LOCUS       NM_001272013            6585 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor interacting
            protein (ITPRIP), transcript variant 3, mRNA.
ACCESSION   NM_001272013
VERSION     NM_001272013.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6585)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6585)
  AUTHORS   Cao,C., He,K., Li,S., Ge,Q., Liu,L., Zhang,Z., Zhang,H., Wang,X.,
            Sun,X. and Ding,L.
  TITLE     ITPRIP promotes glioma progression by linking MYL9 to DAPK1
            inhibition
  JOURNAL   Cell Signal 85, 110062 (2021)
   PUBMED   34111521
  REMARK    GeneRIF: ITPRIP promotes glioma progression by linking MYL9 to
            DAPK1 inhibition.
REFERENCE   3  (bases 1 to 6585)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6585)
  AUTHORS   Xie,Q., Chen,S., Tian,R., Huang,X., Deng,R., Xue,B., Qin,Y., Xu,Y.,
            Wang,J., Guo,M., Chen,J., Tang,S., Li,G. and Zhu,H.
  TITLE     Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune
            Response through Promotion of Oligomerization and Activation of
            MDA5
  JOURNAL   J Virol 92 (17), e00507-18 (2018)
   PUBMED   29899107
  REMARK    GeneRIF: The suggested model of how long noncoding RNAs (lncI)
            TPRIP-1 orchestrates signal transduction for IFN production
            illustrates the essential role of lncRNAs in virus elimination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6585)
  AUTHORS   Kwon,T., Youn,H., Son,B., Kim,D., Seong,K.M., Park,S., Kim,W. and
            Youn,B.
  TITLE     DANGER is involved in high glucose-induced radioresistance through
            inhibiting DAPK-mediated anoikis in non-small cell lung cancer
  JOURNAL   Oncotarget 7 (6), 7193-7206 (2016)
   PUBMED   26769850
  REMARK    GeneRIF: High DANGER expression is involved in high glucose-induced
            radioresistance through inhibiting DAPK-mediated anoikis in
            non-small cell lung cancer.
REFERENCE   6  (bases 1 to 6585)
  AUTHORS   Bhardwaj,G., Ko,K.D., Hong,Y., Zhang,Z., Ho,N.L., Chintapalli,S.V.,
            Kline,L.A., Gotlin,M., Hartranft,D.N., Patterson,M.E., Dave,F.,
            Smith,E.J., Holmes,E.C., Patterson,R.L. and van Rossum,D.B.
  TITLE     PHYRN: a robust method for phylogenetic analysis of highly
            divergent sequences
  JOURNAL   PLoS One 7 (4), e34261 (2012)
   PUBMED   22514627
REFERENCE   7  (bases 1 to 6585)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 6585)
  AUTHORS   Nikolaidis,N., Chalkia,D., Watkins,D.N., Barrow,R.K., Snyder,S.H.,
            van Rossum,D.B. and Patterson,R.L.
  TITLE     Ancient origin of the new developmental superfamily DANGER
  JOURNAL   PLoS One 2 (2), e204 (2007)
   PUBMED   17301879
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6585)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
REFERENCE   10 (bases 1 to 6585)
  AUTHORS   van Rossum,D.B., Patterson,R.L., Cheung,K.H., Barrow,R.K.,
            Syrovatkina,V., Gessell,G.S., Burkholder,S.G., Watkins,D.N.,
            Foskett,J.K. and Snyder,S.H.
  TITLE     DANGER, a novel regulatory protein of inositol
            1,4,5-trisphosphate-receptor activity
  JOURNAL   J Biol Chem 281 (48), 37111-37116 (2006)
   PUBMED   16990268
  REMARK    GeneRIF: DANGER appears to allosterically modulate the sensitivity
            of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated
            Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162742.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001272013.1.
