LOCUS       NM_001039846             975 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens IZUMO family member 4 (IZUMO4), transcript variant 3,
            mRNA.
ACCESSION   NM_001039846
VERSION     NM_001039846.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 975)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive Selection and the Evolution of izumo Genes in Mammals
  JOURNAL   Int J Evol Biol 2012, 958164 (2012)
   PUBMED   22957301
REFERENCE   2  (bases 1 to 975)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 975)
  AUTHORS   Ellerman,D.A., Pei,J., Gupta,S., Snell,W.J., Myles,D. and
            Primakoff,P.
  TITLE     Izumo is part of a multiprotein family whose members form large
            complexes on mammalian sperm
  JOURNAL   Mol Reprod Dev 76 (12), 1188-1199 (2009)
   PUBMED   19658160
REFERENCE   4  (bases 1 to 975)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX378854.2, BI827974.1, AW182303.1 and AC005328.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001039846.1.
            
            Transcript Variant: This variant (3) encodes the longer protein
            (isoform 3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ196310.1, SRR1163658.222766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395301.8/ ENSP00000378712.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               BX378854.2         47-863
            818-841             BI827974.1         719-742
            842-969             AW182303.1         6-133               c
            970-975             AC005328.1         31439-31444
FEATURES             Location/Qualifiers
     source          1..975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..975
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /note="IZUMO family member 4"
                     /db_xref="GeneID:113177"
                     /db_xref="HGNC:HGNC:26950"
                     /db_xref="MIM:618897"
     exon            1..248
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..730
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; izumo sperm-egg fusion protein 4; sperm 22 kDa
                     protein c113"
                     /codon_start=1
                     /product="izumo sperm-egg fusion protein 4 isoform 3
                     precursor"
                     /protein_id="NP_001034935.1"
                     /db_xref="CCDS:CCDS42458.1"
                     /db_xref="GeneID:113177"
                     /db_xref="HGNC:HGNC:26950"
                     /db_xref="MIM:618897"
                     /translation="MALLLCLVCLTAALAHGCLHCHSNFSKKFSFYRHHVNFKSWWVG
                     DIPVSGALLTDWSDDTMKELHLAIPAKITREKLDQVATAVYQMMDQLYQGKMYFPGYF
                     PNELRNIFREQVHLIQNAIIESRIDCQHRCGIFQYETISCNNCTDSHVACFGYNCESS
                     AQWKSAVQGLLNYINNWHKQDTSMRPRSSAFSWPGTHRATPAFLVSPALRCLEPPHLA
                     NLTLEDAAECLKQH"
     exon            249..329
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            330..401
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            402..428
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            429..504
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            505..552
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            553..567
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            568..585
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            586..639
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     exon            640..975
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /inference="alignment:Splign:2.1.0"
     regulatory      948..953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /note="hexamer: ATTAAA"
     polyA_site      975
                     /gene="IZUMO4"
                     /gene_synonym="C19orf36; IMAGE:4215339"
                     /note="major polyA site"
ORIGIN      
        1 gttggttggc cggcggcggg ccgggacggg catggccctg ctgctgtgcc tggtgtgcct
       61 gacggcggcg ctggcccacg gctgtctgca ctgccacagc aacttctcca agaagttctc
      121 cttctaccgc caccatgtga acttcaagtc ctggtgggtg ggcgacatcc ccgtgtcagg
      181 ggcgctgctc accgactgga gcgacgacac gatgaaggag ctgcacctgg ccatccccgc
      241 caagatcacc cgggagaagc tggaccaagt ggcgacagca gtgtaccaga tgatggatca
      301 gctgtaccag gggaagatgt acttccccgg gtatttcccc aacgagctgc gaaacatctt
      361 ccgggagcag gtgcacctca tccagaacgc catcatcgaa agccgcatcg actgtcagca
      421 ccgctgtggc atcttccagt acgagaccat ctcctgcaac aactgcacag actcgcacgt
      481 cgcctgcttt ggctataact gcgagtcctc ggcgcagtgg aagtcagctg tccagggcct
      541 cctgaactac ataaataact ggcacaaaca ggacacgagc atgagaccac gctcctctgc
      601 cttctcctgg cctgggacac acagagccac cccggccttc ctggtatcgc cagccttaag
      661 gtgtctggag cccccacact tggccaacct gaccttggaa gatgctgctg agtgtctcaa
      721 gcagcactga cagcagctgg gcctgcccca gggcaacgtg ggggcggaga ctcagctgga
      781 cagcccctgc ctgtcactct ggagctgggc tgctgctgcc tcaggacccc ctctccgacc
      841 ccggacagag ctgagctggc cagggccagg agggcgggag ggagggaatg ggggtgggct
      901 gtgcgcagca tcagcgcctg ggcaggtccg cagagctgcg ggatgtgatt aaagtccctg
      961 atgtttctct ttgca
//
