LOCUS       NM_005546               4508 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens IL2 inducible T cell kinase (ITK), mRNA.
ACCESSION   NM_005546
VERSION     NM_005546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4508)
  AUTHORS   Chen,Y., Liang,R., Shi,X., Shen,R., Liu,L., Liu,Y., Xue,Y., Guo,X.,
            Dang,J., Zeng,D., Huang,F., Sun,J., Zhang,J., Wang,J., Olsen,N.,
            August,A., Huang,W., Pan,Y. and Zheng,S.G.
  TITLE     Targeting kinase ITK treats autoimmune arthritis via orchestrating
            T cell differentiation and function
  JOURNAL   Biomed Pharmacother 169, 115886 (2023)
   PUBMED   37992572
  REMARK    GeneRIF: Targeting kinase ITK treats autoimmune arthritis via
            orchestrating T cell differentiation and function.
REFERENCE   2  (bases 1 to 4508)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4508)
  AUTHORS   Ogishi,M., Yang,R., Rodriguez,R., Golec,D.P., Martin,E.,
            Philippot,Q., Bohlen,J., Pelham,S.J., Arias,A.A., Khan,T., Ata,M.,
            Al Ali,F., Rozenberg,F., Kong,X.F., Chrabieh,M., Laine,C.,
            Lei,W.T., Han,J.E., Seeleuthner,Y., Kaul,Z., Jouanguy,E.,
            Beziat,V., Youssefian,L., Vahidnezhad,H., Rao,V.K., Neven,B.,
            Fieschi,C., Mansouri,D., Shahrooei,M., Pekcan,S., Alkan,G.,
            Emiroglu,M., Tokgoz,H., Uitto,J., Hauck,F., Bustamante,J., Abel,L.,
            Keles,S., Parvaneh,N., Marr,N., Schwartzberg,P.L., Latour,S.,
            Casanova,J.L. and Boisson-Dupuis,S.
  TITLE     Inherited human ITK deficiency impairs IFN-gamma immunity and
            underlies tuberculosis
  JOURNAL   J Exp Med 220 (1) (2023)
   PUBMED   36326697
  REMARK    GeneRIF: Inherited human ITK deficiency impairs IFN-gamma immunity
            and underlies tuberculosis.
REFERENCE   4  (bases 1 to 4508)
  AUTHORS   Elmore,J., Carter,C., Redko,A., Koylass,N., Bennett,A., Mead,M.,
            Ocasio-Rivera,M., Huang,W., Singh,A. and August,A.
  TITLE     ITK independent development of Th17 responses during
            hypersensitivity pneumonitis driven lung inflammation
  JOURNAL   Commun Biol 5 (1), 162 (2022)
   PUBMED   35210549
  REMARK    GeneRIF: ITK independent development of Th17 responses during
            hypersensitivity pneumonitis driven lung inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4508)
  AUTHORS   Xu,M., Huang,S., Chen,J., Xu,W., Xiang,R., Piao,Y. and Zhao,S.
  TITLE     Cytotoxic lymphocytes-related gene ITK from a systematic CRISPR
            screen could predict prognosis of ovarian cancer patients with
            distant metastasis
  JOURNAL   J Transl Med 19 (1), 447 (2021)
   PUBMED   34702300
  REMARK    GeneRIF: Cytotoxic lymphocytes-related gene ITK from a systematic
            CRISPR screen could predict prognosis of ovarian cancer patients
            with distant metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4508)
  AUTHORS   Rawlings,D.J., Scharenberg,A.M., Park,H., Wahl,M.I., Lin,S.,
            Kato,R.M., Fluckiger,A.C., Witte,O.N. and Kinet,J.P.
  TITLE     Activation of BTK by a phosphorylation mechanism initiated by SRC
            family kinases
  JOURNAL   Science 271 (5250), 822-825 (1996)
   PUBMED   8629002
REFERENCE   7  (bases 1 to 4508)
  AUTHORS   Langhans-Rajasekaran,S.A., Wan,Y. and Huang,X.Y.
