LOCUS       NM_002220               1825 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens inositol-trisphosphate 3-kinase A (ITPKA), mRNA.
ACCESSION   NM_002220
VERSION     NM_002220.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Zhang,X., He,J. and Ren,D.
  TITLE     Commentary on: The actin bundling activity of ITPKA mainly accounts
            for its migration-promoting effect in lung cancer cells
  JOURNAL   Biosci Rep 43 (9) (2023)
   PUBMED   37664985
  REMARK    GeneRIF: Commentary on: The actin bundling activity of ITPKA mainly
            accounts for its migration-promoting effect in lung cancer cells.
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Kuster,L., Paraschiakos,T., Karakurt,K.E., Schumacher,U.,
            Diercks,B.P. and Windhorst,S.
  TITLE     The actin bundling activity of ITPKA mainly accounts for its
            migration-promoting effect in lung cancer cells
  JOURNAL   Biosci Rep 43 (2) (2023)
   PUBMED   36688944
  REMARK    GeneRIF: The actin bundling activity of ITPKA mainly accounts for
            its migration-promoting effect in lung cancer cells.
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Shaosheng,W., Shaochuang,W., Lichun,F., Na,X. and Xiaohong,Z.
  TITLE     ITPKA induces cell senescence, inhibits ovarian cancer
            tumorigenesis and can be downregulated by miR-203
  JOURNAL   Aging (Albany NY) 13 (8), 11822-11832 (2021)
   PUBMED   33879633
  REMARK    GeneRIF: ITPKA induces cell senescence, inhibits ovarian cancer
            tumorigenesis and can be downregulated by miR-203.
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Zhang,J., Zhang,S., Li,X. and Pi,H.
  TITLE     Relationship of ITPKA expression with the prognosis of breast
            cancer
  JOURNAL   Mol Genet Genomic Med 9 (4), e1598 (2021)
   PUBMED   33624455
  REMARK    GeneRIF: Relationship of ITPKA expression with the prognosis of
            breast cancer.
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Guoren,Z., Zhaohui,F., Wei,Z., Mei,W., Yuan,W., Lin,S., Xiaoyue,X.,
            Xiaomei,Z. and Bo,S.
  TITLE     TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1
            in Lung Adenocarcinoma
  JOURNAL   Int J Biol Sci 16 (3), 504-514 (2020)
   PUBMED   32015686
  REMARK    GeneRIF: TFAP2A Induced ITPKA Serves as an Oncogene and Interacts
            with DBN1 in Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1825)
  AUTHORS   Erneux,C., Roeckel,N., Takazawa,K., Mailleux,P., Vassart,G. and
            Mattei,M.G.
  TITLE     Localization of the genes for human inositol 1,4,5-trisphosphate
            3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21
            and 1q41-q43, respectively, by in situ hybridization
  JOURNAL   Genomics 14 (2), 546-547 (1992)
   PUBMED   1330886
REFERENCE   7  (bases 1 to 1825)
  AUTHORS   Takazawa,K. and Erneux,C.
  TITLE     Identification of residues essential for catalysis and binding of
            calmodulin in rat brain inositol 1,4,5-trisphosphate 3-kinase
  JOURNAL   Biochem J 280 (Pt 1) (Pt 1), 125-129 (1991)
   PUBMED   1660262
REFERENCE   8  (bases 1 to 1825)
  AUTHORS   Takazawa,K., Perret,J., Dumont,J.E. and Erneux,C.
  TITLE     Molecular cloning and expression of a new putative inositol
            1,4,5-trisphosphate 3-kinase isoenzyme
  JOURNAL   Biochem J 278 (Pt 3) (Pt 3), 883-886 (1991)
   PUBMED   1654894
REFERENCE   9  (bases 1 to 1825)
  AUTHORS   Takazawa,K., Perret,J., Dumont,J.E. and Erneux,C.
  TITLE     Molecular cloning and expression of a human brain inositol
            1,4,5-trisphosphate 3-kinase
  JOURNAL   Biochem Biophys Res Commun 174 (2), 529-535 (1991)
   PUBMED   1847047
REFERENCE   10 (bases 1 to 1825)
  AUTHORS   Lin,A.N., Barnes,S. and Wallace,R.W.
  TITLE     Phosphorylation by protein kinase C inactivates an inositol
            1,4,5-trisphosphate 3-kinase purified from human platelets
  JOURNAL   Biochem Biophys Res Commun 170 (3), 1371-1376 (1990)
   PUBMED   2167676
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087721.4, X54938.1 and
            DB543073.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002220.2.
            
            Summary: Regulates inositol phosphate metabolism by phosphorylation
            of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4.
