LOCUS       NM_003024              16972 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens intersectin 1 (ITSN1), transcript variant 1, mRNA.
ACCESSION   NM_003024
VERSION     NM_003024.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16972)
  AUTHORS   Lan,C., Zhang,H., Wang,K., Liu,X., Zhao,Y., Guo,Z., Zhang,N.,
            Zhou,Y., Gao,M., Gu,F. and Ma,Y.
  TITLE     The alternative splicing of intersectin 1 regulated by PTBP1
            promotes human glioma progression
  JOURNAL   Cell Death Dis 13 (9), 835 (2022)
   PUBMED   36171198
  REMARK    GeneRIF: The alternative splicing of intersectin 1 regulated by
            PTBP1 promotes human glioma progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16972)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16972)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 16972)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 16972)
  AUTHORS   Bruel,A.L., Vitobello,A., Thiffault,I., Manwaring,L., Willing,M.,
            Agrawal,P.B., Bayat,A., Kitzler,T.M., Brownstein,C.A.,
            Genetti,C.A., Gonzalez-Heydrich,J., Jayakar,P., Zyskind,J.W.,
            Zhu,Z., Vachet,C., Wilson,G.R., Pruniski,B., Goyette,A.M.,
            Duffourd,Y., Thauvin-Robinet,C., Philippe,C. and Faivre,L.
  TITLE     ITSN1: a novel candidate gene involved in autosomal dominant
            neurodevelopmental disorder spectrum
  JOURNAL   Eur J Hum Genet 30 (1), 111-116 (2022)
   PUBMED   34707297
  REMARK    GeneRIF: ITSN1: a novel candidate gene involved in autosomal
            dominant neurodevelopmental disorder spectrum.
REFERENCE   6  (bases 1 to 16972)
  AUTHORS   Sengar,A.S., Wang,W., Bishay,J., Cohen,S. and Egan,S.E.
  TITLE     The EH and SH3 domain Ese proteins regulate endocytosis by linking
            to dynamin and Eps15
  JOURNAL   EMBO J 18 (5), 1159-1171 (1999)
   PUBMED   10064583
REFERENCE   7  (bases 1 to 16972)
  AUTHORS   Yamabhai,M., Hoffman,N.G., Hardison,N.L., McPherson,P.S.,
            Castagnoli,L., Cesareni,G. and Kay,B.K.
  TITLE     Intersectin, a novel adaptor protein with two Eps15 homology and
            five Src homology 3 domains
  JOURNAL   J Biol Chem 273 (47), 31401-31407 (1998)
   PUBMED   9813051
REFERENCE   8  (bases 1 to 16972)
  AUTHORS   Guipponi,M., Scott,H.S., Chen,H., Schebesta,A., Rossier,C. and
            Antonarakis,S.E.
  TITLE     Two isoforms of a human intersectin (ITSN) protein are produced by
            brain-specific alternative splicing in a stop codon
  JOURNAL   Genomics 53 (3), 369-376 (1998)
   PUBMED   9799604
REFERENCE   9  (bases 1 to 16972)
  AUTHORS   Chen,H. and Antonarakis,S.E.
  TITLE     The SH3D1A gene maps to human chromosome 21q22.1-->q22.2
  JOURNAL   Cytogenet Cell Genet 78 (3-4), 213-215 (1997)
   PUBMED   9465890
REFERENCE   10 (bases 1 to 16972)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058925.1, AF114487.1,
            AF064244.1 and AP000313.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003024.2.
