LOCUS       NM_002223              12564 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor type 2 (ITPR2),
            transcript variant 1, mRNA.
ACCESSION   NM_002223
VERSION     NM_002223.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12564)
  AUTHORS   Zhou,S., Wang,Z., Liu,Z., Mu,G., Xie,Q., Wang,Z., Xiang,Q., Gong,Y.
            and Cui,Y.
  TITLE     Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses
            for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients
  JOURNAL   Cardiovasc Drugs Ther 37 (3), 507-518 (2023)
   PUBMED   34860335
  REMARK    GeneRIF: Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway
            Analyses for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients.
REFERENCE   2  (bases 1 to 12564)
  AUTHORS   Chen,J., Zhou,J., Jiang,Y., Wang,Y., Chen,C., Jiang,T. and Du,J.
  TITLE     Inositol 1,4,5-trisphosphate receptor gene variants are related to
            the risk of breast cancer in a Chinese population
  JOURNAL   J Gene Med 25 (2), e3463 (2023)
   PUBMED   36350267
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate receptor gene variants are
            related to the risk of breast cancer in a Chinese population.
REFERENCE   3  (bases 1 to 12564)
  AUTHORS   Ziegler,D.V., Vindrieux,D., Goehrig,D., Jaber,S., Collin,G.,
            Griveau,A., Wiel,C., Bendridi,N., Djebali,S., Farfariello,V.,
            Prevarskaya,N., Payen,L., Marvel,J., Aubert,S., Flaman,J.M.,
            Rieusset,J., Martin,N. and Bernard,D.
  TITLE     Calcium channel ITPR2 and mitochondria-ER contacts promote cellular
            senescence and aging
  JOURNAL   Nat Commun 12 (1), 720 (2021)
   PUBMED   33526781
  REMARK    GeneRIF: Calcium channel ITPR2 and mitochondria-ER contacts promote
            cellular senescence and aging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12564)
  AUTHORS   Klar,J., Hisatsune,C., Baig,S.M., Tariq,M., Johansson,A.C.,
            Rasool,M., Malik,N.A., Ameur,A., Sugiura,K., Feuk,L., Mikoshiba,K.
            and Dahl,N.
  TITLE     Abolished InsP3R2 function inhibits sweat secretion in both humans
            and mice
  JOURNAL   J Clin Invest 124 (11), 4773-4780 (2014)
   PUBMED   25329695
  REMARK    GeneRIF: Loss of InsP3R2-mediated calcium release causes isolated
            anhidrosis in humans.
REFERENCE   5  (bases 1 to 12564)
  AUTHORS   Sankar,N., deTombe,P.P. and Mignery,G.A.
  TITLE     Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate
            receptor (InsP3R2) expression during cardiac remodeling
  JOURNAL   J Biol Chem 289 (9), 6188-6198 (2014)
   PUBMED   24415751
  REMARK    GeneRIF: ITPR2 and hypertrophy specific gene expression is
            regulated, in part, by a positive feedback regulation between
            InsP3R2 and calcineurin-NFATc signaling pathways.
REFERENCE   6  (bases 1 to 12564)
  AUTHORS   Tanimura,A., Tojyo,Y. and Turner,R.J.
  TITLE     Evidence that type I, II, and III inositol 1,4,5-trisphosphate
            receptors can occur as integral plasma membrane proteins
  JOURNAL   J Biol Chem 275 (35), 27488-27493 (2000)
   PUBMED   10874040
REFERENCE   7  (bases 1 to 12564)
  AUTHORS   Mayne,M., Holden,C.P., Nath,A. and Geiger,J.D.
  TITLE     Release of calcium from inositol 1,4,5-trisphosphate
            receptor-regulated stores by HIV-1 Tat regulates TNF-alpha
            production in human macrophages
  JOURNAL   J Immunol 164 (12), 6538-6542 (2000)
   PUBMED   10843712
REFERENCE   8  (bases 1 to 12564)
  AUTHORS   El-Daher,S.S., Patel,Y., Siddiqua,A., Hassock,S., Edmunds,S.,
            Maddison,B., Patel,G., Goulding,D., Lupu,F., Wojcikiewicz,R.J. and
            Authi,K.S.
