LOCUS       NM_006469               4113 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens influenza virus NS1A binding protein (IVNS1ABP), mRNA.
ACCESSION   NM_006469
VERSION     NM_006469.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Waldran,M.J., Wegman,A.D., Bahr,L.E., Roy,N.H., Currier,J.R. and
            Waickman,A.T.
  TITLE     Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic
            Phagocytosis of DENV Infected Cells
  JOURNAL   J Infect Dis 228 (1), 70-79 (2023)
   PUBMED   37103221
  REMARK    GeneRIF: Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic
            Phagocytosis of DENV Infected Cells.
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Zhang,K., Shang,G., Padavannil,A., Wang,J., Sakthivel,R., Chen,X.,
            Kim,M., Thompson,M.G., Garcia-Sastre,A., Lynch,K.W., Chen,Z.J.,
            Chook,Y.M. and Fontoura,B.M.A.
  TITLE     Structural-functional interactions of NS1-BP protein with the
            splicing and mRNA export machineries for viral and host gene
            expression
  JOURNAL   Proc Natl Acad Sci U S A 115 (52), E12218-E12227 (2018)
   PUBMED   30538201
  REMARK    GeneRIF: The central BACK domain of NS1-BP interacts directly with
            splicing factors such as hnRNP K and PTBP1 and with the viral NS1
            protein.
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Thompson,M.G., Munoz-Moreno,R., Bhat,P., Roytenberg,R.,
            Lindberg,J., Gazzara,M.R., Mallory,M.J., Zhang,K.,
            Garcia-Sastre,A., Fontoura,B.M.A. and Lynch,K.W.
  TITLE     Co-regulatory activity of hnRNP K and NS1-BP in influenza and human
            mRNA splicing
  JOURNAL   Nat Commun 9 (1), 2407 (2018)
   PUBMED   29921878
  REMARK    GeneRIF: Data show that heterogeneous nuclear ribonucleoprotein K
            (hnRNP K) and influenza virus NS1A binding protein (NS1-BP)
            regulate host splicing events and that viral infection causes
            mis-splicing of some of these transcripts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Wang,Y., Cheng,J., Xie,D., Ding,X., Hou,H., Chen,X., Er,P.,
            Zhang,F., Zhao,L., Yuan,Z., Pang,Q., Wang,P. and Qian,D.
  TITLE     NS1-binding protein radiosensitizes esophageal squamous cell
            carcinoma by transcriptionally suppressing c-Myc
  JOURNAL   Cancer Commun (Lond) 38 (1), 33 (2018)
   PUBMED   29871674
  REMARK    GeneRIF: In esophageal squamous cell carcinoma (ESCC) tissues,
            c-Myc expression was inversely correlated with NS1-binding protein
            (NS1-BP) levels, and was associated with a shorter disease-specific
            survival (DSS).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Guo,L. and Liu,Y.
  TITLE     Crystal structure of the Kelch domain of human NS1-binding protein
            at 1.98 A resolution
  JOURNAL   Acta Crystallogr F Struct Biol Commun 74 (Pt 3), 174-178 (2018)
   PUBMED   29497022
  REMARK    GeneRIF: Comparison of the Kelch-domain structures of NS1-BP and
            its homologues showed that the Gly-Gly pair in beta-strand B and
            the hydrophobic Trp residue in beta-strand D are highly conserved,
            while the B-C loops in blades 2 and 6 are variable
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Naukkarinen,J., Surakka,I., Pietilainen,K.H., Rissanen,A.,
            Salomaa,V., Ripatti,S., Yki-Jarvinen,H., van Duijn,C.M.,
            Wichmann,H.E., Kaprio,J., Taskinen,M.R. and Peltonen,L.
  CONSRTM   ENGAGE Consortium
  TITLE     Use of genome-wide expression data to mine the 'Gray Zone' of GWA
            studies leads to novel candidate obesity genes
  JOURNAL   PLoS Genet 6 (6), e1000976 (2010)
   PUBMED   20532202
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Perconti,G., Ferro,A., Amato,F., Rubino,P., Randazzo,D., Wolff,T.,
            Feo,S. and Giallongo,A.
  TITLE     The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is
            involved in c-Myc gene transcriptional control
  JOURNAL   Biochim Biophys Acta 1773 (12), 1774-1785 (2007)
   PUBMED   17996313
  REMARK    GeneRIF: These findings further support the distinct roles of
            alpha-enolase and its MBP-1 variant in maintaining cell
            homeostasis. Moreover, these data suggest a novel function for
            NS1-BP in the control of cell proliferation.
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Dunham,E.E., Stevens,E.A., Glover,E. and Bradfield,C.A.
  TITLE     The aryl hydrocarbon receptor signaling pathway is modified through
            interactions with a Kelch protein
  JOURNAL   Mol Pharmacol 70 (1), 8-15 (2006)
   PUBMED   16582008
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Harris,C.E., Boden,R.A. and Astell,C.R.
  TITLE     A novel heterogeneous nuclear ribonucleoprotein-like protein
            interacts with NS1 of the minute virus of mice
  JOURNAL   J Virol 73 (1), 72-80 (1999)
   PUBMED   9847309
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Wolff,T., O'Neill,R.E. and Palese,P.
