LOCUS       NM_002221               6269 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens inositol-trisphosphate 3-kinase B (ITPKB), transcript
            variant 1, mRNA.
ACCESSION   NM_002221
VERSION     NM_002221.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6269)
  AUTHORS   Yan,Y., Zhou,S., Chen,X., Yi,Q., Feng,S., Zhao,Z., Liu,Y.,
            Liang,Q., Xu,Z., Li,Z. and Sun,L.
  TITLE     Suppression of ITPKB degradation by Trim25 confers TMZ resistance
            in glioblastoma through ROS homeostasis
  JOURNAL   Signal Transduct Target Ther 9 (1), 58 (2024)
   PUBMED   38438346
  REMARK    GeneRIF: Suppression of ITPKB degradation by Trim25 confers TMZ
            resistance in glioblastoma through ROS homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6269)
  AUTHORS   Gelemanovic,A., Catipovic Ardalic,T., Pribisalic,A., Hayward,C.,
            Kolcic,I. and Polasek,O.
  TITLE     Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants
            to Predict Common Human Infectious Diseases Risk
  JOURNAL   Int J Mol Sci 24 (8), 7006 (2023)
   PUBMED   37108169
  REMARK    GeneRIF: Genome-Wide Meta-Analysis Identifies Multiple Novel Rare
            Variants to Predict Common Human Infectious Diseases Risk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6269)
  AUTHORS   Di Leva,F., Filosi,M., Oyston,L., Silvestri,E., Picard,A.,
            Lavdas,A.A., Lobbestael,E., Baekelandt,V., Neely,G.G.,
            Pramstaller,P.P., Hicks,A.A. and Corti,C.
  TITLE     Increased Levels of the Parkinson's Disease-Associated Gene ITPKB
            Correlate with Higher Expression Levels of alpha-Synuclein,
            Independent of Mutation Status
  JOURNAL   Int J Mol Sci 24 (3), 1984 (2023)
   PUBMED   36768321
  REMARK    GeneRIF: Increased Levels of the Parkinson's Disease-Associated
            Gene ITPKB Correlate with Higher Expression Levels of
            alpha-Synuclein, Independent of Mutation Status.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6269)
  AUTHORS   Fang,H.S., Wang,C.C., Chao,C.Y., Fan,W.L., Su,S.C. and Wu,Y.R.
  TITLE     Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in
            Taiwan
  JOURNAL   J Formos Med Assoc 121 (3), 679-686 (2022)
   PUBMED   34244037
  REMARK    GeneRIF: Association of ITPKB, IL1R2 and COQ7 with Parkinson's
            disease in Taiwan.
REFERENCE   5  (bases 1 to 6269)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6269)
  AUTHORS   Millard,T.H., Cullen,P.J. and Banting,G.
  TITLE     Effects of elevated expression of inositol 1,4,5-trisphosphate
            3-kinase B on Ca2+ homoeostasis in HeLa cells
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 709-715 (2000)
   PUBMED   11104677
REFERENCE   7  (bases 1 to 6269)
  AUTHORS   Woodring,P.J. and Garrison,J.C.
  TITLE     Expression, purification, and regulation of two isoforms of the
            inositol 1,4,5-trisphosphate 3-kinase
  JOURNAL   J Biol Chem 272 (48), 30447-30454 (1997)
   PUBMED   9374536
REFERENCE   8  (bases 1 to 6269)
  AUTHORS   Erneux,C., Roeckel,N., Takazawa,K., Mailleux,P., Vassart,G. and
            Mattei,M.G.
  TITLE     Localization of the genes for human inositol 1,4,5-trisphosphate
            3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21
            and 1q41-q43, respectively, by in situ hybridization
  JOURNAL   Genomics 14 (2), 546-547 (1992)
   PUBMED   1330886
REFERENCE   9  (bases 1 to 6269)
  AUTHORS   Takazawa,K., Perret,J., Dumont,J.E. and Erneux,C.
  TITLE     Molecular cloning and expression of a new putative inositol
            1,4,5-trisphosphate 3-kinase isoenzyme
  JOURNAL   Biochem J 278 (Pt 3) (Pt 3), 883-886 (1991)
   PUBMED   1654894
REFERENCE   10 (bases 1 to 6269)
  AUTHORS   Takazawa,K., Vandekerckhove,J., Dumont,J.E. and Erneux,C.
  TITLE     Cloning and expression in Escherichia coli of a rat brain cDNA
            encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate
            3-kinase
  JOURNAL   Biochem J 272 (1), 107-112 (1990)
   PUBMED   2176078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365444.11, BC015009.1,
            Y18024.2, AJ242780.1 and AK313801.1.
