTEKKEKVKAGPDSVLGQLAGLSTS
                     FPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFM
                     RDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKG
                     GQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVP
                     GPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFS
                     DGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS"
     exon            343..400
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            401..495
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            496..653
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            654..814
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1026
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1194
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1311
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1776
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1894
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2023
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..6757
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /note="hexamer: AATATA"
     polyA_site      3005
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /note="major polyA site"
     regulatory      6737..6742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /note="hexamer: AATAAA"
     polyA_site      6757
                     /gene="JADE2"
                     /gene_synonym="JADE-2; PHF15"
                     /note="major polyA site"
ORIGIN      
        1 agaaacatac acagggggtt ggtgaatggt gccgaccgcg gccatcgcag ttggaggcta
       61 ttttttgggg ggggtgagta gcgtccatgg agttactttg cgcccactcc tagcggcacc
      121 ggcttaggtc ctgcgggccg accgtccccg gcggggggcg tggggcctgg gacgccgcgg
      181 gcccggccgc ctccctcgcc gcgaccccgg atggatgcgc gccccccgcc ctcccgcgcc
      241 ggccccagga gctcccggct tcgggagcat ccttcccgcg ccggtccctg cagcggcgcg
      301 tagccgaggg cagcgcccgt caggggggca ccgcggagca agatggaaga gaagaggcga
      361 aaatactcca tcagcagtga caactctgac accactgaca gtcatgcgac atctacatcc
      421 gcatcaagat gctccaaact gcccagcagc accaagtcgg gctggccccg acagaacgaa
      481 aagaagccct ccgaggtttt ccggacagac ttgatcacag ccatgaagat cccggactca
      541 taccagctca gcccggatga ctactacatc ctggcagacc catggcgaca ggaatgggag
      601 aaaggtgtgc aggtgcctgc cggggcagag gccatcccag agcccgtggt gaggatcctc
      661 ccaccactgg aaggcccccc tgcccaggca tccccgagca gcaccatgct tggtgagggc
      721 tcccagcctg attggccagg gggcagccgc tatgacttgg acgagattga tgcctactgg
      781 ctggagctca tcaactcgga gcttaaggag atggagaggc cggagctgga cgagctgaca
      841 ttagagcgtg tgctggagga gctggagacc ctgtgccacc agaatatggc cagggccatt
      901 gagacgcagg aggggctggg catcgagtac gacgaggatg ttgtctgcga cgtgtgtcgc
      961 tctcctgagg gcgaggatgg caacgagatg gtcttctgtg acaagtgcaa cgtctgtgtg
     1021 catcaggcat gctacgggat cctcaaggtg cccacgggca gctggctgtg ccggacgtgt
     1081 gccctgggtg tccagccaaa gtgcctgctc tgccccaagc gaggaggagc cttgaagccc
     1141 actagaagtg ggaccaagtg ggtgcatgtc agctgtgccc tatggattcc tgaggtcagc
     1201 atcggctgcc cagagaagat ggagcccatc accaagatct cgcatatccc agccagccgc
     1261 tgggctctgt cctgcagcct ctgcaaggaa tgcacaggca cctgcatcca gtgttccatg
     1321 ccttcctgcg tcacagcgtt ccatgtcaca tgcgcctttg accacggcct ggaaatgcgg
     1381 actatattag cagacaacga tgaggtcaag ttcaagtcat tctgccagga gcacagtgac