            
            Summary: The protein encoded by this gene is a cytoplasmic
            membrane-associated protein that indirectly coordinates endocytic
            membrane traffic with the actin assembly machinery. In addition,
            the encoded protein may regulate the formation of clathrin-coated
            vesicles and could be involved in synaptic vesicle recycling. This
            protein has been shown to interact with dynamin, CDC42, SNAP23,
            SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript
            variants encoding different isoforms have been found for this gene,
            but the full-length nature of only two of them have been
            characterized so far. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (ITSN-l).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF064244.1, AF114487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381318.8/ ENSP00000370719.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2069              BC058925.1         51-2119
            2070-5706           AF114487.1         2093-5729
            5707-6416           AF064244.1         5568-6277
            6417-16972          AP000313.1         44108-54663
FEATURES             Location/Qualifiers
     source          1..16972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..16972
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /note="intersectin 1"
                     /db_xref="GeneID:6453"
                     /db_xref="HGNC:HGNC:6183"
                     /db_xref="MIM:602442"
     exon            1..213
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            214..273
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..5411
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /note="isoform ITSN-l is encoded by transcript variant 1;
                     human intersectin-SH3 domain-containing protein SH3P17;
                     Src homology 3 domain-containing protein; SH3
                     domain-containing protein 1A; intersectin 1 (SH3 domain
                     protein)"
                     /codon_start=1
                     /product="intersectin-1 isoform ITSN-l"
                     /protein_id="NP_003015.2"
                     /db_xref="CCDS:CCDS33545.1"
                     /db_xref="GeneID:6453"
                     /db_xref="HGNC:HGNC:6183"
                     /db_xref="MIM:602442"
                     /translation="MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQA
                     RNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVM
                     KQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLAN
                     GAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVP
                     QSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTA
                     EEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPV
                     LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQE
                     RKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWE
                     RNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQ
                     EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLV
                     TLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKS
                     MEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKL
                     KREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENV
                     KVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPA
                     NYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSST
                     WPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVE
                     GLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGP
                     IRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL
                     VTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT
                     GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPT
                     EPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLF
                     PSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEI
