LOCUS       NM_002224               9079 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor type 3 (ITPR3),
            mRNA.
ACCESSION   NM_002224
VERSION     NM_002224.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9079)
  AUTHORS   Molitor,A., Lederle,A., Radosavljevic,M., Sapuru,V., Zavorka
            Thomas,M.E., Yang,J., Shirin,M., Collin-Bund,V., Jerabkova-Roda,K.,
            Miao,Z., Bernard,A., Rolli,V., Grenot,P., Castro,C.N.,
            Rosenzwajg,M., Lewis,E.G., Person,R., Esperon-Moldes,U.S.,
            Kaare,M., Nokelainen,P.T., Batzir,N.A., Hoffer,G.Z., Paul,N.,
            Stemmelen,T., Naegely,L., Hanauer,A., Bibi-Triki,S., Grun,S.,
            Jung,S., Busnelli,I., Tripolszki,K., Al-Ali,R., Ordonez,N.,
            Bauer,P., Song,E., Zajo,K., Partida-Sanchez,S., Robledo-Avila,F.,
            Kumanovics,A., Louzoun,Y., Hirschler,A., Pichot,A., Toker,O.,
            Mejia,C.A.M., Parvaneh,N., Knapp,E., Hersh,J.H., Kenney,H.,
            Delmonte,O.M., Notarangelo,L.D., Goetz,J.G., Kahwash,S.B.,
            Carapito,C., Bajwa,R.P.S., Thomas,C., Ehl,S., Isidor,B.,
            Carapito,R., Abraham,R.S., Hite,R.K., Marcus,N., Bertoli-Avella,A.
            and Bahram,S.
  TITLE     A pleiotropic recurrent dominant ITPR3 variant causes a complex
            multisystemic disease
  JOURNAL   Sci Adv 10 (37), eado5545 (2024)
   PUBMED   39270020
  REMARK    GeneRIF: A pleiotropic recurrent dominant ITPR3 variant causes a
            complex multisystemic disease.
REFERENCE   2  (bases 1 to 9079)
  AUTHORS   Paknejad,N., Sapuru,V. and Hite,R.K.
  TITLE     Structural titration reveals Ca2+-dependent conformational
            landscape of the IP3 receptor
  JOURNAL   Nat Commun 14 (1), 6897 (2023)
   PUBMED   37898605
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9079)
  AUTHORS   Chen,J., Zhou,J., Jiang,Y., Wang,Y., Chen,C., Jiang,T. and Du,J.
  TITLE     Inositol 1,4,5-trisphosphate receptor gene variants are related to
            the risk of breast cancer in a Chinese population
  JOURNAL   J Gene Med 25 (2), e3463 (2023)
   PUBMED   36350267
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate receptor gene variants are
            related to the risk of breast cancer in a Chinese population.
REFERENCE   4  (bases 1 to 9079)
  AUTHORS   Neumann,J., Van Nieuwenhove,E., Terry,L.E., Staels,F., Knebel,T.R.,
            Welkenhuyzen,K., Ahmadzadeh,K., Baker,M.R., Gerbaux,M.,
            Willemsen,M., Barber,J.S., Serysheva,I.I., De Waele,L.,
            Vermeulen,F., Schlenner,S., Meyts,I., Yule,D.I., Bultynck,G.,
            Schrijvers,R., Humblet-Baron,S. and Liston,A.
  TITLE     Disrupted Ca2+ homeostasis and immunodeficiency in patients with
            functional IP3 receptor subtype 3 defects
  JOURNAL   Cell Mol Immunol 20 (1), 11-25 (2023)
   PUBMED   36302985
  REMARK    GeneRIF: Disrupted Ca[2+] homeostasis and immunodeficiency in
            patients with functional IP3 receptor subtype 3 defects.
            Erratum:[Cell Mol Immunol. 2023 Jan;20(1):114. doi:
            10.1038/s41423-022-00960-4.. PMID: 36471115]
REFERENCE   5  (bases 1 to 9079)
  AUTHORS   Rodrigues,M.A., Gomes,D.A., Cosme,A.L., Sanches,M.D., Resende,V.
            and Cassali,G.D.
  TITLE     Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is
            overexpressed in cholangiocarcinoma and its expression correlates
            with S100 calcium-binding protein A4 (S100A4)
  JOURNAL   Biomed Pharmacother 145, 112403 (2022)
   PUBMED   34798470
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is
            overexpressed in cholangiocarcinoma and its expression correlates
            with S100 calcium-binding protein A4 (S100A4).
