LOCUS       NM_199320               5695 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens jade family PHD finger 1 (JADE1), transcript variant
            1, mRNA.
ACCESSION   NM_199320
VERSION     NM_199320.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5695)
  AUTHORS   Kalantzakos,T., Hooper,K., Das,S., Sullivan,T., Canes,D.,
            Moinzadeh,A. and Rieger-Christ,K.
  TITLE     MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration,
            and Invasion in Clear Cell Renal Cell Carcinoma Cells
  JOURNAL   Int J Mol Sci 24 (9), 7825 (2023)
   PUBMED   37175531
  REMARK    GeneRIF: MicroRNA-155-5p Targets JADE-1, Promoting Proliferation,
            Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5695)
  AUTHORS   Farrell,K., Kim,S., Han,N., Iida,M.A., Gonzalez,E.M.,
            Otero-Garcia,M., Walker,J.M., Richardson,T.E., Renton,A.E.,
            Andrews,S.J., Fulton-Howard,B., Humphrey,J., Vialle,R.A.,
            Bowles,K.R., de Paiva Lopes,K., Whitney,K., Dangoor,D.K., Walsh,H.,
            Marcora,E., Hefti,M.M., Casella,A., Sissoko,C.T., Kapoor,M.,
            Novikova,G., Udine,E., Wong,G., Tang,W., Bhangale,T.,
            Hunkapiller,J., Ayalon,G., Graham,R.R., Cherry,J.D., Cortes,E.P.,
            Borukov,V.Y., McKee,A.C., Stein,T.D., Vonsattel,J.P., Teich,A.F.,
            Gearing,M., Glass,J., Troncoso,J.C., Frosch,M.P., Hyman,B.T.,
            Dickson,D.W., Murray,M.E., Attems,J., Flanagan,M.E., Mao,Q.,
            Mesulam,M.M., Weintraub,S., Woltjer,R.L., Pham,T., Kofler,J.,
            Schneider,J.A., Yu,L., Purohit,D.P., Haroutunian,V., Hof,P.R.,
            Gandy,S., Sano,M., Beach,T.G., Poon,W., Kawas,C.H., Corrada,M.M.,
            Rissman,R.A., Metcalf,J., Shuldberg,S., Salehi,B., Nelson,P.T.,
            Trojanowski,J.Q., Lee,E.B., Wolk,D.A., McMillan,C.T., Keene,C.D.,
            Latimer,C.S., Montine,T.J., Kovacs,G.G., Lutz,M.I., Fischer,P.,
            Perrin,R.J., Cairns,N.J., Franklin,E.E., Cohen,H.T., Raj,T.,
            Cobos,I., Frost,B., Goate,A., White Iii,C.L. and Crary,J.F.
  TITLE     Genome-wide association study and functional validation implicates
            JADE1 in tauopathy
  JOURNAL   Acta Neuropathol 143 (1), 33-53 (2022)
   PUBMED   34719765
  REMARK    GeneRIF: Genome-wide association study and functional validation
            implicates JADE1 in tauopathy.
REFERENCE   3  (bases 1 to 5695)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5695)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5695)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5695)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   7  (bases 1 to 5695)
  AUTHORS   Zhou,M.I., Foy,R.L., Chitalia,V.C., Zhao,J., Panchenko,M.V.,
            Wang,H. and Cohen,H.T.
  TITLE     Jade-1, a candidate renal tumor suppressor that promotes apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 102 (31), 11035-11040 (2005)
   PUBMED   16046545
  REMARK    GeneRIF: Jade-1 may suppress renal cancer cell growth in part by
            increasing apoptosis.
REFERENCE   8  (bases 1 to 5695)
  AUTHORS   Panchenko,M.V., Zhou,M.I. and Cohen,H.T.
  TITLE     von Hippel-Lindau partner Jade-1 is a transcriptional co-activator
            associated with histone acetyltransferase activity
  JOURNAL   J Biol Chem 279 (53), 56032-56041 (2004)
   PUBMED   15502158
  REMARK    GeneRIF: Jade-1 is a novel candidate transcriptional co-activator
            associated with HAT activity and may play a key role in the
            pathogenesis of renal cancer and von Hippel-Lindau disease
REFERENCE   9  (bases 1 to 5695)
  AUTHORS   Tzouanacou,E., Tweedie,S. and Wilson,V.
