LOCUS       NM_001414174           12561 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor type 2 (ITPR2),
            transcript variant 2, mRNA.
ACCESSION   NM_001414174
VERSION     NM_001414174.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12561)
  AUTHORS   Zhou,S., Wang,Z., Liu,Z., Mu,G., Xie,Q., Wang,Z., Xiang,Q., Gong,Y.
            and Cui,Y.
  TITLE     Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses
            for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients
  JOURNAL   Cardiovasc Drugs Ther 37 (3), 507-518 (2023)
   PUBMED   34860335
  REMARK    GeneRIF: Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway
            Analyses for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients.
REFERENCE   2  (bases 1 to 12561)
  AUTHORS   Chen,J., Zhou,J., Jiang,Y., Wang,Y., Chen,C., Jiang,T. and Du,J.
  TITLE     Inositol 1,4,5-trisphosphate receptor gene variants are related to
            the risk of breast cancer in a Chinese population
  JOURNAL   J Gene Med 25 (2), e3463 (2023)
   PUBMED   36350267
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate receptor gene variants are
            related to the risk of breast cancer in a Chinese population.
REFERENCE   3  (bases 1 to 12561)
  AUTHORS   Ziegler,D.V., Vindrieux,D., Goehrig,D., Jaber,S., Collin,G.,
            Griveau,A., Wiel,C., Bendridi,N., Djebali,S., Farfariello,V.,
            Prevarskaya,N., Payen,L., Marvel,J., Aubert,S., Flaman,J.M.,
            Rieusset,J., Martin,N. and Bernard,D.
  TITLE     Calcium channel ITPR2 and mitochondria-ER contacts promote cellular
            senescence and aging
  JOURNAL   Nat Commun 12 (1), 720 (2021)
   PUBMED   33526781
  REMARK    GeneRIF: Calcium channel ITPR2 and mitochondria-ER contacts promote
            cellular senescence and aging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12561)
  AUTHORS   Klar,J., Hisatsune,C., Baig,S.M., Tariq,M., Johansson,A.C.,
            Rasool,M., Malik,N.A., Ameur,A., Sugiura,K., Feuk,L., Mikoshiba,K.
            and Dahl,N.
  TITLE     Abolished InsP3R2 function inhibits sweat secretion in both humans
            and mice
  JOURNAL   J Clin Invest 124 (11), 4773-4780 (2014)
   PUBMED   25329695
  REMARK    GeneRIF: Loss of InsP3R2-mediated calcium release causes isolated
            anhidrosis in humans.
REFERENCE   5  (bases 1 to 12561)
  AUTHORS   Sankar,N., deTombe,P.P. and Mignery,G.A.
  TITLE     Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate
            receptor (InsP3R2) expression during cardiac remodeling
  JOURNAL   J Biol Chem 289 (9), 6188-6198 (2014)
   PUBMED   24415751
  REMARK    GeneRIF: ITPR2 and hypertrophy specific gene expression is
            regulated, in part, by a positive feedback regulation between
            InsP3R2 and calcineurin-NFATc signaling pathways.
REFERENCE   6  (bases 1 to 12561)
  AUTHORS   Tanimura,A., Tojyo,Y. and Turner,R.J.
  TITLE     Evidence that type I, II, and III inositol 1,4,5-trisphosphate
            receptors can occur as integral plasma membrane proteins
  JOURNAL   J Biol Chem 275 (35), 27488-27493 (2000)
   PUBMED   10874040
REFERENCE   7  (bases 1 to 12561)
  AUTHORS   Mayne,M., Holden,C.P., Nath,A. and Geiger,J.D.
  TITLE     Release of calcium from inositol 1,4,5-trisphosphate
            receptor-regulated stores by HIV-1 Tat regulates TNF-alpha
            production in human macrophages
  JOURNAL   J Immunol 164 (12), 6538-6542 (2000)
   PUBMED   10843712
REFERENCE   8  (bases 1 to 12561)
  AUTHORS   El-Daher,S.S., Patel,Y., Siddiqua,A., Hassock,S., Edmunds,S.,
            Maddison,B., Patel,G., Goulding,D., Lupu,F., Wojcikiewicz,R.J. and
            Authi,K.S.
  TITLE     Distinct localization and function of (1,4,5)IP(3) receptor
            subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly
            purified human platelet membranes
  JOURNAL   Blood 95 (11), 3412-3422 (2000)
   PUBMED   10828023
  REMARK    Erratum:[Blood 2000 Sep 1;96(5):1684]
REFERENCE   9  (bases 1 to 12561)
  AUTHORS   Futatsugi,A., Kuwajima,G. and Mikoshiba,K.