  TITLE     NS1-Binding protein (NS1-BP): a novel human protein that interacts
            with the influenza A virus nonstructural NS1 protein is relocalized
            in the nuclei of infected cells
  JOURNAL   J Virol 72 (9), 7170-7180 (1998)
   PUBMED   9696811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB020657.1, AK000931.1, AL137640.1 and AF205218.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006469.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ012449.1, AF205218.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367498.8/ ENSP00000356468.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3589              AB020657.1         94-3682
            3590-3617           AK000931.1         2317-2344
            3618-3921           AL137640.1         1032-1335
            3922-4073           AF205218.1         3940-4091
            4074-4113           AL137640.1         1488-1527
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..4113
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="influenza virus NS1A binding protein"
                     /db_xref="GeneID:10625"
                     /db_xref="HGNC:HGNC:16951"
                     /db_xref="MIM:609209"
     exon            1..291
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            292..519
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            520..648
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..2466
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="NS1-binding protein; NCX downstream gene 1; aryl
                     hydrocarbon receptor-associated 3; aryl hydrocarbon
                     receptor-associated protein 3; kelch-like family member
                     39; kelch-like protein 39"
                     /codon_start=1
                     /product="influenza virus NS1A-binding protein"
                     /protein_id="NP_006460.2"
                     /db_xref="CCDS:CCDS1368.1"
                     /db_xref="GeneID:10625"
                     /db_xref="HGNC:HGNC:16951"
                     /db_xref="MIM:609209"
                     /translation="MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEML
                     AHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELV
                     KDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEH
                     LLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELME
                     EVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLS
                     SPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLS
                     KSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHT
                     DHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELR
                     TNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVC
                     ELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGG
                     FDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVE
                     VYNLESNEWSPYTKIFQF"
     exon            649..818
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            819..894
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1068
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1194
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1302
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1432
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1657
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1779
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1906
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2038
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2212
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..4113
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="hexamer: AATAAA"
     polyA_site      2736
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="major polyA site"
     regulatory      3571..3576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="hexamer: ATTAAA"
     polyA_site      3592
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="major polyA site"
     regulatory      4081..4086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="hexamer: AATAAA"
     polyA_site      4113
                     /gene="IVNS1ABP"
                     /gene_synonym="ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1;
                     NS-1; NS1-BP; NS1BP"
                     /note="major polyA site"
ORIGIN      
        1 agtgtctccc ggtcgcgcgt ggaggtcggt cgctcagagc tgctgggcgc agtttctccg
       61 cctgctgctt cggcgcggct gtatcggcga gcgagcgagt tcccgcgagt tctcggtggc
      121 gctccccctt cctttcagtc tccacggact ggcccctcgt ccttctactt gaccgctccc
      181 gtcttccgcc gccttctggc gctttccgtt gggccgattc ccgcccgctt cctcctgctt
      241 cccatcgaag ctctagaaat gaatgtttcc atctcttcag agatgaacca gattatgatg