                     FQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILS
                     AQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKP
                     MQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWI
                     QAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITK
                     PLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLR
                     AESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKP
                     CRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQ
                     FSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP"
     exon            274..366
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            367..430
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            431..591
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            592..771
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            772..868
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            869..969
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1033
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1171
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1287
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1550
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1700
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1841
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1929
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2069
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2197
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2427
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2549
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2564
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2812
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2972
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3178
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3261
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3428
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3474
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3596
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3714
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3906
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4028
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4135
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4319
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4418
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4586
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..4799
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..4921
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            4922..5004
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5088
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            5089..5262
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..16972
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16953..16958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /note="hexamer: AATAAA"
     polyA_site      16972
                     /gene="ITSN1"
                     /gene_synonym="ITSN; SH3D1A; SH3P17"
                     /note="major polyA site"
ORIGIN      
        1 gtagagaaga gtggaggcgc caggggaggg agcgtagctt ggttgctccg tagtacggcg
       61 gctcgcgagg aagaatcccg agcgggctcc gggacggaca gagaggcggg cggggatggt
      121 gtgcggggct gcggctcctg cgtccctccc agcggcgcgt gagcggcact gatttgtccc
      181 tggggcggca gcgcggaccc gcccggagat gaggcgtcga ttagcaaggt aaaagtaaca
      241 gaaccatggc tcagtttcca acaccttttg gtggcagcct ggatatctgg gccataactg
      301 tagaggaaag agcgaagcat gatcagcagt tccatagttt aaagccaata tctggattca
      361 ttactggtga tcaagctaga aacttttttt ttcaatctgg gttacctcaa cctgttttag
      421 cacagatatg ggcactagct gacatgaata atgatggaag aatggatcaa gtggagtttt
      481 ccatagctat gaaacttatc aaactgaagc tacaaggata tcagctaccc tctgcacttc
      541 cccctgtcat gaaacagcaa ccagttgcta tttctagcgc accagcattt ggtatgggag
      601 gtatcgccag catgccaccg cttacagctg ttgctccagt gccaatggga tccattccag