  TITLE     Identification of Jade1, a gene encoding a PHD zinc finger protein,
            in a gene trap mutagenesis screen for genes involved in
            anteroposterior axis development
  JOURNAL   Mol Cell Biol 23 (23), 8553-8552 (2003)
   PUBMED   14612400
REFERENCE   10 (bases 1 to 5695)
  AUTHORS   Zhou,M.I., Wang,H., Ross,J.J., Kuzmin,I., Xu,C. and Cohen,H.T.
  TITLE     The von Hippel-Lindau tumor suppressor stabilizes novel plant
            homeodomain protein Jade-1
  JOURNAL   J Biol Chem 277 (42), 39887-39898 (2002)
   PUBMED   12169691
  REMARK    GeneRIF: Jade-1 protein is a novel candidate regulatory factor in
            Von Hippel Lindau-mediated renal tumor suppression
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI463062.1, AK027620.1, BN000287.1 and AC093783.2.
            
            On Nov 22, 2018 this sequence version replaced NM_199320.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 4, 5, 7, and 8 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.241355.1,
                                           SRR1803611.109182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226319.11/ ENSP00000226319.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               BI463062.1         83-185
            104-204             AK027620.1         101-201
            205-2733            BN000287.1         1-2529
            2734-5695           AC093783.2         11765-14726
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.2"
     gene            1..5695
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /note="jade family PHD finger 1"
                     /db_xref="GeneID:79960"
                     /db_xref="HGNC:HGNC:30027"
                     /db_xref="MIM:610514"
     exon            1..178
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            179..256
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2733
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /note="isoform 1 is encoded by transcript variant 1; PHD
                     protein Jade-1; gene for apoptosis and differentiation in
                     epithelia; PHD finger protein 17; jade family PHD finger
                     protein 1"
                     /codon_start=1
                     /product="protein Jade-1 isoform 1"
                     /protein_id="NP_955352.1"
                     /db_xref="CCDS:CCDS34062.1"
                     /db_xref="GeneID:79960"
                     /db_xref="HGNC:HGNC:30027"
                     /db_xref="MIM:610514"
                     /translation="MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKP
                     SEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVS
                     EEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKE
                     MGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN
                     EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTK
                     WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCR
                     TAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECS
                     PRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFL
                     YQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYM
                     VTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDA
                     PKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGM
                     VVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSH
                     KPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTT
                     PASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDN
                     ENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS"
     exon            257..342
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            343..500
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            501..688