  TITLE     Distinct localization and function of (1,4,5)IP(3) receptor
            subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly
            purified human platelet membranes
  JOURNAL   Blood 95 (11), 3412-3422 (2000)
   PUBMED   10828023
  REMARK    Erratum:[Blood 2000 Sep 1;96(5):1684]
REFERENCE   9  (bases 1 to 12564)
  AUTHORS   Futatsugi,A., Kuwajima,G. and Mikoshiba,K.
  TITLE     Muscle-specific mRNA isoform encodes a protein composed mainly of
            the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor
  JOURNAL   Biochem J 334 (Pt 3) (Pt 3), 559-563 (1998)
   PUBMED   9729462
REFERENCE   10 (bases 1 to 12564)
  AUTHORS   Yamamoto-Hino,M., Sugiyama,T., Hikichi,K., Mattei,M.G.,
            Hasegawa,K., Sekine,S., Sakurada,K., Miyawaki,A., Furuichi,T.,
            Hasegawa,M. et al.
  TITLE     Cloning and characterization of human type 2 and type 3 inositol
            1,4,5-trisphosphate receptors
  JOURNAL   Recept Channels 2 (1), 9-22 (1994)
   PUBMED   8081734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024093.46, D26350.1,
            BX495410.1, AL711179.1, BP314401.1, BP364657.1, BU173910.1,
            DB144849.1, AC055720.17, BE439696.1, AI339141.1 and CA419735.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002223.3.
            
            Summary: The protein encoded by this gene belongs to the inositol
            1,4,5-triphosphate receptor family, whose members are second
            messenger intracellular calcium release channels. These proteins
            mediate a rise in cytoplasmic calcium in response to receptor
            activated production of inositol triphosphate. Inositol
            triphosphate receptor-mediated signaling is involved in many
            processes including cell migration, cell division, smooth muscle
            contraction, and neuronal signaling. This protein is a type 2
            receptor that consists of a cytoplasmic amino-terminus that binds
            inositol triphosphate, six membrane-spanning helices that
            contribute to the ion pore, and a short cytoplasmic
            carboxy-terminus. A mutation in this gene has been associated with
            anhidrosis, suggesting that intracellular calcium release mediated
            by this protein is required for eccrine sweat production. [provided
            by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26350.1, SRR1803613.259045.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381340.8/ ENSP00000370744.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AC024093.46        126484-126900
            418-907             D26350.1           423-912
            908-1264            BX495410.1         132-488
            1265-2201           D26350.1           1270-2206
            2202-2584           AL711179.1         232-614
            2585-3295           D26350.1           2590-3300
            3296-3296           BP314401.1         525-525
            3297-3620           D26350.1           3302-3625
            3621-3816           BP364657.1         386-581
            3817-3946           D26350.1           3822-3951
            3947-4512           BU173910.1         236-801
            4513-7948           D26350.1           4518-7953
            7949-8350           DB144849.1         133-534
            8351-8913           D26350.1           8356-8918
            8914-8914           AC055720.17        56796-56796         c
            8915-10504          D26350.1           8919-10508
            10505-11579         AC055720.17        54131-55205         c
            11580-12195         BE439696.1         19-634
            12196-12461         AI339141.1         111-376             c
            12462-12564         CA419735.1         32-134              c
FEATURES             Location/Qualifiers
     source          1..12564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..12564
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="inositol 1,4,5-trisphosphate receptor type 2"
                     /db_xref="GeneID:3709"