      301 catcattatc acagaagaaa ttcgtgtcta tagcttttaa ggacttgatt acatcatttt
      361 caagcctgat agttttggaa tcaccattag agcttaagac acacctgcct tcatttcaac
      421 cacctgtctt cataccctga cgaagtgcac cttttaacac tcctttgtcc ttggattact
      481 taagagttcc cagaaataca tttgccacca acagagtagc caaatttata aggaaaaatg
      541 attcccaatg gatatttgat gtttgaggat gaaaatttta ttgagtcttc tgttgccaaa
      601 ttaaatgccc tgaggaaaag tggccagttc tgtgatgttc gacttcaggt ctgtggccat
      661 gaaatgttag cacacagagc agtgctagct tgctgcagtc cctatttatt tgaaatcttt
      721 aatagtgata gtgatcctca tggaatttct cacgttaaat ttgatgatct caatccagaa
      781 gctgttgaag tcttgttgaa ttatgcctac actgctcagt tgaaagcaga taaggaattg
      841 gtaaaagatg tttattctgc agcaaaaaag ctgaagatgg atcgagtaaa gcaggtttgt
      901 ggtgattatt tactgtctag aatggatgtt accagctgca tctcttaccg aaattttgca
      961 agttgtatgg gagactcccg tttgttgaat aaggttgatg cttatattca ggagcatttg
     1021 ttacaaattt ctgaagagga ggagtttctt aagcttccaa ggctaaagtt ggaggtaatg
     1081 cttgaagata atgtttgctt gcccagcaat ggcaaattat atacaaaggt aatcaactgg
     1141 gtgcagcgta gcatctggga gaatggagac agtctggaag agctgatgga agaggttcaa
     1201 accttgtact actcagctga tcacaagctg cttgatggga acctactaga tggacaggct
     1261 gaggtgtttg gcagtgatga tgaccacatt cagtttgtgc agaaaaagcc accacgtgag
     1321 aatggccata agcagataag tagcagttca actggatgtc tctcttctcc aaatgctaca
     1381 gtacaaagcc ctaagcatga gtggaaaatc gttgcttcag aaaagacttc aaataacact
     1441 tacttgtgcc tggctgtgct ggatggtata ttctgtgtca tttttcttca tgggagaaac
     1501 agcccacaga gctcaccaac aagtactcca aaactaagta agagtttaag ctttgagatg
     1561 caacaagatg agctaatcga aaagcccatg tctcctatgc agtacgcacg atctggtctg
     1621 ggaacagcag agatgaatgg caaactcata gctgcaggtg gctataacag agaggaatgt
     1681 cttcgaacag tcgaatgcta taatccacat acagatcact ggtcctttct tgctcccatg
     1741 agaacaccaa gagcccgatt tcaaatggct gtactcatgg gccagctcta tgtggtaggt
     1801 ggatcaaatg gccactcaga tgacctgagt tgtggagaga tgtatgattc aaacatagat
     1861 gactggattc ctgttccaga attgagaact aaccgttgta atgcaggagt gtgtgctctg
     1921 aatggaaagt tatacatcgt tggtggctct gatccatatg gtcaaaaagg actgaaaaat
     1981 tgtgatgtat ttgatcctgt aacaaagttg tggacaagct gtgcccctct taacattcgg
     2041 agacaccagt ctgcagtctg tgagcttggt ggttatttgt acataatcgg aggtgcagaa
     2101 tcttggaatt gtctgaacac agtagaacga tacaatcctg aaaataatac ctggacttta
     2161 attgcaccca tgaatgtggc taggcgagga gctggagtgg ctgttcttaa tggaaaactg
     2221 tttgtatgtg gtggctttga tggttctcat gccatcagtt gtgtggaaat gtatgatcca
     2281 actagaaatg aatggaagat gatgggaaat atgacttcac caaggagcaa tgctgggatt
     2341 gcaactgtag ggaacaccat ttatgcagtg ggaggattcg atggcaatga atttctgaat
     2401 acggtggaag tctataacct tgagtcaaat gaatggagcc cctatacaaa gattttccag
     2461 ttttaacaaa tttaagaccc tctcaaacta acaggcttag tgatgtaatt atggttagta
     2521 gaggtacact tgtgaataaa gagggtgggt gggtatagat gttgctaaca gcaacacaaa
     2581 gcttttgcat attgcatact attaaacatg ctgtacatac tttttgggtt tatttggaaa
     2641 ggaatgcaaa gatgaaggtc tgttttgtgt acttttaaga ctttggttat tttacttttt
     2701 ggaaaagaat aaaccaagaa ttgattgggc acatcatttc aagaagtccc ctctcctcca
     2761 catttgtttt gccaatttgc acattaaatg actcttccct caaatgtgta ctatggggta
     2821 aaaggggtag ggtttaaaga tgtagacagt tgggtttttt aagggccctt tttcaataac
     2881 tggaacactc tataacaaag gatacttatt taaatagatg acattgacta tttttgtttt
     2941 tattaaaagg aagcttacat gcctaccaat atttaatctt ttatgattgc ctttttataa
     3001 ctttttatat tctcagcaga gtgctttacc aattgaagta aaatgtggca ggctggagtt
     3061 attgaagcag agtggcagtc ttcagtttgc agagtagggg tctgtctttt aaactctgag
     3121 tgcaaacttc agagttcttg ccttggctgc agtttttttc cttcaagaat gcagtactaa
     3181 catttatttg agtggagtta ctgaacagta acatagctgt gatttttggt atttgaaaca
     3241 ctggttttaa atattttgac ttgttgaggg tatgttttat atagcaagac attatatagc
     3301 agtaaaaaat ggtgttttat cttctatata attcctgttt ttattattaa caaaacagtc
     3361 ctaaatagca gccctcaatt gtgaaaaaat ttactttaaa ctacattagg ttgtgaatgc
     3421 aggttttatc agaactatgt ttttgttcag tttatctgtt catatggata aatattggtt
     3481 gggatgactt ggtgtctaat gtgtagtgct acacacctaa cttatggggc caaaatagca
     3541 tgtcctaatg cttgctgctg atttaaacac attaaaggta ctttgcagga aatccttgca
     3601 ccatgggatt aatatccaat tgctgcttgt acactcattc attactaaaa gttttgagaa
     3661 attttttttt ccagtaatga gcttaagaaa tttgtggaaa ataactcacc tggcatctta
     3721 catctgaaat aaggaatgat ataaggtttt tttttctcac agaagatgaa gcacacagga
     3781 acctaatggg ccaactggga tgaggtgact attctgagat gactattcag tggctaactt
     3841 gggttaggaa gaaaataatt aggtattttc tccaaatgtt cactggtact ctgccacttt
     3901 atttctctca tctgttacac aaagaaccac caggaaagca aatcagtttg gttggtaact
     3961 ctgtaattcc taactatcac tggtttggtt ctggactaaa actacattga cagattgaat
     4021 ttgcctaata tgatgactgt ttttaatatg gatctgtatg tgttctattc agcacaagga
     4081 aataaaattt tagttgagga ttcagcacta aaa
//