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            689..900
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1068
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1185
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1707
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1825
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..5695
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5669..5674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /note="hexamer: AATAAA"
     polyA_site      5695
                     /gene="JADE1"
                     /gene_synonym="PHF17"
                     /note="major polyA site"
ORIGIN      
        1 ctccataaca agccaaacgc cagaccgaga gtgcctccgt gcgcgagtgc ccggtgtgtg
       61 cgcgccggcg agagcagggg cccgcccggc tccccgcccg ccgcggcccg aactcatgca
      121 gctccgagcg agcgagcggc gcccagccca gcgcctcggc cgaacccctc cgcagcaggc
      181 tgcctgctgt ttcccgggga gatcatgaaa cgaggtcgcc ttcccagcag cagtgaggat
      241 tctgacgaca atggcagcct gtcaactact tggtcccaga attcccgatc ccagcatagg
      301 agaagctcct gctccagaca tgaagatcga aagccttcag aggtgtttag gacagacctg
      361 atcactgcca tgaagttgca tgactcctac cagctgaatc cggatgagta ctatgtgttg
      421 gcagatccct ggagacagga atgggagaaa ggggtccagg tgcctgtgag cccggggacc
      481 atccctcagc ctgtggccag ggttgtgtct gaagagaaat ccctcatgtt catcaggccc
      541 aagaagtaca tcgtgtcatc aggctctgag cctcccgagt tgggctatgt ggacatccgg
      601 acgctggctg acagcgtgtg tcgctatgac ctcaatgaca tggatgctgc atggctggaa
      661 ctgaccaatg aagaatttaa ggagatggga atgcctgaac tagatgaata caccatggag
      721 agggtcctag aggaatttga gcagcgatgc tacgacaata tgaatcatgc catagagact
      781 gaggaaggcc tggggatcga atatgatgaa gatgttgtct gtgatgtctg ccagtctcct
      841 gatggtgagg acggcaatga gatggtgttc tgtgacaaat gcaacatctg tgtgcaccag
      901 gcctgttatg gaatcctcaa ggtaccagag ggcagctggc tgtgccggac atgtgccctg
      961 ggggttcagc caaaatgtct gctgtgtccg aagaagggtg gagctatgaa gcccacccgt
     1021 agcggaacca agtgggtcca cgttagctgt gctctgtgga tccctgaggt gagcattggc
     1081 agcccagaga agatggagcc catcaccaag gtgtcacaca ttcccagcag ccggtgggcg
     1141 ctagtgtgca gcctctgcaa tgagaagttt ggggcctcta tacagtgctc tgtgaagaac
     1201 tgccgcacag ccttccatgt gacctgtgct tttgaccggg gcctggagat gaagaccatc
     1261 ttagcagaga atgatgaagt caagttcaag tcctattgcc caaagcacag ctcacatagg
     1321 aaacccgagg agagtcttgg caagggggct gcacaggaga atggggcccc tgagtgttcc
     1381 ccccggaatc cgctggagcc ctttgccagc cttgagcaga accgggagga ggcccaccgg
     1441 gtgagtgtcc gtaagcagaa gctgcagcag ttggaggatg agttctacac cttcgtcaac
     1501 ctgctggatg ttgccagggc tctgcggctg cctgaggaag tagtggattt cctgtaccag
     1561 tactggaagt tgaagaggaa ggtcaacttc aacaagcccc tgatcacccc aaagaaagat
     1621 gaagaggaca atctagccaa gcgggagcag gatgtcttat ttaggaggct gcagctgttc
     1681 acgcacctgc ggcaggacct ggagagggtt cggaacctca cttacatggt gacccgcagg
     1741 gaaaagatta aacggtctgt gtgcaaagtc caggaacaga tattcaatct ttacactaag
     1801 cttttggagc aagaaagagt ttcaggtgtg ccttcttcct gctcctcctc ctcactggaa
     1861 aacatgcttt tgtttaacag tccttctgtt ggccctgatg ctcccaagat agaggacttg
     1921 aagtggcatt ctgcattctt cagaaaacaa atgggtactt ccttggttca ttcgctgaaa
     1981 aagccccata agcgagatcc tttgcagaat agccctggaa gtgaaggcaa aaccctgctg
     2041 aagcagccag acctgtgtgg tagaagggag gggatggtgg tcccagagag ctttttgggt
     2101 ttagaaaaga cctttgcaga agcacgtctc atatcagcac aacagaaaaa tggtgtggtg
     2161 atgccagacc atgggaaaag aagagacaat cgttttcatt gtgatctcat taaaggagac
     2221 ttaaaggaca aatcttttaa acagagtcac aagcctctca ggtccacaga tgtgtcccag
     2281 aggcatctgg acaacacaag agctgccacc tcccctggag tggggcagtc agcacctggc
     2341 acaaggaagg agatagtgcc caagtgcaat ggctccctaa tcaaagtaaa ctataatcag
     2401 actgcagtca aagtgcctac aacacctgcc agcccagtga aaaactgggg aggattccgg
     2461 attccaaaga agggggaacg gcagcagcag ggagaggccc acgatggggc ctgccaccag
     2521 cactcagact acccatattt gggcttaggc cgagttccag ccaaggaaag ggcaaaaagc