                     /db_xref="HGNC:HGNC:6181"
                     /db_xref="MIM:600144"
     exon            1..505
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..8519
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="isoform 1 is encoded by transcript variant 1; IP3R
                     2; type 2 InsP3 receptor; IP3 receptor; cilia and flagella
                     associated protein 48; inositol 1,4,5-trisphosphate-gated
                     calcium channel ITPR2"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR2 isoform 1"
                     /protein_id="NP_002214.2"
                     /db_xref="CCDS:CCDS41764.1"
                     /db_xref="GeneID:3709"
                     /db_xref="HGNC:HGNC:6181"
                     /db_xref="MIM:600144"
                     /translation="MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAG
                     DLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQ
                     NESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSW
                     FYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSW
                     KITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSAT
                     SSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRD
                     GVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHL
                     CTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANK
                     VLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKL
                     MREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQD
                     YRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRR
                     NREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESS
                     ILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARM
                     CLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPV
                     RYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKE
                     KNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGG
                     NNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLK
                     IIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEI
                     AAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRA
                     EVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQV
                     KGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQ
                     RLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNL
                     FLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
                     GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITL
                     VELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEV
                     EMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSP
                     FSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIP
                     VDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVV
                     ASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEE
                     KLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQV
                     GGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEG
                     GNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNE
                     LMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGN
                     TEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQF
                     LDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGID
                     IIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELV
                     DVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDP
                     DEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQG
                     SKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFY
                     PFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGP
                     TLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHE
                     FFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFT
                     MEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCD
                     TLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFG
                     VIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFI
                     VLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLE
                     STMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH"
     exon            506..576
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..692
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..779
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..938
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1037
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1121
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1268
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1364
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1409
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1561
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1661
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1822
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1964
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2126
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2299
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2419
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2605
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2857
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3002
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3153
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3347
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3477
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3535
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3701
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3875
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..3965
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4091
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4214
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4415
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4416..4667
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4668..4793
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4794..4922
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4923..5043
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5044..5234
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5377
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5378..5486
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5487..5595
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5596..5783
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5784..5967
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5968..6224
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6225..6425
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6426..6536
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6537..6632
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6633..6755
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6756..6863
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6864..7056
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7057..7182
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7183..7358
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7359..7523
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7524..7719
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7720..7812
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7813..7943
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7944..8109
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            8110..8270
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            8271..8432
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            8433..12564
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11380..11385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="hexamer: AATAAA"
     polyA_site      11401
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="major polyA site"
     regulatory      12544..12549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="hexamer: AATAAA"
     polyA_site      12564
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="major polyA site"
ORIGIN      
        1 cagctcccgc cgggcggctg tgacggccgc agcgggtcgc agagcaggga gtggacacgg
       61 agtggggagc ggagagggaa ggaggaggag gaggagcaaa ggtgttggag agaaaacttc
      121 agaaaggaac aggaaacctg ccggggaggc ggcggcggct gcggcttctc tgggcgcctg
      181 ggctgcgctc ttcgcggggt gtccgcagct gcggcttggc cccggtctgg cttccccggc
      241 gcgcacgcac ggctgagccg cgacgctcag tggctcgggc cgtgccctcc gccgcggctc
      301 ttggccgctg tagtcccgcg atccgatccg cttctgccgc ggcggctccc tggagagagg
      361 gcggcgaggg cgcagggaag aagagggacg tccactgtgg aacatgaagc agcatgactg
      421 agaaaatgtc cagcttcctc tacatagggg acatcgtgtc cctgtacgcg gagggctcgg
      481 tcaacggctt catcagcacc ttggggttag tggatgacag atgtgtggtg cacccagagg
      541 ccggggacct tgccaaccct cccaagaagt tcagagactg ccttttcaag gtgtgcccta
      601 tgaacagata ttctgcccag aagcaatatt ggaaagcaaa gcaagccaaa caagggaacc
      661 acaccgaggc agccttgctg aagaaactac agcacgctgc agaactggaa caaaaacaaa
      721 atgaatcgga gaataagaaa ctgttgggag aaattgtaaa atacagtaat gttatacaac
      781 tactgcatat aaaaagcaac aaatatctta ctgtcaacaa gagattacct gctttactgg
      841 agaagaatgc catgcgtgtg tccttggatg ctgcaggaaa tgaagggtct tggttttata
      901 ttcatccgtt ctggaaactg agaagcgagg gtgacaatat tgttgtagga gataaagttg
      961 ttttgatgcc tgtgaatgca gggcagccac tacatgccag caacatagag cttcttgata
     1021 acccagggtg taaagaggtg aatgctgtca attgcaacac cagctggaaa atcactttat
     1081 tcatgaaata tagttcctat cgagaggatg tattaaaagg aggggacgtt gttagattat
     1141 ttcatgcgga acaagagaag tttttgactt gtgatgaata tgagaaaaaa cagcacattt
     1201 tccttcgtac gaccttgcgc caatcagcta cttctgctac tagttctaaa gcactctggg
     1261 aaatagaggt ggttcatcat gacccatgcc gtgggggtgc aggacagtgg aacagcttgt
     1321 tcagatttaa gcatcttgca actggaaact atttagctgc agagcttaat cctgattatc
     1381 gagatgccca aaatgaagga aaaaatgtga gagatggagt ccctccaact tcaaagaaaa
     1441 aacgccaggc aggggagaag atcatgtata ctttggtttc agtcccgcat ggcaatgaca
     1501 ttgcatccct ttttgaacta gatgccacaa ctcttcagag agctgactgc ctggttccaa
     1561 ggaactcata tgttcggtta aggcatttat gcaccaacac atgggtaacc agtactagta
     1621 tccccataga cacagatgaa gagaggcctg ttatgttaaa gattggaacc tgccaaacca
     1681 aagaagataa agaagcgttc gcaatcgtgt ctgttccact gtctgaagtt cgagacttag
     1741 actttgccaa tgatgccaat aaagtactag cgaccacagt taaaaagcta gaaaacggca
     1801 caataactca gaatgaaagg aggtttgtaa ccaaattatt ggaagatctc atattctttg
     1861 ttgctgatgt gcctaataat ggacaagaag ttctggatgt ggttatcact aagccaaacc
     1921 gagagcgtca aaaattgatg agggaacaaa acatactggc acaggtattt ggaattctta
     1981 aagcaccctt taaagagaaa gcaggagaag gctcgatgct gagacttgaa gatctggggg
     2041 atcaaagata tgcaccctac aagtacatgc tgcggctctg ttaccgcgtc ctgagacact
     2101 cgcagcagga ttaccggaaa aatcaggaat atattgctaa gaatttctgt gtcatgcagt
     2161 cccagattgg ctatgatatt ttggcagaag atactatcac agctttgttg cacaacaaca
     2221 gaaaactact agagaaacat atcacagcaa aagaaataga aacatttgtc agtttactca
     2281 ggagaaatcg ggagccaagg tttttggatt atttgtcaga tctgtgtgtg tctaatacca
     2341 ctgctatccc tgtaactcaa gaactcatct gtaaatttat gttgagtcca ggcaatgcag
     2401 acattctcat tcaaactaag gtggtctcaa tgcaagcaga caaccccatg gagagctcca
     2461 tcctttcaga tgacattgat gatgaagaag tttggctcta ttggattgac agcaacaagg
     2521 aacctcatgg caaagctatc aggcaccttg ctcaagaggc aaaagaaggc accaaagctg
     2581 acttagaagt tcttacctat tacaggtacc agctaaacct ctttgcaagg atgtgcttgg
     2641 atcgccagta tctggccata aaccagattt ctacacagct gtctgtagac ctgatcctgc
     2701 ggtgtgtgtc ggatgagagc ctgccgttcg acctccgagc gtccttctgt cgcctcatgc
     2761 tccacatgca cgttgaccgg gatccccagg agtccgtggt gcctgttcgc tatgccaggc
     2821 tctggacaga aatccccaca aagatcacaa ttcatgaata tgattctata acagactctt
     2881 ccagaaatga tatgaagagg aaatttgccc tgacaatgga atttgttgaa gaatatttga