      661 ttgttggaat gtctccaacc ctagtatctt ctgttcccac agcagctgtg ccccccctgg
      721 ctaacggggc tccccctgtt atacaacctc tgcctgcatt tgctcatcct gcagccacat
      781 tgccaaagag ttcttccttt agtagatctg gtccagggtc acaactaaac actaaattac
      841 aaaaggcaca gtcatttgat gtggccagtg tcccaccagt ggcagagtgg gctgttcctc
      901 agtcatcaag actgaaatac aggcaattat tcaatagtca tgacaaaact atgagtggac
      961 acttaacagg tccccaagca agaactattc ttatgcagtc aagtttacca caggctcagc
     1021 tggcttcaat atggaatctt tctgacattg atcaagatgg aaaacttaca gcagaggaat
     1081 ttatcctggc aatgcacctc attgatgtag ctatgtctgg ccaaccactg ccacctgtcc
     1141 tgcctccaga atacattcca ccttctttta gaagagttcg atctggcagt ggtatatctg
     1201 tcataagctc aacatctgta gatcagaggc taccagagga accagtttta gaagatgaac
     1261 aacaacaatt agaaaagaaa ttacctgtaa cgtttgaaga taagaagcgg gagaactttg
     1321 aacgtggcaa cctggaactg gagaaacgaa ggcaagctct cctggaacag cagcgcaagg
     1381 agcaggagcg cctggcccag ctggagcggg cggagcagga gaggaaggag cgtgagcgcc
     1441 aggagcaaga gcgcaaaaga caactggaac tggagaagca actggaaaag cagcgggagc
     1501 tagaacggca gagagaggag gagaggagga aagaaattga gaggcgagag gctgcaaaac
     1561 gggaacttga aaggcaacga caacttgagt gggaacggaa tcgaaggcaa gaactactaa
     1621 atcaaagaaa caaagaacaa gaggacatag ttgtactgaa agcaaagaaa aagactttgg
     1681 aatttgaatt agaagctcta aatgataaaa agcatcaact agaagggaaa cttcaagata
     1741 tcagatgtcg attgaccacc caaaggcaag aaattgagag cacaaacaaa tctagagagt
     1801 tgagaattgc cgaaatcacc catctacagc aacaattaca ggaatctcag caaatgcttg
     1861 gaagacttat tccagaaaaa cagatactca atgaccaatt aaaacaagtt cagcagaaca
     1921 gtttgcacag agattcactt gttacactta aaagagcctt agaagcaaaa gaactagctc
     1981 ggcagcacct acgagaccaa ctggatgaag tggagaaaga aactagatca aaactacagg
     2041 agattgatat tttcaataat cagctgaagg aactaagaga aatacacaat aagcaacaac
     2101 tccagaagca aaagtccatg gaggctgaac gactgaaaca gaaagaacaa gaacgaaaga
     2161 tcatagaatt agaaaaacaa aaagaagaag cccaaagacg agctcaggaa agggacaagc
     2221 agtggctgga gcatgtgcag caggaggacg agcatcagag accaagaaaa ctccacgaag
     2281 aggaaaaact gaaaagggag gagagtgtca aaaagaagga tggcgaggaa aaaggcaaac
     2341 aggaagcaca agacaagctg ggtcggcttt tccatcaaca ccaagaacca gctaagccag
     2401 ctgtccaggc accctggtcc actgcagaaa aaggtccact taccatttct gcacaggaaa
     2461 atgtaaaagt ggtgtattac cgggcactgt acccctttga atccagaagc catgatgaaa
     2521 tcactatcca gccaggagac atagtcatgg ttaaagggga atgggtggat gaaagccaaa
     2581 ctggagaacc cggctggctt ggaggagaat taaaaggaaa gacagggtgg ttccctgcaa
     2641 actatgcaga gaaaatccca gaaaatgagg ttcccgctcc agtgaaacca gtgactgatt
     2701 caacatctgc ccctgccccc aaactggcct tgcgtgagac ccccgcccct ttggcagtaa
     2761 cctcttcaga gccctccacg acccctaata actgggccga cttcagctcc acgtggccca
     2821 ccagcacgaa tgagaaacca gaaacggata actgggatgc atgggcagcc cagccctctc
     2881 tcaccgttcc aagtgccggc cagttaaggc agaggtccgc ctttactcca gccacggcca
     2941 ctggctcctc cccgtctcct gtgctaggcc agggtgaaaa ggtggagggg ctacaagctc
     3001 aagccctata tccttggaga gccaaaaaag acaaccactt aaattttaac aaaaatgatg
     3061 tcatcaccgt cctggaacag caagacatgt ggtggtttgg agaagttcaa ggtcagaagg
     3121 gttggttccc caagtcttac gtgaaactca tttcagggcc cataaggaag tctacaagca
     3181 tggattctgg ttcttcagag agtcctgcta gtctaaagcg agtagcctct ccagcagcca
     3241 agccggtcgt ttcgggagaa gaatttattg ccatgtacac ttacgagagt tctgagcaag
     3301 gagatttaac ctttcagcaa ggggatgtga ttttggttac caagaaagat ggtgactggt
     3361 ggacaggaac agtgggcgac aaggccggag tcttcccttc taactatgtg aggcttaaag
     3421 attcagaggg ctctggaact gctgggaaaa cagggagttt aggaaaaaaa cctgaaattg
     3481 cccaggttat tgcctcatac accgccaccg gccccgagca gctcactctc gcccctggtc
     3541 agctgatttt gatccgaaaa aagaacccag gtggatggtg ggaaggagag ctgcaagcac
     3601 gtgggaaaaa gcgccagata ggctggttcc cagctaatta tgtaaagctt ctaagccctg
     3661 ggacgagcaa aatcactcca acagagccac ctaagtcaac agcattagcg gcagtgtgcc
     3721 aggtgattgg gatgtacgac tacaccgcgc agaatgacga tgagctggcc ttcaacaagg
     3781 gccagatcat caacgtcctc aacaaggagg accctgactg gtggaaagga gaagtcaatg
     3841 gacaagtggg gctcttccca tccaattatg tgaagctgac cacagacatg gacccaagcc
