LOCUS       NM_001163523            1961 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens ITPRIP like 1 (ITPRIPL1), transcript variant 3, mRNA.
ACCESSION   NM_001163523
VERSION     NM_001163523.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Deng,S., Zhang,Y., Wang,H., Liang,W., Xie,L., Li,N., Fang,Y.,
            Wang,Y., Liu,J., Chi,H., Sun,Y., Ye,R., Shan,L., Shi,J., Shen,Z.,
            Wang,Y., Wang,S., Brosseau,J.P., Wang,F., Liu,G., Quan,Y. and Xu,J.
  TITLE     ITPRIPL1 binds CD3epsilon to impede T cell activation and enable
            tumor immune evasion
  JOURNAL   Cell 187 (9), 2305-2323 (2024)
   PUBMED   38614099
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1961)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1961)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021188.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001163523.1.
            
            Transcript Variant: This variant (3) represents use of an alternate
            promoter and 5' UTR and uses a downstream start codon, compared to
            variant 1. The resulting isoform (3) has a shorter N-terminus,
            compared to isoform 1. Variants 3, 4, and 5 all encode the same
            isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.16425.1,
                                           SRR11853559.18864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC021188.6         59737-59985
            250-1961            AC021188.6         61062-62773
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1961
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /note="ITPRIP like 1"
                     /db_xref="GeneID:150771"
                     /db_xref="HGNC:HGNC:29371"
                     /db_xref="MIM:620821"
     exon            1..249
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /inference="alignment:Splign:2.1.0"
     exon            250..1961
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1907
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /note="isoform 3 is encoded by transcript variant 3;
                     inositol 1,4,5-trisphosphate receptor interacting
                     protein-like 1; inositol 1,4,5-triphosphate
                     receptor-interacting protein-like 1; DANGER family member
                     1B"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate
                     receptor-interacting protein-like 1 isoform 3"
                     /protein_id="NP_001156995.1"
                     /db_xref="CCDS:CCDS54378.1"
                     /db_xref="GeneID:150771"
                     /db_xref="HGNC:HGNC:29371"
                     /db_xref="MIM:620821"
                     /translation="MAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEM
                     RLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLG
                     NLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEAL
                     DSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKW
                     GTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLC
                     LVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLS
                     LPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVA
                     CEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLL
                     RLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPV
                     NLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP"
ORIGIN      
        1 ggacggcggg agcggctgcg gcgcgcgggc gccctcggag ccgcgtgctg ggggtcgtag
       61 gggcccaccg cgctcagcca gacgttcaga cgctcggaca agcatggtct ataacccagg
      121 aaaggggagc agggccactc ccgcgggcgg ccccagcgat gaaccggacg cccccaccct
      181 gccgggaaaa aagcagtggc ggtcaggccg cgctgtctct ttaagatcgt gttcctacta
      241 acactgacga tgcagaggcc tccatggctg tgataagcct gctgttcttg gcagtgatgt
      301 atgttgttca ccaccctctg atggtcagtg atcggatgga cctggacaca ttagccagga
      361 gtcggcagct ggagaagcga atgagtgagg agatgcgcct gctagagatg gagtttgaag
      421 agagaaagcg agccgctgag cagaggcaga aggcagagaa cttctggaca ggagacacat
      481 ccagtgacca gttagtgctg gggaagaaag acatggggtg gccgttccag gccgatggcc
      541 aggaagggcc tctgggctgg atgctgggaa acctgtggaa cactggcctc ttttgccttt
      601 ttctcgtctt tgagctcctg cgacagaaca tgcagcatga accggccttt gattccagca
      661 gtgaggagga ggaggaggaa gtccgtgttg tccctgtcac ctcttacaac tggcttactg
      721 acttcccctc ccaggaggcc ctggactcct tttacaaaca ctatgtccaa aatgccatcc
      781 gtgacctgcc ctgcacctgt gagtttgtgg agagttttgt ggatgatctc attgaggcct
      841 gtcgggtgct cagccgccaa gaggctcacc cacaattgga agactgcctg ggcatcgggg
      901 ctgcctttga gaaatgggga accctccatg agacccagaa atttgatatc ctggtgccca
      961 ttgtcccccc acagggcacc atgtttgtcc tggagatgag ggacccagcc ctgggccgcc
     1021 gctgtggctg tgtgctggtg gagtcagaat gtgtgtgcaa gcgtgagaaa ctcctagggg
     1081 acgtgctgtg cctggtgcac caccacaggg acccctcggc agtcttgggg aagtgtagta
     1141 gctccatcaa ggcagctctc tgcaccggct tccacctaga cgtgtgcaag actgtgcagt
     1201 ggttccggaa catgatgggc aatgcctggg cccttgtggc ccacaagtat gactttaaac
     1261 tcagtctccc accgtctacc acctcctgca agctccggct ggactatcgc tcaggccgct
     1321 ttctctcaat ccacttggtc ctgggggtgc aacgagaaga caccttggtc tacctggtga
     1381 gtcaggctcc tgaccaggag cagctcacca gtgtggactg gcctgagtcc tttgtggcct
     1441 gtgagcacct gttcctgaag ctggtggggc gctttgcccc cgagaacacc tgtcacctca
     1501 agtgcctcca gatcatttta agtctccggc agcatcagag cttaccccat ggagcatccc
     1561 gccccatcct cacttcttac cattttaaaa cagctctcat gcacctcttg ctacggctgc
     1621 ccctcacgga ctgggcccac aacatgctct ctcagcggct ccaggacatt ctctggttct
     1681 tgggccgtgg cctccagcaa aggtccctcc atcatttcct cattggtaac aattttctgc
     1741 ccctgaccat cccaatccct aagacattta ggaatgctga gccggtcaat ctcttccaac
     1801 acctggtgct caaccccaag gcacattcac aggcagtgga agagttccaa aaccttctga
     1861 cccaggtgaa aactctgcct catgccccac tggctgcagc accttgatgt aaagaccatt
     1921 aaaaaaaaaa cagaggaagg tatttctaat tccttgggct a
//