  TITLE     Muscle-specific mRNA isoform encodes a protein composed mainly of
            the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor
  JOURNAL   Biochem J 334 (Pt 3) (Pt 3), 559-563 (1998)
   PUBMED   9729462
REFERENCE   10 (bases 1 to 12561)
  AUTHORS   Yamamoto-Hino,M., Sugiyama,T., Hikichi,K., Mattei,M.G.,
            Hasegawa,K., Sekine,S., Sakurada,K., Miyawaki,A., Furuichi,T.,
            Hasegawa,M. et al.
  TITLE     Cloning and characterization of human type 2 and type 3 inositol
            1,4,5-trisphosphate receptors
  JOURNAL   Recept Channels 2 (1), 9-22 (1994)
   PUBMED   8081734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024093.46, AC023051.21,
            AC023425.20, AC024145.34 and AC055720.17.
            
            Summary: The protein encoded by this gene belongs to the inositol
            1,4,5-triphosphate receptor family, whose members are second
            messenger intracellular calcium release channels. These proteins
            mediate a rise in cytoplasmic calcium in response to receptor
            activated production of inositol triphosphate. Inositol
            triphosphate receptor-mediated signaling is involved in many
            processes including cell migration, cell division, smooth muscle
            contraction, and neuronal signaling. This protein is a type 2
            receptor that consists of a cytoplasmic amino-terminus that binds
            inositol triphosphate, six membrane-spanning helices that
            contribute to the ion pore, and a short cytoplasmic
            carboxy-terminus. A mutation in this gene has been associated with
            anhidrosis, suggesting that intracellular calcium release mediated
            by this protein is required for eccrine sweat production. [provided
            by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1663738.1,
                                           SRR14038191.2025162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AC024093.46        126484-126988
            506-576             AC023051.21        163277-163347       c
            577-692             AC023051.21        98770-98885         c
            693-779             AC023051.21        97776-97862         c
            780-938             AC023051.21        95517-95675         c
            939-1037            AC023051.21        89264-89362         c
            1038-1121           AC023051.21        88872-88955         c
            1122-1268           AC023051.21        88419-88565         c
            1269-1364           AC023051.21        84293-84388         c
            1365-1406           AC023051.21        68729-68770         c
            1407-1558           AC023051.21        59601-59752         c
            1559-1658           AC023051.21        55694-55793         c
            1659-1819           AC023051.21        54994-55154         c
            1820-1961           AC023051.21        39030-39171         c
            1962-2123           AC023051.21        36805-36966         c
            2124-2296           AC023051.21        32233-32405         c
            2297-2416           AC023051.21        31131-31250         c
            2417-2602           AC023051.21        30827-31012         c
            2603-2854           AC023051.21        29417-29668         c
            2855-2999           AC023051.21        28828-28972         c
            3000-3150           AC023051.21        27096-27246         c
            3151-3344           AC023425.20        181209-181402       c
            3345-3474           AC023425.20        177376-177505       c
            3475-3532           AC023425.20        173642-173699       c
            3533-3698           AC023425.20        171583-171748       c
            3699-3872           AC023425.20        170466-170639       c
            3873-3962           AC023425.20        151960-152049       c
            3963-4088           AC023425.20        151713-151838       c
            4089-4211           AC023425.20        149330-149452       c
            4212-4412           AC023425.20        148488-148688       c
            4413-4664           AC023425.20        146226-146477       c
            4665-4790           AC023425.20        144808-144933       c
            4791-4919           AC023425.20        129370-129498       c