REFERENCE   6  (bases 1 to 9079)
  AUTHORS   Joseph,S.K., Lin,C., Pierson,S., Thomas,A.P. and Maranto,A.R.
  TITLE     Heteroligomers of type-I and type-III inositol trisphosphate
            receptors in WB rat liver epithelial cells
  JOURNAL   J Biol Chem 270 (40), 23310-23316 (1995)
   PUBMED   7559486
  REMARK    Erratum:[J Biol Chem 1996 Mar 29;271(13):7874]
REFERENCE   7  (bases 1 to 9079)
  AUTHORS   Maranto,A.R.
  TITLE     Primary structure, ligand binding, and localization of the human
            type 3 inositol 1,4,5-trisphosphate receptor expressed in
            intestinal epithelium
  JOURNAL   J Biol Chem 269 (2), 1222-1230 (1994)
   PUBMED   8288584
REFERENCE   8  (bases 1 to 9079)
  AUTHORS   Yamamoto-Hino,M., Sugiyama,T., Hikichi,K., Mattei,M.G.,
            Hasegawa,K., Sekine,S., Sakurada,K., Miyawaki,A., Furuichi,T.,
            Hasegawa,M. et al.
  TITLE     Cloning and characterization of human type 2 and type 3 inositol
            1,4,5-trisphosphate receptors
  JOURNAL   Recept Channels 2 (1), 9-22 (1994)
   PUBMED   8081734
REFERENCE   9  (bases 1 to 9079)
  AUTHORS   Bourguignon,L.Y., Jin,H., Iida,N., Brandt,N.R. and Zhang,S.H.
  TITLE     The involvement of ankyrin in the regulation of inositol
            1,4,5-trisphosphate receptor-mediated internal Ca2+ release from
            Ca2+ storage vesicles in mouse T-lymphoma cells
  JOURNAL   J Biol Chem 268 (10), 7290-7297 (1993)
   PUBMED   8385102
REFERENCE   10 (bases 1 to 9079)
  AUTHORS   Mahaut-Smith,M.P., Sage,S.O. and Rink,T.J.
  TITLE     Receptor-activated single channels in intact human platelets
  JOURNAL   J Biol Chem 265 (18), 10479-10483 (1990)
   PUBMED   1693919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139044.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002224.3.
            
            Summary: This gene encodes a receptor for inositol
            1,4,5-trisphosphate, a second messenger that mediates the release
            of intracellular calcium. The receptor contains a calcium channel
            at the C-terminus and the ligand-binding site at the N-terminus.
            Knockout studies in mice suggest that type 2 and type 3 inositol
            1,4,5-trisphosphate receptors play a key role in exocrine secretion
            underlying energy metabolism and growth. [provided by RefSeq, Aug
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U01062.1, D26351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605930.3/ ENSP00000475177.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AL139044.15        6749-7118
            371-441             AL139044.15        25911-25981
            442-563             AL139044.15        41193-41314
            564-650             AL139044.15        43359-43445
            651-809             AL139044.15        44097-44255
            810-908             AL139044.15        44448-44546
            909-992             AL139044.15        44893-44976
            993-1139            AL139044.15        47955-48101
            1140-1235           AL139044.15        48338-48433
            1236-1286           AL139044.15        48927-48977
            1287-1429           AL139044.15        49165-49307
            1430-1529           AL139044.15        50297-50396
            1530-1690           AL139044.15        50480-50640
            1691-1832           AL139044.15        51262-51403
            1833-1994           AL139044.15        52556-52717
            1995-2167           AL139044.15        53219-53391
            2168-2287           AL139044.15        53942-54061
            2288-2470           AL139044.15        54401-54583
            2471-2722           AL139044.15        55752-56003
            2723-2867           AL139044.15        56098-56242
            2868-3009           AL139044.15        56592-56733
            3010-3209           AL139044.15        57456-57655
            3210-3339           AL139044.15        59018-59147
            3340-3397           AL139044.15        59635-59692
            3398-3563           AL139044.15        61118-61283
            3564-3728           AL139044.15        62195-62359
            3729-3803           AL139044.15        62442-62516
            3804-3929           AL139044.15        62931-63056
            3930-4052           AL139044.15        63848-63970