            
            Summary: This gene encodes a membrane-associated protein that binds
            the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded
            protein enhances the sensitivity of ITPR to intracellular calcium
            signaling. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA243255.1, SRR1660805.244758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337478.3/ ENSP00000337178.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AL162742.9         64710-64929         c
            221-6585            AL162742.9         36164-42528         c
FEATURES             Location/Qualifiers
     source          1..6585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1"
     gene            1..6585
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="inositol 1,4,5-trisphosphate receptor interacting
                     protein"
                     /db_xref="GeneID:85450"
                     /db_xref="HGNC:HGNC:29370"
                     /db_xref="MIM:620205"
     exon            1..220
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /inference="alignment:Splign:2.1.0"
     exon            221..6585
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1877
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="inositol 1,4,5-triphosphate receptor-interacting
                     protein; DANGER family member 1A"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate
                     receptor-interacting protein precursor"
                     /protein_id="NP_001258942.1"
                     /db_xref="CCDS:CCDS7557.1"
                     /db_xref="GeneID:85450"
                     /db_xref="HGNC:HGNC:29370"
                     /db_xref="MIM:620205"
                     /translation="MAMGLFRVCLVVVTAIINHPLLFPRENATVPENEEEIIRKMQAH
                     QEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEV
                     WRQDHQEGPSPECLGGEEDELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAART
                     REFLEGFVDDLLEALRSLCNRDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPE
                     PYRFHPELWCSGRSVPLDRQGYGQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSM
                     APPCGDMENLLCATDSLYLDTMQVMKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSL
                     KIKFRSGKFMPFNLIPVIQCDDSDLYFVSHLPREPSEGTPASSTDWLLSFAVYERHFL
                     RTTLKALPEGACHLSCLQIASFLLSKQSRLTGPSGLSSYHLKTALLHLLLLRQAADWK
                     AGQLDARLHELLCFLEKSLLQKKLHHFFIGNRKVPEAMGLPEAVLRAEPLNLFRPFVL
                     QRSLYRKTLDSFYEMLKNAPALISEYSLHVPSDQPTPKS"
     regulatory      4119..4124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="hexamer: ATTAAA"
     regulatory      4131..4136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="hexamer: ATTAAA"
     polyA_site      4147
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="major polyA site"
     polyA_site      4154
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
     regulatory      6566..6571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="hexamer: CATAAA"
     polyA_site      6585
                     /gene="ITPRIP"
                     /gene_synonym="bA127L20; bA127L20.2; D1A; DANGER;
                     KIAA1754"
                     /note="major polyA site"
ORIGIN      
        1 aggaaatgag taactctgaa gttcagtaga gccggccgct gcaggccaga aggtgggagc
       61 cagcgggggc atcgccgccc gcgcccctct aagtgccggg ccgcaagctc caccgcagcc
      121 gcctgcaagc agcggcgcct cggccctcga cctgcgcgca aagcctgtgc tggagccgtc
      181 ctcccgcggc ggggaccggg accggggacc caagccaatc gaaagctcca accatggcca
      241 tggggctctt ccgcgtgtgt ctggtggtgg tgacggccat catcaaccac ccgctgctgt
      301 tcccgcggga gaacgccaca gtccccgaga acgaggagga gatcatccgc aagatgcagg
      361 cgcaccagga gaagctgcag ctggagcagt tgcgcctgga ggaggaggtg gctcggctgg
      421 cggccgaaaa ggaggcactg gagcaggtgg cggaggaggg caggcagcag aacgagacac