     2581 aaattaaaat ccgacaatga gaatgacggg tatgtccccg atgtggaaat gagtgactca
     2641 gagagtgagg catcagaaaa gaaatgtata cacaccagca gcactatcag cagaaggaca
     2701 gacattatca ggagaagcat cttggcttct tgatgcaaca gagatgatgc ggaagccctt
     2761 tgggctcgtc attgggtttg ctagaggaga gctctgatgt gggggagaag cagaaaccca
     2821 ttaatcctga gctacacaaa cacatttact tgcaattcag attaattttt ttccagagtc
     2881 atttttaaat catttttgtg agaagtttgt gttatttgca acttgttgag gaaacagaag
     2941 agtagattgt aaccataaga cactgctaag actagaaccc gaactgaaca ctaaaataaa
     3001 aatgaaatgt tttaaagaag gcaaggctta aataagcctc atgaattttt atagccctct
     3061 gcattcttcc caaagcacaa actcatggtt acctgaatat agggaaccag atatggttct
     3121 tgagaaaccc tcatggtacc attcacagcc cataaagttt attttctagg actgtggtag
     3181 atcttgaaat catatttata tttggccctc aaggctattt ttgttgcatt atagcatata
     3241 ggcagcagct ctgaagcttc agtaacacta agaaatttat gtgtaaatat agcagtcagg
     3301 gaagagaatt ttaaaaaagg tcattattga agaagctgag gggacagggt agagctgctg
     3361 caatatggag atttagggta atatggcaag gtcctgctgc ttgaagcctg tgagtgggtt
     3421 gtggatatgg gactggtgga gagtgagact gttaggaaag ttgtatctat gaataagggc
     3481 agttgaagta gaatttttac cagtccactt gaccttcttc ttccctaacc actggctctt
     3541 gagccagctt gggatttccc tggccattgc caatacctgg ccatctggct tccaatagta
     3601 cagtggctac tcaagttcaa gcgaagaact tccagactct ggtgactgtt acttcccaga
     3661 gccaaccact agtgcatatg ttagggaatc tgggcttcca acatgaatgg attccttaag
     3721 aaaaaggaaa aaaaaaaaaa aaagaaaaaa agaaaaaaaa aagaaaaaag aaaaaaagag
     3781 aaaaaagcga aataggttat attttaaaaa caatagaaag gcaataagtt gcgataagct
     3841 cttactattg accaaggtta tacaggaaag agactgaagt gtacccttga ataggttttc
     3901 tgtagtcaga gttctaaact ctaatttgta acttggactt tctaattgca aatggcaata
     3961 actattaagt tatcagcaat aataaattta gcattaaatt tgagtacaat gttttgtttt
     4021 tgcactcccc atagtgcgta tgtattaaga cagtggatag tgtttaggtc ctgttaattt
     4081 tctttggaat tcaatgtggt tgtgaatcaa acttaaggaa ggaacgttta aatagcaatg
     4141 agatacagaa ttatgggcct ttggaacaag cccgacttcc cctaaattct ccttagtttg
     4201 ttaataccag tattcagatt cctgattcat ttatacatct gtttccatat ggcagggaca
     4261 ttatgatact taatgaataa tgctttgagg agttctgcag ttaactttca agtcttccag
     4321 atgattgtca acaacaaaaa aggcttattg aatcccatct tgctatgcaa gttttatcag
     4381 atgatcaaat agtagatctg atacatcccc attgtatgta cgacattttc aaaccaagtc
     4441 ttaacttttc aaggacattt tagtagctaa ttcaggggag ggggaagaat gatgcaggtt
     4501 tttagattga ctgactattt ttgagttatg gggctcattt tgaaagactg ctgtccagat
     4561 cagcttgttg ctgcagataa tagaaggttc ttatgaatcc aagttgtata ttcacttgta
     4621 ggataattta aaaattagat tttttttgca tatgagcaaa aaccttttgc tggatacagg
     4681 agaaggttgg actttatcta cagttatctt ttgattacag caacagctct gggtgagagt
     4741 agaatttata gagggataat ttgtcaagcc atagaaagaa aatctaaatt aatctagtaa
     4801 gtgtatgacc tctcaccatt ttaagaggta tcagattcat ttgcactatt aggaatgcta
     4861 gttttgtgca aaaataatgc cttacctgtt ttttccccac atttaggttg aaaagctttc
     4921 aaatgttcca agttatgctg aaccaaaaaa aacaaaacaa aaacaaaaca aaaaatatta
     4981 aaaaaaaccc acacaaaaac aaaacacaca aaaataaaaa gcccacactt tttattcctg
     5041 cttcgaaatg caaatggata gagcacggtt tctctgacag tataatgata gctttgtgag
     5101 ttagtttcat gtcatgctgg gaactctcta tgaggtggcc ataagcagca accagcccaa
     5161 acacccactt gcgttctatt agtatggaac catttgcatt tgtttttttt aagctttatc
     5221 tttccttgtg catcctgacc aagaaatatc tttgattatg attaatgtat tatgtcaaaa
     5281 tgtaggctag ttaaactttt gtaaagttgc ctggaatgtc atttgttagg ttataaacac
     5341 aagatctaaa tgaagggttt tatgtgttgt gtacaaatct tattttgaaa tggacaaact
     5401 tgtcattaca tttgtaacct tgtacagagg atttttcact atgtgcctag cttggtgtcc
     5461 attcagctaa aattgaaaaa aaaaaaaagg tgcatgaaga gttaaaaatc aaattaaagt
     5521 atatgtagag atgactattt tatattacat gacccaatcc tgtatttatt tctaccccct
     5581 ttttgaaagt atttataaaa ctagttgagg acagctgtat ttttttgttg aactatttag
     5641 tagaattgtg cctttttgtc tgtatgtgaa taaatgctgt acattttgca ataca
//