     2941 aagaagttgt aaaccagccc tttccttttg gggataaaga aaaaaataaa ctgacatttg
     3001 aggtggtcca cttggctcgg aatcttatat actttggatt ttatagtttc agtgagttat
     3061 taaggctaac aagaacactt ctggctattt tagacattgt acaggccccc atgtcatcat
     3121 actttgaaag attaagcaaa tttcaagatg gaggaaacaa tgtgatgaga accattcatg
     3181 gggtgggaga gatgatgacc cagatggtac tcagtagagg ctccatcttc cccatgagcg
     3241 tgccggatgt gccacccagc atccacccga gcaagcaagg gagccccacc gagcacgagg
     3301 atgtgactgt gatggacacc aagctgaaga tcattgagat tttgcagttt atcctgagtg
     3361 tcagactgga ttataggatc tcatatatgc tgtcaatata taagaaggag tttggagagg
     3421 acaatgacaa tgcggagaca tctgccagtg gatctccaga cactttacta ccatcagcta
     3481 ttgttcctga tatagatgaa attgcagctc aggcagaaac tatgtttgcg ggaagaaaag
     3541 aaaaaaatcc agttcaactt gacgatgaag gaggcaggac gtttttacgg gtcctcattc
     3601 atctgatcat gcacgactac ccgcctttgc tgtctggagc cctgcagctg ttgtttaagc
     3661 acttcagcca gagggcagag gttttacagg catttaagca ggtgcaatta ctggtgtcta
     3721 atcaagacgt agataactac aagcaaatca aggcagatct agaccagctt cgactgacag
     3781 tagaaaagtc tgagctatgg gtggagaaga gcagcaacta tgagaatgga gaaatagggg
     3841 aaagtcaagt gaaaggtggt gaagagccaa ttgaggaatc aaacatttta agtccagtgc
     3901 aggatggaac aaagaaacct cagattgaca gcaacaagag caataactac cggattgtaa
     3961 aggagatttt gatcaggcta agtaaactct gtgtgcagaa taaaaagtgt cggaatcaac
     4021 atcaacgatt actgaaaaat atgggggcgc attcggtggt gttggatctt ctgcagatac
     4081 cctatgaaaa gaatgatgaa aagatgaatg aagtaatgaa tctagcccat acatttctgc
     4141 agaatttctg tcgaggaaat ccacagaatc aagttcttct tcataaacat ctgaatttgt
     4201 ttttaactcc aggtctcctt gaagcagaaa ccatgcggca catcttcatg aacaattacc
     4261 atctgtgcaa cgaaattagc gagagagttg tacaacactt tgtgcactgc attgagacac
     4321 atggccgcca cgtggagtac ctgaggtttt tgcaaacaat tgtaaaagca gatggtaaat
     4381 atgtgaagaa atgccaggat atggtaatga cagagttgat aaatgggggt gaagacgtgc
     4441 tgatatttta caatgataga gcatcatttc caatccttct ccatatgatg tgttcagaga
     4501 gagaccgagg ggatgagagt ggccccttag cctaccacat caccctggtg gagttgctgg
     4561 cagcatgcac agaggggaaa aatgtctaca ctgaaatcaa gtgtaattcc cttctcccgc
     4621 tggacgacat agtgagggtg gtgacccatg acgactgcat ccctgaggtt aaaattgctt
     4681 atgtgaactt tgttaatcac tgttatgttg acactgaagt ggaaatgaaa gaaatctata
     4741 caagtaacca catttggaaa ttatttgaga acttcttggt ggatatggca agggtttgca
     4801 acacaactac agacaggaaa catgcagaca tctttttgga aaagtgtgtt actgagtcaa
     4861 taatgaatat tgtgagcggc ttctttaatt ctcccttttc agacaatagt accagcctcc
     4921 agacacatca gccagttttt attcagctac tgcaatctgc cttcagaatt tacaattgca
     4981 cctggccaaa cccagcgcag aaagcctcag tggaatcctg tatcagaact ttggctgaag
     5041 tggcaaaaaa tcgtggaatt gccattccag tggatttgga cagccaagtt aatactcttt
     5101 tcatgaagag ccattcaaat atggtgcaga gagcagcaat gggttggaga ctatcagctc
     5161 gctctgggcc acgctttaag gaagctcttg gagggcctgc ttgggattac agaaatatta
     5221 ttgaaaagtt acaggatgta gtggcctcct tggagcacca gttcagccca atgatgcagg
     5281 ctgaattctc agtgttggtt gatgtattgt acagtccaga actgctgttc cctgagggaa
     5341 gcgatgcaag aataagatgt ggcgctttca tgtcgaagtt gattaatcat acaaagaaac
     5401 taatggagaa agaagaaaaa ctgtgcatta aaattcttca gacattacga gaaatgttag
     5461 agaagaaaga cagctttgtg gaagagggta acacattaag aaagatactt ctgaatcgat
     5521 actttaaagg tgattatagt attggtgtga atggacacct atcaggagcc tactccaaaa
     5581 ctgcacaggt gggaggaagc ttttctggac aagattcaga taagatgggg atatcaatgt
     5641 cagacattca gtgtctgctg gataaagaag gtgcatcaga acttgtcatc gatgttatag
     5701 tgaacaccaa aaatgacaga attttttcag aaggcatttt cctcggcatt gccttgcttg
     5761 aaggaggaaa tacacaaaca cagtattctt tctaccagca gttgcatgaa caaaaaaagt
     5821 cagaaaaatt ctttaaagtt ctctatgatc gaatgaaggc tgctcagaaa gaaataagat
     5881 caacagtgac agttaatacc atagatttag gtaacaaaaa aagggacgat gacaatgaat
     5941 tgatgacatc tggtccacga atgagagtaa gagattcaac actacattta aaagagggaa
     6001 tgaaagggca attaacagaa gcttcttcag caacatccaa agcatattgt gtatacagaa
     6061 gagaaatgga tccagaaata gacattatgt gcacaggacc agaagcggga aacactgagg
     6121 aaaaatccgc agaggaagta acaatgagtc ccgcaattgc catcatgcag ccaatactga
