LOCUS       NM_001199206            1513 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens IZUMO1 receptor, JUNO (IZUMO1R), transcript variant 1,
            mRNA.
ACCESSION   NM_001199206
VERSION     NM_001199206.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Allingham,J. and Floriano,W.B.
  TITLE     Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved
            in human reproduction
  JOURNAL   PLoS One 16 (12), e0260692 (2021)
   PUBMED   34879103
  REMARK    GeneRIF: Genetic diversity in the IZUMO1-JUNO protein-receptor pair
            involved in human reproduction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Jean,C., Haghighirad,F., Zhu,Y., Chalbi,M., Ziyyat,A.,
            Rubinstein,E., Gourier,C., Yip,P., Wolf,J.P., Lee,J.E., Boucheix,C.
            and Barraud-Lange,V.
  TITLE     JUNO, the receptor of sperm IZUMO1, is expressed by the human
            oocyte and is essential for human fertilisation
  JOURNAL   Hum Reprod 34 (1), 118-126 (2019)
   PUBMED   30517645
  REMARK    GeneRIF: Study revealed a progressive expression of JUNO according
            to oocyte maturity and showed that human zona-free oocytes,
            inseminated in the presence of anti-hJUNO mAb, were not fertilized
            by human sperm.
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Yu,M., Zhao,H., Chen,T., Tian,Y., Li,M., Wu,K., Bian,Y., Su,S.,
            Cao,Y., Ning,Y., Liu,H. and Chen,Z.J.
  TITLE     Mutational analysis of IZUMO1R in women with fertilization failure
            and polyspermy after in vitro fertilization
  JOURNAL   J Assist Reprod Genet 35 (3), 539-544 (2018)
   PUBMED   29243140
  REMARK    GeneRIF: Juno single nucleotide polymorphisms associated with
            fertilization failure and polyspermy after in vitro fertilization
            in women.
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Kato,K., Satouh,Y., Nishimasu,H., Kurabayashi,A., Morita,J.,
            Fujihara,Y., Oji,A., Ishitani,R., Ikawa,M. and Nureki,O.
  TITLE     Structural and functional insights into IZUMO1 recognition by JUNO
            in mammalian fertilization
  JOURNAL   Nat Commun 7, 12198 (2016)
   PUBMED   27416963
  REMARK    GeneRIF: JUNO interacts with IZUMO1 during sperm binding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Aydin,H., Sultana,A., Li,S., Thavalingam,A. and Lee,J.E.
  TITLE     Molecular architecture of the human sperm IZUMO1 and egg JUNO
            fertilization complex
  JOURNAL   Nature 534 (7608), 562-565 (2016)
   PUBMED   27309818
  REMARK    GeneRIF: crystal structures of human IZUMO1 and JUNO in unbound and
            bound conformations
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Ohto,U., Ishida,H., Krayukhina,E., Uchiyama,S., Inoue,N. and
            Shimizu,T.
  TITLE     Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during
            mammalian fertilization
  JOURNAL   Nature 534 (7608), 566-569 (2016)
   PUBMED   27309808
  REMARK    GeneRIF: crystal structures of human IZUMO1, JUNO and the
            IZUMO1-JUNO complex, establishing the structural basis for the
            IZUMO1-JUNO-mediated sperm-oocyte interaction
REFERENCE   7  (bases 1 to 1513)
  AUTHORS   Bianchi,E., Doe,B., Goulding,D. and Wright,G.J.
  TITLE     Juno is the egg Izumo receptor and is essential for mammalian
            fertilization
  JOURNAL   Nature 508 (7497), 483-487 (2014)
   PUBMED   24739963
REFERENCE   8  (bases 1 to 1513)
  AUTHORS   Spiegelstein,O., Eudy,J.D. and Finnell,R.H.
  TITLE     Identification of two putative novel folate receptor genes in
            humans and mouse
  JOURNAL   Gene 258 (1-2), 117-125 (2000)
   PUBMED   11111049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002784.4.
