LOCUS       NM_017625               1192 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens intelectin 1 (ITLN1), mRNA.
ACCESSION   NM_017625
VERSION     NM_017625.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Yang,Y. and Chen,L.
  TITLE     Omentin-1 attenuates lipopolysaccharide-induced inflammation and
            osteogenic differentiation in periodontal ligament stem cells and
            reduces M1 macrophages polarization through repressing endoplasmic
            reticulum stress
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106882 (2024)
   PUBMED   39151819
  REMARK    GeneRIF: Omentin-1 attenuates lipopolysaccharide-induced
            inflammation and osteogenic differentiation in periodontal ligament
            stem cells and reduces M1 macrophages polarization through
            repressing endoplasmic reticulum stress.
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Czechowski,P., Hagemann,T., Ghosh,A., Sun,W., Dong,H., Noe,F.,
            Niersmann,C., Reinisch,I., Wolfrum,C., Herder,C., Dietrich,A.,
            Bluher,M. and Hoffmann,A.
  TITLE     Expression of Intelectin-1, also known as Omentin-1, is related to
            clinical phenotypes such as overweight, obesity, insulin
            resistance, and changes after bariatric surgery
  JOURNAL   Sci Rep 14 (1), 22286 (2024)
   PUBMED   39333229
  REMARK    GeneRIF: Expression of Intelectin-1, also known as Omentin-1, is
            related to clinical phenotypes such as overweight, obesity, insulin
            resistance, and changes after bariatric surgery.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Everman,J.L., Sajuthi,S.P., Liegeois,M.A., Jackson,N.D.,
            Collet,E.H., Peters,M.C., Chioccioli,M., Moore,C.M., Patel,B.B.,
            Dyjack,N., Powell,R., Rios,C., Montgomery,M.T., Eng,C.,
            Elhawary,J.R., Mak,A.C.Y., Hu,D., Huntsman,S., Salazar,S.,
            Feriani,L., Fairbanks-Mahnke,A., Zinnen,G.L., Michel,C.R.,
            Gomez,J., Zhang,X., Medina,V., Chu,H.W., Cicuta,P., Gordon,E.D.,
            Zeitlin,P., Ortega,V.E., Reisdorph,N., Dunican,E.M., Tang,M.,
            Elicker,B.M., Henry,T.S., Bleecker,E.R., Castro,M., Erzurum,S.C.,
            Israel,E., Levy,B.D., Mauger,D.T., Meyers,D.A., Sumino,K.,
            Gierada,D.S., Hastie,A.T., Moore,W.C., Denlinger,L.C.,
            Jarjour,N.N., Schiebler,M.L., Wenzel,S.E., Woodruff,P.G.,
            Rodriguez-Santana,J., Pearson,C.G., Burchard,E.G., Fahy,J.V. and
            Seibold,M.A.
  TITLE     A common polymorphism in the Intelectin-1 gene influences mucus
            plugging in severe asthma
  JOURNAL   Nat Commun 15 (1), 3900 (2024)
   PUBMED   38724552
  REMARK    GeneRIF: A common polymorphism in the Intelectin-1 gene influences
            mucus plugging in severe asthma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Shi,W., Zhang,Q., Lu,Y., Liu,J., Ma,X., Xie,Z., Zhang,G., Chang,M.
            and Tian,Y.
  TITLE     Association of single nucleotide polymorphisms in ITLN1 gene with
            ischemic stroke risk in Xi'an population, Shaanxi province
  JOURNAL   PeerJ 12, e16934 (2024)
   PUBMED   38529304
  REMARK    GeneRIF: Association of single nucleotide polymorphisms in ITLN1
            gene with ischemic stroke risk in Xi'an population, Shaanxi
            province.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1192)
  AUTHORS   Al-Barwani,R. and Sarhat,E.
  TITLE     BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS
  JOURNAL   Georgian Med News (347), 66-69 (2024)
   PUBMED   38609116
  REMARK    GeneRIF: BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS.
REFERENCE   6  (bases 1 to 1192)
  AUTHORS   Chang,B.Y., Peavy,T.R., Wardrip,N.J. and Hedrick,J.L.
  TITLE     The Xenopus laevis cortical granule lectin: cDNA cloning,
            developmental expression, and identification of the eglectin family
            of lectins
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 137 (1), 115-129 (2004)
   PUBMED   14720597
REFERENCE   7  (bases 1 to 1192)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1192)
  AUTHORS   Suzuki,Y.A., Shin,K. and Lonnerdal,B.