     6181 gatttcttca gttactgtgt gagaatcaca accgggaatt gcagaacttc ttgaggaatc
     6241 aaaacaacaa aacaaattac aacctagtct gtgagaccct tcagtttctg gactgcattt
     6301 gtggaagtac aaccggtggc ctgggcctgt tgggtctcta catcaatgag aagaatgtag
     6361 cgctggtcaa ccagaacctg gagagcttga ctgagtattg ccagggccct tgccatgaaa
     6421 atcagacctg tatcgctaca catgagtcta atgggattga tatcatcatt gctttgattc
     6481 tgaatgacat aaaccctctt ggtaaatacc gaatggacct ggtgctccag ctaaagaaca
     6541 atgcatctaa acttttgctg gccattatgg aaagcagaca tgacagtgag aatgcagaaa
     6601 gaattctttt taacatgaga cccagagaac tggtggatgt gatgaagaat gcctataacc
     6661 aaggattgga atgtgaccat ggggatgatg agggtggaga tgatggtgtt tctccaaaag
     6721 atgttggaca caatatctat attctggccc atcagttggc ccgccacaat aaactgttgc
     6781 agcagatgct caaaccagga tcggatccag atgaaggaga tgaagcctta aagtattatg
     6841 ccaaccacac tgcacagatt gagattgtcc ggcatgatag gaccatggaa caaatagttt
     6901 ttcctgtccc caatatatgt gaatacctca ctcgagaatc caagtgccgt gtgttcaata
     6961 caactgaaag ggatgaacaa ggaagtaaag tgaatgactt tttccagcaa acagaagatc
     7021 tctacaatga aatgaagtgg cagaagaaaa tcaggaataa ccctgcactg ttctggttct
     7081 cgaggcacat ctctctctgg gggagcattt ccttcaacct ggctgtgttc atcaatttag
     7141 ctgttgctct cttctaccca tttggggatg atggagatga aggtacactt tctccattgt
     7201 tctcggttct tctttggata gcagttgcga tctgcacatc tatgctgttt ttcttctcca
     7261 agcctgtggg tattcggccg tttcttgtat caataatgct cagatcaata tatacaatag
     7321 gtcttgggcc tacattaata cttcttggtg cagctaatct ttgtaataaa attgtttttc
     7381 tggtgagttt tgttggaaat cgtggcacgt tcacccgtgg gtaccgagca gtcatcctgg
     7441 atatggcctt tctctatcac gtggcgtatg tcctggtttg catgctgggc ctttttgtcc
     7501 atgaattctt ctatagcttc ctgctttttg atttggtgta cagggaagag actttgctga
     7561 atgtcataaa aagtgtcaca cgaaatggcc gctctattat tctaactgca gtcctggctc
     7621 tcatcctcgt ctacctgttt tccattattg ggttcctttt tttgaaggat gacttcacta
     7681 tggaagttga taggctgaaa aaccgaactc ctgttacagg cagtcatcaa gtgcctacta
     7741 tgactttaac taccatgatg gaagcatgtg ccaaggagaa ctgttcaccc acaattccag
     7801 cttcaaatac agctgatgaa gagtatgaag atggaattga aaggacgtgt gacactctcc
     7861 ttatgtgcat tgtcaccgtg ctgaaccagg gcctcaggaa tggcggtggt gtgggggatg
     7921 tgctaagaag gccatcgaaa gatgagccct tgtttgctgc ccgagtggtt tatgaccttc
     7981 ttttttattt cattgttatc attattgttc tgaacttgat ttttggtgtt atcatcgata
     8041 cttttgctga tctcagaagc gaaaaacaga aaaaagaaga aattctaaag acaacttgtt
     8101 tcatctgtgg acttgagaga gacaagtttg ataataaaac ggtttcattt gaggagcaca
     8161 ttaagtcaga acacaatatg tggcattatt tgtacttcat agtcctggtg aaagttaaag
     8221 acccaacaga atacactgga cctgaaagtt atgtggctca aatgattgtg gagaagaatt
     8281 tggattggtt tcctcggatg cgagccatgt ccctcgttag caatgaaggc gacagtgagc
     8341 aaaatgaaat tcggagcctt caggagaagt tggaatcgac catgagtctg gtcaaacagc
     8401 tgtcgggtca gctggcggag ctcaaggagc agatgacaga acaaaggaag aataagcaga
     8461 gactgggctt cctcggatca aacacacccc atgtgaatca tcacatgcca ccacactgat
     8521 accatggggg gaagccgtga ctagcctttc atcagtgtcc tgcctgatca ctgaataaag
     8581 aactgagatg gaggggagtg aacagtgcct attgttgaaa agttaaaaac aaccaagtgc
     8641 caagatgttg agtgggttag ctccgagaac aatttataac tgtgttttca tggttgcgaa
     8701 gacctaacct caaatgcatc tgctagaaag cgtacatcac acattcgcaa tgcatcagga
     8761 agaaaaggct tgcccaaaag gctggagagg gcagggagcg gcaggatgga aggagacacg
     8821 gggcagggag aactctcttc tgctaaatcg ataggagtca gttttgtctt aaatgctgac
     8881 tacagccact gacatggttg gctggaattt ctttctttta attgtggcat ataggtttgt
     8941 gacacaagaa gtcatacttt ggtggctaag ttttactaag gaaaataact gaaaagatta
     9001 aaagtgagag ctgaaaagag aaatgataat gcttccaaac tgtagctgtc acagggcaat
     9061 ttctttattt ataacatgaa gcacaatgga tttacagctc taggaactta gtactttgga
     9121 gcttttgcct ctcacactga caacataaca ggatgtgatt gccttctctg ggattcagac
     9181 aggctctgtc aatgtggagc acaaaaggag attttcatat aacttgttaa aaacatgttc
     9241 taagtcatgt ataggctaag attttaagaa gatctggggg aataaaaagc caacagtaag
     9301 ccccaggaaa gggttttttg agaccatatg tatgctatta aaatatattg agattaatac