     3901 agcaatggtg ttcagactta catctcttgg atatgttgac cccaactgaa agaaagcgac
     3961 aaggatacat ccacgagctc attgtcaccg aggagaacta tgtgaatgac ctgcagctgg
     4021 tcacagagat ttttcaaaaa cccctgatgg agtctgagct gctgacagaa aaagaggttg
     4081 ctatgatttt tgtgaactgg aaggagctga ttatgtgtaa tatcaaacta ctaaaagcgc
     4141 tgagagtccg caagaagatg tccggggaga agatgcctgt gaagatgatt ggagacatcc
     4201 tgagcgcaca gctgccgcac atgcagccct acatccgctt ctgcagccgc cagctcaacg
     4261 gggctgccct gatccagcag aagacggatg aggccccaga cttcaaggag ttcgtcaaaa
     4321 gattggcaat ggatcctcgg tgtaaaggga tgccactctc tagttttata ctgaagccta
     4381 tgcaacgggt aacaagatac ccactgatca ttaaaaatat cctggaaaac acccctgaaa
     4441 accacccgga ccacagccac ttgaagcacg ccctggagaa ggcggaagag ctctgttccc
     4501 aggtgaacga aggggtgcgg gagaaggaga actctgaccg gctggagtgg atccaggccc
     4561 acgtgcagtg tgaaggcctg tctgagcaac ttgtgttcaa ttcagtgacc aattgcttgg
     4621 ggccgcgcaa atttctgcac agtgggaagc tctacaaggc caagagcaac aaggagctgt
     4681 atggcttcct tttcaacgac ttcctcctgc tgactcagat cacgaagcct ttggggtctt
     4741 ctggcaccga caaagtcttc agccccaaat caaacctgca gtataaaatg tataaaacac
     4801 ctattttcct aaatgaggtt ctagtaaaat tacccaccga cccttctgga gacgagccca
     4861 tcttccacat ctcccacatt gaccgcgtct atactctccg agcagaaagc ataaatgaaa
     4921 ggactgcctg ggtgcagaaa atcaaagctg cttctgaact ctacatagag actgagaaaa
     4981 agaagcgcga gaaagcgtac ctggtccgtt cccaaagggc aacaggcatt ggaaggttga
     5041 tggtgaacgt ggttgaaggc atcgagttga aaccctgtcg gtcacatgga aagagcaacc
     5101 cgtactgtga ggtgaccatg ggttcccagt gccacatcac caagacgatc caggacactc
     5161 tgaaccccaa gtggaattcc aactgccagt tcttcatccg agacctggag caggaagtcc
     5221 tctgcatcac tgtgttcgag agggaccagt tctcaccaga tgattttttg ggtcggacgg
     5281 agatccgtgt ggcggacatc aagaaagacc agggctccaa aggtccagtt acgaagtgtc
     5341 ttctgctgca cgaagtcccc acgggagaga ttgtggtccg cttggacctg cagttgtttg
     5401 atgagccgta ggcagcgggc tcagggtgtg ctcagcaggg tcccagccca cggccacaca
     5461 tgctgtctgg aaattgtatt ccttttctaa gaaaccacca tttggtattc agtcacaggg
     5521 atatgggatg gcaaagacag gcccctcaaa gctcctagga atcattctcg acaatcctcc
     5581 ctgccccgaa acaatttcct gtttcatgaa acaaagctgt gttttccttt gtcctcacta
     5641 caggtctcat tatggcttct agggtcgctg aaatcccata gccctcaaca gggtgcagct
     5701 gggagtctag ccccttcccg ggcttgaggg atgggtctgg ttactataaa atagatttat
     5761 aaatgcaatg tctatatttt tggagaactc atgtaaccct cctgtttctt acatccacca
     5821 gtccccaagt agacttcttg gcctacaatg cccagtcctt ggtgtgagtt tagaaacaat
     5881 tatgacggtc ctgtcattgc ttcagaatcc catctctcct gcagggaaat gctgcctaga
     5941 gctgatcact cggtgagacg gtctgatcag gccctggctt agctctttga agagctggtc
     6001 tatggaagtt tccagcatgt gcaccgttat agccgttcct tccccctcta ggccttgtat
     6061 taatatatgt caatgaaaac acactggtgt attgttgcgt ggattcagtt ctgattccca
     6121 gcatgcttag aatatggtca cagaaagtca ttatctagaa agtcacccct ctgctggatc
     6181 agatcactac aggtcactgg aaaggcaact ttacaatgtt gggtcactgg gtctcggttg
     6241 gcagccatgt tggaaaaatc tcttttggct cggaggcctg tgatatttca tagcagcagt
     6301 cgttgctggt gacctgttct gtgcttgaat gtgctgaatc ctgattgttg taggacattt
     6361 caacagctct ttttggtacg ttccccaaaa agccatgtcc tagatcccca aggcgtgaaa
     6421 aggaaaaata tcaagctgga ggttgggaaa gaaaatgaag gcagtccatt atgtggtggg
     6481 tgaaagaccc taggaggatg caagccccgc acatcccggg gcaaagacct aagacacttt
     6541 tccaccctcc accaccccaa cctcacataa tatgcttgtt gcaagagtca ggactttatg
     6601 actatgtgcc aagctgtttg gtttgagttc tttaattttt ttttccctta aatgccagga
     6661 gatcatctgg ttagttagat agtaacttga tttgctaatg aaaagtgggg gccgtgtttt
     6721 gtttgcatgt taatattctc ataatcctag tttgttgtgg tcatgaaatg tcctttgcat
     6781 gttctgttgg tactggagtc tagctttcct gtactagatg gtgttctctt tgattgtagg
     6841 tccttagact ttaattaggg ttatcaaagt gctttctaaa tgatagcatc agcgttgtgg
     6901 cagagtacct cctttgctgg gaactgaatg tgtagtgtta tcatttccca tgagagcccg
     6961 gtcatacttc aagcaatttt tttaaaagtg tgtgttggaa aggacaacaa agtttacatt
     7021 tcatactttt aagaaatact ttattattta tttattgaag atagtgtaga attttgtatc
     7081 aagaacaaca gacataagta ttttttgaaa caagcaaata taccctgtag ttagaaactt
     7141 tcaactgaac atgttagaga ccaagtttaa cttcaggcat gcatttgttt accatttccc