            The activity of the inositol 1,4,5-trisphosphate 3-kinase is
            responsible for regulating the levels of a large number of inositol
            polyphosphates that are important in cellular signaling. Both
            calcium/calmodulin and protein phosphorylation mechanisms control
            its activity. It is also a substrate for the cyclic AMP-dependent
            protein kinase, calcium/calmodulin- dependent protein kinase II,
            and protein kinase C in vitro.[provided by RefSeq, Apr 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026331.1, X54938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260386.7/ ENSP00000260386.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC087721.4         180945-180994
            51-1823             X54938.1           8-1780
            1824-1825           DB543073.1         466-467
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1825
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /note="inositol-trisphosphate 3-kinase A"
                     /db_xref="GeneID:3706"
                     /db_xref="HGNC:HGNC:6178"
                     /db_xref="MIM:147521"
     exon            1..543
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1440
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /EC_number="2.7.1.127"
                     /note="inositol 1,4,5-trisphosphate 3-kinase A; IP3K A;
                     IP3 3-kinase A; insP 3-kinase A"
                     /codon_start=1
                     /product="inositol-trisphosphate 3-kinase A"
                     /protein_id="NP_002211.1"
                     /db_xref="CCDS:CCDS10076.1"
                     /db_xref="GeneID:3706"
                     /db_xref="HGNC:HGNC:6178"
                     /db_xref="MIM:147521"
                     /translation="MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAA
                     VAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERE
                     RDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGED
                     VGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYC
                     LARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELT
                     KARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEG
                     IKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRR
                     HEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDN
                     LIGILASLAER"
     exon            544..640
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            641..857
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1062
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1164
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1236
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1825
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /note="major polyA site"
ORIGIN      
        1 agtccccggc gcgccgcggg ctggtgggct cagcggcggc gccggcactg ggaaatgacc
       61 ctgcccgggg gcccaacggg catggcgcgg ccggggggcg cgaggccctg cagcccgggg
      121 ctggagcggg ccccgcgccg gagtgtcggg gagctgcgcc tgctcttcga ggcgcgctgt
      181 gcggcggtcg ctgcggccgc cgccgcgggg gagccccggg cccgcggggc caagcggcgt
      241 gggggacagg tccccaacgg gcttccgcgg gctcccccgg ccccggtgat ccctcagctg
      301 accgtgacag ccgaggagcc cgacgtgccc ccgaccagcc ctgggccgcc ggagcgggag
      361 agggactgcc tcccggcagc gggctcttcg cacctgcagc agccgcgccg cctttccacc
      421 tcgtcggtct cctccactgg ctcctcgtcg ctgctcgagg actcggagga cgacctgctg
      481 agcgacagtg agagccggag ccgcggcaac gtgcagctgg aagcgggcga ggacgtgggt
      541 cagaaaaacc actggcagaa gatccggacc atggtcaatc tgccggtcat aagccctttc
      601 aagaagcgct acgcctgggt gcagctggca gggcacactg ggagttttaa ggcggcgggc
      661 accagcgggc tgatcctgaa gcgctgctcg gagccggagc gctactgcct ggcgcggctg
      721 atggctgacg cgctgcgcgg ctgcgtgcct gccttccacg gcgtggtgga gcgcgacggc
      781 gaaagctacc tgcagctgca ggacctgctc gatggcttcg acggaccttg tgtgctcgac
      841 tgcaaaatgg gcgtcaggac ttacctagag gaggagctga ccaaggcccg tgagcggccc
      901 aagctgcgga aggacatgta caagaaaatg ctggcggtgg atcctgaagc tcccacggag
      961 gaggagcacg cgcagcgcgc cgtcaccaag ccgcgctaca tgcagtggcg ggaaggcatc
     1021 agctccagca ccaccctcgg cttccgcatc gagggcatca agaaagcgga cggctcctgc
     1081 agcaccgact tcaagactac gcgaagccga gagcaggtgc ttcgcgtctt tgaagagttt
     1141 gtgcaaggag atgaggaagt gctgaggcgg tatctgaacc gcctgcagca gatccgggac
     1201 accctggagg tatccgagtt cttcaggagg cacgaggtga tcggcagctc gctcctcttt
     1261 gtgcacgatc actgccatcg cgccggcgtg tggctcatcg acttcggcaa gaccacgccc
     1321 ctccccgatg gccagatcct ggaccaccgg cggccctggg aggagggcaa ccgcgaggac
     1381 ggctatttgc tggggctgga caatctcatt ggcatcctgg ccagcctggc tgagagatga
     1441 ggctggactc ctgtccccgc gggccgctca cctgacatgt ggacctgcag ctttgtcccc
     1501 actgtgcatg ccggcttgag actggagccc cgcggtgcag ggcagttcac cgggtcctgc
     1561 aggaccaggt gccagccact aagggggggc accgccgatg ccaggggttt tgcccacccg
     1621 ggccccagcg ttcccagagc caaatgacac taacttatag aaggggaggg ggcaaagggc
     1681 ttcttcctca ggccagctct tctgaggagg ctctgccctc tccagaggtg ccagaccgcg
     1741 gattttattt agcaagccca gaccttccgg tctaacgtct cacaccacga cggactcccc
     1801 ttcctaataa aactcaaaga caaga
//