      481 gcgtggcctg ggacctctgg agcaccctct gcatgatcct cttcctgatg atcgaggtgt
      541 ggcggcagga ccaccaggag gggccctcac ctgagtgcct gggcggtgag gaggatgagc
      601 tgcctgggct ggggggcgcc cccttgcagg gcctcaccct gcccaacaag gccacgcttg
      661 gccactttta tgagcgctgc atccgggggg ccacggccga tgcagcccgt acccgggagt
      721 tcctggaagg cttcgtggat gacttgctgg aagccctgag gagcctctgc aaccgggaca
      781 ccgacatgga ggtggaggac ttcattggcg tggacagcat gtacgagaac tggcaggtgg
      841 acaggccact gctgtgccac cttttcgtgc ccttcacacc ccccgagccc taccgcttcc
      901 acccagagct ctggtgctcc ggccgctcag tgcccctgga tcgccagggc tacggccaga
      961 tcaaggtggt ccgcgccgat ggggacacat tgagctgcat ctgcggcaag accaagctcg
     1021 gggaagacat gctgtgtctc ctgcacggca ggaacagcat ggcgcctccc tgcggcgaca
     1081 tggagaacct gctgtgtgcc acagattccc tgtacctgga cacgatgcag gtcatgaagt
     1141 ggttccagac ggccctcacc agagcctgga agggcatcgc ccacaagtac gagttcgacc
     1201 tggcctttgg ccagctggac agcccggggt ccctgaagat caagttccgt tcagggaagt
     1261 tcatgccctt caacctgatt cctgtgatcc agtgtgatga ctcggacctg tactttgtct
     1321 cccaccttcc cagggagccc tctgagggca ccccagcctc cagcacagac tggctcctgt
     1381 cctttgctgt ctatgagcga cacttcctca ggacgacact aaaggcactg cccgagggcg
     1441 cctgccacct cagctgcctg cagatagcat ccttcctgct ctccaagcag agccgcctga
     1501 ccggtcccag cgggctcagc agctaccacc tgaagacggc cctactgcac ctcctactcc
     1561 tccggcaggc cgccgactgg aaggcggggc agctggacgc tcgtctgcac gagttgctgt
     1621 gcttcctgga gaagagcttg ctccagaaga agctccacca cttcttcatc ggcaaccgca
     1681 aggtgcctga ggccatggga ctccctgagg ccgtgctcag ggccgagccc ctcaacctct
     1741 tccggccctt cgtcctgcag cgaagccttt accgtaagac actggactcc ttctatgaga
     1801 tgctcaagaa tgccccagcg ctcattagcg agtattccct acatgtcccc tcagaccagc
     1861 ctaccccaaa aagctgacgt cttttacaga atgtgggatc ctcgagctaa gatgagggca
     1921 tccctcacgt tcacacccct ggtggcatct gccagccctg ttctggggac aaggcgggct
     1981 ttcgtgggag ccgtgctcag cctgccagga agccaagccc tacagtgcag aggaaacaga
     2041 atttcaacgg gaagctggtt tgcttcatac cattgggatc tgctggtaaa gctgttattt
     2101 gggtttaggg actgatccct tgcagtttac ttctggatca ccatgaatgg ccaagatggt
     2161 ggcagaacac gctgtggacc ctgagttaga gacaatgcaa atgttggatt gggtgtaatt
     2221 ctttttgaat cccagatcca gtctgtactt gaatatgagc agaggatcta caagaatgct
     2281 gacagggaac cgtgttaaga cccagcaccc ctattcccag gagcttctgg cctgaccatc
     2341 tgcagccaaa gcactaacag ggacagatat gggaatgtcc acctttgatc cgcatcctgc
     2401 acaatagtgg tcccaccatg gctgccactt ttttatacta tttggagaaa agaccttgta
     2461 taaattcgag gcccaaatga ctaacgtctc tgtcacacgg aaatgggtac ttggtggcat
     2521 agagaaacac aattagccac tttttcagct acacttctca ctcagctgca ccctacactt
     2581 ctcactcagg tgcaccccct tctgctgtcc tttccccaac gtactgggtc ccgagcgtgg
     2641 tgggtatttg ccacactggg tgccagctca gcagcccccc acctctcttt attctctcca
     2701 aagctggtct ttctgactat cattgtggta gggggaggac agatgctaaa ggtggaagct
     2761 gacctggaga aagagacaca cggggtgact gtggcaaagg acagctggaa aagaaactct
     2821 atcacttctt cattggcaac cacaaggcac ctgaggccat ggcactccca gaggctgtgc
     2881 gcagagccaa gcctctcaac ctcttctggc cctgcgtcct gcagcgaagt ctctgctgta
     2941 agacagtaga ctccttcgat gaggtgctca aaaatgctac ccggggtggt ggtgtctggc
     3001 ttgcagtctg gcccagttca gagaaagttg cagagatcag gggccaagga tgtcatagcc
     3061 ccaggttgtc ctcagggtcc caatcctagg gcagggtgtg catggaagca agaactatgg
     3121 aaacctagct ccagtctgca ggctctgagc ccctagttcc tcactccagc ggggctccct
     3181 cactgcacag aacccacccc ttctgtgtgg gcactgctga ccacacagat gacccagacc
     3241 caaagagcct ggcagaagct ctgtggttgg agctgggctc cgtctccagg tctggttcag
     3301 ggggatcagg aaggctcttt tccacctgtg gcttcactgg ccctttgaga tttcctatct
     3361 caccgttact tcagttaccc ttgcaggggg ccagggagtc aagaatatac cgtgttcctc
     3421 cagggtttaa gccggccatg ccttcccgag agcataacca acttgacagg ggtgcccagt
     3481 taccccacaa actgaaggaa ggagatcctt cccccatccc caggagtgct ctcaaccagc