            4053-4253           AL139044.15        64066-64266
            4254-4505           AL139044.15        65309-65560
            4506-4631           AL139044.15        65756-65881
            4632-4757           AL139044.15        65982-66107
            4758-4878           AL139044.15        67951-68071
            4879-5069           AL139044.15        68634-68824
            5070-5218           AL139044.15        69447-69595
            5219-5327           AL139044.15        69784-69892
            5328-5418           AL139044.15        70025-70115
            5419-5588           AL139044.15        70201-70370
            5589-5763           AL139044.15        70786-70960
            5764-5948           AL139044.15        71070-71254
            5949-6149           AL139044.15        71480-71680
            6150-6260           AL139044.15        71836-71946
            6261-6356           AL139044.15        72436-72531
            6357-6458           AL139044.15        72653-72754
            6459-6545           AL139044.15        72905-72991
            6546-6656           AL139044.15        73484-73594
            6657-6849           AL139044.15        73666-73858
            6850-6975           AL139044.15        74083-74208
            6976-7148           AL139044.15        74665-74837
            7149-7313           AL139044.15        75461-75625
            7314-7506           AL139044.15        76344-76536
            7507-7611           AL139044.15        77042-77146
            7612-7739           AL139044.15        77228-77355
            7740-7905           AL139044.15        78155-78320
            7906-8066           AL139044.15        78972-79132
            8067-8228           AL139044.15        80351-80512
            8229-9079           AL139044.15        81139-81989
FEATURES             Location/Qualifiers
     source          1..9079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..9079
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /note="inositol 1,4,5-trisphosphate receptor type 3"
                     /db_xref="GeneID:3710"
                     /db_xref="HGNC:HGNC:6182"
                     /db_xref="MIM:147267"
     exon            1..370
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..8297
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /note="inositol 1,4,5-triphosphate receptor, type 3;
                     insP3R3; type 3 InsP3 receptor; IP3 receptor"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR3"
                     /protein_id="NP_002215.2"
                     /db_xref="CCDS:CCDS4783.1"
                     /db_xref="GeneID:3710"
                     /db_xref="HGNC:HGNC:6182"
                     /db_xref="MIM:147267"
                     /translation="MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGD
                     LDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQK
                     QNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGS
                     WLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTS
                     WKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSA
                     TSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAAG
                     MGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHL
                     CTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASS
                     MLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKL
                     MREQNILKQVFGILKAPFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQED
                     YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRK
                     NREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSHEY
                     LSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMC
                     LDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVK
                     FARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDYLNNVVSEAVPFANEEK
                     NKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPAMLQAYEDPGGKNVR
                     RSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENEDIVVMETKLKIL
                     EILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTTANMNLDRIGE
                     QAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEA
                     MHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVEAGAAKD
                     KKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHK
                     VMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLEAE
                     TMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM
                     IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEG
                     KNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNH
                     IWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTH
                     QTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSML
                     SSGASCAAAAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLV
                     QAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRT
                     LQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQC
                     RLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSER
                     FFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY
                     SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTN
                     YNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTC
                     IVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERI
                     LISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPV
                     KRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRS
                     MEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRS
                     MPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFWILIC
                     FSIAALFTKRYSIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGT
                     FIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTR
                     NGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFV
                     DTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDIL
                     RKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTC
                     FICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKN
                     KNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLTAQLNELKEQMTEQR
                     KRRQRLGFVDVQNCISR"
     exon            371..441
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..563
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..650
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..809
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..908
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..992
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1139
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1235
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1286
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1429
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1529
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1690
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1832
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1994
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2167
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2287
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2470
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2722
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2867
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3009
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3209
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3339
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3397
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3563
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3728
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3803
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..3929
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4052
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4253
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4505
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..4631
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4757
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4878
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..5069
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5070..5218
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5219..5327
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5418
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5419..5588
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5589..5763
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5764..5948
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            5949..6149
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6150..6260
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6261..6356
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6357..6458
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6459..6545
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6546..6656
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6657..6849
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6850..6975
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7148
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            7149..7313
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            7314..7506
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            7507..7611
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            7612..7739
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            7740..7905
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            7906..8066
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            8067..8228
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     exon            8229..9079
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9060..9065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /note="hexamer: AATAAA"
     polyA_site      9079
                     /gene="ITPR3"
                     /gene_synonym="CMT1J; IP3R; IP3R-3; IP3R3"
                     /note="major polyA site"
ORIGIN      
        1 agacttcctg ctccttctac gctgcaggta cgcgcgggcc gggcggggcg ggcgggcggc
       61 gggcgcgcca agacgtgggc acctcctcac ccggaccccg ggccccgccg agccgcctcc
      121 tggctcccgt ggccgccagc ccgccccggc cgcaccgagc gtcgggatcc gaggtgggag
      181 cgtacccctc cccgctcccc ggacgcctca gtcctccgca ctgagcttgg ccacgcgccc
      241 ctaggcgccc cccacgccct gggccccgga gggccgcagc catgagtgaa atgtccagct
      301 ttcttcacat cggggacatc gtctccctgt acgccgaggg ctccgtcaat ggcttcatca
      361 gcactttggg gctggtggat gaccgctgtg tggtggagcc cgcggccggg gacctggaca
      421 acccccctaa gaagttccgt gactgcctct tcaaggtgtg ccccatgaac cgctactcgg
      481 cccagaagca gtactggaag gccaagcaga ctaagcagga caaggagaag atcgctgatg
      541 tggtgttgct gcagaagctg cagcatgcgg cgcagatgga gcagaagcaa aatgacacgg
      601 agaacaagaa ggtgcatggg gatgtcgtga agtatggcag tgtgatccag ctcctgcaca
      661 tgaagagcaa caagtacctg acagtgaaca agcggcttcc ggccttgctg gagaagaacg
      721 ccatgcgggt gactctggat gccacaggca acgagggttc ctggctcttc atccagccct
      781 tctggaagct gcggagcaac ggggacaacg tggtcgtggg ggacaaggtg atcctgaatc
      841 ctgtcaatgc cgggcagcct ctgcatgcca gcaattacga gctcagcgac aacgccggct
      901 gcaaggaggt caattctgtg aactgcaaca ccagctggaa gatcaacctg tttatgcagt
      961 ttcgggacca cctggaggag gtgttgaaag ggggagacgt ggtgcggctg ttccatgcgg
     1021 agcaggagaa gttcctgacg tgtgacgagt acaagggcaa gctgcaggtg ttcctgcgaa
     1081 ctacactgcg ccagtctgcc acctcggcca ccagctccaa tgctctctgg gaggtggagg
     1141 tggtccacca cgacccctgc cgtggaggag ctgggcactg gaatggcttg taccgcttca
     1201 agcacctggc tacaggcaac tacctggctg ctgaggagaa ccccagttac aaaggtgatg
     1261 cctcagatcc caaggcagca ggaatggggg cacagggccg cacaggccgc aggaatgctg
     1321 gggagaagat caagtactgc ctggtggctg tgcctcatgg caatgacatc gcctctctct
     1381 ttgagctgga ccccaccacc ttgcagaaaa ccgactcttt cgtgccccgg aactcgtacg
     1441 tccggctgcg gcacctctgc accaacacgt ggattcagag caccaatgtg cccattgaca
     1501 tcgaggagga gcggcccatc cggctcatgc tgggcacctg ccccaccaag gaggacaagg
     1561 aggcctttgc catcgtgtca gtgcccgtgt ctgagatccg agacctggac tttgccaatg
     1621 acgccagctc catgctggcc agtgccgtgg agaaactcaa cgagggcttc atcagccaga
     1681 atgaccgcag gtttgtcatc cagctgctgg aagacctggt gttctttgtc agcgatgtcc
     1741 ccaacaatgg gcagaatgtc ctggacatca tggtcactaa gcccaaccgg gaacggcaga
     1801 agctgatgag ggagcagaac atcctcaaac aggtctttgg cattctgaag gccccgttcc
     1861 gtgagaaggg gggtgaaggt cccctggtgc ggctggagga gctgtcagac cagaagaacg
     1921 ccccctacca gcacatgttc cgcctgtgct accgcgtgtt gcggcattcc caggaggact
     1981 accgcaagaa ccaggagcac attgccaagc agtttgggat gatgcagtcc cagattggct
     2041 acgacatcct ggccgaggac accatcactg ccctgctgca caacaaccgc aagctcctgg
     2101 aaaagcacat caccaagacc gaggtggaga ccttcgtcag ccttgtgcgc aagaaccggg
