LOCUS       NM_001378452            9908 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens inositol 1,4,5-trisphosphate receptor type 1 (ITPR1),
            transcript variant 4, mRNA.
ACCESSION   NM_001378452 XM_011533683
VERSION     NM_001378452.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9908)
  AUTHORS   Lei,Z., Niu,J., Cai,H., Kong,Z., Ding,X., Dong,Y., Zhang,D., Li,X.,
            Shao,J., Lin,A., Zhou,R., Yang,S. and Yan,Q.
  TITLE     NF2 regulates IP3R-mediated Ca2+ signal and apoptosis in
            meningiomas
  JOURNAL   FASEB J 38 (13), e23737 (2024)
   PUBMED   38953724
  REMARK    GeneRIF: NF2 regulates IP3R-mediated Ca[2+] signal and apoptosis in
            meningiomas.
REFERENCE   2  (bases 1 to 9908)
  AUTHORS   Atakpa-Adaji,P., Ivanova,A., Kujawa,K. and Taylor,C.W.
  TITLE     KRAP regulates mitochondrial Ca2+ uptake by licensing IP3 receptor
            activity and stabilizing ER-mitochondrial junctions
  JOURNAL   J Cell Sci 137 (12) (2024)
   PUBMED   38786982
  REMARK    GeneRIF: KRAP regulates mitochondrial Ca2+ uptake by licensing IP3
            receptor activity and stabilizing ER-mitochondrial junctions.
REFERENCE   3  (bases 1 to 9908)
  AUTHORS   Sanli,F., Tatar,A., Gundogdu,B. and Karatas,O.F.
  TITLE     IP3R1 dysregulation via mir-200c-3p/SSFA2 axis contributes to taxol
            resistance in head and neck cancer
  JOURNAL   Eur J Pharmacol 973, 176592 (2024)
   PUBMED   38642666
  REMARK    GeneRIF: IP3R1 dysregulation via mir-200c-3p/SSFA2 axis contributes
            to taxol resistance in head and neck cancer.
REFERENCE   4  (bases 1 to 9908)
  AUTHORS   Maleki,B., Modarres,P., Salehi,P. and Vallian,S.
  TITLE     Identification of ITPR1 gene as a novel target for hsa-miR-34b-5p
            in non-obstructive azoospermia: a Ca2+/apoptosis pathway cross-talk
  JOURNAL   Sci Rep 13 (1), 21873 (2023)
   PUBMED   38072953
  REMARK    GeneRIF: Identification of ITPR1 gene as a novel target for
            hsa-miR-34b-5p in non-obstructive azoospermia: a Ca[2+]/apoptosis
            pathway cross-talk.
            Erratum:[Sci Rep. 2024 Feb 14;14(1):3722. doi:
            10.1038/s41598-024-53786-7.. PMID: 38355618]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9908)
  AUTHORS   Kirkwood,K.L., Homick,K., Dragon,M.B. and Bradford,P.G.
  TITLE     Cloning and characterization of the type I inositol
            1,4,5-trisphosphate receptor gene promoter. Regulation by
            17beta-estradiol in osteoblasts
  JOURNAL   J Biol Chem 272 (36), 22425-22431 (1997)
   PUBMED   9278393
REFERENCE   6  (bases 1 to 9908)
  AUTHORS   Joseph,S.K., Lin,C., Pierson,S., Thomas,A.P. and Maranto,A.R.
  TITLE     Heteroligomers of type-I and type-III inositol trisphosphate
            receptors in WB rat liver epithelial cells
  JOURNAL   J Biol Chem 270 (40), 23310-23316 (1995)
   PUBMED   7559486
  REMARK    Erratum:[J Biol Chem 1996 Mar 29;271(13):7874]
REFERENCE   7  (bases 1 to 9908)
  AUTHORS   Nucifora,F.C. Jr., Li,S.H., Danoff,S., Ullrich,A. and Ross,C.A.
  TITLE     Molecular cloning of a cDNA for the human inositol
            1,4,5-trisphosphate receptor type 1, and the identification of a
            third alternatively spliced variant
  JOURNAL   Brain Res Mol Brain Res 32 (2), 291-296 (1995)
   PUBMED   7500840
REFERENCE   8  (bases 1 to 9908)
  AUTHORS   Storey,E.
