LOCUS       NM_001008949            2064 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens ITPRIP like 1 (ITPRIPL1), transcript variant 2, mRNA.
ACCESSION   NM_001008949
VERSION     NM_001008949.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Deng,S., Zhang,Y., Wang,H., Liang,W., Xie,L., Li,N., Fang,Y.,
            Wang,Y., Liu,J., Chi,H., Sun,Y., Ye,R., Shan,L., Shi,J., Shen,Z.,
            Wang,Y., Wang,S., Brosseau,J.P., Wang,F., Liu,G., Quan,Y. and Xu,J.
  TITLE     ITPRIPL1 binds CD3epsilon to impede T cell activation and enable
            tumor immune evasion
  JOURNAL   Cell 187 (9), 2305-2323 (2024)
   PUBMED   38614099
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021188.6, CN263466.1, BC073153.1 and R37132.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001008949.2.
            
            Transcript Variant: This variant (2) has an alternate 5' sequence,
            as compared to variant 1. The encoded isoform 2 has a distinct and
            shorter N-terminus, as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073153.1, HY087646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439118.3/ ENSP00000389308.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC021188.6         59737-59743
            8-256               CN263466.1         33-281
            257-257             AC021188.6         60174-60174
            258-2037            BC073153.1         167-1946
            2038-2064           R37132.1           12-38               c
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2064
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /note="ITPRIP like 1"
                     /db_xref="GeneID:150771"
                     /db_xref="HGNC:HGNC:29371"
                     /db_xref="MIM:620821"
     exon            1..249
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /inference="alignment:Splign:2.1.0"
     exon            250..352
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..2010
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     inositol 1,4,5-trisphosphate receptor interacting
                     protein-like 1; inositol 1,4,5-triphosphate
                     receptor-interacting protein-like 1; DANGER family member
                     1B"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate
                     receptor-interacting protein-like 1 isoform 2"
                     /protein_id="NP_001008949.1"
                     /db_xref="CCDS:CCDS46360.1"
                     /db_xref="GeneID:150771"
                     /db_xref="HGNC:HGNC:29371"
                     /db_xref="MIM:620821"
                     /translation="MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQL
                     EKRMSEEMRLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQE
                     GPLGWMLGNLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLT
                     DFPSQEALDSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLG
                     IGAAFEKWGTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKRE
                     KLLGDVLCLVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVA
                     HKYDFKLSLPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSV
                     DWPESFVACEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFK
                     TALMHLLLRLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPK
                     TFRNAEPVNLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP"
     exon            353..2064
                     /gene="ITPRIPL1"
                     /gene_synonym="D1B; KIAA1754L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacggcggg agcggctgcg gcgcgcgggc gccctcggag ccgcgtgctg ggggtcgtag
       61 gggcccaccg cgctcagcca gacgttcaga cgctcggaca agcatggtct ataacccagg
      121 aaaggggagc agggccactc ccgcgggcgg ccccagcgat gaaccggacg cccccaccct
      181 gccgggaaaa aagcagtggc ggtcaggccg cgctgtctct ttaagatcgt gttcctacta
      241 acactgacgg gctcctagag agggcgggga gacgaagcaa ggccaagttc caaagggagg
      301 ataggcccag ctggcttcag cgtccacacg gcatagtcct tcatgaatgt tgatgcagag
      361 gcctccatgg ctgtgataag cctgctgttc ttggcagtga tgtatgttgt tcaccaccct
      421 ctgatggtca gtgatcggat ggacctggac acattagcca ggagtcggca gctggagaag
      481 cgaatgagtg aggagatgcg cctgctagag atggagtttg aagagagaaa gcgagccgct
      541 gagcagaggc agaaggcaga gaacttctgg acaggagaca catccagtga ccagttagtg
      601 ctggggaaga aagacatggg gtggccgttc caggccgatg gccaggaagg gcctctgggc
      661 tggatgctgg gaaacctgtg gaacactggc ctcttttgcc tttttctcgt ctttgagctc
      721 ctgcgacaga acatgcagca tgaaccggcc tttgattcca gcagtgagga ggaggaggag
      781 gaagtccgtg ttgtccctgt cacctcttac aactggctta ctgacttccc ctcccaggag
      841 gccctggact ccttttacaa acactatgtc caaaatgcca tccgtgacct gccctgcacc
      901 tgtgagtttg tggagagttt tgtggatgat ctcattgagg cctgtcgggt gctcagccgc
      961 caagaggctc acccacaatt ggaagactgc ctgggcatcg gggctgcctt tgagaaatgg
     1021 ggaaccctcc atgagaccca gaaatttgat atcctggtgc ccattgtccc cccacagggc
     1081 accatgtttg tcctggagat gagggaccca gccctgggcc gccgctgtgg ctgtgtgctg
     1141 gtggagtcag aatgtgtgtg caagcgtgag aaactcctag gggacgtgct gtgcctggtg
     1201 caccaccaca gggacccctc ggcagtcttg gggaagtgta gtagctccat caaggcagct
     1261 ctctgcaccg gcttccacct agacgtgtgc aagactgtgc agtggttccg gaacatgatg
     1321 ggcaatgcct gggcccttgt ggcccacaag tatgacttta aactcagtct cccaccgtct
     1381 accacctcct gcaagctccg gctggactat cgctcaggcc gctttctctc aatccacttg
     1441 gtcctggggg tgcaacgaga agacaccttg gtctacctgg tgagtcaggc tcctgaccag
     1501 gagcagctca ccagtgtgga ctggcctgag tcctttgtgg cctgtgagca cctgttcctg
     1561 aagctggtgg ggcgctttgc ccccgagaac acctgtcacc tcaagtgcct ccagatcatt
     1621 ttaagtctcc ggcagcatca gagcttaccc catggagcat cccgccccat cctcacttct
     1681 taccatttta aaacagctct catgcacctc ttgctacggc tgcccctcac ggactgggcc
     1741 cacaacatgc tctctcagcg gctccaggac attctctggt tcttgggccg tggcctccag
     1801 caaaggtccc tccatcattt cctcattggt aacaattttc tgcccctgac catcccaatc
     1861 cctaagacat ttaggaatgc tgagccggtc aatctcttcc aacacctggt gctcaacccc
     1921 aaggcacatt cacaggcagt ggaagagttc caaaaccttc tgacccaggt gaaaactctg
     1981 cctcatgccc cactggctgc agcaccttga tgtaaagacc attaaaaaaa aaacagagga
     2041 aggtatttct aattccttgg gcta
//
