LOCUS       NM_002222               9719 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor type 1 (ITPR1),
            transcript variant 2, mRNA.
ACCESSION   NM_002222
VERSION     NM_002222.7
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9719)
  AUTHORS   Lei,Z., Niu,J., Cai,H., Kong,Z., Ding,X., Dong,Y., Zhang,D., Li,X.,
            Shao,J., Lin,A., Zhou,R., Yang,S. and Yan,Q.
  TITLE     NF2 regulates IP3R-mediated Ca2+ signal and apoptosis in
            meningiomas
  JOURNAL   FASEB J 38 (13), e23737 (2024)
   PUBMED   38953724
  REMARK    GeneRIF: NF2 regulates IP3R-mediated Ca[2+] signal and apoptosis in
            meningiomas.
REFERENCE   2  (bases 1 to 9719)
  AUTHORS   Atakpa-Adaji,P., Ivanova,A., Kujawa,K. and Taylor,C.W.
  TITLE     KRAP regulates mitochondrial Ca2+ uptake by licensing IP3 receptor
            activity and stabilizing ER-mitochondrial junctions
  JOURNAL   J Cell Sci 137 (12) (2024)
   PUBMED   38786982
  REMARK    GeneRIF: KRAP regulates mitochondrial Ca2+ uptake by licensing IP3
            receptor activity and stabilizing ER-mitochondrial junctions.
REFERENCE   3  (bases 1 to 9719)
  AUTHORS   Sanli,F., Tatar,A., Gundogdu,B. and Karatas,O.F.
  TITLE     IP3R1 dysregulation via mir-200c-3p/SSFA2 axis contributes to taxol
            resistance in head and neck cancer
  JOURNAL   Eur J Pharmacol 973, 176592 (2024)
   PUBMED   38642666
  REMARK    GeneRIF: IP3R1 dysregulation via mir-200c-3p/SSFA2 axis contributes
            to taxol resistance in head and neck cancer.
REFERENCE   4  (bases 1 to 9719)
  AUTHORS   Maleki,B., Modarres,P., Salehi,P. and Vallian,S.
  TITLE     Identification of ITPR1 gene as a novel target for hsa-miR-34b-5p
            in non-obstructive azoospermia: a Ca2+/apoptosis pathway cross-talk
  JOURNAL   Sci Rep 13 (1), 21873 (2023)
   PUBMED   38072953
  REMARK    GeneRIF: Identification of ITPR1 gene as a novel target for
            hsa-miR-34b-5p in non-obstructive azoospermia: a Ca[2+]/apoptosis
            pathway cross-talk.
            Erratum:[Sci Rep. 2024 Feb 14;14(1):3722. doi:
            10.1038/s41598-024-53786-7.. PMID: 38355618]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9719)
  AUTHORS   Kirkwood,K.L., Homick,K., Dragon,M.B. and Bradford,P.G.
  TITLE     Cloning and characterization of the type I inositol
            1,4,5-trisphosphate receptor gene promoter. Regulation by
            17beta-estradiol in osteoblasts
  JOURNAL   J Biol Chem 272 (36), 22425-22431 (1997)
   PUBMED   9278393
REFERENCE   6  (bases 1 to 9719)
  AUTHORS   Joseph,S.K., Lin,C., Pierson,S., Thomas,A.P. and Maranto,A.R.
  TITLE     Heteroligomers of type-I and type-III inositol trisphosphate
            receptors in WB rat liver epithelial cells
  JOURNAL   J Biol Chem 270 (40), 23310-23316 (1995)
   PUBMED   7559486
  REMARK    Erratum:[J Biol Chem 1996 Mar 29;271(13):7874]
REFERENCE   7  (bases 1 to 9719)
  AUTHORS   Nucifora,F.C. Jr., Li,S.H., Danoff,S., Ullrich,A. and Ross,C.A.
  TITLE     Molecular cloning of a cDNA for the human inositol
            1,4,5-trisphosphate receptor type 1, and the identification of a
            third alternatively spliced variant
  JOURNAL   Brain Res Mol Brain Res 32 (2), 291-296 (1995)
   PUBMED   7500840
REFERENCE   8  (bases 1 to 9719)
  AUTHORS   Storey,E.