  TITLE     Spinocerebellar Ataxia Type 15 - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301536
REFERENCE   9  (bases 1 to 9908)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   10 (bases 1 to 9908)
  AUTHORS   Mahaut-Smith,M.P., Sage,S.O. and Rink,T.J.
  TITLE     Receptor-activated single channels in intact human platelets
  JOURNAL   J Biol Chem 265 (18), 10479-10483 (1990)
   PUBMED   1693919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024168.5, AC090944.2,
            AC069248.4 and AC018816.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 13, 2020 this sequence version replaced XM_011533683.3.
            
            Summary: This gene encodes an intracellular receptor for inositol
            1,4,5-trisphosphate. Upon stimulation by inositol
            1,4,5-trisphosphate, this receptor mediates calcium release from
            the endoplasmic reticulum. Mutations in this gene cause
            spinocerebellar ataxia type 15, a disease associated with an
            heterogeneous group of cerebellar disorders. Multiple transcript
            variants have been identified for this gene. [provided by RefSeq,
            Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649015.2/ ENSP00000497605.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC024168.5         133408-133665
            259-334             AC024168.5         134491-134566
            335-442             AC024168.5         156536-156643
            443-513             AC024168.5         161084-161154
            514-629             AC090944.2         8403-8518           c
            630-716             AC069248.4         108159-108245       c
            717-875             AC069248.4         105378-105536       c
            876-974             AC069248.4         103395-103493       c
            975-1058            AC069248.4         102159-102242       c
            1059-1205           AC069248.4         101901-102047       c
            1206-1301           AC069248.4         95411-95506         c
            1302-1346           AC069248.4         93743-93787         c
            1347-1501           AC069248.4         89351-89505         c
            1502-1601           AC069248.4         86542-86641         c
            1602-1762           AC069248.4         85387-85547         c
            1763-1904           AC069248.4         84423-84564         c
            1905-2063           AC069248.4         82333-82491         c
            2064-2236           AC069248.4         80080-80252         c
            2237-2356           AC069248.4         77856-77975         c
            2357-2554           AC069248.4         76703-76900         c
            2555-2806           AC069248.4         74242-74493         c
            2807-2948           AC069248.4         73286-73427         c
            2949-3129           AC069248.4         72381-72561         c
            3130-3317           AC069248.4         70828-71015         c
            3318-3456           AC069248.4         66938-67076         c
            3457-3511           AC069248.4         66211-66265         c
            3512-3677           AC069248.4         64078-64243         c
            3678-3848           AC069248.4         63831-64001         c
            3849-3914           AC069248.4         63283-63348         c
            3915-4052           AC069248.4         62423-62560         c
            4053-4178           AC069248.4         59009-59134         c
            4179-4379           AC069248.4         56285-56485         c
            4380-4631           AC069248.4         53888-54139         c
            4632-4757           AC069248.4         50357-50482         c
            4758-4886           AC069248.4         47688-47816         c
            4887-5007           AC069248.4         44679-44799         c
            5008-5192           AC069248.4         41278-41462         c
            5193-5341           AC069248.4         37156-37304         c
            5342-5453           AC069248.4         35761-35872         c
            5454-5486           AC069248.4         30230-30262         c
            5487-5522           AC069248.4         22048-22083         c
            5523-5570           AC069248.4         20456-20503         c
            5571-5703           AC069248.4         14409-14541         c
            5704-5894           AC069248.4         12275-12465         c
            5895-6075           AC018816.6         147939-148119       c
            6076-6329           AC018816.6         145885-146138       c