            
            On Aug 13, 2020 this sequence version replaced NM_002221.3.
            
            Summary: The protein encoded by this protein regulates inositol
            phosphate metabolism by phosphorylation of second messenger
            inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of
            this encoded protein is responsible for regulating the levels of a
            large number of inositol polyphosphates that are important in
            cellular signaling. Both calcium/calmodulin and protein
            phosphorylation mechanisms control its activity. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ242780.1, X57206.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429204.6/ ENSP00000411152.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AL365444.11        48198-48304
            108-964             BC015009.1         1-857
            965-1668            Y18024.2           518-1221
            1669-2101           AJ242780.1         1279-1711
            2102-2102           AL365444.11        51676-51676
            2103-2728           AK313801.1         461-1086
            2729-4380           AJ242780.1         2339-3990
            4381-6269           AL365444.11        153902-155790
FEATURES             Location/Qualifiers
     source          1..6269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..6269
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /note="inositol-trisphosphate 3-kinase B"
                     /db_xref="GeneID:3707"
                     /db_xref="HGNC:HGNC:6179"
                     /db_xref="MIM:147522"
     exon            1..242
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            243..2379
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2479
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2693
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2898
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3000
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3072
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..6269
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6251..6256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /note="hexamer: AATAAA"
     polyA_site      6269
                     /gene="ITPKB"
                     /gene_synonym="IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37"
                     /note="major polyA site"
ORIGIN      
        1 gggcagtatc tccacggtcg aaaagggcgt gcagggccgg cttggcgtcg ccactgccgg
       61 gatcgccggg cccctgaacc gaagagcttt cccccctctt tcgcactcct cttttttgtc
      121 ttccatagct tgtgagaaaa taatttctga gcatttttac ttttaaagcc atctcgtccc
      181 tacgaggttt gcgcctctgg gcatgtagtc tacacaggac ctgagaatct gagaaactgc
      241 agccgcacgg ttgtttatgg agctttgggc gggggctgag cccgcggtcg tgcccccagc
      301 ccgctgccca ggccatgccg ccccatctgc gcgcggagcc gcggctgccg ggcctccggg
      361 gctgagccgg gagcgccggg aggaggaggc gccggcggcg gagcaggagc gggagccgcg
      421 gcggcgggca gcgcgggacc cagtactatg gctgtgtact gctatgcgct caatagcctg
      481 gtgatcatga atagcgccaa cgagatgaag agcggcggcg gcccggggcc cagtggcagc
      541 gagacgcccc cgcccccgag gagggcagtg ctgagccccg gcagcgtttt cagccccggg
      601 agaggcgcct ctttcctctt ccccccagcc gagtcgctgt cccccgagga gccccggagc
      661 cccgggggct ggcggagcgg ccggcgcagg ctgaatagta gcagcggcag tggcagcggc
      721 agcagcggca gtagcgtgag cagcccaagt tgggctggtc gcctgcgagg ggaccggcag
      781 caggtggtgg cagccggtac cctctccccg ccagggccgg aggaggccaa gaggaagctg