  TITLE     Activation of Tsk and Btk tyrosine kinases by G protein beta gamma
            subunits
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8601-8605 (1995)
   PUBMED   7567982
REFERENCE   8  (bases 1 to 4508)
  AUTHORS   Janis,E.M., Siliciano,J.D., Isaac,D.D., Griffin,C.A., Hawkins,A.L.,
            Kozak,C.A. and Desiderio,S.
  TITLE     Mapping of the gene for the tyrosine kinase Itk to a region of
            conserved synteny between mouse chromosome 11 and human chromosome
            5q
  JOURNAL   Genomics 23 (1), 269-271 (1994)
   PUBMED   7829087
REFERENCE   9  (bases 1 to 4508)
  AUTHORS   Gibson,S., Leung,B., Squire,J.A., Hill,M., Arima,N., Goss,P.,
            Hogg,D. and Mills,G.B.
  TITLE     Identification, cloning, and characterization of a novel human
            T-cell-specific tyrosine kinase located at the hematopoietin
            complex on chromosome 5q
  JOURNAL   Blood 82 (5), 1561-1572 (1993)
   PUBMED   8364206
REFERENCE   10 (bases 1 to 4508)
  AUTHORS   Tanaka,N., Asao,H., Ohtani,K., Nakamura,M. and Sugamura,K.
  TITLE     A novel human tyrosine kinase gene inducible in T cells by
            interleukin 2
  JOURNAL   FEBS Lett 324 (1), 1-5 (1993)
   PUBMED   8504851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB150488.1, D13720.1,
            AC010609.7 and BX538196.1.
            
            On Sep 27, 2019 this sequence version replaced NM_005546.3.
            
            Summary: This gene encodes an intracellular tyrosine kinase
            expressed in T-cells. The protein contains both SH2 and SH3 domains
            which are often found in intracellular kinases. It is thought to
            play a role in T-cell proliferation and differentiation. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13720.1, SRR14038195.530147.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422843.8/ ENSP00000398655.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DB150488.1         1-56
            57-230              D13720.1           1-174
            231-231             AC010609.7         62931-62931
            232-2387            D13720.1           176-2331
            2388-2388           AC010609.7         134925-134925
            2389-4422           D13720.1           2333-4366
            4423-4508           BX538196.1         3107-3192
FEATURES             Location/Qualifiers
     source          1..4508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..4508
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /note="IL2 inducible T cell kinase"
                     /db_xref="GeneID:3702"
                     /db_xref="HGNC:HGNC:6171"
                     /db_xref="MIM:186973"
     exon            1..276
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2001
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /EC_number="2.7.10.2"
                     /note="tyrosine-protein kinase LYK; homolog of mouse
                     T-cell itk/tsk; kinase EMT; T-cell-specific kinase;
                     IL-2-inducible T-cell kinase; interleukin-2-inducible
                     T-cell kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase ITK/TSK"
                     /protein_id="NP_005537.3"
                     /db_xref="CCDS:CCDS4336.1"
                     /db_xref="GeneID:3702"
                     /db_xref="HGNC:HGNC:6171"
                     /db_xref="MIM:186973"
                     /translation="MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDR
                     HGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRW
                     VLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPT
                     PEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHE
                     GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVS
                     VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRL
                     RYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKT
                     IREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ
                     RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL
                     DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE
                     VVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL"
     exon            277..381
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..463
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..592
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            593..633
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..785
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..851
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..906
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..989
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1123
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1198
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1370
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1587
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1652
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1771
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1929
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..4508
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /note="hexamer: ATTAAA"
     regulatory      4489..4494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /note="hexamer: AATAAA"
     polyA_site      4494
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
     polyA_site      4508
                     /gene="ITK"
                     /gene_synonym="EMT; LPFS1; LYK; PSCTK2"
                     /note="major polyA site"
ORIGIN      
        1 aacgttgaag gcaagttgcc cttgagcagc tctctgaaga tcaactgcct ccacattgca
       61 ttctttgccc caaaactctt tcctttggtt gtgctaagag gtgatgccca aggtgcacca
      121 cctttcaaga actggatcat gaacaacttt atcctcctgg aagaacagct catcaagaaa
      181 tcccaacaaa agagaagaac ttctccctcg aactttaaag tccgcttctt tgtgttaacc
      241 aaagccagcc tggcatactt tgaagatcgt catgggaaga agcgcacgct gaaggggtcc
      301 attgagctct cccgaatcaa atgtgttgag attgtgaaaa gtgacatcag catcccatgc
      361 cactataaat acccgtttca ggtggtgcat gacaactacc tcctatatgt gtttgctcca
      421 gatcgtgaga gccggcagcg ctgggtgctg gcccttaaag aagaaacgag gaataataac
      481 agtttggtgc ctaaatatca tcctaatttc tggatggatg ggaagtggag gtgctgttct
      541 cagctggaga agcttgcaac aggctgtgcc caatatgatc caaccaagaa tgcttcaaag
      601 aagcctcttc ctcctactcc tgaagacaac aggcgaccac tttgggaacc tgaagaaact
      661 gtggtcattg ccttatatga ctaccaaacc aatgatcctc aggaactcgc actgcggcgc
      721 aacgaagagt actgcctgct ggacagttct gagattcact ggtggagagt ccaggacagg
      781 aatgggcatg aaggatatgt accaagcagt tatctggtgg aaaaatctcc aaataatctg
      841 gaaacctatg agtggtacaa taagagtatc agccgagaca aagctgaaaa acttcttttg
      901 gacacaggca aagaaggagc cttcatggta agggattcca ggactgcagg aacatacacc
      961 gtgtctgttt tcaccaaggc tgttgtaagt gagaacaatc cctgtataaa gcattatcac
     1021 atcaaggaaa caaatgacaa tcctaagcga tactatgtgg ctgaaaagta tgtgttcgat
     1081 tccatccctc ttctcatcaa ctatcaccaa cataatggag gaggcctggt gactcgactc
     1141 cggtatccag tttgttttgg gaggcagaaa gccccagtta cagcagggct gagatacggg
     1201 aaatgggtga tcgacccctc agagctcact tttgtgcaag agattggcag tgggcaattt
     1261 gggttggtgc atctgggcta ctggctcaac aaggacaagg tggctatcaa aaccattcgg
     1321 gaaggggcta tgtcagaaga ggacttcata gaggaggctg aagtaatgat gaaactctct
     1381 catcccaaac tggtgcagct gtatggggtg tgcctggagc aggcccccat ctgcctggtg
     1441 tttgagttca tggagcacgg ctgcctgtca gattatctac gcacccagcg gggacttttt