  TITLE     Spinocerebellar Ataxia Type 15 - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301536
REFERENCE   9  (bases 1 to 9719)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   10 (bases 1 to 9719)
  AUTHORS   Mahaut-Smith,M.P., Sage,S.O. and Rink,T.J.
  TITLE     Receptor-activated single channels in intact human platelets
  JOURNAL   J Biol Chem 265 (18), 10479-10483 (1990)
   PUBMED   1693919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024168.5, AC090944.2,
            AC069248.4 and AC018816.6.
            
            On May 20, 2020 this sequence version replaced NM_002222.6.
            
            Summary: This gene encodes an intracellular receptor for inositol
            1,4,5-trisphosphate. Upon stimulation by inositol
            1,4,5-trisphosphate, this receptor mediates calcium release from
            the endoplasmic reticulum. Mutations in this gene cause
            spinocerebellar ataxia type 15, a disease associated with an
            heterogeneous group of cerebellar disorders. Multiple transcript
            variants have been identified for this gene. [provided by RefSeq,
            Nov 2009].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in a shorter isoform (2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC024168.5         133408-133665
            259-334             AC024168.5         134491-134566
            335-442             AC024168.5         156536-156643
            443-513             AC024168.5         161084-161154
            514-629             AC090944.2         8403-8518           c
            630-716             AC069248.4         108159-108245       c
            717-875             AC069248.4         105378-105536       c
            876-974             AC069248.4         103395-103493       c
            975-1058            AC069248.4         102159-102242       c
            1059-1205           AC069248.4         101901-102047       c
            1206-1301           AC069248.4         95411-95506         c
            1302-1456           AC069248.4         89351-89505         c
            1457-1556           AC069248.4         86542-86641         c
            1557-1717           AC069248.4         85387-85547         c
            1718-1859           AC069248.4         84423-84564         c
            1860-2018           AC069248.4         82333-82491         c
            2019-2191           AC069248.4         80080-80252         c
            2192-2311           AC069248.4         77856-77975         c
            2312-2509           AC069248.4         76703-76900         c
            2510-2761           AC069248.4         74242-74493         c
            2762-2903           AC069248.4         73286-73427         c
            2904-3057           AC069248.4         72408-72561         c
            3058-3245           AC069248.4         70828-71015         c
            3246-3384           AC069248.4         66938-67076         c
            3385-3439           AC069248.4         66211-66265         c
            3440-3605           AC069248.4         64078-64243         c
            3606-3776           AC069248.4         63831-64001         c
            3777-3842           AC069248.4         63283-63348         c
            3843-3980           AC069248.4         62423-62560         c
            3981-4106           AC069248.4         59009-59134         c
            4107-4307           AC069248.4         56285-56485         c
            4308-4559           AC069248.4         53888-54139         c
            4560-4685           AC069248.4         50357-50482         c
            4686-4814           AC069248.4         47688-47816         c
            4815-4935           AC069248.4         44679-44799         c
            4936-5120           AC069248.4         41278-41462         c
            5121-5269           AC069248.4         37156-37304         c
            5270-5381           AC069248.4         35761-35872         c
            5382-5514           AC069248.4         14409-14541         c
            5515-5705           AC069248.4         12275-12465         c
            5706-5886           AC018816.6         147939-148119       c
            5887-6140           AC018816.6         145885-146138       c
            6141-6341           AC018816.6         139207-139407       c
            6342-6452           AC018816.6         137275-137385       c