     3541 ctcagaaagc ttgagaagat ggaccctttg cccaccaggg ttaattcctg gtggggcagc
     3601 tcggctgtga tcagggcaac caaacctata ggaagccttc cagtgtgagc tggaattaga
     3661 ctgaacatgt gcttgggcct gcctctccct agacgcagtt gcggggcact ccagggaatg
     3721 aaccagctca agtgtgtccc taacagcagc ctggagctac ccccaatccc tcacagcctg
     3781 accctcctca ttccatcaga tgcatttgta gaatcggggc aaatttcctt atttatttat
     3841 ggcccatgcc tttccccctc ttcatcctga tcccgttttg ctttgaagag accccagtaa
     3901 ccaaaaaaca gcctccagaa gccaaaacca tgcctggatc tcccatagct tctcctttgc
     3961 ttccaggaga aagttcactg aaaaaaaaat atcttctggc ttcttgtgtg tacagagaca
     4021 acagaactcg gtggggaaac gggaatcttt tctgcaccaa agctgcttct aaagcagaaa
     4081 gcagtggggc tcttggtgtt tcatgctgcc ttatttatat taaaggaaga attaaatctt
     4141 gcaaggagta gaaatggtca ctgtttgttt ttaacttcag gaaatctgtg aggctcccag
     4201 ggcagagttg gggacagggg ggtggatttc ctattgacaa agcagaagct ttcactccct
     4261 ttttattctt acactttcag gagactttaa aaaataacaa aacagaacat ttctaccctg
     4321 tctttgaggc aacttgtgtg ctgcccgcag ggctccagaa agggcctttg aaagctggct
     4381 gtagggtgga ttccagccta agaccttatt tcacagagct aatgtcagcg agaaatatag
     4441 gagctggaac taacaggaag cttttgggtt ttaaagaaag agattgtatt ttaaatagag
     4501 gattttgagt cctctagggg actttggcct ttccactaag gacaaccctg ccctctttcc
     4561 ccagagtctc tttcccaagg atgcttgact ttccccagca actgctcact tgctttgcaa
     4621 aataacaagg gtgaaatgaa tagagttggc ccctaggcca agaggctggt tatgttgggg
     4681 aagggcctta tatcctcaaa agctctagcc cctctgcatg cctggctgaa gcacagcccc
     4741 cgttgagaac ctgggggtgg agctctggtt catcatcaag ggtgtcatcc gaatcaccca
     4801 gacaacctgg tccattgccc cgaccccgcc ttgaacctac atggtgctca gaatccagtc
     4861 tggagtggtc aggctaggct cgatttttaa agatttcccc caagtgactg atggtacccc
     4921 tagctgagga agccctctca ctttctttct taatggaaag ttaaagaaaa cccaagtgga
     4981 ctactttccc tacagatcta ttggaagata gatagacctg ggaaaagcca atgagcctgc
     5041 ttggaatctg tggtctaagt ggcatcagct acaccacaag cttctcatga gggcacccac
     5101 attcacgcta gtgccgtaag cctcagagag agggtgggaa ggcataagat ggtgagccct
     5161 tctcccaagc aggtcatgaa tagtccacaa gcatttgtca ggagcctaac gtgcatgaga
     5221 cattgtggaa gatgggaaaa tgaataggac caagcctgtt ccctaggaga ggcagcagaa
     5281 ggtggccttc caagtactga gctattccaa gtgtgaccct gcactacaca tacgggtgtc
     5341 acctgggggc agcttcctgg gccgtgtcac agactccagt gggatcctga gaagttaggt
     5401 agaagaatct gcacttcacc aagttcccca cctgattctg gatgtccaag aaccactggt
     5461 acctgggctg attagggaag gcctcatggt ggggcgctgc cagatagaga ctctgaaaaa
     5521 tgaccaggac tgtggccagg aaagacattc cagccagaag catggagtga gggtgggaag
     5581 cacctactgt atggcaggca ccgttccgca cacacatttg ttaatgcaca cagttccatg
     5641 tcagtcctat gatgtaggtg ctattcttat cctccctgct ttccagataa ggaaacaggc
     5701 actgaagggg caactgactt acctactgtc acagtggtaa gtagcacagc ccagattcca
     5761 acccaggcag tcctggtgta catgttggca tatactgaga agtcgtagca aatgaggttg
     5821 aaaagataag agtggggctg aaccatgcaa agccttgaat gctaatacaa ggtaaatttg
     5881 gacctcacaa caagcagagg tgggccattg gcgggttttg agtgagacag taacttgatt
     5941 cacccccaaa ctaaggagtc cttatctatg tgatcagtgc catccatgtc ctgtgctgta
     6001 gggtacatgg ccggcttccc gagcagggtt ggtggcagct ggcagtggtt ggtgaatgtc
     6061 caggaagtct taactcaagc caccccaagg ctgtgattca gaacattttc gtggtccgtc
     6121 tcatctccac ctcacgggac agagctggaa ggctgtttgg tttggccagc gaccgaaagc
     6181 agagggagcc aagagtcaca gagtgaaggg caatgtgtgc cttcaacagg gccctccctc
     6241 tccgccccac tctgccttgc cccacccctg tccctgggaa gggcatcttt tagagttaac
     6301 ttttctcatt gccatccaaa aatagcttgc ttgtttaact agtttgttgt ttaaaaaata
     6361 aacataaaag caataataca gtcataattt taaaattcaa gtactaacag gaaaattaag
     6421 taacagacta acggtcccac ttctgacttc ttagtccact ccccagagat aaccaatatg
     6481 aagtttttgg tgtatccttc caaaattttt ctgtgtatgt gtcacatgta tgtatatata
     6541 tatgcatcct tttagtcctt ttttacataa atggcatcat accga
//
