LOCUS       NM_152358                814 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens IZUMO family member 2 (IZUMO2), transcript variant 1,
            mRNA.
ACCESSION   NM_152358
VERSION     NM_152358.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 814)
  AUTHORS   Higashi,T., Hayashi,H., Hanamatsu,Y., Saigo,C., Matsuhashi,N. and
            Takeuchi,T.
  TITLE     Expression of IZUMO2 in colorectal cancer in association with
            clinicopathological features
  JOURNAL   Pathol Res Pract 256, 155263 (2024)
   PUBMED   38484656
  REMARK    GeneRIF: Expression of IZUMO2 in colorectal cancer in association
            with clinicopathological features.
REFERENCE   2  (bases 1 to 814)
  AUTHORS   Grayson,P. and Civetta,A.
  TITLE     Positive Selection and the Evolution of izumo Genes in Mammals
  JOURNAL   Int J Evol Biol 2012, 958164 (2012)
   PUBMED   22957301
REFERENCE   3  (bases 1 to 814)
  AUTHORS   Ellerman,D.A., Pei,J., Gupta,S., Snell,W.J., Myles,D. and
            Primakoff,P.
  TITLE     Izumo is part of a multiprotein family whose members form large
            complexes on mammalian sperm
  JOURNAL   Mol Reprod Dev 76 (12), 1188-1199 (2009)
   PUBMED   19658160
REFERENCE   4  (bases 1 to 814)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020906.6.
            
            On May 11, 2021 this sequence version replaced NM_152358.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358196.1, BC029535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293405.8/ ENSP00000293405.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AC020906.6         95802-96120
            320-394             AC020906.6         96270-96344
            395-481             AC020906.6         99503-99589
            482-502             AC020906.6         99833-99853
            503-583             AC020906.6         100735-100815
            584-710             AC020906.6         104357-104483
            711-814             AC020906.6         106432-106535
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..814
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /note="IZUMO family member 2"
                     /db_xref="GeneID:126123"
                     /db_xref="HGNC:HGNC:28518"
                     /db_xref="MIM:618895"
     exon            1..319
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..753
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; izumo sperm-egg fusion protein 2"
                     /codon_start=1
                     /product="izumo sperm-egg fusion protein 2 isoform 1
                     precursor"
                     /protein_id="NP_689571.2"
                     /db_xref="CCDS:CCDS12792.2"
                     /db_xref="GeneID:126123"
                     /db_xref="HGNC:HGNC:28518"
                     /db_xref="MIM:618895"
                     /translation="MPLALTLLLLSGLGAPGGWGCLQCDPLVLEALGHLRSALIPSRF
                     QLEQLQARAGAVLMGMEGPFFRDYALNVFVGKVETNQLDLVASFVKNQTQHLMGNSLK
                     DEPLLEELVTLRANVIKEFKKVLISYELKACNPKLCRLLKEEVLDCLHCQRITPKCIH
                     KKYCFVDRQPRVALQYQMDSKYPRNQALLGILISVSLAVFVFVVIVVSACTYRQNRKL
                     LLQ"
     exon            320..394
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     exon            395..481
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     exon            482..502
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     exon            503..583
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     exon            584..710
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     exon            711..814
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      793..798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /note="hexamer: AATAAA"
     polyA_site      814
                     /gene="IZUMO2"
                     /gene_synonym="C19orf41; PLAL6978; PRO21961; SCRL"
                     /note="major polyA site"
ORIGIN      
        1 gtgatgctcc ctgggcctcc tgaccgcgcc ctcgcctggg aggcggggcg ggccgggttc
       61 tctctgtgac gtcacaaagg ccccgccatg cctctggctt tgacccttct gctgctctcg
      121 ggcttgggcg cccccggagg ctggggctgc ctgcagtgcg accccttggt gctggaggcc
      181 ctgggtcacc tgcgctccgc cctcatcccc agtcgcttcc agttggagca gctgcaggcg
      241 cgcgccgggg ccgtgctgat gggcatggag gggcctttct tccgggacta cgcgctgaac
      301 gtgtttgtgg ggaaagtgga gacaaatcaa ctggaccttg tggcgtcctt tgtcaagaac
      361 caaacgcagc acttaatggg taactctctg aaagatgagc ctctgctgga agagctggtg
      421 accctcaggg cgaatgtgat caaggaattc aagaaagttt taatttcata tgaattaaaa
      481 gcctgcaacc ccaaactttg ccgcttgcta aaagaagagg tgttggactg tttacattgc
      541 cagaggatca ctcccaagtg tatccacaaa aagtactgct ttgtcgaccg gcaaccccgc
      601 gtggccctgc agtaccagat ggacagcaaa tacccgagga accaggcgct gttgggcatc
      661 ctcatttctg tgtctctggc tgtctttgtc ttcgtggtca tcgtggtctc ggcttgtaca
      721 tacagacaaa accgaaaact cctgctgcag taggacggtg gtttgggggt aaggagaaag
      781 gaaaataaat ttaataaaat tggtgacaaa tcca
//