            4920-5040           AC023425.20        128056-128176       c
            5041-5231           AC023425.20        111105-111295       c
            5232-5374           AC023425.20        105576-105718       c
            5375-5483           AC023425.20        99590-99698         c
            5484-5592           AC023425.20        44495-44603         c
            5593-5780           AC023425.20        43496-43683         c
            5781-5964           AC023425.20        36411-36594         c
            5965-6221           AC023425.20        35447-35703         c
            6222-6422           AC023425.20        33041-33241         c
            6423-6533           AC023425.20        30474-30584         c
            6534-6629           AC023425.20        26255-26350         c
            6630-6752           AC023425.20        24639-24761         c
            6753-6860           AC024145.34        66676-66783         c
            6861-7053           AC024145.34        62260-62452         c
            7054-7179           AC024145.34        59354-59479         c
            7180-7355           AC024145.34        51046-51221         c
            7356-7520           AC024145.34        42182-42346         c
            7521-7716           AC024145.34        38436-38631         c
            7717-7809           AC024145.34        34453-34545         c
            7810-7940           AC024145.34        23261-23391         c
            7941-8106           AC024145.34        22009-22174         c
            8107-8267           AC024145.34        10567-10727         c
            8268-8429           AC055720.17        57961-58122         c
            8430-12561          AC055720.17        53146-57277         c
FEATURES             Location/Qualifiers
     source          1..12561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..12561
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="inositol 1,4,5-trisphosphate receptor type 2"
                     /db_xref="GeneID:3709"
                     /db_xref="HGNC:HGNC:6181"
                     /db_xref="MIM:600144"
     exon            1..505
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..8516
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="isoform 2 is encoded by transcript variant 2; IP3R
                     2; type 2 InsP3 receptor; IP3 receptor; cilia and flagella
                     associated protein 48; inositol 1,4,5-trisphosphate-gated
                     calcium channel ITPR2"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR2 isoform 2"
                     /protein_id="NP_001401103.1"
                     /db_xref="GeneID:3709"
                     /db_xref="HGNC:HGNC:6181"
                     /db_xref="MIM:600144"
                     /translation="MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAG
                     DLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQ
                     NESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSW
                     FYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSW
                     KITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSAT
                     SSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNRDG
                     VPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLC
                     TNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKV
                     LATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLM
                     REQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDY
                     RKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRN
                     REPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSI
                     LSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMC
                     LDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVR
                     YARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEK
                     NKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGN
                     NVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKI
                     IEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIA
                     AQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAE
                     VLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVK
                     GGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQR
                     LLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLF
                     LTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADG
                     KYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLV
                     ELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVE
                     MKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPF
                     SDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPV
                     DLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVA
                     SLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEK
                     LCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVG
                     GSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGG
                     NTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNEL
                     MTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNT
                     EEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFL
                     DCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDI
                     IIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVD
                     VMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPD
                     EGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGS
                     KVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYP
                     FGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPT
                     LILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEF
                     FYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTM
                     EVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDT
                     LLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGV
                     IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIV
                     LVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLES
                     TMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH"
     exon            506..576
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..692
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..779
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..938
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1037
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1121
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1268
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1364
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1406
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1558
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1658
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1819
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1961
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2123
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2296
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2416
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2602
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2854
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2999
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3150
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3344
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3474
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3532
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3698
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3872
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..3962
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4088
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4211
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4412
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4664
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4790
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4791..4919
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4920..5040
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5041..5231
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5232..5374
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5483
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5592
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5593..5780
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5781..5964
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            5965..6221
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6222..6422
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6423..6533
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6534..6629
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6630..6752
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6753..6860
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            6861..7053
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7054..7179
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7180..7355
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7356..7520
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7521..7716
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7717..7809
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7810..7940
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            7941..8106
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            8107..8267
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            8268..8429
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     exon            8430..12561
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11377..11382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="hexamer: AATAAA"
     polyA_site      11398
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="major polyA site"
     regulatory      12541..12546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="hexamer: AATAAA"
     polyA_site      12561
                     /gene="ITPR2"
                     /gene_synonym="ANHD; CFAP48; INSP3R2; IP3R2"
                     /note="major polyA site"
ORIGIN      
        1 cagctcccgc cgggcggctg tgacggccgc agcgggtcgc agagcaggga gtggacacgg
       61 agtggggagc ggagagggaa ggaggaggag gaggagcaaa ggtgttggag agaaaacttc
      121 agaaaggaac aggaaacctg ccggggaggc ggcggcggct gcggcttctc tgggcgcctg
      181 ggctgcgctc ttcgcggggt gtccgcagct gcggcttggc cccggtctgg cttccccggc
      241 gcgcacgcac ggctgagccg cgacgctcag tggctcgggc cgtgccctcc gccgcggctc
      301 ttggccgctg tagtcccgcg atccgatccg cttctgccgc ggcggctccc tggagagagg
      361 gcggcgaggg cgcagggaag aagagggacg tccactgtgg aacatgaagc agcatgactg
      421 agaaaatgtc cagcttcctc tacatagggg acatcgtgtc cctgtacgcg gagggctcgg
      481 tcaacggctt catcagcacc ttggggttag tggatgacag atgtgtggtg cacccagagg
      541 ccggggacct tgccaaccct cccaagaagt tcagagactg ccttttcaag gtgtgcccta
      601 tgaacagata ttctgcccag aagcaatatt ggaaagcaaa gcaagccaaa caagggaacc
      661 acaccgaggc agccttgctg aagaaactac agcacgctgc agaactggaa caaaaacaaa
      721 atgaatcgga gaataagaaa ctgttgggag aaattgtaaa atacagtaat gttatacaac
      781 tactgcatat aaaaagcaac aaatatctta ctgtcaacaa gagattacct gctttactgg
      841 agaagaatgc catgcgtgtg tccttggatg ctgcaggaaa tgaagggtct tggttttata
      901 ttcatccgtt ctggaaactg agaagcgagg gtgacaatat tgttgtagga gataaagttg
      961 ttttgatgcc tgtgaatgca gggcagccac tacatgccag caacatagag cttcttgata
     1021 acccagggtg taaagaggtg aatgctgtca attgcaacac cagctggaaa atcactttat
     1081 tcatgaaata tagttcctat cgagaggatg tattaaaagg aggggacgtt gttagattat
     1141 ttcatgcgga acaagagaag tttttgactt gtgatgaata tgagaaaaaa cagcacattt
     1201 tccttcgtac gaccttgcgc caatcagcta cttctgctac tagttctaaa gcactctggg
     1261 aaatagaggt ggttcatcat gacccatgcc gtgggggtgc aggacagtgg aacagcttgt
     1321 tcagatttaa gcatcttgca actggaaact atttagctgc agagcttaat cctgattatc
     1381 gagatgccca aaatgaagga aaaaatagag atggagtccc tccaacttca aagaaaaaac
     1441 gccaggcagg ggagaagatc atgtatactt tggtttcagt cccgcatggc aatgacattg
     1501 catccctttt tgaactagat gccacaactc ttcagagagc tgactgcctg gttccaagga
     1561 actcatatgt tcggttaagg catttatgca ccaacacatg ggtaaccagt actagtatcc
     1621 ccatagacac agatgaagag aggcctgtta tgttaaagat tggaacctgc caaaccaaag
     1681 aagataaaga agcgttcgca atcgtgtctg ttccactgtc tgaagttcga gacttagact
     1741 ttgccaatga tgccaataaa gtactagcga ccacagttaa aaagctagaa aacggcacaa
     1801 taactcagaa tgaaaggagg tttgtaacca aattattgga agatctcata ttctttgttg
     1861 ctgatgtgcc taataatgga caagaagttc tggatgtggt tatcactaag ccaaaccgag
     1921 agcgtcaaaa attgatgagg gaacaaaaca tactggcaca ggtatttgga attcttaaag
     1981 caccctttaa agagaaagca ggagaaggct cgatgctgag acttgaagat ctgggggatc
     2041 aaagatatgc accctacaag tacatgctgc ggctctgtta ccgcgtcctg agacactcgc
     2101 agcaggatta ccggaaaaat caggaatata ttgctaagaa tttctgtgtc atgcagtccc