     1501 gctgcagaga ccctgctggg catgtgtctg gatgtgtgtg agggcatggc ctacctggaa
     1561 gaggcatgtg tcatccacag agacttggct gccagaaatt gtttggtggg agaaaaccaa
     1621 gtcatcaagg tgtctgactt tgggatgaca aggttcgttc tggatgatca gtacaccagt
     1681 tccacaggca ccaaattccc ggtgaagtgg gcatccccag aggttttctc tttcagtcgc
     1741 tatagcagca agtccgatgt gtggtcattt ggtgtgctga tgtgggaagt tttcagtgaa
     1801 ggcaaaatcc cgtatgaaaa ccgaagcaac tcagaggtgg tggaagacat cagtaccgga
     1861 tttcggttgt acaagccccg gctggcctcc acacacgtct accagattat gaatcactgc
     1921 tggaaagaga gaccagaaga tcggccagcc ttctccagac tgctgcgtca actggctgaa
     1981 attgcagaat caggacttta gtagagactg agtaccaggc cacgggctgc agatcctgaa
     2041 tggaggaagg atatgtcctc attccataga gcattagaag ctgccaccag cccaggaccc
     2101 tccagaggca gcctggcctg tggcatcagt ccctgagtca ccatggaagc agcatcctga
     2161 ccacagctgg cagtcaagcc acagctggag ggtcagccac caagctggga gctgagccag
     2221 aacaggagtg atgtctctgc ccttcctcta gcctcttgtc acatgtggtg cacaaacctc
     2281 aacctgacag ctttcagaca gcattcttgc acttcttagc aacagagaga gacatgagta
     2341 agacccagat tgctattttt attgttattt ttaacatgaa tctaaagttt atggttccag
     2401 ggacttttta tttgacccaa caacacagta tcccaggata tggaggcaag gggaacaaag
     2461 agcatgagtc tttttccaag aaaactggtg agttaagtaa gattagagtg agtgtgctct
     2521 gttgctgtga tgctgtcagc cacagcttcc tgccgtagag aatgatagag cagctgctca
     2581 cacaggaggc cggatattct gagaagcagc tttatgaggt tttacagagt atgctgctac
     2641 ctctctcctt gaagggagca tggcgagacc cattggatgg attggggtga acagttcagg
     2701 tcccatgctt ggagcattgg gtatctgatg tctgcaccag aacaagagaa cctctgacgg
     2761 tggagaacca tgtggtgcaa gaagagatct taggtctctt cttttatacc aagctcatct
     2821 tttataccaa gctgtgcagg tgactatgcc tcctcttctg cacagaatgc ttccaccagc
     2881 atcctgagaa gaaatgatta cttctgaaaa acatcctttt ttccagcctc tgggaatcag
     2941 ccccccctct ctgcactatc cgatcctcat caacagaggg cagcattgtg ttggtcaatg
     3001 ttcccttggc gagcaattga aacttgttta ggccctaggg ttgagcaatt ttaaggttga
     3061 gactccaagt ctcctaaaat tctaggagag aaataaagag tctgtttttg ctcaaaccat
     3121 caggatggaa acagtcaggc actgactggg gtgcttccaa gaggcatgag agtgcctact
     3181 ctggcttgag cacttctata tgcaaggtga atatgtactg agctaggaga cttccctgca
     3241 aaatctctgt tcaccctggg ttcacatccc catgaggtaa tattattatt cccattttac
     3301 aaataatgta actgaggctt taaaaagcca agacatctgc ccaaagtgat ggaactagaa
     3361 agtctagagc tggtattcta gcccaaatct gtctgaccgc aatacacaga ttctttattc
     3421 ctattcgaca ctggcttcta ctgaaaatga aacggattgc agagggaata aatacaaaga
     3481 tggaaagcca gtaaagaagt cagtatagaa ccactagcga atagtgttgc tctggcacag
     3541 accactgtgg ttgatggcat ggccctccaa cttggaatag gattttcctt ttcctattct
     3601 gtatccttac cttggtcatg ttaatgactt tggagttatt cagttaatga ccctttaatt
     3661 ctcacaacca accagtcatg ttgcttgaag ccatttatag acgagcttca aagcaacttt
     3721 aaaagattct tctgtagaag tatgagttct tcctttaatt atcattccaa ctttcagctg
     3781 tagtcttctt gaacacttca tgaggaggga cattccctga tataagagag gatggtgttg
     3841 caattggctc tttctaaatc atgtgacgtt ttgactggct tgagattcag atgcataatt
     3901 tttaattata attattgtga agtggagagc ctcaagataa aactctgtca ttcagaagat
     3961 gattttactc agcttatcca aaattatctc tgtttacttt ttagaatttt gtacattatc
     4021 ttttgggatc cttaattaga gatgatttct ggaacattca gtctagaaag aaaacattgg
     4081 aattgactga tctctgtggt ttggtttaga aaattcccct gtgcatggta ttaccttttt
     4141 caagctcaga ttcatctaat cctcaactgt acatgtgtac attcttcacc tcctggtgcc
     4201 ctatcccgca aaatgggctt cctgcctggt ttttctcttc tcacattttt taaatggtcc
     4261 cctgtgtttg tagagaactc ccttatacag agttttggtt ctagttttat ttcgtagatt
     4321 ttgcattttg taccttttga gactatgtat ttatatttgg atcagatgca tatttattaa
     4381 tgtacagtca ctgctagtgt tcaaaataaa aatgttacaa atacctgtta tcctttgtag
     4441 agcacacaga gttaaaagtt gaatatagca atattaaagc tgcattttaa taaatatggt
     4501 gcataggg
//