            6330-6530           AC018816.6         139207-139407       c
            6531-6641           AC018816.6         137275-137385       c
            6642-6737           AC018816.6         135004-135099       c
            6738-6860           AC018816.6         131908-132030       c
            6861-6965           AC018816.6         130729-130833       c
            6966-7158           AC018816.6         126510-126702       c
            7159-7281           AC018816.6         119462-119584       c
            7282-7457           AC018816.6         114049-114224       c
            7458-7622           AC018816.6         108382-108546       c
            7623-7818           AC018816.6         103189-103384       c
            7819-7911           AC018816.6         101415-101507       c
            7912-8051           AC018816.6         100087-100226       c
            8052-8217           AC018816.6         99431-99596         c
            8218-8378           AC018816.6         96407-96567         c
            8379-8540           AC018816.6         77714-77875         c
            8541-9908           AC018816.6         67143-68510         c
FEATURES             Location/Qualifiers
     source          1..9908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.1"
     gene            1..9908
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="inositol 1,4,5-trisphosphate receptor type 1"
                     /db_xref="GeneID:3708"
                     /db_xref="HGNC:HGNC:6180"
                     /db_xref="MIM:147265"
     exon            1..258
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            259..334
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            335..442
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..8627
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="isoform 4 is encoded by transcript variant 4;
                     inositol 1,4,5-triphosphate receptor, type 1; protein
                     phosphatase 1, regulatory subunit 94; type 1 InsP3
                     receptor; IP3 receptor; IP3R 1; type 1 inositol
                     1,4,5-trisphosphate receptor; inositol 1,4,5 trisphosphate
                     receptor; inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR1"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR1 isoform 4"
                     /protein_id="NP_001365381.1"
                     /db_xref="CCDS:CCDS93191.1"
                     /db_xref="GeneID:3708"
                     /db_xref="HGNC:HGNC:6180"
                     /db_xref="MIM:147265"
                     /translation="MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETG
                     DLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQ
                     NETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSW
                     FYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSW
                     KIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSAT
                     SSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVD
                     PDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRH
                     LCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDAS
                     KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQK
                     LMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQD
                     YRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRK
                     NREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSS
                     TGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNL
                     FARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQ
                     VTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFS
                     DKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGE
                     ENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEK
                     EDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEG
                     PSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSG
                     ALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKG
                     QGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASV
                     RKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQ
                     ALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIK
                     FLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDEN
                     SPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFL
                     NHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMS
                     IVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDV
                     AKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNII
                     ERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKH
                     TKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKLISIDELDNAELPPAPDSENATEEL
                     EPSPPLRQLEDHKRGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGG
                     GGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEG
                     GNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVD
                     RDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATA
                     DKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLD
                     CICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDII
                     TALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEV
                     IKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDG
                     DEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKI
                     NDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFK
                     GVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFL
                     LGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYS
                     LLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVD
                     RLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCET
                     LLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGV
                     IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIV
                     LVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLES
                     TMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA"
     exon            443..513
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            514..629
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            630..716
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            717..875
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            876..974
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1058
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1205
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1301
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1346
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1501
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1601
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1762
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1904
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2063
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2236
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2356
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2554
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2806
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2948
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3129
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3317
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3456
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3511
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3677
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3848
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3914
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4052
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4178
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4379
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4631
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4757
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4886
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..5007
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5192
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5193..5341
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5342..5453
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5454..5486
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5487..5522
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5570
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5571..5703
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5704..5894
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            5895..6075
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6076..6329
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6330..6530
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6531..6641
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6642..6737
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6738..6860
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6861..6965
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            6966..7158
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7159..7281
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7282..7457
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7458..7622
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7623..7818
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7819..7911
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            7912..8051
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8052..8217
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8218..8378
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8379..8540
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     exon            8541..9908
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9883..9888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="hexamer: AATAAA"
     polyA_site      9908
                     /gene="ITPR1"
                     /gene_synonym="ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94;
                     SCA15; SCA16; SCA29"
                     /note="major polyA site"
ORIGIN      
        1 gcagtaacca tgtggatgtg ctgctgaagc gtttcctcaa gctcgctggg gtgggaggag
       61 aggaggagga ggaggtggtg gtggaggagg aggcaggggg tggagagaga gaaagcgcac
      121 gccgagagga ggtgtgggtg ttccgcttcc atcctaacgg aacgagctcc ctcttcgcgg
      181 acatgggatt acccagcggc tgctaacccc tctcctcgcc ctgctccccc aaaccggcgt
      241 ggctccccgg gcaccaagga gctgactaca gaggagcagg atttgcaccc ctcgctgggc
      301 ttgctttggc aacagagtgc ctgacccagg tcaggatttt caagaaagac atgtctgaca
      361 aaatgtctag cttcctacat attggagaca tttgttctct gtacgcggag ggatcgacaa
      421 atggatttat tagcaccttg ggcctggttg atgatcgttg tgttgtacag ccagaaaccg
      481 gggaccttaa caatccacct aagaaattca gagactgcct ctttaagcta tgtcccatga
      541 accgctactc tgcccaaaag cagttctgga aagccgctaa gcctggggcc aacagcacca
      601 cagacgcagt gctactcaac aaactgcacc acgctgcaga cttggaaaag aagcagaatg
      661 agacagaaaa caggaaattg ctggggaccg taatccagta tggcaatgtg atccagctcc
      721 tgcatttgaa aagtaataaa tacctaacag tgaataagag gcttcctgct ctgttggaga
      781 agaatgccat gagagtcaca ttggacgagg ctggaaatga agggtcctgg ttttatattc
      841 agccattcta caagctgcga tccattggag acagcgtggt cataggtgac aaggtggttc
      901 tgaaccccgt caatgctggt cagcccctac atgctagcag ccatcaactg gtagataacc
      961 caggctgcaa tgaggtcaat tccgtcaact gcaatacaag ctggaaaata gtccttttca
     1021 tgaaatggag tgataacaaa gacgacatat taaagggggg tgacgtggtg aggctgtttc
     1081 atgctgagca ggagaagttt ctcacctgtg acgaacacag gaagaagcag cacgtcttcc
     1141 tgagaaccac gggccggcag tcggccacat ctgccaccag ttcaaaagcc ctgtgggagg
     1201 tggaggtggt ccagcatgac ccatgtcggg gcggagcagg gtattggaac agccttttcc
     1261 gtttcaagca tctggccacg gggcattact tggcagcaga ggtagaccct gactttgagg
     1321 aagaatgcct ggagtttcag ccctcagtgg accctgatca ggacgcctct cgaagtaggt
     1381 tgcggaatgc ccaagaaaag atggtatact ccctggtctc tgtgcctgaa ggcaatgaca
     1441 tctcctccat tttcgagcta gatcccacca ctctgcgtgg aggtgacagc cttgtcccaa
     1501 ggaactctta tgttcggctc agacacctat gtactaatac ctgggttcac agcacaaata
     1561 ttcctattga caaggaagaa gaaaagcccg tgatgctgaa aattggcacc tctcctgtga
     1621 aggaggataa ggaagcattt gccatagttc cggtttctcc tgctgaagtt cgggacctgg
     1681 actttgccaa tgatgccagc aaggtgctgg gctccattgc tgggaagcta gagaagggca
     1741 ccatcaccca gaatgaaagg aggtctgtaa ccaagctgct agaagatttg gtttacttcg
     1801 tcactggtgg aactaattct ggtcaagatg ttctcgaagt tgtcttctcc aagcccaaca
     1861 gagaacggca gaaactgatg agagaacaga atattctcaa gcagatcttc aagttgttac
     1921 aagccccatt cacagactgc ggtgatggcc caatgcttcg gctggaagag ctcggggacc
     1981 agcggcacgc tcctttcaga cacatctgcc ggctctgcta cagggtgctg agacactcgc
     2041 agcaagacta caggaagaac caggagtata tagccaagca gtttggcttc atgcagaagc
     2101 agattggcta tgatgtgttg gctgaagaca ctatcactgc cctgctccac aataatcgga
     2161 aactcctgga aaaacacatt accgcggcag agattgacac atttgtcagc ctggtgcgaa
     2221 agaacaggga gcccagattc ttagattacc tctccgacct ctgtgtctcc atgaacaaat
     2281 caattccagt gacccaggaa ctgatatgta aagctgtgct gaaccccacc aacgctgaca
     2341 tcctgattga gaccaagttg gttctttctc gttttgaatt tgaaggtgtc tcttccactg
     2401 gagagaatgc tctggaggca ggagaagacg aggaagaggt gtggctgttt tggagggaca
     2461 gcaacaaaga gattcgcagc aagagtgtga gggaattggc tcaggatgct aaagaagggc
     2521 agaaggagga ccgagacgtt ctcagctact acagatatca gctgaacctc tttgcgagga
     2581 tgtgtctgga ccgccaatac ctggccatca acgaaatctc aggccagctg gatgtcgatc