            6453-6548           AC018816.6         135004-135099       c
            6549-6671           AC018816.6         131908-132030       c
            6672-6776           AC018816.6         130729-130833       c
            6777-6969           AC018816.6         126510-126702       c
            6970-7092           AC018816.6         119462-119584       c
            7093-7268           AC018816.6         114049-114224       c
            7269-7433           AC018816.6         108382-108546       c
            7434-7629           AC018816.6         103189-103384       c
            7630-7722           AC018816.6         101415-101507       c
            7723-7862           AC018816.6         100087-100226       c
            7863-8028           AC018816.6         99431-99596         c
            8029-8189           AC018816.6         96407-96567         c
            8190-8351           AC018816.6         77714-77875         c
            8352-9719           AC018816.6         67143-68510         c
FEATURES             Location/Qualifiers
     source          1..9719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.1"
     gene            1..9719
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="inositol 1,4,5-trisphosphate receptor type 1"
                     /db_xref="GeneID:3708"
                     /db_xref="HGNC:HGNC:6180"
                     /db_xref="MIM:147265"
     exon            1..258
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            259..334
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            335..442
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..8438
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="isoform 2 is encoded by transcript variant 2;
                     inositol 1,4,5-triphosphate receptor, type 1; protein
                     phosphatase 1, regulatory subunit 94; type 1 InsP3
                     receptor; IP3 receptor; IP3R 1; type 1 inositol
                     1,4,5-trisphosphate receptor; inositol 1,4,5 trisphosphate
                     receptor; inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR1"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR1 isoform 2"
                     /protein_id="NP_002213.5"
                     /db_xref="CCDS:CCDS54550.1"
                     /db_xref="GeneID:3708"
                     /db_xref="HGNC:HGNC:6180"
                     /db_xref="MIM:147265"
                     /translation="MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETG
                     DLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQ
                     NETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSW
                     FYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSW
                     KIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSAT
                     SSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQE
                     KMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPID
                     KEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTI
                     TQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLL
                     QAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFM
                     QKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCV
                     SMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEV
                     WLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINE
                     ISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPS
                     EIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLA
                     RNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGEENKGSNVMRSIHGVG
                     ELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRL
                     DYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGS
                     EENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQL
                     LVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGNN
                     KPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELL
                     QIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHI
                     FMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAEL
                     VNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYT
                     EIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLF
                     ENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVF
                     VQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSH
                     SIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSV
                     LVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMM
                     TKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSG
                     SSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTI
                     QHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPS
                     RKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKD
                     DLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGS
                     TTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALIL
                     NDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAY
                     MQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALE
                     FYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFL
                     RSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGG
                     TLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFN
                     VCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFD
                     LVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNE
                     TAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCI
                     VTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTF
                     ADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVK
                     DSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLV
                     TNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA"
     exon            443..513
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            514..629
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            630..716
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            717..875
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            876..974
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1058
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1205
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1301
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1456
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1556
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1717
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1859
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2018
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2191
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2311
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2509
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2761
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2903
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3057
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3245
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3384
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3439
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3605
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3776
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3842
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3980
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4106
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4307
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4559
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..4685
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4686..4814
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4935
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5120
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5121..5269
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5270..5381
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5382..5514
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5515..5705
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5886
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5887..6140
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6141..6341
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6342..6452
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6453..6548
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6549..6671
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6672..6776
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6777..6969
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6970..7092
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7093..7268
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7269..7433
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7434..7629
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7630..7722
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7723..7862
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7863..8028
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8029..8189
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8190..8351
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8352..9719
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9694..9699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="hexamer: AATAAA"
     polyA_site      9719
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="major polyA site"
ORIGIN      
        1 gcagtaacca tgtggatgtg ctgctgaagc gtttcctcaa gctcgctggg gtgggaggag
       61 aggaggagga ggaggtggtg gtggaggagg aggcaggggg tggagagaga gaaagcgcac
      121 gccgagagga ggtgtgggtg ttccgcttcc atcctaacgg aacgagctcc ctcttcgcgg
      181 acatgggatt acccagcggc tgctaacccc tctcctcgcc ctgctccccc aaaccggcgt
      241 ggctccccgg gcaccaagga gctgactaca gaggagcagg atttgcaccc ctcgctgggc
      301 ttgctttggc aacagagtgc ctgacccagg tcaggatttt caagaaagac atgtctgaca
      361 aaatgtctag cttcctacat attggagaca tttgttctct gtacgcggag ggatcgacaa
      421 atggatttat tagcaccttg ggcctggttg atgatcgttg tgttgtacag ccagaaaccg
      481 gggaccttaa caatccacct aagaaattca gagactgcct ctttaagcta tgtcccatga
      541 accgctactc tgcccaaaag cagttctgga aagccgctaa gcctggggcc aacagcacca
      601 cagacgcagt gctactcaac aaactgcacc acgctgcaga cttggaaaag aagcagaatg
      661 agacagaaaa caggaaattg ctggggaccg taatccagta tggcaatgtg atccagctcc
      721 tgcatttgaa aagtaataaa tacctaacag tgaataagag gcttcctgct ctgttggaga
      781 agaatgccat gagagtcaca ttggacgagg ctggaaatga agggtcctgg ttttatattc
      841 agccattcta caagctgcga tccattggag acagcgtggt cataggtgac aaggtggttc
      901 tgaaccccgt caatgctggt cagcccctac atgctagcag ccatcaactg gtagataacc
      961 caggctgcaa tgaggtcaat tccgtcaact gcaatacaag ctggaaaata gtccttttca
     1021 tgaaatggag tgataacaaa gacgacatat taaagggggg tgacgtggtg aggctgtttc
     1081 atgctgagca ggagaagttt ctcacctgtg acgaacacag gaagaagcag cacgtcttcc
     1141 tgagaaccac gggccggcag tcggccacat ctgccaccag ttcaaaagcc ctgtgggagg
     1201 tggaggtggt ccagcatgac ccatgtcggg gcggagcagg gtattggaac agccttttcc
     1261 gtttcaagca tctggccacg gggcattact tggcagcaga ggtggaccct gatcaggacg
     1321 cctctcgaag taggttgcgg aatgcccaag aaaagatggt atactccctg gtctctgtgc
     1381 ctgaaggcaa tgacatctcc tccattttcg agctagatcc caccactctg cgtggaggtg
     1441 acagccttgt cccaaggaac tcttatgttc ggctcagaca cctatgtact aatacctggg
     1501 ttcacagcac aaatattcct attgacaagg aagaagaaaa gcccgtgatg ctgaaaattg
     1561 gcacctctcc tgtgaaggag gataaggaag catttgccat agttccggtt tctcctgctg
     1621 aagttcggga cctggacttt gccaatgatg ccagcaaggt gctgggctcc attgctggga
     1681 agctagagaa gggcaccatc acccagaatg aaaggaggtc tgtaaccaag ctgctagaag
     1741 atttggttta cttcgtcact ggtggaacta attctggtca agatgttctc gaagttgtct
     1801 tctccaagcc caacagagaa cggcagaaac tgatgagaga acagaatatt ctcaagcaga
     1861 tcttcaagtt gttacaagcc ccattcacag actgcggtga tggcccaatg cttcggctgg
     1921 aagagctcgg ggaccagcgg cacgctcctt tcagacacat ctgccggctc tgctacaggg
     1981 tgctgagaca ctcgcagcaa gactacagga agaaccagga gtatatagcc aagcagtttg
     2041 gcttcatgca gaagcagatt ggctatgatg tgttggctga agacactatc actgccctgc
     2101 tccacaataa tcggaaactc ctggaaaaac acattaccgc ggcagagatt gacacatttg
     2161 tcagcctggt gcgaaagaac agggagccca gattcttaga ttacctctcc gacctctgtg
     2221 tctccatgaa caaatcaatt ccagtgaccc aggaactgat atgtaaagct gtgctgaacc
     2281 ccaccaacgc tgacatcctg attgagacca agttggttct ttctcgtttt gaatttgaag
     2341 gtgtctcttc cactggagag aatgctctgg aggcaggaga agacgaggaa gaggtgtggc
     2401 tgttttggag ggacagcaac aaagagattc gcagcaagag tgtgagggaa ttggctcagg
     2461 atgctaaaga agggcagaag gaggaccgag acgttctcag ctactacaga tatcagctga
     2521 acctctttgc gaggatgtgt ctggaccgcc aatacctggc catcaacgaa atctcaggcc
     2581 agctggatgt cgatctcatt ctccgctgca tgtctgacga gaacctgccc tatgacctca
     2641 gggcgtcctt ctgccgcctc atgcttcaca tgcatgtgga ccgagatccc caggaacaag
     2701 tcacccccgt gaaatatgcc cgcctctggt cggagattcc ctcggagatc gccattgacg