     2161 agattggcta tgatattttg gcagaagata ctatcacagc tttgttgcac aacaacagaa
     2221 aactactaga gaaacatatc acagcaaaag aaatagaaac atttgtcagt ttactcagga
     2281 gaaatcggga gccaaggttt ttggattatt tgtcagatct gtgtgtgtct aataccactg
     2341 ctatccctgt aactcaagaa ctcatctgta aatttatgtt gagtccaggc aatgcagaca
     2401 ttctcattca aactaaggtg gtctcaatgc aagcagacaa ccccatggag agctccatcc
     2461 tttcagatga cattgatgat gaagaagttt ggctctattg gattgacagc aacaaggaac
     2521 ctcatggcaa agctatcagg caccttgctc aagaggcaaa agaaggcacc aaagctgact
     2581 tagaagttct tacctattac aggtaccagc taaacctctt tgcaaggatg tgcttggatc
     2641 gccagtatct ggccataaac cagatttcta cacagctgtc tgtagacctg atcctgcggt
     2701 gtgtgtcgga tgagagcctg ccgttcgacc tccgagcgtc cttctgtcgc ctcatgctcc
     2761 acatgcacgt tgaccgggat ccccaggagt ccgtggtgcc tgttcgctat gccaggctct
     2821 ggacagaaat ccccacaaag atcacaattc atgaatatga ttctataaca gactcttcca
     2881 gaaatgatat gaagaggaaa tttgccctga caatggaatt tgttgaagaa tatttgaaag
     2941 aagttgtaaa ccagcccttt ccttttgggg ataaagaaaa aaataaactg acatttgagg
     3001 tggtccactt ggctcggaat cttatatact ttggatttta tagtttcagt gagttattaa
     3061 ggctaacaag aacacttctg gctattttag acattgtaca ggcccccatg tcatcatact
     3121 ttgaaagatt aagcaaattt caagatggag gaaacaatgt gatgagaacc attcatgggg
     3181 tgggagagat gatgacccag atggtactca gtagaggctc catcttcccc atgagcgtgc
     3241 cggatgtgcc acccagcatc cacccgagca agcaagggag ccccaccgag cacgaggatg
     3301 tgactgtgat ggacaccaag ctgaagatca ttgagatttt gcagtttatc ctgagtgtca
     3361 gactggatta taggatctca tatatgctgt caatatataa gaaggagttt ggagaggaca
     3421 atgacaatgc ggagacatct gccagtggat ctccagacac tttactacca tcagctattg
     3481 ttcctgatat agatgaaatt gcagctcagg cagaaactat gtttgcggga agaaaagaaa
     3541 aaaatccagt tcaacttgac gatgaaggag gcaggacgtt tttacgggtc ctcattcatc
     3601 tgatcatgca cgactacccg cctttgctgt ctggagccct gcagctgttg tttaagcact
     3661 tcagccagag ggcagaggtt ttacaggcat ttaagcaggt gcaattactg gtgtctaatc
     3721 aagacgtaga taactacaag caaatcaagg cagatctaga ccagcttcga ctgacagtag
     3781 aaaagtctga gctatgggtg gagaagagca gcaactatga gaatggagaa ataggggaaa
     3841 gtcaagtgaa aggtggtgaa gagccaattg aggaatcaaa cattttaagt ccagtgcagg
     3901 atggaacaaa gaaacctcag attgacagca acaagagcaa taactaccgg attgtaaagg
     3961 agattttgat caggctaagt aaactctgtg tgcagaataa aaagtgtcgg aatcaacatc
     4021 aacgattact gaaaaatatg ggggcgcatt cggtggtgtt ggatcttctg cagataccct
     4081 atgaaaagaa tgatgaaaag atgaatgaag taatgaatct agcccataca tttctgcaga
     4141 atttctgtcg aggaaatcca cagaatcaag ttcttcttca taaacatctg aatttgtttt
     4201 taactccagg tctccttgaa gcagaaacca tgcggcacat cttcatgaac aattaccatc
     4261 tgtgcaacga aattagcgag agagttgtac aacactttgt gcactgcatt gagacacatg
     4321 gccgccacgt ggagtacctg aggtttttgc aaacaattgt aaaagcagat ggtaaatatg
     4381 tgaagaaatg ccaggatatg gtaatgacag agttgataaa tgggggtgaa gacgtgctga
     4441 tattttacaa tgatagagca tcatttccaa tccttctcca tatgatgtgt tcagagagag
     4501 accgagggga tgagagtggc cccttagcct accacatcac cctggtggag ttgctggcag
     4561 catgcacaga ggggaaaaat gtctacactg aaatcaagtg taattccctt ctcccgctgg
     4621 acgacatagt gagggtggtg acccatgacg actgcatccc tgaggttaaa attgcttatg
     4681 tgaactttgt taatcactgt tatgttgaca ctgaagtgga aatgaaagaa atctatacaa
     4741 gtaaccacat ttggaaatta tttgagaact tcttggtgga tatggcaagg gtttgcaaca
     4801 caactacaga caggaaacat gcagacatct ttttggaaaa gtgtgttact gagtcaataa
     4861 tgaatattgt gagcggcttc tttaattctc ccttttcaga caatagtacc agcctccaga
     4921 cacatcagcc agtttttatt cagctactgc aatctgcctt cagaatttac aattgcacct
     4981 ggccaaaccc agcgcagaaa gcctcagtgg aatcctgtat cagaactttg gctgaagtgg
     5041 caaaaaatcg tggaattgcc attccagtgg atttggacag ccaagttaat actcttttca
     5101 tgaagagcca ttcaaatatg gtgcagagag cagcaatggg ttggagacta tcagctcgct
     5161 ctgggccacg ctttaaggaa gctcttggag ggcctgcttg ggattacaga aatattattg
     5221 aaaagttaca ggatgtagtg gcctccttgg agcaccagtt cagcccaatg atgcaggctg
     5281 aattctcagt gttggttgat gtattgtaca gtccagaact gctgttccct gagggaagcg
     5341 atgcaagaat aagatgtggc gctttcatgt cgaagttgat taatcataca aagaaactaa
     5401 tggagaaaga agaaaaactg tgcattaaaa ttcttcagac attacgagaa atgttagaga
     5461 agaaagacag ctttgtggaa gagggtaaca cattaagaaa gatacttctg aatcgatact
     5521 ttaaaggtga ttatagtatt ggtgtgaatg gacacctatc aggagcctac tccaaaactg
     5581 cacaggtggg aggaagcttt tctggacaag attcagataa gatggggata tcaatgtcag