      841 cggatcttgc agcgcgagtt gcagaacgtg caggtgaacc agaaagtggg catgtttgag
      901 gcgcacatcc aggcacagag ctccgccatt caagcgcccc gcagcccgcg tttgggcagg
      961 gctcgctcgc cctccccgtg ccccttccgc agcagcagtc agccccctgg aagggtcctg
     1021 gttcagggcg cccggagcga ggaacggagg acaaagtcct ggggggagca atgtccagag
     1081 acttcaggaa ccgactccgg gaggaaagga gggcccagcc tatgctcctc gcaggtgaag
     1141 aaaggaatgc cacctcttcc cggccgggct gcccctacag gatcagaggc tcagggtcca
     1201 tccgcttttg taaggatgga gaagggtatc cctgccagtc cccgctgtgg ctcacccaca
     1261 gctatggaaa ttgacaaaag gggctctcct accccgggaa ctcggagctg cctagctccc
     1321 tcattggggc tgttcggagc tagcttaacg atggccacgg aagtggcagc gagagttaca
     1381 tccactgggc cacaccgtcc acaggatctt gccctcactg agccgtctgg gagagcccgt
     1441 gagcttgagg acctgcagcc cccagaggcc ctggtggaga ggcaggggca gtttctgggc
     1501 agtgagacaa gcccagcccc agaaaggggc gggccccgcg atggagaacc ccctgggaag
     1561 atggggaaag gatatctgcc ctgtggcatg ccgggctctg gggagcctga agtgggcaaa
     1621 aggccagagg agacgactgt gagcgtgcaa agcgcagagt cctctgattc cctgagctgg
     1681 tccaggctgc ccagggccct ggcctccgta ggccctgagg aggcccgaag tggggccccc
     1741 gtgggcgggg ggcgttggca gctctccgac agagtggagg gagggtcccc aacgctgggc
     1801 ttgcttgggg gcagcccctc agcacagccg gggaccggga atgtggaggc gggaattcct
     1861 tctggcagaa tgctggagcc tttgccctgt tgggacgctg cgaaagatct gaaagaacct
     1921 cagtgccctc ctggggacag ggtgggtgtg cagcctggga actccagggt ttggcagggc
     1981 accatggaga aagccggttt ggcttggacg cgtggcacag gggtgcaatc agaggggact
     2041 tgggaaagcc agcggcagga cagtgatgcc ctcccaagtc cggagctgct accccaagat
     2101 ccggacaagc ctttcctgag gaaggcctgc agccccagca acatacctgc tgtcatcatt
     2161 acagacatgg gcacccagga ggatggggcc ttggaggaga cgcagggaag ccctcggggc
     2221 aacctgcccc tgaggaaact gtcctcttcc tcggcctcct ccacgggctt ctcctcatcc
     2281 tacgaagact cagaggagga catctccagt gaccctgagc gcaccctgga ccccaactca
     2341 gccttcctgc ataccctgga ccagcagaaa cctagagtga gcaaatcatg gaggaagata
     2401 aaaaacatgg tgcactggtc tcccttcgtc atgtccttca agaagaagta cccctggatc
     2461 cagctggcag gacacgcagg gagtttcaag gcagctgcca atggcaggat cctgaagaag
     2521 cactgtgagt cagagcagcg ctgcctggac cggctgatgg tggatgtgct gaggcccttc
     2581 gtacctgcct accatgggga tgtggtgaag gacggggagc gctacaacca gatggacgac
     2641 ctgctggccg acttcgactc gccctgtgtg atggactgca agatgggaat caggacctac
     2701 ctggaggagg agctcacgaa ggcccggaag aagcccagcc tgcggaagga catgtaccag
     2761 aagatgatcg aggtggaccc cgaggccccc accgaggagg aaaaagcaca gcgggctgtg
     2821 accaagccac ggtacatgca gtggcgggag accatcagct ccacggccac cctggggttc
     2881 aggatcgagg gaatcaagaa agaagacggc accgtgaacc gggacttcaa gaagaccaaa
     2941 acgagggagc aggtcaccga ggccttcaga gagttcacta aaggaaacca taacatcctg
     3001 atcgcctatc gggaccggct gaaggccatt cgaaccactc tagaagtttc tcccttcttc
     3061 aagtgccacg aggtcattgg cagctccctc ctcttcatcc acgacaagaa ggaacaggcc
     3121 aaagtgtgga tgatcgactt tgggaaaacc acgcccctgc ctgagggcca gaccctgcag
     3181 catgacgtcc cctggcagga ggggaaccgg gaggatggct acctctcggg gctcaataac
     3241 ctcgtcgaca tcctgaccga gatgtcccag gatgccccac tcgcctgagc tgcccacgcc
     3301 ctccctggcc cccgcctggg cctcctttcc tcctcctgtg cttcctttct cgttcctaac
     3361 ttttccttca cttacacctg actgaccctc ctgaactgca ctacaagaca ctttgtagaa
     3421 gaggagatga gagtttctag tcattttcct aacttcaggg cttggaggtg gtgtttgcac
     3481 tgctttttgt agagagggtc acctactaga agagaaatgc ccagtcttag aggtgggtca