     2761 actatgatag tagtggagct tccaaagatg aaattaagga gagatttgct cagaccatgg
     2821 agtttgtgga ggagtattta agagatgtgg tttgtcagag gttccctttc tctgataaag
     2881 agaagaataa gcttacgttt gaggttgtaa atttagctag gaatctcata tactttggtt
     2941 tctacaactt ctctgacctt ctacgattaa ctaagatcct tctggccata ttggactgtg
     3001 tacatgtgac aacaatcttc cccattagca agatggcgaa aggagaagag aataaaggca
     3061 gtaacgtgat gagatctatt catggcgtgg gagagctgat gacccaggtg gtgctccggg
     3121 gaggaggctt tttgcccatg actcccatgg ctgctgcccc tgaaggcaat gtgaagcagg
     3181 cagagcctga gaaggaggac atcatggtca tggacaccaa gctgaagatc attgagatac
     3241 tccagtttat tttgaatgtg aggttggatt ataggatctc ctgcctcctg tgtatattta
     3301 agcgagagtt tgatgaaagc aattcccaga cttcagaaac atcctccgga aacagcagcc
     3361 aagaagggcc aagtaatgta ccaggtgctc ttgactttga acacattgaa gaacaagcag
     3421 aaggcatctt tggaggaagt gaggagaaca ccccactgga cttggatgac cacggcggca
     3481 gaacctttct ccgtgtcctg ctccacttga cgatgcatga ctacccaccc ctggtgtcag
     3541 gggccctgca gctcctcttc cggcacttca gccagaggca ggaggtgctc caggccttca
     3601 aacaggttca actgctggtt accagccaag atgtggacaa ctacaaacag atcaaacaag
     3661 acttggatca actgaggtcc atcgtggaaa agtcagagct ttgggtgtac aaagggcagg
     3721 gccccgatga gactatggat ggtgcatctg gagaaaatga acataagaaa acggaggagg
     3781 gaaataacaa gccacaaaag catgaaagca ccagcagcta caactacaga gtggtcaaag
     3841 agattttgat tcggcttagc aaactctgtg ttcaagagag tgcctcagtg agaaagagca
     3901 ggaagcagca acagcgtctg ctccggaaca tgggcgcgca cgccgtggtg ctggagctgc
     3961 tgcagattcc ctatgagaag gccgaagata ccaagatgca agagataatg aggttggctc
     4021 atgaattttt gcagaatttc tgcgcaggca accagcagaa tcaagctttg ctacataaac
     4081 acataaacct gtttctcaac ccagggatcc tggaggcagt aaccatgcag cacatcttca
     4141 tgaacaattt ccagctttgc agtgagatca acgagagagt tgttcagcac ttcgttcact
     4201 gcatagagac tcacggtcgg aatgtccagt atataaagtt cttacagaca attgtcaagg
     4261 cagaagggaa atttattaaa aaatgccaag acatggttat ggccgagctg gtcaattcgg
     4321 gagaggatgt cctcgtgttc tacaacgaca gagcctcttt ccagactctg atccagatga
     4381 tgcggtcaga acgggatcgg atggatgaga acagccctct catgtaccac atccacttgg
     4441 tcgagctcct ggctgtgtgc acggagggta agaatgtcta cacagagatc aagtgcaact
     4501 ccctgctccc gctggatgac atcgttcgcg tggtgaccca cgaggactgc atccctgagg
     4561 ttaaaattgc atacattaac ttcctgaatc actgctatgt ggatacagag gtggaaatga
     4621 aggagattta taccagcaat cacatgtgga aattgtttga gaatttcctt gtagacatct
     4681 gcagggcctg taacaacact agtgacagga aacatgcaga ctcgattttg gagaagtatg
     4741 tcaccgaaat cgtcatgagt attgttacta ctttcttcag ctctcccttc tcagaccaga
     4801 gtacgacttt gcagactcgc cagcctgtct ttgtgcaact gctgcaaggc gtgttcaggg
     4861 tttaccactg caactggtta atgccaagcc aaaaagcctc cgtggagagc tgtattcggg
     4921 tgctgtctga tgtagccaag agccgggcca ttgccattcc cgtggacctg gacagccaag
     4981 tcaacaacct ctttctcaag tcccacagca ttgtgcagaa aacagccatg aactggcggc
     5041 tctcagcccg caatgccgca cgcagggact ctgttctggc agcttccaga gactaccgga
     5101 atatcattga gagattgcag gacatcgtct ccgcgctgga ggaccgtctc aggcccctgg
     5161 tgcaggcaga gttatctgtg ctcgtggatg ttctccacag acccgagctg cttttcccag
     5221 agaacacaga cgccagaagg aaatgtgaaa gtggcggttt catttgcaag ttaataaagc
     5281 atacaaaaca gctgctagaa gaaaatgaag agaagctctg cattaaggtc ctacagaccc
     5341 tgagggaaat gatgaccaaa gatagaggct atggagaaaa gggtgaggcg ctcaggcaag
     5401 ttctggtcaa ccgttactat ggaaacgtca gaccttcggg acgaagagag agccttacca
     5461 gctttggcaa tggcccactg tcagcaggag gacccggcaa gcccggggga ggagggggag
     5521 gttccggatc cagctctatg agcaggggtg agatgagtct ggccgaggtt cagtgtcacc
     5581 ttgacaagga gggggcttcc aatctagtta tcgacctcat catgaacgca tccagtgacc
     5641 gagtgttcca tgaaagcatt ctcctggcca ttgcccttct ggaaggaggc aacaccacca
     5701 tccagcactc ctttttctgt cgcttgacag aagataagaa gtcagagaaa ttctttaagg
     5761 tgttttatga ccggatgaag gtggcccagc aagaaatcaa agcaacagtg acagtgaaca
     5821 ccagtgactt gggaaataaa aagaaagacg atgaggtaga cagggatgcc ccatcacgga
     5881 aaaaagctaa agagcccaca acacagataa cagaagaggt ccgggatcag ctcctggagg
     5941 cctccgctgc caccaggaaa gccttcacca ctttcaggag ggaggctgat cccgacgacc
     6001 actaccagcc tggagagggc acccaggcca ctgccgacaa ggccaaggac gacctggaga
     6061 tgagcgcggt catcaccatc atgcagccca tcctccgctt ccttcagctc ctgtgtgaaa
     6121 accacaaccg agacctgcag aacttcctcc gttgccaaaa taacaagacc aactacaatt
     6181 tggtatgtga gaccctgcag tttctggact gtatttgtgg aagcacaact ggaggccttg