     2161 agcccaggtt cctggactac ctctctgacc tgtgtgtgtc caaccacatc gccatccccg
     2221 tcacccaaga gctcatctgc aagtgtgtgc tggaccccaa gaacagtgac attctcatcc
     2281 ggaccgagct tcggcccgtg aaggagatgg cccaatccca cgagtacctg agcatcgagt
     2341 actcagaaga ggaagtgtgg ctcacgtgga ctgacaagaa taacgagcat catgagaaga
     2401 gtgtgaggca gctggcccag gaggcgcggg ccggcaacgc ccacgacgag aatgtgctca
     2461 gctactacag gtaccagctg aagctctttg cccgcatgtg cttggaccgc cagtacttgg
     2521 ccatcgacga gatctcccag cagctgggcg tggacctgat tttcctgtgc atggcagacg
     2581 agatgctgcc ctttgacctg cgcgcctcct tctgccacct gatgctgcac gtgcacgtgg
     2641 accgtgaccc ccaggagctg gtcacgccgg tcaagtttgc ccgtctctgg actgagatcc
     2701 ccacagccat caccatcaag gactatgatt ccaacctcaa cgcgtcccga gatgacaaga
     2761 agaacaagtt tgccaacacc atggagttcg tggaggacta cctcaacaat gtagtcagcg
     2821 aggccgtgcc ctttgccaac gaggagaaga acaagctcac ttttgaggtg gtcagcctgg
     2881 cgcacaatct catctacttc ggcttctaca gcttcagcga gctgctgcgg ctcactcgca
     2941 cactgctggg catcatcgac tgtgtgcagg ggcccccggc catgctgcag gcctatgagg
     3001 accccggtgg caagaatgtg cggcggtcca tccagggcgt ggggcacatg atgtccacca
     3061 tggtgctgag ccgcaagcag tccgtcttca gtgcccccag cctgtctgct ggggccagtg
     3121 ctgctgagcc gctggacaga agcaagtttg aggagaatga ggacattgtg gtgatggaga
     3181 ccaagctgaa gatcctggaa atccttcagt tcatcctcaa tgtccgcctg gattaccgca
     3241 tatcctacct gctgtctgtc ttcaagaagg agtttgtgga ggtgtttccc atgcaggaca
     3301 gtggggctga tggcacagcc cctgccttcg actctaccac tgccaacatg aacctggatc
     3361 gcatcgggga gcaggcggag gccatgtttg gagtggggaa gacaagcagc atgctggagg
     3421 tggatgacga gggcggccgc atgttcctgc gcgtgctcat ccacctcacc atgcacgact
     3481 atgcgccgct ggtctcgggt gccctgcagc tgctcttcaa gcacttcagc cagcgccagg
     3541 aggccatgca caccttcaag caggttcagc tgctgatctc agcgcaggac gtggagaact
     3601 acaaggtgat caagtcggag ctggaccggc tgcggaccat ggtggagaag tcagagctgt
     3661 gggtggacaa gaagggcagt ggcaagggtg aggaggtgga ggcaggcgcc gccaaggaca
     3721 agaaagagcg tcccacggac gaggagggct ttctgcaccc accaggggag aaaagcagtg
     3781 agaactacca gatcgtcaag ggcatcctgg aaaggctgaa caagatgtgc ggggttgggg
     3841 agcaaatgag gaagaagcag caacggctgc tgaagaacat ggatgcccac aaggtcatgc
     3901 tggacctgct gcagatcccc tatgacaagg gtgatgccaa gatgatggag atcctgcgct
     3961 acacgcacca gttcctgcag aagttctgtg cagggaaccc cggcaaccag gccctgctgc
     4021 acaaacacct gcacctcttc ctcacgccag ggctcctgga ggcagagacc atgcagcaca
     4081 tcttcctgaa caactatcag ctctgctccg agatcagcga gcctgtgttg cagcacttcg
     4141 tgcacctgct ggccacgcac gggcgccatg tgcagtacct ggacttcctg cacaccgtca
     4201 ttaaggccga gggcaagtac gtcaagaagt gccaggacat gatcatgact gagctgacca
     4261 atgcaggtga cgatgtggtc gtgttctaca atgataaggc atcgctggcc cacctgctgg
     4321 acatgatgaa ggccgcccgc gacggcgtgg aggaccacag ccccctcatg taccacattt
     4381 ccctggtgga cctgctggcc gcctgtgccg agggcaaaaa cgtctacact gagatcaagt
     4441 gcacctccct gctgccgctg gaggacgtgg tgtctgtggt gacgcatgag gactgcatca
     4501 ctgaggtgaa aatggcctat gtgaacttcg tgaaccactg ctacgtggac acggaggtgg
     4561 agatgaagga gatctacacc agcaaccaca tctggacgct ctttgagaac ttcaccctgg
     4621 acatggcccg ggtctgcagc aagcgtgaga agcgcgtggc tgaccccacc ttggagaagt
     4681 acgtgctgag cgttgtgctg gacaccatca acgccttctt cagctcccca ttctctgaga
     4741 acagcacttc cctgcagaca caccagacga ttgtggtgca gctgctgcag tctaccacac
     4801 gcctcctcga gtgtccgtgg ctacagcagc agcacaaggg ctccgtggag gcctgcatcc
     4861 ggaccctcgc catggtggcc aagggccggg ccatcttgct gcccatggac ctggatgccc
     4921 acatcagctc gatgctcagc agtggagcca gctgtgcagc tgccgcccag cggaacgcct
     4981 ccagctacaa ggcaaccacg cgggccttcc cccgcgtcac ccccaccgcc aaccagtggg
     5041 actacaagaa catcattgag aagctgcagg acatcatcac agccctggag gagcggctga
     5101 agcccctggt acaggctgag ctgtccgtgc tggtggatgt cctgcactgg cctgagctgc
     5161 tcttcctgga gggcagtgag gcctaccagc gctgcgagag tgggggcttc ctgtccaagc
     5221 tgatccagca caccaaggac ctcatggagt cggaggagaa gctgtgcatc aaggtgctgc
     5281 ggaccctgca gcagatgctg ctcaagaaga ccaagtacgg ggaccggggc aaccagctgc
     5341 gcaagatgct gctgcaaaac tacctccaga accggaagtc cacctcgcgg ggggaccttc
     5401 ccgaccccat aggcactggc ctggacccag actggtcggc aatcgcagcc acccagtgcc
     5461 ggctggacaa ggagggggcc accaagttgg tatgcgacct catcaccagc accaagaacg
     5521 agaagatctt ccaggagagc atcggcctgg ccatccacct gctggatggt ggcaacacag
     5581 agatccagaa atccttccac aacctgatga tgagtgacaa gaagtcagag cgcttcttca