     3541 ggtgtagagc tggagggggt ccctggctgc tgaggggacc ctaccagatg agccctgcct
     3601 ctgggagccc cctaggaagc accagcctgg acctaccacc tgcggaggcc tgctgccccc
     3661 tggcggccag tgctgttaga gtgctgccaa gcacagcctt atttctgccg gggcctcccc
     3721 accggagagc ccagggggcc ggccgggttc ctggtccctg gctgggagca gggctttctg
     3781 gtagttgggg cacaaaacca tcggggaacc acatgttgac tgtgagcaaa gtgtcttccg
     3841 attagcagcc tcagggatgc cctggtggcc tctccagggc tgctcaggca aggcccccca
     3901 cccatctggt atggaaacct gccggctcca ggccagaccc aggagccaag agaaggctga
     3961 agccagcttg gctgtgttct ctgatctagg ccttcccaga ggaggcgagc agaagctgtg
     4021 ccacttggaa ttgcaaccca tgagttcaga aggcacactc tgccatgctg agctccaagg
     4081 gtgctaccag gggaagatgg gatctataga gtctctgggc cctggcccca gggaggagca
     4141 catttttctt gaccctcacc tacctggtgc tagttggtca accctgcctg catacatggg
     4201 ctcctgtcat ggggcccaga gtcccttgca gatatagaaa taggggagga gctcaggtct
     4261 gcgccaggca ggaagaaggc aggcttctgg cttccagagg tgccgcggtg gcctcctggc
     4321 atcatttgtt attgcctctg aaacaagcct tactgcctgg agggcttaga ttcctgcttc
     4381 tccaatgtag tgtgggtatc ttgtagggta tgtggtggat gccagggcgt gctccaggca
     4441 cctcttcctg aagtctctgc atttggagat tcgtggagaa cctatttaag cccaatttta
     4501 actgaaagcc agtgagtctg atatggaagg gaatgtaaaa tttgcctgac ttcttaagaa
     4561 caaaaccccc agctctgtgc cccatgctcc ttggggcttg ccacccactc ctttgctgtc
     4621 agaggtacag gagctgggag agtccaggag ctagggacac agagggagac tatggaccaa
     4681 ggtgtgtgtg tctggaggaa ccactgccca ccccaccacc ccggggtctc tggggaactg
     4741 tcaacctgcc cacgggacat gtacatttcc ccttttgtgc tggaagtgtg agtgacactt
     4801 gctgggggtg gagggtggga cacatgagga tgtataagta cagattttaa aaaaggaaat
     4861 caacttacac ttcctggctc ttgtttaaaa cagtggtgag ctcctgtgtg ggccgacttg
     4921 ctaaaggtca cacacgcgcc cggtggagca cgagagacct cgtggcagca tgtgatctgg
     4981 aaggcaggca ggacgggggc gttggggagc caaagtcaac tctgggcctc tggagctata
     5041 gtgacttttg ggctagaagg gaccctggtg gtctgtgctt cagccatttg cagggcaggg
     5101 gcatcattaa ttcagacgta aagattctat gaatatggac tggccaaaag ttatccttac
     5161 tccatctgtg aaagaagttt gctaaagcaa atcatgatat gaacaaaaat tacaggggac
     5221 ctgtttaaga gaacaaaatg ttccaagcac tttaggcaga caccagctgt ttgcaaacaa
     5281 tgtgctaata tgcaaatgat gtgcttatta aaggaggccc atggggcctc ttattggcaa
     5341 tacttggctg tgggttacat taaatatgtg aacatagtat gaagtagcat cattttaggg
     5401 ttattctgtt acttagggtt tttgttttct gttttttttt tctctttttt tgtatttacc
     5461 gtgctagttc tcttctacac ctactctgtc tctcaagcca ttttgccact cgcttccctg
     5521 ccatctggcc cttccctttg tctcagtggg atagatggat tgtgaaatgg aatctcccag
     5581 aacccctgcc ctggcagcct ggaagaccgt gcctgcccag ccctcgtcac cacagggact
     5641 ccttgggtcc tggcagtgca tgtgccagca ggcaggacaa actctgtgta cctgtgccca
     5701 ggtgaatggg cgcagggtcc tcttgccctg tcctgcgggg ggccccacga gttcctggca
     5761 ttcagcactg cttagcattc tcggaaggtt tcttcaactg cttgcttttc ccaggcttgc
     5821 ctttagtgtc atgtaagaca tttttaagtt atatttattt tgttgggttt taaaattgca
     5881 cagaacacta agaccgaaag gctggactct tgtttctcct tgaaagcttt gcctttgttt
     5941 tgaacttcct ttcccacttg gtagaaagag cccagaagca gccctggccc tgtaagatgg
     6001 actctttcat ccttcagttg tatttagctt tgagtttctc tgcatctgtc caccccatgt
     6061 gtatataacc cagcccctgg ctctggggtg gtcacctcgt cagtgccttt tgttctggag
     6121 gagaggaccc cccccgcctg ccgagaggct ctcttcctgt tctgcacccc tctccccatg
     6181 ggaccttgga gaaaactgaa ctgttacaaa cccctgcaca gtgcctgtca aacagatgca
     6241 aaccttcctg aataaagcct tggagacca
//