     6241 gtcttctggg cttgtatata aatgaaaaga atgtagcgct tatcaaccaa accctggaaa
     6301 gtctgaccga atactgtcaa ggaccttgcc atgagaacca gaactgcata gccacccatg
     6361 aatccaatgg cattgacatc atcacagccc tgatcctcaa tgatatcaat cctttgggaa
     6421 agaagaggat ggaccttgtg ttagaactga agaacaatgc ctcgaagttg ctcctggcca
     6481 tcatggaaag caggcacgac agtgaaaacg cagagaggat actttataac atgaggccca
     6541 aggaactggt ggaagtgatc aagaaagcct acatgcaagg tgaagtggaa tttgaggatg
     6601 gagaaaacgg tgaggatggg gcggcgtccc ccaggaacgt ggggcacaac atctacatat
     6661 tagcccatca gttggctcgg cataacaaag aacttcagag catgctgaaa cctggtggcc
     6721 aagtggacgg agatgaagcc ctggagtttt atgccaagca cacggcgcag atagagattg
     6781 tcagattaga ccgaacaatg gaacagatag tctttcccgt gcccagcata tgtgaattcc
     6841 taaccaagga gtcaaaacta cgaatttact atactacaga gagagacgaa caaggcagca
     6901 aaatcaatga tttctttctg cggtctgaag acctcttcaa tgaaatgaat tggcagaaga
     6961 aactgagagc ccagcccgtg ttgtactggt gtgcccgcaa catgtctttc tggagcagca
     7021 tttcgtttaa cctggccgtc ctgatgaacc tgctggtggc gtttttctac ccgtttaagg
     7081 gagtccgagg aggaaccctg gagccccact ggtcgggact cctgtggaca gccatgctca
     7141 tctctctggc catcgtcatt gccctcccca agccccatgg catccgggcc ttaattgcct
     7201 ccacaattct acgactgata ttttcagtcg ggttacaacc cacgttgttt cttctgggcg
     7261 ctttcaatgt atgcaataaa atcatctttc taatgagctt tgtgggcaac tgtgggacat
     7321 tcacaagagg ctaccgagcc atggttctgg atgttgagtt cctctatcat ttgttgtatc
     7381 tggtgatctg tgccatgggg ctctttgtcc atgaattctt ctacagtctg ctgctttttg
     7441 atttagtgta cagagaagag actttgctta atgtcattaa aagtgtcact cgcaatggac
     7501 ggtccatcat cctgacagca gttctggctc tgatcctcgt ttacctgttc tcaatagtgg
     7561 gctatctttt cttcaaggat gactttatct tggaagtaga taggctgccc aatgaaacag
     7621 ctgttccaga aaccggcgag agtttggcaa gcgagttcct gttctccgat gtgtgtaggg
     7681 tggagagtgg ggagaactgc tcctctcctg cacccagaga agagctggtc cctgcagaag
     7741 agacggaaca ggataaagag cacacatgtg agacgctgct gatgtgcatt gtcactgtgc
     7801 tgagtcacgg gctgcggagc gggggtggag taggagatgt actcaggaag ccgtccaaag
     7861 aggaacccct gtttgctgct agagttattt atgacctctt gttcttcttc atggtcatca
     7921 tcattgttct taacctgatt tttggggtta tcattgacac ttttgctgac ctgaggagtg
     7981 agaagcagaa gaaggaagag atcttgaaga ccacgtgctt tatctgtggc ttggaaagag
     8041 acaagtttga caacaagact gtcacctttg aagagcacat caaggaagaa cacaacatgt
     8101 ggcactatct gtgcttcatc gtcctggtga aagtaaagga ctccaccgaa tatactgggc
     8161 ctgagagtta cgtggcagaa atgatcaagg aaagaaacct tgactggttc cccaggatga
     8221 gagccatgtc attggtcagc agtgattctg aaggagaaca gaatgagctg agaaacctgc
     8281 aggagaagct ggagtccacc atgaaacttg tcacgaacct ttctggccag ctgtcggaat
     8341 taaaggatca gatgacagaa caaaggaagc agaaacaaag aattggtctt ctaggacatc
     8401 ctcctcacat gaatgtcaac ccacaacaac cagcataagc aaatgaaaga aaggaattgt
     8461 atttaccttt tataattatt attagtgtgg gtatggctaa tgagttctga ttcacccacg
     8521 aaggttacat ttatgctgaa tacatttgta aatactcagt tttatactgt atgtatatga
     8581 ttgctactct aaaggtttgg atatatgtat tgtaattaga attgttggca tgatgacatt
     8641 tcatttgtgc caaaaatatt aaaaatgcct tttttggaag gactaacaga aagcacctga
     8701 tttgcacttg aaccagatta tagatttaaa agtatatgac atgtattttg tatttaaaac
     8761 tagaatagcc agtatttatg ttttttataa aactgtgcaa tacgaattat gcaatcacaa
     8821 tacatttgta gctcccgagt gtcctaaagg gagtgcactt ctttgaagct ggtgtgttaa
     8881 tactatgtaa taaatggtta actttcaaat gatgctgctg ccaaaattat attaatagtg
     8941 agtttcaggc ccctgggcat tttgtaccat gtaattatcc tctggtgatg ctgtttctcg
     9001 ttagtggcag tagtgcctcc gtctcctagt gataatgctc caagtctatg aactgttaaa
     9061 tcagcattca ttttaagaaa agcaacttta gtttcaaaga tacttttaag cttctaaatt
     9121 gatcatttaa actatttctt taaataagag agccaaatta gaggctcata ctttagcttg
     9181 tgaagaagat aatgaatttt ttaaagggaa ctttctatgc aatgttcagg ataaatgcat
     9241 actgctggcc aatcagtgtc atctcctggg taaattttga tgtcgcatta taaagacatg
     9301 cataattgat ggtttctaga ttatctagtc caaacaatag agtttatttt ttcttcatct
     9361 gaaccaacat gctacagtag ctaagaagta ttaaaactat atacatccat ataaagatga
     9421 aatatgaact atctcattag aagtcatagt tgaccacaga catgttattc ttctgaaaga
     9481 gccacatttt ggttttattt cttgtcacat gatttctttt cttgatggat gaaaaatatg
     9541 aaaggaaact tttatatctg ttgcctagtt ttgtacatgg atctcatttt acaagagaat
     9601 ctctctgcaa aaaaaaaaaa aacagtttaa aaatgcattg aaagcagagt tctgaaatga
     9661 gtaaagtttg taaatgcata tataaaaata tttaataaat gatgcagaat atacagtga
//