  TITLE     Molecular cloning and functional expression of a human intestinal
            lactoferrin receptor
  JOURNAL   Biochemistry 40 (51), 15771-15779 (2001)
   PUBMED   11747454
REFERENCE   9  (bases 1 to 1192)
  AUTHORS   Tsuji,S., Uehori,J., Matsumoto,M., Suzuki,Y., Matsuhisa,A.,
            Toyoshima,K. and Seya,T.
  TITLE     Human intelectin is a novel soluble lectin that recognizes
            galactofuranose in carbohydrate chains of bacterial cell wall
  JOURNAL   J Biol Chem 276 (26), 23456-23463 (2001)
   PUBMED   11313366
REFERENCE   10 (bases 1 to 1192)
  AUTHORS   Lee,J.K., Schnee,J., Pang,M., Wolfert,M., Baum,L.G., Moremen,K.W.
            and Pierce,M.
  TITLE     Human homologs of the Xenopus oocyte cortical granule lectin XL35
  JOURNAL   Glycobiology 11 (1), 65-73 (2001)
   PUBMED   11181563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354714.22 and BC020664.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017625.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020664.1, AY549722.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326245.4/ ENSP00000323587.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL354714.22        78469-78478         c
            11-1192             BC020664.1         1-1182
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1192
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /note="intelectin 1"
                     /db_xref="GeneID:55600"
                     /db_xref="HGNC:HGNC:18259"
                     /db_xref="MIM:609873"
     exon            1..120
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     exon            121..184
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1068
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /note="intestinal lactoferrin receptor; endothelial lectin
                     HL-1; ITLN-1; galactofuranose-binding lectin; intelectin 1
                     (galactofuranose binding)"
                     /codon_start=1
                     /product="intelectin-1 precursor"
                     /protein_id="NP_060095.2"
                     /db_xref="CCDS:CCDS1211.1"
                     /db_xref="GeneID:55600"
                     /db_xref="HGNC:HGNC:18259"
                     /db_xref="MIM:609873"
                     /translation="MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEI
                     KDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSS
                     QQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQH
                     WRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQK
                     TASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEAS
                     PQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR"
     exon            185..283
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     exon            284..531
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     exon            532..690
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     exon            691..811
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     exon            812..915
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1192
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1173..1178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /note="hexamer: AATAAA"
     polyA_site      1192
                     /gene="ITLN1"
                     /gene_synonym="hIntL; HL-1; HL1; INTL; ITLN; LFR; omentin"
                     /note="major polyA site"
ORIGIN      
        1 attccacatc aggagcgttt ttggagaaag ctgcactctg ttgagctcca gggcgcagtg
       61 gagggaggga gtgaaggagc tctctgtacc caaggaaagt gcagctgaga ctcagacaag
      121 attacaatga accaactcag cttcctgctg tttctcatag cgaccaccag aggatggagt
      181 acagatgagg ctaatactta cttcaaggaa tggacctgtt cttcgtctcc atctctgccc
      241 agaagctgca aggaaatcaa agacgaatgt cctagtgcat ttgatggcct gtattttctc
      301 cgcactgaga atggtgttat ctaccagacc ttctgtgaca tgacctctgg gggtggcggc
      361 tggaccctgg tggccagcgt gcacgagaat gacatgcgtg ggaagtgcac ggtgggcgat
      421 cgctggtcca gtcagcaggg cagcaaagca gtctacccag agggggacgg caactgggcc
      481 aactacaaca cctttggatc tgcagaggcg gccacgagcg atgactacaa gaaccctggc
      541 tactacgaca tccaggccaa ggacctgggc atctggcacg tgcccaataa gtcccccatg
      601 cagcactgga gaaacagctc cctgctgagg taccgcacgg acactggctt cctccagaca
      661 ctgggacata atctgtttgg catctaccag aaatatccag tgaaatatgg agaaggaaag
      721 tgttggactg acaacggccc ggtgatccct gtggtctatg attttggcga cgcccagaaa
      781 acagcatctt attactcacc ctatggccag cgggaattca ctgcgggatt tgttcagttc
      841 agggtattta ataacgagag agcagccaac gccttgtgtg ctggaatgag ggtcaccgga
      901 tgtaacactg agcaccactg cattggtgga ggaggatact ttccagaggc cagtccccag
      961 cagtgtggag atttttctgg ttttgattgg agtggatatg gaactcatgt tggttacagc
     1021 agcagccgtg agataactga ggcagctgtg cttctattct atcgttgaga gttttgtggg
     1081 agggaaccca gacctctcct cccaaccatg agatcccaag gatggagaac aacttaccca
     1141 gtagctagaa tgttaatggc agaagagaaa acaataaatc atattgactc aa
//
