LOCUS       NM_080878               1161 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens intelectin 2 (ITLN2), mRNA.
ACCESSION   NM_080878
VERSION     NM_080878.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Nonnecke,E.B., Castillo,P.A., Johansson,M.E.V., Hollox,E.J.,
            Shen,B., Lonnerdal,B. and Bevins,C.L.
  TITLE     Human intelectin-2 (ITLN2) is selectively expressed by secretory
            Paneth cells
  JOURNAL   FASEB J 36 (3), e22200 (2022)
   PUBMED   35182405
  REMARK    GeneRIF: Human intelectin-2 (ITLN2) is selectively expressed by
            secretory Paneth cells.
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1161)
  AUTHORS   Yan,J., Xu,L., Zhang,Y., Zhang,C., Zhang,C., Zhao,F. and Feng,L.
  TITLE     Comparative genomic and phylogenetic analyses of the intelectin
            gene family: implications for their origin and evolution
  JOURNAL   Dev Comp Immunol 41 (2), 189-199 (2013)
   PUBMED   23643964
  REMARK    GeneRIF: Studies indicate that ITLN1 and ITLN2 intelectins are
            positioned on a single chromosome 1, suggesting mammalian
            intelectins have been independently expanded by partial gene
            duplication.
REFERENCE   5  (bases 1 to 1161)
  AUTHORS   Jablonski,K.A., McAteer,J.B., de Bakker,P.I., Franks,P.W.,
            Pollin,T.I., Hanson,R.L., Saxena,R., Fowler,S., Shuldiner,A.R.,
            Knowler,W.C., Altshuler,D. and Florez,J.C.
  CONSRTM   Diabetes Prevention Program Research Group
  TITLE     Common variants in 40 genes assessed for diabetes incidence and
            response to metformin and lifestyle intervention in the diabetes
            prevention program
  JOURNAL   Diabetes 59 (10), 2672-2681 (2010)
   PUBMED   20682687
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 1161)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 1161)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1161)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1161)
  AUTHORS   Lee,J.K., Schnee,J., Pang,M., Wolfert,M., Baum,L.G., Moremen,K.W.
            and Pierce,M.
  TITLE     Human homologs of the Xenopus oocyte cortical granule lectin XL35
  JOURNAL   Glycobiology 11 (1), 65-73 (2001)
   PUBMED   11181563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591806.16, AY358905.1 and AL354714.22.
            
            On Nov 23, 2018 this sequence version replaced NM_080878.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358905.1, AY065973.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368029.4/ ENSP00000357008.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL591806.16        8802-8811           c
            11-1160             AY358905.1         1-1150
            1161-1161           AL354714.22        138323-138323       c
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1161
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /note="intelectin 2"
                     /db_xref="GeneID:142683"
                     /db_xref="HGNC:HGNC:20599"
                     /db_xref="MIM:609874"
     exon            1..83
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1046
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /note="PRO7179; endothelial lectin HL-2"
                     /codon_start=1
                     /product="intelectin-2 precursor"
                     /protein_id="NP_543154.1"
                     /db_xref="CCDS:CCDS1212.1"
                     /db_xref="GeneID:142683"
                     /db_xref="HGNC:HGNC:20599"
                     /db_xref="MIM:609874"
                     /translation="MLSMLRTMTRLCFLLFFSVATSGCSAAAASSLEMLSREFETCAF
                     SFSSLPRSCKEIKERCHSAGDGLYFLRTKNGVVYQTFCDMTSGGGGWTLVASVHENDM
                     RGKCTVGDRWSSQQGNKADYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLG
                     IWHVPNKSPMQHWRNSALLRYRTNTGFLQRLGHNLFGIYQKYPVKYRSGKCWNDNGPA
                     IPVVYDFGDAKKTASYYSPYGQREFVAGFVQFRVFNNERAANALCAGIKVTGCNTEHH
                     CIGGGGFFPQGKPRQCGDFSAFDWDGYGTHVKSSCSREITEAAVLLFYR"
     exon            84..147
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..261
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..509
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..668
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..789
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..893
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1161
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /note="hexamer: ACTAAA"
     polyA_site      1161
                     /gene="ITLN2"
                     /gene_synonym="HL-2; HL2"
                     /note="major polyA site"
ORIGIN      
        1 aggatcctct gcaggggagc tccgagtgtc cacaggaagg gaactatcag ctcctggcat
       61 ctgtaaggat gctgtccatg ctgaggacaa tgaccagact ctgcttcctg ttattcttct
      121 ctgtggccac cagtgggtgc agtgcagcag cagcctcttc tcttgagatg ctctcgaggg
      181 aattcgaaac ctgtgccttc tccttttctt ccctgcctag aagctgcaaa gaaatcaagg
      241 aacgctgcca tagtgcaggt gatggcctgt attttctccg caccaagaat ggtgttgtct
      301 accagacctt ctgtgacatg acttctgggg gtggcggctg gaccctggtg gccagcgtgc
      361 acgagaatga catgcgtggg aagtgcacgg tgggtgatcg ctggtccagt cagcagggca
      421 acaaagcaga ctacccagag ggggatggca actgggccaa ctacaacacc tttggatctg
      481 cagaggcggc cacgagcgat gactacaaga accctggcta ctacgacatc caggccaagg
      541 acctgggcat ctggcatgtg cccaacaagt cccccatgca gcattggaga aacagcgccc
      601 tgctgaggta ccgcaccaac actggcttcc tccagagact gggacataat ctgtttggca
      661 tctaccagaa atacccagtg aaatacagat cagggaaatg ttggaatgac aatggcccag
      721 ccatacctgt ggtctatgac tttggtgatg ctaagaagac tgcatcttat tactcaccgt
      781 atggtcaacg ggaatttgtt gcaggattcg ttcagttccg ggtgtttaat aacgagagag
      841 cagccaacgc cctttgtgct gggataaaag ttactggctg taacactgag catcactgca
      901 tcggtggagg agggttcttc ccacagggca aaccccgtca gtgtggggac ttctccgcct
      961 ttgactggga tggatatgga actcacgtta agagcagctg cagtcgggag ataacggagg
     1021 cggctgtact cttgttctat agatgagaca gagctctgcg gtgtcagggc gagaacccat
     1081 cttccaaccc cggctatttg gagacggaaa aactggaatt ctaacaagga ggagaggaga
     1141 ctaaatcaca tcaatttgca a
//