     7201 agcagaaaac atggttaaaa tactttaagt ttatattttt tgatgttgtt aagaaacttt
     7261 taaattaaat ctataaatag acatgcaact catgctttcc tatttctata accaacaccg
     7321 tttgtttagt gtatttatga aagatatgct accatggtag aaagaaaagt attcaatgtg
     7381 taaatggggt agtgtgggtc accattccga tctctttttg ttttctgtcc tgtcttttct
     7441 tcattgactt tatttgcgtg ttaatgttgg acatcattgt tcatgtaggt agcgtatggt
     7501 atgcacaatg acaaacaatc gttttaggtc ccaggtcacc cactcatagt gtcctattat
     7561 tggaattaat gtagcatgag aaagcaatat gtgactcttt ttcctcaagt gactctgttg
     7621 agcatccttg agatgctcct gccatgtagc aagttctgga ttagtgtcct tgtatttact
     7681 ggtgtaattt gtaatgtaac caattgtccg tatggaggag tcgggctggc cctcggaccc
     7741 agctgtgatt catgagttgt gtcacaggga ttgagaaaca tgggtgatgc atggagtctc
     7801 aaaccattgg gcctctctgt tccttcacct ctaccttctt gaccacctgg gctatatttc
     7861 atagaaatta aatgctcctt gccaacaagg agtctgtctc ctagctcttt gttttctaaa
     7921 tataggagtt ctctaggcca ctgcatcccg gcatcctgat cccagccttt tagacacccc
     7981 tgcaagcgtt cctctgctct gagccacact gctagcttct cctgcacact ctgatctcct
     8041 ttagcccaag aaggggctgt gctggtcata gggttatgct gtaaccctca gtcttccctg
     8101 agaactgaac tatcctggga cctcttgggc tgagccttct tcacagagca gttctctaga
     8161 aggcagagtc cacatcctgg tccctctggg gcagggcctg tctggctgct ggcatcaccc
     8221 tggcaggtgg atggacagca tcatctcctg gaaccaggtt tgctgtgacc atgagagcct
     8281 gaagatgtgg ctcattcgga tccaggcctg gactaatctg gaaagaggga ctttctaggt
     8341 gcaggtcacc agggatgctt gagaaactag agccagactt ccttgtttgt ttggataata
     8401 tgtccctgtc ctctgatagc agaggaaaga gctctgctcc caaagaacat tcatgtaaga
     8461 ggaggcattt ttttcttctt tgcttttttt aaacaaccta aagtatgacc taagtgtatg
     8521 aaactaactg atttctttgg gtagagtagc cctgaattta actggggaaa aaatcccatc
     8581 agactatgag taaattgacc acccacatta agtcttatct cggtgacctg gtaccaaagc
     8641 ccaggtgtcc tccaggggag tattctgggg tggcaggggg attaggtgct agcgccagca
     8701 gggaaggaca cttgcaggtc tgccttccaa ggctaagcag gccggctgtc tctccaggaa
     8761 ctggctagga caagtgtaaa gccactgacc acacagaacc aggatgttct agaatctgat
     8821 ggggctgaag atgaagggag aaatggacaa ggcacttctg gctttattga aaaggtgaag
     8881 ctcttggagt atattttaga gtaggccagt accttgtata agcagaaaaa gacttctcta
     8941 tctccactcc aagtcgtttt tttctagttg attgggcctt tttgattgat aagaagaaaa
     9001 tgtgttttgt acgtgtaaca actttaagaa tttccattgg aaacaaagta tgatttgatt
     9061 tgatttgatt tctaagttct cccttccttt tcaaggttag cgatgtgctt tatagcagac
     9121 actagcactt ttacatgaat acctggtgtg ctttggatgt aacagggtca ttttgggctc
     9181 gaggtgagtg tgcaattagc agcaggtctg cttggtccag atatgcttgt ttacaagttt
     9241 agagcatcct atgccagaaa gtgagatgaa aacaaaggca cctggattgc tttgttttgc
     9301 ttttagataa aagagcttta gctcacacca ggcagaagca taaccagtag ccccagaaac
     9361 cggtagcatg atgaagccct cagacagtat agtctgagcc accataagag gcattaggga
     9421 aaactaacac ctccttcttt ttgcaccgtg gggtgctgaa attcctgcta gagacttccc
     9481 cttacttcca tgaatggccc aggggctgct tagtatatca ttagaatgtt cattctcctc
     9541 cttttccctg gagtggacca gtgagaccaa atgcttgtgt ttctctatgt tttcagttca
     9601 tttgttcaaa tgacccagaa gatgaatcca tttctgggaa ggctgagctc agatgaggat
     9661 tgctaggcca gcctaggttc tggggcggat ctcagggaca gaaacaggct tgtattaagt
     9721 atgagtggca ggtacttctc tagaacagcc ctaacctgca ctagtgaggg gggctcagga
     9781 attcccatga cattgatcta gcagcctcct gcacgtagac actcagttca ttttagggac
     9841 gttcaatgct tgatcaaatg gggggcattt tctttctttc tttttttccc cagctacagt
     9901 gtaattgcct acctgcctgg gccccttcta gaggaaggtg ggctttcctt gtccgtcagg
     9961 ctgcactcat gaggtgatat cgtaaagcag cagaaagact gagggtgcaa agaaaccaca
    10021 gctgccattc acggggcagc tccctctagc tcttctgccc agtgacctta caggctttag
    10081 aggagcctga tgagagctat cctgggggcc aagggatgca ttccctgcag cttcctcctg
    10141 ggggacccac aggtcagccc attccaggag aagcagtctt aggcccgttt gcatcccctg
    10201 ccactgccat gtgcctgcca gcccggtttc tgatgaagac gtggctcagt ccctgctctc
    10261 cttgtcgcag tggcttgtac ttcatgtgca gtagcccagg gcccgccttc tagagtgaat
    10321 gtttccctcg agcccttgga tatttttatt ctattttgaa tggttccgat caattaatgt
    10381 tgctttgtgt ggggttcttc agagaaataa tgcaaaccgg ccaggtgcgg tggctcacac