     1441 gggggcccac gtaatgagcc cacatctgag cccacggaac ccagccaggc tggcgaggac
     1501 ctggaaaagg tgaccctgcg caagcagcgg ctgcagcagc tagaggagga cttctacgag
     1561 ctggtggagc cggctgaggt ggctgagcgg ctggacctgg ctgaggcact ggtcgacttc
     1621 atctaccagt actggaagct gaagaggaaa gccaatgcca accagccgct gctgaccccc
     1681 aagaccgacg aggtggacaa cctggcccag caggagcagg acgtcctcta ccgccgcctg
     1741 aagctcttca cccatctgcg gcaggaccta gagagggtta gaaatctgtg ctacatggtg
     1801 acaaggcgcg agagaacgaa acacgccatc tgcaaactcc aggagcagat attccacctg
     1861 cagatgaaac ttattgaaca ggatctgtgt cgagagcggt ctgggaggag agcaaagggc
     1921 aagaagagtg actcgaagag gaagggctgc gagggctcca agggcagcac tgagaagaaa
     1981 gagaaagtga aggcggggcc tgactcagtc ctggggcagc tggcaggcct gtccacctca
     2041 ttccccatcg atggcacctt cttcaacagc tggctggcac agtcggtgca gatcacagca
     2101 gagaacatgg ccatgagcga gtggccactg aacaatgggc accgcgagga ccctgctcca
     2161 gggctgctgt cagaggaact gctgcaggac gaggagacac tgctcagctt catgcgggac
     2221 ccctcgctgc gacctggtga ccctgctagg aaggcccgag gccgcacccg cctgcctgcc
     2281 aagaagaaac caccaccacc accaccgcag gacgggcctg gttcacggac gactccagac
     2341 aaagccccca agaagacctg gggccaggat gcaggcagtg gcaagggggg tcaagggcca
     2401 cctaccagga agccaccacg tcggacatct tctcacttgc cgtccagccc tgcagccggg
     2461 gactgtccca tcctagccac ccctgaaagc cccccgccac tggcccctga gaccccggac
     2521 gaggcagcct cagtagctgc tgactcagat gtccaagtgc ctggccctgc agcaagccct
     2581 aagcctttgg gccggctccg gccaccccgc gagagcaagg taacccggag attgccgggt
     2641 gccaggcctg atgctgggat gggaccacct tcagctgtgg ctgagaggcc caaggtcagc
     2701 ctgcattttg acactgagac tgatggctac ttctctgatg gggagatgag cgactcagat
     2761 gtagaggccg aggacggtgg ggtgcagcgg ggtccccggg aggcaggggc agaggaggtg
     2821 gtccgcatgg gcgtactggc ctcctaactc acccccttcc ctgtcccagg ccctgccctg
     2881 gtccccccac aaggcctcag cccagtcaca actgccattt ccagtctctg ctgagtgtcc
     2941 cagaccctcg aggctgccac tccgtcgtgg ttttattttt aatatagaga gagttttgaa
     3001 ttctacactg ttgtctttcc tctgtgctgg cctaggacat taggattcct tccacggctc
     3061 cggccgctag gaccctgcca ggtcccgcgc accatccctg ccctgcccac gtggtattgc
     3121 tgggctcctg gctagatgca agcaaggtgg acaagagctc aggactccag cccactgcca
     3181 ctgggtgaca cagactgtcg tttgggcatt atttcatggc agatgggcca gtccagggcc
     3241 taccccgcct tgcccccaga tcccactggg gtccatttgg ggggtcctgc tacactccac
     3301 cgatccccaa ggaagtataa taaacgatac ccagccagag tctactcact gtcacaagca
     3361 caacgagttt atatgagaaa gcactgaggg ggtgcagagg gcccgctagt tccaggggaa
     3421 ctgaaagctg ttcctgatca gcccgtatca tctgaggcct gcctgcccac cctgccaccc
     3481 tcccctccct tgctgctctg cccctgccag tgcccagccc agcggctctg ggaaggggtt
     3541 cccagaatcc ctcctgagct gtgccattta ctcaggggac tcccaaacag ccagctgcca
     3601 gtgcaggtgg agggctgtag gggagggcca gtgcccagac agggtcatgg ggctcagacc
     3661 agcccactgt agagaatcac tctgaggctc caacttcctt ccttccttcg gggccagtct
     3721 cggccgaagt ctggtcacgc tcagacagag ctgaccagac cagaccgttt gccttttcaa
     3781 gtttcctagt cctgctacaa gatgagcttc ttccgtggtt tccttttgga aactcctcct
     3841 tccaacaagc agtgggatcc cggggcccag ggcgggccgg tgttggccgc tggggctgtt
     3901 gtaagtcttg ctggatgttc ccctgttcct gagccttaac ccctcgcaca gccatccccc
     3961 cccccgtcct gccatccccc cccgccgtcc tgccttcccc accccaccct taggtcccag
     4021 gtagttgctc tgaagagttt cagtagagtg gccccagggt gatagctcag ggaacaacaa