     5641 aggtgctgca cgaccgcatg aagcgggccc agcaggagac caagtccacg gtggcagtca
     5701 acatgaatga cctgggcagc cagccacatg aggaccgcga gccagtcgac cccaccacca
     5761 aaggccgcgt ggcctccttc tcgatacctg gctcctcatc ccgctactcg ctgggcccca
     5821 gcctgcgccg ggggcacgag gtgagcgaac gtgtgcagag cagtgagatg ggcacatccg
     5881 tgctcatcat gcagcccatc ctgcgctttc tgcagctgct gtgtgagaac cacaaccggg
     5941 acctgcagaa cttcctgcgc tgtcagaaca acaaaaccaa ctacaacttg gtatgcgaga
     6001 cgctgcagtt cctggacatc atgtgcggca gcaccacggg cggcctgggg ctgctggggc
     6061 tctacatcaa tgaggacaac gtgggcctcg tcatccagac cttggagacc ctcactgagt
     6121 actgccaggg cccctgccat gagaaccaga cttgcattgt gactcacgag tccaatggca
     6181 tagacatcat caccgcactg atcctcaatg acatcagccc cctgtgcaag taccgcatgg
     6241 atctggtgct gcagctcaag gacaatgcct ccaagctgct cctggctctg atggagagcc
     6301 ggcatgacag tgaaaatgct gagcgaatcc tcatcagcct gcggccccag gagctggtgg
     6361 acgtcatcaa gaaggcctac ctgcaggagg aagagcgtga gaactcggag gtgagcccac
     6421 gtgaagtggg ccataacatc tatatcctgg cgctgcagct ctccaggcac aataaacagc
     6481 tgcagcacct gctgaagccg gtgaagcgca ttcaagagga ggaggccgag ggtatctctt
     6541 ccatgctcag cctcaacaac aagcagctgt cacagatgct caagtcctca gcgccagcac
     6601 aggaggagga ggaagacccc ctggcctact atgagaacca cacgtcccag atcgagattg
     6661 tgcggcagga ccgcagcatg gagcagatcg tgttcccagt gcccggcatc tgccagttcc
     6721 tgacggagga aaccaagcac cggctcttca ccactactga gcaggacgag cagggcagca
     6781 aagtgagcga cttcttcgac cagtcctcct tcctgcacaa cgagatggag tggcagcgca
     6841 agctccgcag catgccgctg atctactggt tctcccgccg catgaccctg tggggcagca
     6901 tctccttcaa cctggccgtg tttatcaaca tcatcattgc cttcttctac ccttacatgg
     6961 agggcgcgtc cacaggcgtg ctggactccc ctctcatctc attgctcttc tggatcctca
     7021 tctgcttctc catcgcggcc ctgttcacca agcgctacag catccgcccc ctcatcgtgg
     7081 cgctcatcct gcgctccatc tactatctgg gcatcgggcc cacactcaac atcctgggtg
     7141 ccctcaatct gaccaacaag atcgtgtttg tggtgagctt cgtgggcaac cgtggcacct
     7201 tcatccgggg ctataaggcc atggtcatgg acatggaatt cctctaccac gtgggctaca
     7261 tcctgaccag tgtcctgggc ctctttgctc atgagctgtt ctacagcatc ctgctctttg
     7321 acctcatcta ccgcgaggag acgctgttca acgtcatcaa gagtgtgacc cgcaatggcc
     7381 gctccatcct gctgacagcc ctgctggccc tcatcctggt ctacctcttc tccatcgtcg
     7441 gcttcctctt cctcaaggat gacttcattc tcgaggtcga ccggctgccc aacaaccact
     7501 ccacagccag ccccctgggg atgccacatg gagctgctgc atttgtggac acctgcagtg
     7561 gggacaagat ggactgtgtc tcagggctct cggtgcctga ggtcctggaa gaggacaggg
     7621 agctggacag cacagagcgg gcctgtgaca ctctgttgat gtgcatcgtc actgtcatga
     7681 accatgggct acgcaacggt ggtggcgtgg gcgacattct ccgcaagccc tccaaagatg
     7741 agtctctctt cccagcccga gtggtctatg acctcctgtt cttcttcatc gtcatcatca
     7801 ttgtgctgaa cctcatcttt ggggtaatca tcgacacctt cgctgacctg cgtagtgaga
     7861 agcagaagaa ggaggagatt cttaagacga catgcttcat ctgtggtctg gagagggaca
     7921 agtttgataa caagacagtg tcatttgagg aacacatcaa gctggagcac aacatgtgga
     7981 actacttgta cttcattgtg ctggtccgcg tgaagaacaa gaccgactac acgggccctg
     8041 agagctacgt ggcccagatg atcaagaaca agaacctgga ctggttcccc cggatgcggg
     8101 ccatgtccct tgtcagcaat gagggcgagg gggagcagaa tgagattcgg attctccagg
     8161 acaagctcaa ctccaccatg aagctggtgt cccacctcac tgcccagctc aacgagctca
     8221 aggagcagat gacggagcag cggaaacgca ggcaacgcct aggctttgtg gatgtccaga
     8281 actgcattag ccgctgagga gagccaccga aggccccaac aggggatgct catcactgga
     8341 gactgcgact gggaagaaca ctgccccctc cctcgggttg ggtggcccag ccagctggcc
     8401 agcctccact cccactctgc cagacaccct gacacccacc caggctttga agagcatgga
     8461 gggggagcct cagagctgac agtcctgctt agagccctta aaaagacttg aaagttcact
     8521 gggactcagt ttaccttaat gccttagcag aagataaatc ctacctagag acctttgttc
     8581 cttaaagcaa taactgacaa ctctttgtag tcctccttgt gggtagttaa gagtggggtc
     8641 acccctttaa ctccaagcac tacattttgg cggctgccgg cctctggggg aggtggcagt
     8701 tatgctgtta ctagtgattt tagggctttg ttatttaact tatttcaagg gtgctgtgct
     8761 cagccctgcc catggctgtg cagctccctc cgtgcctcag atctgctgta gccagtgcag
     8821 acctcactgt cgtgtccatg ccacccccgg catggctcca ggtggcctgg tgactccatg
     8881 atggacgatc ttgctcccag gacctgcctc ttcccaggct tcctggggaa gagttgtacg
     8941 cccaggcaac aagggctgag ctgcgcttgc gtggctgttt catgaccgct tgtttttctc
     9001 cttttggtgt aatgttttac aaatcctttg gcctgagaac taatatgtta attgccttaa
     9061 ataaattaat agaaatcta
//