    10441 ctgtaatccc aacactttga ggggctgagg caggtggatc acctgaggtc aggagttcga
    10501 gaacagcctg gccaacgtgg cgaaaccttg tctctactaa aaatacaaaa attagccagg
    10561 ggtggtggca ggcacctgta atcccagcta ctcaggaggc tgaggcagga gaatcactcg
    10621 aacctgggag gcggaggttg cagtgagccg agatcacgcc actgcactcc agcctgggta
    10681 acagagcgag agtccttctc aaaacaaaca aaaaaagagc taatgcagac ctcttctggt
    10741 tagacctgac acggaggaag taattggctg gtcaacttaa tggcgcccca cagcttcctc
    10801 tggatcctgc ttctttgtac ttggaacaca gtttatttga gctagaggaa aggaaagttc
    10861 tagaattcct gtttcctcag cctgcactgt atcagatcca ggatatgtct gcatttcatc
    10921 aggatcaagt aagatacata accttatatc tgtaggagcc agaaaaaaaa aaatctattc
    10981 ctgataggca tggaaactta gtccacatga aagacagaag acatctaaca gctgtctgtc
    11041 ttgggagcat taaaacccag acaccaagac acactagaca gtccatctct gggttgtgat
    11101 ctctcagaaa catcttagta gttaatgcac tgttcattta gggagtcccc atcctggtcc
    11161 aggccaccct cctagaagct gggcggcagc tggacgggcc tgccttggtg gcattcaagc
    11221 aagcctaatt ggattaggtt ggtgcaaaag tgattgcggt ttttgccatt gcttttgatg
    11281 gcaaactaac tttaagtcat taaaataaga cccaacgctt ataaaagagt tcatatccac
    11341 ctcccaataa cttctttagt tccatgcagc ctcaatcagt tcctccattc aaaggaaccc
    11401 tctttaccct ggccctgggg gagccatatt acacccacat cataattttt ctgacactat
    11461 gtgtgcttgt caaatttcag ggtcagtttc cccttattgg atgtcagggg tgttttgtga
    11521 gttgtgtttt aataggattc tgttcgattt tctataccag cctatattgt tactatcatc
    11581 tgcctagtat gaatatttta gtattcaaag cccaccagat aaagctgtgt tcagaagtgg
    11641 actttttggt cagccttgaa aaaaaaaaaa tcagcatttc tctgatattt cctgaggatt
    11701 aaccagaaac taaggtttct ttttaggcag tggtaagaat gcgtattttc ttcttccaga
    11761 agttctggtt ttatactttt atcttttgaa agaataacat tcctgtgcga ctctgcttct
    11821 cttcgctttt gcatttctct tttttaactc aaatctctta tttcctgccg ttcctgtatc
    11881 taaacagaat gggggcctca ggcagacagg aaccaaagaa agggtgtagt ggctttgcag
    11941 cgttgggtga gcagcagccg ctgccattct gtgcactgtc accggcgggg gtggagggtc
    12001 tccctgtagg aggaggaaac tcgctgtttt cactggcaga tttcaaggtg ccggctccac
    12061 ctaccgcagc tgctaggcat tgctcttgtg tagatcgcag aaggagttat tggtgatgtg
    12121 gggtgtaggg gaagacagga aaacggactc agagctagga atgtgggcct ggcagagacc
    12181 gaaggctggg tgggaaggaa gctcgcggcg agcctagggt tcaagcctag cgcgccaggg
    12241 gtctccagtg agaccttgct cttccctgcc gctgaggctg gggctgcacg gaggtcctca
    12301 ggcttcccac cctttctgca tcagctttag tgtctgtcgg ctgggtggac tgcagggcag
    12361 gtgacctgga ggaggccctg ctccccagca agcgttctag gagttacggt gtgctctatt
    12421 gggattggat tacagtctct acttgtagac tttgacttct ggaattttag gtggaaggga
    12481 atttttgttg gtgggacgca gcagctcagt gcgtggtgtg tgcatgcgtg tttgtgcgtg
    12541 cgtgtgcatg tatgtgtttg tgcgtgcacg tgtgcgtgtg tgtgcatggg tttgcgtgca
    12601 tgcatgtgtg tgcgtgcgcg tgtttgtgtg tgcatgtgtg tgtgtctacg tgtgtgtgca
    12661 cgcatgtgtg tgcgtgtatg tgtgcgtgtg tgcatgtttg tgagtgcatg tgtttgtgcg
    12721 tgtgtgcgta tttgtgtgtg tgcgtgtgtg tgcgtgtgta tgtgcgtgta tgcatgtgca
    12781 tgtttgtgtg tgcgtgcata tgtgtatgtg tgtgcgcgtg cgtgtgcgtg catgtgtgcg
    12841 catgcgtgtg tacctaccca cacctagggg gatgcatggc tctgtgcctt ggagagggaa
    12901 acaggaaata cgttgctcca cagtcctgtc atcctggtca ggactagtcg cgtggtttgc
    12961 ggacagagtg caaaatgaaa atgcgaggcc ccttgttcag gtgatgaagc atttctagac
    13021 agtgagagga gagcattaag ccaagctcag gtcccttctg agtgcatagc cccttgtggc
    13081 tgccaggcag cacacccagg aggccggccc tgaccacact gttctctgct ggttcccgaa
    13141 gctgatgggc tctgtcttag gtcttcttac tttgaaaggt ctcccggcag gctgtggcaa
    13201 gctgcgcgga tacacttttc taaacgtctg catttatttc ctaaaagcac aaatggcctg
    13261 gactagctag tgggtgtgga accgagcccc tagttcacag ctgtacccca aggctggaga
    13321 gggggttgcc ggtggtggca ggagctctgg gctcccagtt caggatgggc cacagggcgt
    13381 caagcagctg tgagccttta ccattgagct cactgcttgg aaataaaacc cttcctctgg
    13441 gccttgggca tccactggga gcttttctcc cctttcctgg gaggacagca agccttttcc
    13501 aaccttctgc cttcaaagag aagcagggtc atagaagtgc tcagtgtccc ttccccagtg
    13561 gctggacact tgctcctcca gccttcaccc cctggagaga aggggagtct gcggagccag
    13621 tgcctccctg cccagctggg ccacacgatc tggtctgcgg gtgtctggga ggaacctgct
    13681 tcggagaggc tgcgacctcc cagctagact ctccccttag gatcccatgt atggggatgg