     4081 aaaaggaatt ccgtgaaaac attttttttt ctttgatgaa ttactcctgg gtcacttcca
     4141 ccactggtaa agccagaact tctccaaaaa gaaccttgca aaaagtccag tgaatcagtc
     4201 gaatcattct gtggatgcca aagaatattt tgaccataat acagcacagc ctggacctga
     4261 caacttgtca tttggacttt tttttaaatg gagttcttta gcaacaaagt atagaaacat
     4321 gttcattgca cacacccaag gagaagagct caagcgcttg gaagaggatg ctttgctgct
     4381 gctgaagtgt acctgggtgt tagatttcag atcctgggct gagcccactg tgagctttcc
     4441 taaactgtga gactcacaga ggggaaagat actgacggtg aaaccagcat ggaaaacgtc
     4501 tttaccatgt ggttccctcc tccccaaata cataaagcaa ataagcagga tggggaacag
     4561 cttgaccttc atccacccct aactccaaaa ctatcaaggt acgacagtgg cattgtcatc
     4621 gacactcaat ttcatgtgaa ttttagcaaa acaggaaaca aagataatga ctcagttcag
     4681 aggatcggac aaatgtgtct agtccgggtg gactcggagg gagtggggtg ggcttcaagg
     4741 attctgggcg ttgggatggc atgagctacc ctgtagagtt tagtctgcct gcccgccttg
     4801 gtagtagtga ccagtcagtg tcagcatcag tgtcccaacc ccagtctctg tttactgcct
     4861 ttgaacagaa cttcttcctt ccccatgctt tgggtcacct cgggctgcaa ccctgtctgt
     4921 gccagattgc ccggtctgac cctgcaggaa gcaaagaggt gagcttaaag aacaaccaaa
     4981 ctctgccagg ggtcccagaa agcccagggt ccagcagtct cagcacttgg ccccttgccc
     5041 cttcacacca tcctggggca ggggctgggc ctccctggtg gcaggggtgg gtggagaatt
     5101 agggagaggg tgcaacgagt ctggcccctt gcctcgggct ggctggtgtt cttccaagag
     5161 cctctgctca cattgttggc ctctggattc tggcccttct tcattggctg ttgctttgga
     5221 ctggactgtt gctgagcctg tgtcctgcag aacccagatg tctgttaggc tggctggctg
     5281 ctgcgagggg aggggggtgg cctttcattt ggggtgccct ttcactccca ggccaagccc
     5341 tggagcaatc ttcttcaggc agctgtctcc acctccagga tgtccagcag gctgcaagga
     5401 gaaggatgcc agccacccat cctcccccag ttcccagcct ttcccctgtt ggtcacagcc
     5461 gcttctgtct ttttccggtc tactgtcccc agtgtagagg gctttgctgt ccctgagact
     5521 gaggcaggtt ccttttccag gtcagaggtg gaggtagatc tttctctcaa ccacatctgc
     5581 ctccacacac agctcctccg cagggaagga gaagctgctc tgtaactcat tctggctatc
     5641 gtcccccttc tcactgacct gaccgcccac cacctccttc cccctcatca catgacaaag
     5701 gataatgtgc aagaaaagta tttttatgta tcataaatgt attttgaaac aaatgagaag
     5761 aagaaaggta gaagggttta ttttattaaa tgagcctgac ttagtgacag tgtgtgagca
     5821 tttgcaatgt aagggcctca gcttccttgg agaagccacc ccaggtttcc agacatagat
     5881 gttgaattgt ttgtgggggg tgtgccaggc cacgtctcgt gtgtccgtat gcaggcatgc
     5941 ctgtgtatac tgtgtatggg cacactggga ctagctggga caattcctag agattcaact
     6001 gcccaattct aaccaacatt ggcagcggct gaacttggca tttccttgct aactgccaga
     6061 tgtggccaac ctttgtccat atgcaaacca ctgaaaaatg atctggattt ctatagcaag
     6121 gcccttgggg agggcactct cccatgccct tggcctcgct ggccacattg gccaatgagc
     6181 cagggctgga gtctgagacc tttggttgtt ctttaaggca cctcctgcca ctttctccct
     6241 cagaggcaca aacactttgt gttccacgtc agtttgaggg gacggtgggg ggatgatatg
     6301 aatgtcacag gaggagacac cttctgtctt tgtttcaaag aaagtgatgt gccatttgtt
     6361 aatatacaag agaaatattg aaaatatatt gaaaagagca attttaaatt atttttggct
     6421 tatgttgcaa tatttatttt cttgtattag aaaagattcc tttgtagaga aaaaatgtat
     6481 ttttcattaa cgcaaagacc tatttctcct ttttgtacat tgtccatgtg cgcaaccctt
     6541 aacgagcaat agaatgtatg gtcacctggg tgtggccagt gcccgctgtg ccctgcatga
     6601 ttctgtgttg ccgctgctgc atagttccca gccccatcct gtcctgctca ctcatggggg
     6661 cttccagacc ccggccccac cagggcttgt gtcataggga gccctttgca ctcctcgtgt
     6721 gttggcaaac gcagttaata aagcagtgtt ttctgtg
//