     5641 acattcagtg tctgctggat aaagaaggtg catcagaact tgtcatcgat gttatagtga
     5701 acaccaaaaa tgacagaatt ttttcagaag gcattttcct cggcattgcc ttgcttgaag
     5761 gaggaaatac acaaacacag tattctttct accagcagtt gcatgaacaa aaaaagtcag
     5821 aaaaattctt taaagttctc tatgatcgaa tgaaggctgc tcagaaagaa ataagatcaa
     5881 cagtgacagt taataccata gatttaggta acaaaaaaag ggacgatgac aatgaattga
     5941 tgacatctgg tccacgaatg agagtaagag attcaacact acatttaaaa gagggaatga
     6001 aagggcaatt aacagaagct tcttcagcaa catccaaagc atattgtgta tacagaagag
     6061 aaatggatcc agaaatagac attatgtgca caggaccaga agcgggaaac actgaggaaa
     6121 aatccgcaga ggaagtaaca atgagtcccg caattgccat catgcagcca atactgagat
     6181 ttcttcagtt actgtgtgag aatcacaacc gggaattgca gaacttcttg aggaatcaaa
     6241 acaacaaaac aaattacaac ctagtctgtg agacccttca gtttctggac tgcatttgtg
     6301 gaagtacaac cggtggcctg ggcctgttgg gtctctacat caatgagaag aatgtagcgc
     6361 tggtcaacca gaacctggag agcttgactg agtattgcca gggcccttgc catgaaaatc
     6421 agacctgtat cgctacacat gagtctaatg ggattgatat catcattgct ttgattctga
     6481 atgacataaa ccctcttggt aaataccgaa tggacctggt gctccagcta aagaacaatg
     6541 catctaaact tttgctggcc attatggaaa gcagacatga cagtgagaat gcagaaagaa
     6601 ttctttttaa catgagaccc agagaactgg tggatgtgat gaagaatgcc tataaccaag
     6661 gattggaatg tgaccatggg gatgatgagg gtggagatga tggtgtttct ccaaaagatg
     6721 ttggacacaa tatctatatt ctggcccatc agttggcccg ccacaataaa ctgttgcagc
     6781 agatgctcaa accaggatcg gatccagatg aaggagatga agccttaaag tattatgcca
     6841 accacactgc acagattgag attgtccggc atgataggac catggaacaa atagtttttc
     6901 ctgtccccaa tatatgtgaa tacctcactc gagaatccaa gtgccgtgtg ttcaatacaa
     6961 ctgaaaggga tgaacaagga agtaaagtga atgacttttt ccagcaaaca gaagatctct
     7021 acaatgaaat gaagtggcag aagaaaatca ggaataaccc tgcactgttc tggttctcga
     7081 ggcacatctc tctctggggg agcatttcct tcaacctggc tgtgttcatc aatttagctg
     7141 ttgctctctt ctacccattt ggggatgatg gagatgaagg tacactttct ccattgttct
     7201 cggttcttct ttggatagca gttgcgatct gcacatctat gctgtttttc ttctccaagc
     7261 ctgtgggtat tcggccgttt cttgtatcaa taatgctcag atcaatatat acaataggtc
     7321 ttgggcctac attaatactt cttggtgcag ctaatctttg taataaaatt gtttttctgg
     7381 tgagttttgt tggaaatcgt ggcacgttca cccgtgggta ccgagcagtc atcctggata
     7441 tggcctttct ctatcacgtg gcgtatgtcc tggtttgcat gctgggcctt tttgtccatg
     7501 aattcttcta tagcttcctg ctttttgatt tggtgtacag ggaagagact ttgctgaatg
     7561 tcataaaaag tgtcacacga aatggccgct ctattattct aactgcagtc ctggctctca
     7621 tcctcgtcta cctgttttcc attattgggt tccttttttt gaaggatgac ttcactatgg
     7681 aagttgatag gctgaaaaac cgaactcctg ttacaggcag tcatcaagtg cctactatga
     7741 ctttaactac catgatggaa gcatgtgcca aggagaactg ttcacccaca attccagctt
     7801 caaatacagc tgatgaagag tatgaagatg gaattgaaag gacgtgtgac actctcctta
     7861 tgtgcattgt caccgtgctg aaccagggcc tcaggaatgg cggtggtgtg ggggatgtgc
     7921 taagaaggcc atcgaaagat gagcccttgt ttgctgcccg agtggtttat gaccttcttt
     7981 tttatttcat tgttatcatt attgttctga acttgatttt tggtgttatc atcgatactt
     8041 ttgctgatct cagaagcgaa aaacagaaaa aagaagaaat tctaaagaca acttgtttca
     8101 tctgtggact tgagagagac aagtttgata ataaaacggt ttcatttgag gagcacatta
     8161 agtcagaaca caatatgtgg cattatttgt acttcatagt cctggtgaaa gttaaagacc
     8221 caacagaata cactggacct gaaagttatg tggctcaaat gattgtggag aagaatttgg
     8281 attggtttcc tcggatgcga gccatgtccc tcgttagcaa tgaaggcgac agtgagcaaa
     8341 atgaaattcg gagccttcag gagaagttgg aatcgaccat gagtctggtc aaacagctgt
     8401 cgggtcagct ggcggagctc aaggagcaga tgacagaaca aaggaagaat aagcagagac
     8461 tgggcttcct cggatcaaac acaccccatg tgaatcatca catgccacca cactgatacc
     8521 atggggggaa gccgtgacta gcctttcatc agtgtcctgc ctgatcactg aataaagaac
     8581 tgagatggag gggagtgaac agtgcctatt gttgaaaagt taaaaacaac caagtgccaa
     8641 gatgttgagt gggttagctc cgagaacaat ttataactgt gttttcatgg ttgcgaagac
     8701 ctaacctcaa atgcatctgc tagaaagcgt acatcacaca ttcgcaatgc atcaggaaga
     8761 aaaggcttgc ccaaaaggct ggagagggca gggagcggca ggatggaagg agacacgggg
     8821 cagggagaac tctcttctgc taaatcgata ggagtcagtt ttgtcttaaa tgctgactac
     8881 agccactgac atggttggct ggaatttctt tcttttaatt gtggcatata ggtttgtgac
     8941 acaagaagtc atactttggt ggctaagttt tactaaggaa aataactgaa aagattaaaa
     9001 gtgagagctg aaaagagaaa tgataatgct tccaaactgt agctgtcaca gggcaatttc
     9061 tttatttata acatgaagca caatggattt acagctctag gaacttagta ctttggagct