    13741 taggagagaa aagatccctc tgtgtaagta gcctcaagtt ctagaagacc atggccccgg
    13801 gaggcagctg accatgaagc tgggcttcct gttgttgctt tctttcacga gcttttactt
    13861 ttcctgggct ggacgctcca aaatgtttgc agttccattt gctttttgca agtaggtccc
    13921 catctccata tacattgagc aataatcctc actatgtttc ctgattctgt ctgggattat
    13981 atttgctaag taaaaatgtt gacagaaatt gcaaactcat ctcacctgga tttgattgag
    14041 tcaccttgaa tgacataaca aattatggct ttgttttcat gcgtcatgca atcttccgga
    14101 ctacgggaag ttctgcaagt gttctccagg ggcatttcat taatagcgtg tcagcattag
    14161 ttttaatgaa tgaacatttg aggtacattc tataaatcaa tatccttaaa atgtcatctg
    14221 ctaaacattc actgtgacag aaagtagata ttttagcaag atctatgtta atgctactta
    14281 attttagaca tgcatttaaa gcctacatgg ccaatagccc aagtatcttt gaactgtgaa
    14341 atcaacctca gatctcatct gctgtagccc cgcaagccgg agtctgtgcc ctccatgacc
    14401 cttcttatcc cttggtggcc ctgcatagat aggggagttg gcccctgccc accccgtgtt
    14461 gtattgcctt agctccatca gctttgtacc ctcacacgta taggtggtga acttatgtgt
    14521 aaatacatgt gtacagatga gaaactgcaa caaaaatgtc ctgtggatga taatcagctc
    14581 agtttccggt tttctacatt ctgtgctgtt tccagctaag aaaaaggcga actcccacta
    14641 tataaaggga aaaggttgta ttcatttcat gttcctcatg aaatctctgc tgtatgttta
    14701 tggaatggcc atgactaaat gtatatatgg tatgtaagag gccatgctgt taaatgttgc
    14761 ataaactaac acagattctg tagtcaaaaa tatttaactt gttattgtaa aatgtgattt
    14821 gtcattgaga gattattttt ctgtatgtat atgagagtat tttaggaatc taatttaagt
    14881 gcataaaact atagaaaaaa atttaaaacc tattccaaga gtagaaaatg cttaatgaga
    14941 ttacttgggt tcaactcaac taaatttctt atattaaaaa aaaattccaa gttgtatatg
    15001 ttagaaatca aatgagtcat tttttttcct gcaggaaata tgataaattt cagtgtaatg
    15061 gatggtggcg tgatcaaatg aaaagtatcc tgtagctatg acctcgcatg ggaccttggt
    15121 gttgcattaa aaatggattt ttgcagatca catatctgag agggtacttg tgtcaggaag
    15181 gatgagagga tagggagcct gtttttcatc agatccatgt gccacgcagg cttccttggg
    15241 ttctagtgga tttgttaggg atctggggct gacgcagcta tcccactaga gaggccactc
    15301 tctgacttcc aggtcgccct ttctacttct gtatctggat tgattcagtt tatccctaat
    15361 tagcgtttgc gttttccatg aaatttcctg atgcatcctc actgtcttca actgttgcat
    15421 agccaggtgg gtggatggat ggtttagggt ttctgagtta agccgttttg gggcaggctt
    15481 ctggatgccc atgtttccat ggagacccca gggggaagat gccttcctcc cgtctgcatt
    15541 cccagaaaag gatcagaagt ccaggctgct tctggggcac agactttctg tacttggcca
    15601 ccagaagtgc cccttaggcc acctaaggag gattctgtga aactcaatgt ctaaacccct
    15661 gagaaaggca ttcagaaatg atttcaggag ggggcaaccc caggagtcca gcctcccctg
    15721 gcagcctgga aatactgcag taacaaaaag agctggtttc tggtgatctg aatgcattgt
    15781 gtttgggggt gacaccgctg gtggaaggtt gagggcctgt ggtctgaaaa gacatctgaa
    15841 gaatgtgtta ggttttcaac atttctttga acaggctgcg tgcatcttaa tgctgtcaac
    15901 cagcaactgg agcccctttt ttgagaggcc cgaaccagta aagctgctga cttcaggagt
    15961 atgggaagct gtgatttctg gaagcttcct ggaatctatt taggtgcatg aataatctgc
    16021 aaatcactta gaggcactgt ccatgtggtc cataactggc tttattccca aagatggagc
    16081 tgttcagaga tttctttgtt caggcgcagc cttggaaggc cacctaaggc ctgccagcag
    16141 aggagatgag ctctggtcta ccaaccccaa acaggccctg actctccttc cttagaacga
    16201 tgccctctgg ctggggtggc aagagggctg tgagtggaaa caagtcagcc agtcaactgt
    16261 cccttgggcc ttggttgttt caaaaaagtc tggggacaag aaaagctaga acatggggcc
    16321 ctcccttccc aggagtgcta gcgaaccctc ccagatagcc tttgcctgtt tggaaaagaa
    16381 tgtaatccat cagaacgtga gctccttgtg cttccagtga caagcgggcc acagtgctgg
    16441 tggcatgttg cttccctcac agccctgccc aggggtagga ccaggcccgc cccttgatgg
    16501 atgtgctgtt gattgtaata tacttctgtt gccaaataat ggtactgttt aattttccat
    16561 aaaagagaga ctatattgtc tgatatgtaa tgttaatgga attctaagaa ttactagaca
    16621 ctattataaa ttgtagactt acgtatttgt ctaaaggttt gatgaagcag ggccaaaaca
    16681 ttgtttcttc ttttttgttt gaaagaagct gaggtttgtt tttgctgttt gagtgttcct
    16741 ttggcaactt attatgtgtg aaatgttaaa ttttaccgat taagatgatg gtaactgaga
    16801 cctttcttta aaccagtagc aacatcagta caaattgctc ttcctgtgta tcttgaacct
    16861 aaaaagaaca atctcttcaa aaacaaaaac aaaaacaaaa aacaactctt tggtcatttt
    16921 gacctgtgtg gtttaaattc aaatagttca tgaataaaag gagaaaagcc aa
//