     2641 tcattctccg ctgcatgtct gacgagaacc tgccctatga cctcagggcg tccttctgcc
     2701 gcctcatgct tcacatgcat gtggaccgag atccccagga acaagtcacc cccgtgaaat
     2761 atgcccgcct ctggtcggag attccctcgg agatcgccat tgacgactat gatagtagtg
     2821 gagcttccaa agatgaaatt aaggagagat ttgctcagac catggagttt gtggaggagt
     2881 atttaagaga tgtggtttgt cagaggttcc ctttctctga taaagagaag aataagctta
     2941 cgtttgaggt tgtaaattta gctaggaatc tcatatactt tggtttctac aacttctctg
     3001 accttctacg attaactaag atccttctgg ccatattgga ctgtgtacat gtgacaacaa
     3061 tcttccccat tagcaagatg gcgaaaggag aagagaataa aggtaacaat gatgtggaga
     3121 agctgaagag cagtaacgtg atgagatcta ttcatggcgt gggagagctg atgacccagg
     3181 tggtgctccg gggaggaggc tttttgccca tgactcccat ggctgctgcc cctgaaggca
     3241 atgtgaagca ggcagagcct gagaaggagg acatcatggt catggacacc aagctgaaga
     3301 tcattgagat actccagttt attttgaatg tgaggttgga ttataggatc tcctgcctcc
     3361 tgtgtatatt taagcgagag tttgatgaaa gcaattccca gacttcagaa acatcctccg
     3421 gaaacagcag ccaagaaggg ccaagtaatg taccaggtgc tcttgacttt gaacacattg
     3481 aagaacaagc agaaggcatc tttggaggaa gtgaggagaa caccccactg gacttggatg
     3541 accacggcgg cagaaccttt ctccgtgtcc tgctccactt gacgatgcat gactacccac
     3601 ccctggtgtc aggggccctg cagctcctct tccggcactt cagccagagg caggaggtgc
     3661 tccaggcctt caaacaggtt caactgctgg ttaccagcca agatgtggac aactacaaac
     3721 agatcaaaca agacttggat caactgaggt ccatcgtgga aaagtcagag ctttgggtgt
     3781 acaaagggca gggccccgat gagactatgg atggtgcatc tggagaaaat gaacataaga
     3841 aaacggagga gggaaataac aagccacaaa agcatgaaag caccagcagc tacaactaca
     3901 gagtggtcaa agagattttg attcggctta gcaaactctg tgttcaagag agtgcctcag
     3961 tgagaaagag caggaagcag caacagcgtc tgctccggaa catgggcgcg cacgccgtgg
     4021 tgctggagct gctgcagatt ccctatgaga aggccgaaga taccaagatg caagagataa
     4081 tgaggttggc tcatgaattt ttgcagaatt tctgcgcagg caaccagcag aatcaagctt
     4141 tgctacataa acacataaac ctgtttctca acccagggat cctggaggca gtaaccatgc
     4201 agcacatctt catgaacaat ttccagcttt gcagtgagat caacgagaga gttgttcagc
     4261 acttcgttca ctgcatagag actcacggtc ggaatgtcca gtatataaag ttcttacaga
     4321 caattgtcaa ggcagaaggg aaatttatta aaaaatgcca agacatggtt atggccgagc
     4381 tggtcaattc gggagaggat gtcctcgtgt tctacaacga cagagcctct ttccagactc
     4441 tgatccagat gatgcggtca gaacgggatc ggatggatga gaacagccct ctcatgtacc
     4501 acatccactt ggtcgagctc ctggctgtgt gcacggaggg taagaatgtc tacacagaga
     4561 tcaagtgcaa ctccctgctc ccgctggatg acatcgttcg cgtggtgacc cacgaggact
     4621 gcatccctga ggttaaaatt gcatacatta acttcctgaa tcactgctat gtggatacag
     4681 aggtggaaat gaaggagatt tataccagca atcacatgtg gaaattgttt gagaatttcc
     4741 ttgtagacat ctgcagggcc tgtaacaaca ctagtgacag gaaacatgca gactcgattt
     4801 tggagaagta tgtcaccgaa atcgtcatga gtattgttac tactttcttc agctctccct
     4861 tctcagacca gagtacgact ttgcagactc gccagcctgt ctttgtgcaa ctgctgcaag
     4921 gcgtgttcag ggtttaccac tgcaactggt taatgccaag ccaaaaagcc tccgtggaga
     4981 gctgtattcg ggtgctgtct gatgtagcca agagccgggc cattgccatt cccgtggacc
     5041 tggacagcca agtcaacaac ctctttctca agtcccacag cattgtgcag aaaacagcca
     5101 tgaactggcg gctctcagcc cgcaatgccg cacgcaggga ctctgttctg gcagcttcca
     5161 gagactaccg gaatatcatt gagagattgc aggacatcgt ctccgcgctg gaggaccgtc
     5221 tcaggcccct ggtgcaggca gagttatctg tgctcgtgga tgttctccac agacccgagc
     5281 tgcttttccc agagaacaca gacgccagaa ggaaatgtga aagtggcggt ttcatttgca
     5341 agttaataaa gcatacaaaa cagctgctag aagaaaatga agagaagctc tgcattaagg
     5401 tcctacagac cctgagggaa atgatgacca aagatagagg ctatggagaa aagctaattt
     5461 ccattgatga attggataat gctgagcttc ctccagctcc ggattctgag aacgccactg
     5521 aggagcttga accaagtcca cccctgcggc agctggaaga ccataaaagg ggtgaggcgc
     5581 tcaggcaagt tctggtcaac cgttactatg gaaacgtcag accttcggga cgaagagaga
     5641 gccttaccag ctttggcaat ggcccactgt cagcaggagg acccggcaag cccgggggag
     5701 gagggggagg ttccggatcc agctctatga gcaggggtga gatgagtctg gccgaggttc
     5761 agtgtcacct tgacaaggag ggggcttcca atctagttat cgacctcatc atgaacgcat
     5821 ccagtgaccg agtgttccat gaaagcattc tcctggccat tgcccttctg gaaggaggca
     5881 acaccaccat ccagcactcc tttttctgtc gcttgacaga agataagaag tcagagaaat
     5941 tctttaaggt gttttatgac cggatgaagg tggcccagca agaaatcaaa gcaacagtga
     6001 cagtgaacac cagtgacttg ggaaataaaa agaaagacga tgaggtagac agggatgccc
     6061 catcacggaa aaaagctaaa gagcccacaa cacagataac agaagaggtc cgggatcagc
     6121 tcctggaggc ctccgctgcc accaggaaag ccttcaccac tttcaggagg gaggctgatc
     6181 ccgacgacca ctaccagcct ggagagggca cccaggccac tgccgacaag gccaaggacg
     6241 acctggagat gagcgcggtc atcaccatca tgcagcccat cctccgcttc cttcagctcc