     9121 tttgcctctc acactgacaa cataacagga tgtgattgcc ttctctggga ttcagacagg
     9181 ctctgtcaat gtggagcaca aaaggagatt ttcatataac ttgttaaaaa catgttctaa
     9241 gtcatgtata ggctaagatt ttaagaagat ctgggggaat aaaaagccaa cagtaagccc
     9301 caggaaaggg ttttttgaga ccatatgtat gctattaaaa tatattgaga ttaatacatg
     9361 aaaatgctta aaagtgatag gaattattga gaaacttatg atggtggcat tgccttttat
     9421 aaacatggag tgaaagccat ttgactcaac gtttgctgtg cttaaagaat tgcttcagga
     9481 cccgagcgtt tttatgtatg ctgttcctgc agttaggaaa aaaaaatcca agaaatgtat
     9541 tgaatactca agaaaatgcc acatttcaat tacatattta aaactgtatc tgtaagggct
     9601 tttcaaaatg tagcaagata aaaatctctt attcaaattg tttttgtatt aaatcatgca
     9661 ctcagaattt gtcgagggag agaataacct ggtgtgttca ggttattctt agagactaca
     9721 catttggaat agcagagcaa aatatggata atgaaagtgt tgggaaaaaa gtgatgtgac
     9781 agggagtgaa gacacttgat accagactct gggagatact ctgcaagttg acctggcctc
     9841 tcccccacag gaacaaaaca ctgcctccag agtctttaaa ttctcagtta tcaacgccaa
     9901 ggtttaaggt ctagataggg tttgctatag ggtttgctct gacaattttt aaagcttttg
     9961 gattgttcta acatagctta agctattggt tcctaaaaat cccaaatcaa gatctatgta
    10021 gaatataaag gaagcctgaa ccaatccttc cacatactgt taagatgtag acttggaaca
    10081 aagctgttgg gacccagagc aatgaatttt tgaactgaag ctactggtac tccccagcac
    10141 cacctcatac taagaattcc tcactctgac atgacagtat tttttctgac caggagctga
    10201 aagaccctga cattcatgat ccaaagatat aagaaatttt gatatgtctg catgcagcac
    10261 agaactttga acctaggagg cagtcaataa atacatgaga aattcagctg tcattcagtt
    10321 actcttaatt ctttataaaa ctttaaatga taccacatat ttgtttgttt aaaatggctt
    10381 tcccaaaatc aaagtagact aaagcagcca tctttaaaat ccaggatcat caatgctatt
    10441 aacagtatca ggtaaaaagt acactttaaa atattttaat caggcagagt tttatggata
    10501 gagaatagaa gagaaaggta gtaaatattg aacatattcc aatataggaa cctatctctg
    10561 ttttagtaca aaatatttct gacatctgaa ctagaggtca agagaataaa ttcatttgta
    10621 tacatctgag caacctgtct ttcagatgat aaagtatcta gccttttctg acaccataat
    10681 agttcatttt gtagggaata agccattagg tgtatataat tgctttctag aaatgaccta
    10741 atgtccccaa ccactttgta gtggcagatc actgtttcac agcatatttt ctcccaagga
    10801 aagtattcaa aagagactgc aactaacaag actcttattt catcaaaatt taaatatttc
    10861 tgagttgtat ttttaatgcc tctttctttt ctgcctaaat gcttagaaat tataaagcaa
    10921 aaaaaaaaaa aacagcaaca aaaaatcgaa gcagacaaaa aaggcacttt tcagaacatc
    10981 aaattcctaa tgaagaagag gagaagataa tggggaaatt tgacatttga tataaattta
    11041 tatttgttat gtgtatgttt gttaatgcaa ctggaatatt tgacttaggt gagtatcagt
    11101 taacatcctt gtatttatat agtgacatca aaataaatgc aatcatcttg aactttgatg
    11161 ttaagggaga ttttgaaaaa atatttagtt atttcaaatt catattggtt caaaagtatc
    11221 agtttctgct gaataatatt tttaatttca aaagggtttt gttccctctg tgctccattc
    11281 tgaggctcaa gagcttaatg ccagtatgtt ttctgagtta aaataacact tttagatgag
    11341 aaaatgcttg tatcatacag ggctataata taaataaata aattgtatgt atgcaaaatt
    11401 tatcatattt tctacccctt aaaaaattaa gttagaaata agcttatttt cttgcacatc
    11461 aatatttttc tgttggtaaa gaggacacaa tttctagtag attgttaata acatcaggaa
    11521 gatatttctt tcgtcagaac taattgtgtg cttattccca tattctcagc tcataactcc
    11581 ctgttttggc tgctctcttt attttacaat tgtttcattg caaacagcaa ggcagtatag
    11641 cccacactca gccactagcc cccagtcccc aggactgaga atgagtgggg aggctgggga
    11701 gttggtgaga gaaggtggag atagggattt ctgcttccca gtactctatc attagagaaa
    11761 aggaggggta aatattagct aagaagaaga aaaaagctta ttcttcaggg acccagtaga
    11821 ttggacgtaa gcaagtaaat attgcacagg catcatgatg taatagttga tggaccccag
    11881 agatacccct cacccatgca gagaacaaag ctgtgtggaa gagcaactac cataagatgg
    11941 tgtgttcctt ccagcggctg ttaaagccat cctgaataac aaatcagcta ttcctaccta
    12001 cagacccatt ccaatatgct gtgatacacg acacggtgca ccgcagagga gacagacatc
    12061 ttcagcacaa acacagatgc ctgcaggagc ttggcaagtc actaaattgc atgaaattgt
    12121 gaggtgcaca ccaaatgcag ggatggggga ggccgtggga agctctgtat tctcaaaatt
    12181 tgacagctaa ttccggtttt tagaaaatgc ctgaggccag tagaggccct ctagtcactc
    12241 actgctgctg tttctgatat aattattgag aaagctatct cacttaatag aagaaaacac
    12301 gcactatcaa aaccagatag cctaacgtgc atgtgaaaat cgagaaagct gaaaacaaat
    12361 ccaggtaccc ttctctgaac tggagtgttt ccacagactt gaataattta tgaaattatc
    12421 acaccagtat ttctcatatc accaagaaga ctttctctcc tgcagtagag gattgttata
    12481 tttgcctaaa aaacacgatt ccaatatatg acaagggcag ataatttata agtgaatgtt
    12541 aataaaattg gatgtgtata a
//