     9361 atgaaaatgc ttaaaagtga taggaattat tgagaaactt atgatggtgg cattgccttt
     9421 tataaacatg gagtgaaagc catttgactc aacgtttgct gtgcttaaag aattgcttca
     9481 ggacccgagc gtttttatgt atgctgttcc tgcagttagg aaaaaaaaat ccaagaaatg
     9541 tattgaatac tcaagaaaat gccacatttc aattacatat ttaaaactgt atctgtaagg
     9601 gcttttcaaa atgtagcaag ataaaaatct cttattcaaa ttgtttttgt attaaatcat
     9661 gcactcagaa tttgtcgagg gagagaataa cctggtgtgt tcaggttatt cttagagact
     9721 acacatttgg aatagcagag caaaatatgg ataatgaaag tgttgggaaa aaagtgatgt
     9781 gacagggagt gaagacactt gataccagac tctgggagat actctgcaag ttgacctggc
     9841 ctctccccca caggaacaaa acactgcctc cagagtcttt aaattctcag ttatcaacgc
     9901 caaggtttaa ggtctagata gggtttgcta tagggtttgc tctgacaatt tttaaagctt
     9961 ttggattgtt ctaacatagc ttaagctatt ggttcctaaa aatcccaaat caagatctat
    10021 gtagaatata aaggaagcct gaaccaatcc ttccacatac tgttaagatg tagacttgga
    10081 acaaagctgt tgggacccag agcaatgaat ttttgaactg aagctactgg tactccccag
    10141 caccacctca tactaagaat tcctcactct gacatgacag tattttttct gaccaggagc
    10201 tgaaagaccc tgacattcat gatccaaaga tataagaaat tttgatatgt ctgcatgcag
    10261 cacagaactt tgaacctagg aggcagtcaa taaatacatg agaaattcag ctgtcattca
    10321 gttactctta attctttata aaactttaaa tgataccaca tatttgtttg tttaaaatgg
    10381 ctttcccaaa atcaaagtag actaaagcag ccatctttaa aatccaggat catcaatgct
    10441 attaacagta tcaggtaaaa agtacacttt aaaatatttt aatcaggcag agttttatgg
    10501 atagagaata gaagagaaag gtagtaaata ttgaacatat tccaatatag gaacctatct
    10561 ctgttttagt acaaaatatt tctgacatct gaactagagg tcaagagaat aaattcattt
    10621 gtatacatct gagcaacctg tctttcagat gataaagtat ctagcctttt ctgacaccat
    10681 aatagttcat tttgtaggga ataagccatt aggtgtatat aattgctttc tagaaatgac
    10741 ctaatgtccc caaccacttt gtagtggcag atcactgttt cacagcatat tttctcccaa
    10801 ggaaagtatt caaaagagac tgcaactaac aagactctta tttcatcaaa atttaaatat
    10861 ttctgagttg tatttttaat gcctctttct tttctgccta aatgcttaga aattataaag
    10921 caaaaaaaaa aaaaacagca acaaaaaatc gaagcagaca aaaaaggcac ttttcagaac
    10981 atcaaattcc taatgaagaa gaggagaaga taatggggaa atttgacatt tgatataaat
    11041 ttatatttgt tatgtgtatg tttgttaatg caactggaat atttgactta ggtgagtatc
    11101 agttaacatc cttgtattta tatagtgaca tcaaaataaa tgcaatcatc ttgaactttg
    11161 atgttaaggg agattttgaa aaaatattta gttatttcaa attcatattg gttcaaaagt
    11221 atcagtttct gctgaataat atttttaatt tcaaaagggt tttgttccct ctgtgctcca
    11281 ttctgaggct caagagctta atgccagtat gttttctgag ttaaaataac acttttagat
    11341 gagaaaatgc ttgtatcata cagggctata atataaataa ataaattgta tgtatgcaaa
    11401 atttatcata ttttctaccc cttaaaaaat taagttagaa ataagcttat tttcttgcac
    11461 atcaatattt ttctgttggt aaagaggaca caatttctag tagattgtta ataacatcag
    11521 gaagatattt ctttcgtcag aactaattgt gtgcttattc ccatattctc agctcataac
    11581 tccctgtttt ggctgctctc tttattttac aattgtttca ttgcaaacag caaggcagta
    11641 tagcccacac tcagccacta gcccccagtc cccaggactg agaatgagtg gggaggctgg
    11701 ggagttggtg agagaaggtg gagataggga tttctgcttc ccagtactct atcattagag
    11761 aaaaggaggg gtaaatatta gctaagaaga agaaaaaagc ttattcttca gggacccagt
    11821 agattggacg taagcaagta aatattgcac aggcatcatg atgtaatagt tgatggaccc
    11881 cagagatacc cctcacccat gcagagaaca aagctgtgtg gaagagcaac taccataaga
    11941 tggtgtgttc cttccagcgg ctgttaaagc catcctgaat aacaaatcag ctattcctac
    12001 ctacagaccc attccaatat gctgtgatac acgacacggt gcaccgcaga ggagacagac
    12061 atcttcagca caaacacaga tgcctgcagg agcttggcaa gtcactaaat tgcatgaaat
    12121 tgtgaggtgc acaccaaatg cagggatggg ggaggccgtg ggaagctctg tattctcaaa
    12181 atttgacagc taattccggt ttttagaaaa tgcctgaggc cagtagaggc cctctagtca
    12241 ctcactgctg ctgtttctga tataattatt gagaaagcta tctcacttaa tagaagaaaa
    12301 cacgcactat caaaaccaga tagcctaacg tgcatgtgaa aatcgagaaa gctgaaaaca
    12361 aatccaggta cccttctctg aactggagtg tttccacaga cttgaataat ttatgaaatt
    12421 atcacaccag tatttctcat atcaccaaga agactttctc tcctgcagta gaggattgtt
    12481 atatttgcct aaaaaacacg attccaatat atgacaaggg cagataattt ataagtgaat
    12541 gttaataaaa ttggatgtgt ataa
//