     6301 tgtgtgaaaa ccacaaccga gacctgcaga acttcctccg ttgccaaaat aacaagacca
     6361 actacaattt ggtatgtgag accctgcagt ttctggactg tatttgtgga agcacaactg
     6421 gaggccttgg tcttctgggc ttgtatataa atgaaaagaa tgtagcgctt atcaaccaaa
     6481 ccctggaaag tctgaccgaa tactgtcaag gaccttgcca tgagaaccag aactgcatag
     6541 ccacccatga atccaatggc attgacatca tcacagccct gatcctcaat gatatcaatc
     6601 ctttgggaaa gaagaggatg gaccttgtgt tagaactgaa gaacaatgcc tcgaagttgc
     6661 tcctggccat catggaaagc aggcacgaca gtgaaaacgc agagaggata ctttataaca
     6721 tgaggcccaa ggaactggtg gaagtgatca agaaagccta catgcaaggt gaagtggaat
     6781 ttgaggatgg agaaaacggt gaggatgggg cggcgtcccc caggaacgtg gggcacaaca
     6841 tctacatatt agcccatcag ttggctcggc ataacaaaga acttcagagc atgctgaaac
     6901 ctggtggcca agtggacgga gatgaagccc tggagtttta tgccaagcac acggcgcaga
     6961 tagagattgt cagattagac cgaacaatgg aacagatagt ctttcccgtg cccagcatat
     7021 gtgaattcct aaccaaggag tcaaaactac gaatttacta tactacagag agagacgaac
     7081 aaggcagcaa aatcaatgat ttctttctgc ggtctgaaga cctcttcaat gaaatgaatt
     7141 ggcagaagaa actgagagcc cagcccgtgt tgtactggtg tgcccgcaac atgtctttct
     7201 ggagcagcat ttcgtttaac ctggccgtcc tgatgaacct gctggtggcg tttttctacc
     7261 cgtttaaggg agtccgagga ggaaccctgg agccccactg gtcgggactc ctgtggacag
     7321 ccatgctcat ctctctggcc atcgtcattg ccctccccaa gccccatggc atccgggcct
     7381 taattgcctc cacaattcta cgactgatat tttcagtcgg gttacaaccc acgttgtttc
     7441 ttctgggcgc tttcaatgta tgcaataaaa tcatctttct aatgagcttt gtgggcaact
     7501 gtgggacatt cacaagaggc taccgagcca tggttctgga tgttgagttc ctctatcatt
     7561 tgttgtatct ggtgatctgt gccatggggc tctttgtcca tgaattcttc tacagtctgc
     7621 tgctttttga tttagtgtac agagaagaga ctttgcttaa tgtcattaaa agtgtcactc
     7681 gcaatggacg gtccatcatc ctgacagcag ttctggctct gatcctcgtt tacctgttct
     7741 caatagtggg ctatcttttc ttcaaggatg actttatctt ggaagtagat aggctgccca
     7801 atgaaacagc tgttccagaa accggcgaga gtttggcaag cgagttcctg ttctccgatg
     7861 tgtgtagggt ggagagtggg gagaactgct cctctcctgc acccagagaa gagctggtcc
     7921 ctgcagaaga gacggaacag gataaagagc acacatgtga gacgctgctg atgtgcattg
     7981 tcactgtgct gagtcacggg ctgcggagcg ggggtggagt aggagatgta ctcaggaagc
     8041 cgtccaaaga ggaacccctg tttgctgcta gagttattta tgacctcttg ttcttcttca
     8101 tggtcatcat cattgttctt aacctgattt ttggggttat cattgacact tttgctgacc
     8161 tgaggagtga gaagcagaag aaggaagaga tcttgaagac cacgtgcttt atctgtggct
     8221 tggaaagaga caagtttgac aacaagactg tcacctttga agagcacatc aaggaagaac
     8281 acaacatgtg gcactatctg tgcttcatcg tcctggtgaa agtaaaggac tccaccgaat
     8341 atactgggcc tgagagttac gtggcagaaa tgatcaagga aagaaacctt gactggttcc
     8401 ccaggatgag agccatgtca ttggtcagca gtgattctga aggagaacag aatgagctga
     8461 gaaacctgca ggagaagctg gagtccacca tgaaacttgt cacgaacctt tctggccagc
     8521 tgtcggaatt aaaggatcag atgacagaac aaaggaagca gaaacaaaga attggtcttc
     8581 taggacatcc tcctcacatg aatgtcaacc cacaacaacc agcataagca aatgaaagaa
     8641 aggaattgta tttacctttt ataattatta ttagtgtggg tatggctaat gagttctgat
     8701 tcacccacga aggttacatt tatgctgaat acatttgtaa atactcagtt ttatactgta
     8761 tgtatatgat tgctactcta aaggtttgga tatatgtatt gtaattagaa ttgttggcat
     8821 gatgacattt catttgtgcc aaaaatatta aaaatgcctt ttttggaagg actaacagaa
     8881 agcacctgat ttgcacttga accagattat agatttaaaa gtatatgaca tgtattttgt
     8941 atttaaaact agaatagcca gtatttatgt tttttataaa actgtgcaat acgaattatg
     9001 caatcacaat acatttgtag ctcccgagtg tcctaaaggg agtgcacttc tttgaagctg
     9061 gtgtgttaat actatgtaat aaatggttaa ctttcaaatg atgctgctgc caaaattata
     9121 ttaatagtga gtttcaggcc cctgggcatt ttgtaccatg taattatcct ctggtgatgc
     9181 tgtttctcgt tagtggcagt agtgcctccg tctcctagtg ataatgctcc aagtctatga
     9241 actgttaaat cagcattcat tttaagaaaa gcaactttag tttcaaagat acttttaagc
     9301 ttctaaattg atcatttaaa ctatttcttt aaataagaga gccaaattag aggctcatac
     9361 tttagcttgt gaagaagata atgaattttt taaagggaac tttctatgca atgttcagga
     9421 taaatgcata ctgctggcca atcagtgtca tctcctgggt aaattttgat gtcgcattat
     9481 aaagacatgc ataattgatg gtttctagat tatctagtcc aaacaataga gtttattttt
     9541 tcttcatctg aaccaacatg ctacagtagc taagaagtat taaaactata tacatccata
     9601 taaagatgaa atatgaacta tctcattaga agtcatagtt gaccacagac atgttattct
     9661 tctgaaagag ccacattttg gttttatttc ttgtcacatg atttcttttc ttgatggatg
     9721 aaaaatatga aaggaaactt ttatatctgt tgcctagttt tgtacatgga tctcatttta
     9781 caagagaatc tctctgcaaa aaaaaaaaaa acagtttaaa aatgcattga aagcagagtt
     9841 ctgaaatgag taaagtttgt aaatgcatat ataaaaatat ttaataaatg atgcagaata
     9901 tacagtga
//