            
            On Feb 3, 2021 this sequence version replaced NM_001199206.3.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000687084.1/
                                                ENSP00000510041.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AP002784.4         130232-130531
            301-444             AP002784.4         131283-131426
            445-654             AP002784.4         132165-132374
            655-790             AP002784.4         132817-132952
            791-1513            AP002784.4         133076-133798
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1513
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /note="IZUMO1 receptor, JUNO"
                     /db_xref="GeneID:390243"
                     /db_xref="HGNC:HGNC:32565"
                     /db_xref="MIM:615737"
     exon            1..300
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /inference="alignment:Splign:2.1.0"
     exon            301..444
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1059
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /note="probable folate receptor delta; folate receptor 4
                     (delta) homolog; sperm-egg fusion protein Juno; folate
                     receptor 4, delta (putative); IZUMO1 receptor protein
                     JUNO; IZUMO1 receptor, JUNO, FR-delta"
                     /codon_start=1
                     /product="sperm-egg fusion protein Juno precursor"
                     /protein_id="NP_001186135.1"
                     /db_xref="CCDS:CCDS81615.1"
                     /db_xref="GeneID:390243"
                     /db_xref="HGNC:HGNC:32565"
                     /db_xref="MIM:615737"
                     /translation="MACWWPLLLELWTVMPTWAGDELLNICMNAKHHKRVPSPEDKLY
                     EECIPWKDNACCTLTTSWEAHLDVSPLYNFSLFHCGLLMPGCRKHFIQAICFYECSPN
                     LGPWIQPVGSLGWEVAPSGQGERVVNVPLCQEDCEEWWEDCRMSYTCKSNWRGGWDWS
                     QGKNRCPKGAQCLPFSHYFPTPADLCEKTWSNSFKASPERRNSGRCLQKWFEPAQGNP
                     NVAVARLFASSAPSWELSYTIMVCSLFLPFLS"
     exon            445..654
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /inference="alignment:Splign:2.1.0"
     exon            655..790
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1513
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="IZUMO1R"
                     /gene_synonym="Folbp3; FOLR4; FR-delta; JUNO"
                     /note="major polyA site"
ORIGIN      
        1 gcagccagct agtaagtagc agagctgaca gccgaacccg gtaacttatt gtagagcccc
       61 ggatcttgcc tacgatgggg tctgtttctc tgaggaagca aacttcctcg gaacccacag
      121 gcctgcagag ctgggtgaga cagatgctgt ttaatgagag ccacgtggag ttctcctcct
      181 gcacctggac ctagtagaaa tcagactggg taataaatgg gcgggacatg gaactcccct
      241 cagcctcata gtctcagggg gaggagggag caggagcacc tgaaggctcc tgccttgaaa
      301 caggccatgg catgctggtg gccgctcctg ctagagctgt ggacagtcat gcccacctgg
      361 gctggggacg agctgctcaa catctgcatg aatgccaaac accacaagag agtgcccagc
      421 ccagaagaca agctctatga ggagtgcatc ccctggaagg acaatgcctg ctgcaccctc
      481 acgacaagct gggaagccca tctggatgta tccccactct acaacttcag cctgtttcac
      541 tgtggactgc tgatgcctgg ctgtcggaag cacttcatcc aggctatctg cttctatgag
      601 tgctccccaa acctggggcc ctggatccag ccagtgggaa gcctggggtg ggaggtggcc
      661 ccgagtgggc agggagagcg agttgtgaat gtgccgctgt gccaggagga ctgtgaggag
      721 tggtgggaag actgtcgcat gtcttacaca tgcaaatcca actggcgtgg tggctgggac
      781 tggagtcagg ggaagaaccg ctgccccaaa ggggcccagt gcctcccttt ctcccattac
      841 ttccccaccc cagctgacct gtgtgagaag acttggagca attccttcaa agccagccct
      901 gagcgacgga acagtgggcg gtgtctccag aagtggtttg agcctgctca gggcaacccc
      961 aatgtggccg tggcccgcct cttcgccagc tctgccccat cctgggaact gtcctacacc
     1021 atcatggtct gctccctgtt cctgccgttc ctttcctgag agcccttctt ctcccactca
     1081 cattcctgca tgtccaccaa ctgtgggtca ggccaggcca tggcctacct ccttcctcag
     1141 gccctcccct aaaagcagtg gcatgggcta gggactgcag tcccacccag tctagcccat
     1201 gccactgctt ttaggggagg gcctgaggaa ggaagtgccc ctgaggcttc agcggctggt
     1261 gcctgcaacc tgcacatttg gtccgagacc ccctccactg ctctgctcta tcttagctgg
     1321 cctaggaggc agctgggggc tggaagtgcc aaggtgactg gccacctcct gccttgaggg
     1381 atgggagctt tcaaggggct caaggacttt cccatccagt gcacgcctac ccctttctgt
     1441 gacagagctg atggtggcag acctggcctc ccatcctccg acggtgtctt caataaatcg
     1501 gcactcaacc tct
//
